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Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway

  • Authors:
    • Xiaoyu Chai
    • Dan Sun
    • Qian Han
    • Liang Yi
    • Yanping Wu
    • Xinmin Liu
  • View Affiliations / Copyright

    Affiliations: Department of Geriatrics, Peking University First Hospital, Beijing 100034, P.R. China
    Copyright: © Chai et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2461-2472
    |
    Published online on: February 6, 2018
       https://doi.org/10.3892/ijmm.2018.3462
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Abstract

The present study was designed to examine whether hypoxia induces the proliferation, migration and differentiation of pulmonary arterial fibroblasts (PAFs) via the PI3K/Akt/p70S6K signaling pathway. PAFs were subjected to normoxia (21% O2) or hypoxia (1% O2). The proliferation, migration, differentiation and cellular p110α, p‑Akt, and p‑p70S6K expression levels of the PAFs were examined in vitro. In addition, rats were maintained under hypoxic conditions, and the right ventricular systolic pressure (RVSP), right ventricular hypertrophy index (RVHI) and right ventricular weight/body weight ratio (RV/BW) were examined. The expression levels of p110α, p‑Akt, p70S6K, fibronectin and α‑SMA in the rat pulmonary vessels were also examined. Hypoxia significantly elevated the proliferation, migration and differentiation of rat PAFs. It also strongly elevated the expression of p110α, p‑Akt and p‑p70S6K in PAFs in vitro. NVP‑BEZ235 was revealed to significantly reduce the hypoxia‑induced proliferation, migration and differentiation. In vivo experiments demonstrated that hypoxia significantly induced the elevation of RVSP, RVHI, RV/BW, medial thickening, adventitious thickening, and fibronectin and collagen deposition around pulmonary artery walls. The expression of p110α, p‑Akt and p70S6K was evident in the pulmonary arteries of the hypoxic rats. NVP‑BEZ235 significantly reduced the hypoxia‑induced hypoxic pulmonary vascular remodeling, as well as fibronectin and collagen deposition in the pulmonary arteries. Therefore, hypoxia was demonstrated to induce the proliferation, migration and differentiation of PAFs and the hypoxic pulmonary vascular remodeling of rats via the PI3K/Akt/p70S6K signaling pathway.
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View References

1 

Oudiz RJ: Classification of pulmonary hypertension. Cardiol Clin. 34:359–361. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Poor HD, Girgis R and Studer SM: World Health Organization Group III pulmonary hypertension. Prog Cardiovasc Dis. 55:119–127. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Nathan SD and Hassoun PM: Pulmonary hypertension due to lung disease and/or hypoxia. Clin Chest Med. 34:695–705. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Veit F, Pak O, Brandes RP and Weissmann N: Hypoxia-dependent reactive oxygen species signaling in the pulmonary circulation: Focus on ion channels. Antioxid Redox Signal. 22:537–552. 2015. View Article : Google Scholar :

5 

Humbert M, Montani D, Evgenov OV and Simonneau G: Definition and classification of pulmonary hypertension. Handb Exp Pharmacol. 218:3–29. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Veith C, Schermuly RT, Brandes RP and Weissmann N: Molecular mechanisms of hypoxia-inducible factor-induced pulmonary arterial smooth muscle cell alterations in pulmonary hypertension. J Physiol. 594:1167–1177. 2016. View Article : Google Scholar

7 

Stenmark KR, Nozik-Grayck E, Gerasimovskaya E, Anwar A, Li M, Riddle S and Frid M: The adventitia: Essential role in pulmonary vascular remodeling. Compr Physiol. 1:141–161. 2011.PubMed/NCBI

8 

Chazova I, Loyd JE, Zhdanov VS, Newman JH, Belenkov Y and Meyrick B: Pulmonary artery adventitial changes and venous involvement in primary pulmonary hypertension. Am J Pathol. 146:389–397. 1995.PubMed/NCBI

9 

Krick S, Hänze J, Eul B, Savai R, Seay U, Grimminger F, Lohmeyer J, Klepetko W, Seeger W and Rose F: Hypoxia-driven proliferation of human pulmonary artery fibroblasts: Cross-talk between HIF-1alpha and an autocrine angiotensin system. FASEB J. 19:857–859. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Stenmark KR, Davie N, Frid M, Gerasimovskaya E and Das M: Role of the adventitia in pulmonary vascular remodeling. Physiology. 21:134–145. 2006. View Article : Google Scholar : PubMed/NCBI

11 

Das M, Bouchey DM, Moore MJ, Hopkins DC, Nemenoff RA and Stenmark KR: Hypoxia-induced proliferative response of vascular adventitial fibroblasts is dependent on g protein-mediated activation of mitogen-activated protein kinases. J Biol Chem. 276:15631–15640. 2001. View Article : Google Scholar : PubMed/NCBI

12 

Si Y, Ren J, Wang P, Rateri DL, Daugherty A, Shi XD, Kent KC and Liu B: Protein kinase C-delta mediates adventitial cell migration through regulation of monocyte chemoattractant protein-1 expression in a rat angioplasty model. Arterioscler Thromb Vasc Biol. 32:943–954. 2012. View Article : Google Scholar : PubMed/NCBI

