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Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats

  • Authors:
    • Li Ling
    • Zhen Tan
    • Changning Zhang
    • Shuyan Gui
    • Yuanyuan Hu
    • Libo Chen
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Guangdong Medical College Affiliated Shenzhen Nanshan Hospital, Shenzhen, Guangdong 518052, P.R. China, Department of Neurosurgery, Shenzhen Children's Hospital, Shenzhen, Guangdong 518026, P.R. China
    Copyright: © Ling et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2704-2714
    |
    Published online on: February 5, 2018
       https://doi.org/10.3892/ijmm.2018.3457
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Abstract

Diabetic nephropathy (DN) is one of the most common complications associated with type I and II diabetes mellitus. Long noncoding RNAs (lncRNAs) have been implicated in various physiological and pathological processes, and recent evidence has demonstrated that they are involved in the process of the epithelial‑mesenchymal transition (EMT). In the present study, the potential functions of lncRNA ENSRNOG00000037522 during the EMT process in DN were investigated. The results identified that the level of the lncRNA ENSRNOG00000037522 was significantly increased in kidney tissues collected from rats with streptozocin (STZ)‑induced DN accompanied by impairment of the glomerular podocytes. It was further demonstrated that the silencing of lncRNA ENSRNOG00000037522 by small interfering RNA transfection partially restored the podocyte function. In addition, knockdown of lncRNA ENSRNOG00000037522 repaired the damage to the podocytes via regulating vimentin, podocalyxin‑like 1 and nephrin expression. In conclusion, the current results demonstrated that lncRNA ENSRNOG00000037522 serves a pivotal role in the podocyte EMT in DN.
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Copy and paste a formatted citation
Spandidos Publications style
Ling L, Tan Z, Zhang C, Gui S, Hu Y and Chen L: Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats. Int J Mol Med 41: 2704-2714, 2018.
APA
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., & Chen, L. (2018). Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats. International Journal of Molecular Medicine, 41, 2704-2714. https://doi.org/10.3892/ijmm.2018.3457
MLA
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., Chen, L."Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats". International Journal of Molecular Medicine 41.5 (2018): 2704-2714.
Chicago
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., Chen, L."Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats". International Journal of Molecular Medicine 41, no. 5 (2018): 2704-2714. https://doi.org/10.3892/ijmm.2018.3457
Copy and paste a formatted citation
x
Spandidos Publications style
Ling L, Tan Z, Zhang C, Gui S, Hu Y and Chen L: Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats. Int J Mol Med 41: 2704-2714, 2018.
APA
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., & Chen, L. (2018). Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats. International Journal of Molecular Medicine, 41, 2704-2714. https://doi.org/10.3892/ijmm.2018.3457
MLA
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., Chen, L."Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats". International Journal of Molecular Medicine 41.5 (2018): 2704-2714.
Chicago
Ling, L., Tan, Z., Zhang, C., Gui, S., Hu, Y., Chen, L."Long noncoding RNA ENSRNOG00000037522 is involved in the podocyte epithelial‑mesenchymal transition in diabetic rats". International Journal of Molecular Medicine 41, no. 5 (2018): 2704-2714. https://doi.org/10.3892/ijmm.2018.3457
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