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Article Open Access

Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation

Corrigendum in: /10.3892/ijmm.2019.4177
  • Authors:
    • Kou‑Gi  Shyu
    • Marappan  Velusamy
    • Chih‑Wei  Hsia
    • Chih‑Hao  Yang
    • Chih‑Hsuan  Hsia
    • Duen‑Suey  Chou
    • Thanasekaran  Jayakumar
    • Joen‑Rong  Sheu
    • Jiun‑Yi  Li
  • View Affiliations / Copyright

    Affiliations: Division of Cardiology, Shin Kong Wu Ho‑Su Memorial Hospital, Taipei 111, Taiwan, R.O.C., Department of Chemistry, North Eastern Hill University, Shillong, Meghalaya 793022, India, Graduate Institute of Medical Sciences and Department of Pharmacology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 110, Taiwan, R.O.C.
    Copyright: © Shyu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2589-2600
    |
    Published online on: February 7, 2018
       https://doi.org/10.3892/ijmm.2018.3472
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Abstract

Since cisplatin achieved clinical success, transition metal platinum (Pt) drugs have been effectively used for the treatment of cancer. Iridium (Ir) compounds are considered to be potential alternatives to Pt compounds, as they possess promising anticancer effects with minor side effects. Platelet activation is associated with the metastasis and progression of cancer, and also with arterial thrombosis. Therefore, it is necessary to develop novel, effective antithrombotic agents. An Ir (III)‑derived complex, [Ir (Cp*) 1‑(2‑pyridyl)‑3‑(3‑methoxyphenyl)imidazo[1,5‑a]pyridine Cl]BF4 (Ir‑3), was developed as a novel antiplatelet drug. Ir‑3 exerted more potent inhibitory activity on platelet aggregation stimulated by collagen compared with other agonists, including thrombin. In collagen‑activated platelets, Ir‑3 also inhibited adenosine trisphosphate release, intracellular Ca+2 mobilization and surface P‑selectin expression, as well as the phosphorylation of phospholipase Cγ2 (PLCγ2), protein kinase C (PKC), protein kinase B (Akt) and c‑Jun N‑terminal kinase (JNK) 1, but not p38 mitogen‑activated protein kinase or extracellular signal‑regulated kinases. Ir‑3 did not markedly affect phorbol 12, 13‑dibutyrate‑stimulated platelet aggregation. Neither the adenylate cyclase inhibitor SQ22536 nor the guanylate cyclase inhibitor 1H‑[1, 2, 4] oxadiazolo [4,3‑a]quinoxalin‑1‑one significantly reversed the Ir‑3‑mediated inhibition of platelet aggregation. Furthermore, Ir‑3 had no considerable diminishing effects on OH radical signals in collagen‑stimulated platelets or Fenton reaction solution. In conclusion, Ir‑3 serves a novel function in the inhibition of platelet aggregation through inhibiting the PLCγ2‑PKC cascade, and the subsequent suppression of Akt and JNK1 activation. Therefore, Ir‑3 may be a potential novel therapeutic agent for the treatment of thromboembolic disorders, or the interplay between platelets and tumor cells which contributes to tumor cell proliferation and progression.
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Copy and paste a formatted citation
Spandidos Publications style
Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR and Li JY: Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177. Int J Mol Med 41: 2589-2600, 2018.
APA
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D. ... Li, J. (2018). Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177. International Journal of Molecular Medicine, 41, 2589-2600. https://doi.org/10.3892/ijmm.2018.3472
MLA
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D., Jayakumar, T., Sheu, J., Li, J."Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177". International Journal of Molecular Medicine 41.5 (2018): 2589-2600.
Chicago
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D., Jayakumar, T., Sheu, J., Li, J."Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177". International Journal of Molecular Medicine 41, no. 5 (2018): 2589-2600. https://doi.org/10.3892/ijmm.2018.3472
Copy and paste a formatted citation
x
Spandidos Publications style
Shyu KG, Velusamy M, Hsia CW, Yang CH, Hsia CH, Chou DS, Jayakumar T, Sheu JR and Li JY: Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177. Int J Mol Med 41: 2589-2600, 2018.
APA
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D. ... Li, J. (2018). Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177. International Journal of Molecular Medicine, 41, 2589-2600. https://doi.org/10.3892/ijmm.2018.3472
MLA
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D., Jayakumar, T., Sheu, J., Li, J."Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177". International Journal of Molecular Medicine 41.5 (2018): 2589-2600.
Chicago
Shyu, K., Velusamy, M., Hsia, C., Yang, C., Hsia, C., Chou, D., Jayakumar, T., Sheu, J., Li, J."Novel iridium (III)‑derived organometallic compound for the inhibition of human platelet activation Corrigendum in /10.3892/ijmm.2019.4177". International Journal of Molecular Medicine 41, no. 5 (2018): 2589-2600. https://doi.org/10.3892/ijmm.2018.3472
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