13 

Conte E, Fruciano M, Fagone E, Gili E, Caraci F, Iemmolo M, Crimi N and Vancheri C: Inhibition of PI3K prevents the proliferation and differentiation of human lung fibroblasts into myofibroblasts: The role of class I P110 isoforms. PLoS One. 6:e246632011. View Article : Google Scholar : PubMed/NCBI

14 

Das M, Dempsey EC, Reeves JT and Stenmark KR: Selective expansion of fibroblast subpopulations from pulmonary artery adventitia in response to hypoxia. Am J Physiol Lung Cell Mol Physiol. 282:L976–L986. 2002. View Article : Google Scholar : PubMed/NCBI

15 

Zhang L, Li Y, Liu Y, Wang X, Chen M, Xing Y and Zhu D: STAT3-mediated MMP-2 expression is required for 15-HETE-induced vascular adventitial fibroblast migration. J Steroid Biochem Mol Biol. 149:106–117. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Zhang L, Chen Y, Li G, Chen M, Huang W, Liu Y and Li Y: TGF-β1/FGF-2 signaling mediates the 15-HETE-induced differentiation of adventitial fibroblasts into myofibroblasts. Lipids Health Dis. 15:22016. View Article : Google Scholar

17 

Li Y, Zhang L, Wang X, Chen M, Liu Y, Xing Y, Wang X, Gao S and Zhu D: Elk-1-mediated 15-lipoxygenase expression is required for hypoxia-induced pulmonary vascular adventitial fibroblast dynamics. Acta Physiol (Oxf). 218:276–289. 2016. View Article : Google Scholar

18 

Zhang Y, Talwar A, Tsang D, Bruchfeld A, Sadoughi A, Hu M, Omonuwa K, Cheng KF, Al-Abed Y and Miller EJ: Macrophage migration inhibitory factor mediates hypoxia-induced pulmonary hypertension. Mol Med. 18:215–223. 2012. View Article : Google Scholar :

19 

Anwar A, Li M, Frid MG, Kumar B, Gerasimovskaya EV, Riddle SR, McKeon BA, Thukaram R, Meyrick BO, Fini MA and Stenmark KR: Osteopontin is an endogenous modulator of the constitutively activated phenotype of pulmonary adventitial fibroblasts in hypoxic pulmonary hypertension. Am J Physiol Lung Cell Mol Physiol. 303:L1–L11. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Yuan W, Liu W, Cai H, Sun X, Yang D, Xu F and Jin C: SB-431542, a specific inhibitor of the TGF-β type I receptor inhibits hypoxia-induced proliferation of pulmonary artery adventitial fibroblasts. Pharmazie. 71:94–100. 2016.PubMed/NCBI

21 

Welsh DJ, Scott PH and Peacock AJ: p38 MAP kinase isoform activity and cell cycle regulators in the proliferative response of pulmonary and systemic artery fibroblasts to acute hypoxia. Pulm Pharmacol Ther. 19:128–138. 2006. View Article : Google Scholar

22 

Carlin CM, Celnik DF, Pak O, Wadsworth R, Peacock AJ and Welsh DJ: Low-dose fluvastatin reverses the hypoxic pulmonary adventitial fibroblast phenotype in experimental pulmonary hypertension. Am J Respir Cell Mol Biol. 47:140–148. 2012. View Article : Google Scholar : PubMed/NCBI

23 

Panzhinskiy E, Zawada WM, Stenmark KR and Das M: Hypoxia induces unique proliferative response in adventitial fibroblasts by activating PDGFβ receptor-JNK1 signalling. Cardiovasc Res. 95:356–365. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Gerasimovskaya EV, Tucker DA and Stenmark KR: Activation of phosphatidylinositol 3-kinase, Akt, and mammalian target of rapamycin is necessary for hypoxia-induced pulmonary artery adventitial fibroblast proliferation. J Appl Physiol (1985). 98:722–731. 2005. View Article : Google Scholar

25 

Garat CV, Crossno JT Jr, Sullivan TM, Reusch JE and Klemm DJ: Inhibition of phosphatidylinositol 3-kinase/Akt signaling attenuates hypoxia-induced pulmonary artery remodeling and suppresses CREB depletion in arterial smooth muscle cells. J Cardiovasc Pharmacol. 62:539–548. 2013. View Article : Google Scholar : PubMed/NCBI

26 

Fan Z, Li C, Qin C, Xie L, Wang X, Gao Z, Qiangbacuozhen, Wang T, Yu L and Liu H: Role of the PI3K/AKT pathway in modulating cytoskeleton rearrangements and phenotype switching in rat pulmonary arterial vascular smooth muscle cells. DNA Cell Biol. 33:12–19. 2014. View Article : Google Scholar

27 

Woodward HN, Anwar A, Riddle S, Taraseviciene-Stewart L, Fragoso M, Stenmark KR and Gerasimovskaya EV: PI3K, Rho, and ROCK play a key role in hypoxia-induced ATP release and ATP-stimulated angiogenic responses in pulmonary artery vasa vasorum endothelial cells. Am J Physiol Lung Cell Mol Physiol. 297:L954–L964. 2009. View Article : Google Scholar : PubMed/NCBI

28 

Stenmark KR, Tuder RM and El Kasmi KC: Metabolic reprogramming and inflammation act in concert to control vascular remodeling in hypoxic pulmonary hypertension. J Appl Physiol (1985). 119:1164–1172. 2015. View Article : Google Scholar

29 

Weichhart T and Säemann MD: The PI3K/Akt/mTOR pathway in innate immune cells: Emerging therapeutic applications. Ann Rheum Dis. 67(Suppl 3): iii70–iii74. 2008. View Article : Google Scholar : PubMed/NCBI

30 

Committee for the Update of the Guide for the Care and Use of Laboratory Animals: Guide for the Care and Use of Laboratory Animals. 8th edition. The National Academies Press; Washington, DC: pp. 11–151. 2011

31 

Xu X, Wang X, Geng J, Li F, Yang T and Dai H: Rapamycin regulates connective tissue growth factor expression of lung epithelial cells via phosphoinositide 3-kinase. Exp Biol Med (Maywood). 238:1082–1094. 2013. View Article : Google Scholar

32 

Cantley LC: The phosphoinositide 3-kinase pathway. Science. 296:1655–1657. 2002. View Article : Google Scholar : PubMed/NCBI

33 

Fang Y, Vilella-Bach M, Bachmann R, Flanigan A and Chen J: Phosphatidic acid-mediated mitogenic activation of mTOR signaling. Science. 294:1942–1945. 2001. View Article : Google Scholar : PubMed/NCBI

34 

Gesbert F, Sellers WR, Signoretti S, Loda M and Griffin JD: BCR/ABL regulates expression of the cyclin-dependent kinase inhibitor p27Kip1 through the phosphatidylinositol 3-kinase/AKT pathway. J Biol Chem. 275:39223–39230. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Xu EZ, Kantores C, Ivanovska J, Engelberts D, Kavanagh BP, McNamara PJ and Jankov RP: Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. Am J Physiol Heart Circ Physiol. 299:H1854–H1864. 2010. View Article : Google Scholar : PubMed/NCBI

36 

Berven LA and Crouch MF: Cellular function of p70S6K: A role in regulating cell motility. Immunol Cell Biol. 78:447–451. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Marinov M, Fischer B and Arcaro A: Targeting mTOR signaling in lung cancer. Crit Rev Oncol Hematol. 63:172–182. 2007. View Article : Google Scholar : PubMed/NCBI

38 

Maira SM, Stauffer F, Brueggen J, Furet P, Schnell C, Fritsch C, Brachmann S, Chène P, De Pover A, Schoemaker K, et al: Identification and characterization of NVP-BEZ235, a new orally available dual phosphatidylinositol 3-kinase/mammalian target of rapamycin inhibitor with potent in vivo antitumor activity. Mol Cancer Ther. 7:1851–1863. 2008. View Article : Google Scholar : PubMed/NCBI

39 

Cui B, Tao J and Yang Y: Studies on the expression patterns of class I PI3K catalytic subunits and its prognostic significance in colorectal cancer. Cell Biochem Biophys. 62:47–54. 2012. View Article : Google Scholar

40 

Shimoda LA and Laurie SS: HIF and pulmonary vascular responses to hypoxia. J Appl Physiol (1985). 116:867–874. 2014. View Article : Google Scholar

41 

Rogers SC, Said A, Corcuera D, McLaughlin D, Kell P and Doctor A: Hypoxia limits antioxidant capacity in red blood cells by altering glycolytic pathway dominance. FASEB J. 23:3159–3170. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Chai X, Sun D, Han Q, Yi L, Wu Y and Liu X: Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway. Int J Mol Med 41: 2461-2472, 2018.
APA
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., & Liu, X. (2018). Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway. International Journal of Molecular Medicine, 41, 2461-2472. https://doi.org/10.3892/ijmm.2018.3462
MLA
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., Liu, X."Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway". International Journal of Molecular Medicine 41.5 (2018): 2461-2472.
Chicago
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., Liu, X."Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway". International Journal of Molecular Medicine 41, no. 5 (2018): 2461-2472. https://doi.org/10.3892/ijmm.2018.3462
Copy and paste a formatted citation
x
Spandidos Publications style
Chai X, Sun D, Han Q, Yi L, Wu Y and Liu X: Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway. Int J Mol Med 41: 2461-2472, 2018.
APA
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., & Liu, X. (2018). Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway. International Journal of Molecular Medicine, 41, 2461-2472. https://doi.org/10.3892/ijmm.2018.3462
MLA
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., Liu, X."Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway". International Journal of Molecular Medicine 41.5 (2018): 2461-2472.
Chicago
Chai, X., Sun, D., Han, Q., Yi, L., Wu, Y., Liu, X."Hypoxia induces pulmonary arterial fibroblast proliferation, migration, differentiation and vascular remodeling via the PI3K/Akt/p70S6K signaling pathway". International Journal of Molecular Medicine 41, no. 5 (2018): 2461-2472. https://doi.org/10.3892/ijmm.2018.3462
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