Open Access

LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling

  • Authors:
    • Yan-Song Qiu
    • Ning-Ning Jiang
    • Yan Zhou
    • Kuai-Yun Yu
    • Hong-Yan Gong
    • Guang-Jun Liao
  • View Affiliations

  • Published online on: February 8, 2018     https://doi.org/10.3892/ijmm.2018.3476
  • Pages: 2755-2763
  • Copyright: © Qiu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

The present study assessed the biological functions of LIM domain only 3 (LMO3) in gastric cancer (GC) investigated and the underlying molecular mechanisms. It was revealed that the expression of LMO3 was significantly upregulated in GC tissues. A GC tissue microarray (n=164) indicated that LMO3 expression was closely associated with clinicopathological factors, as well as overall survival and disease-free survival of patients. After knockdown of LMO3 in MGC-803 and SGC-7901 cells, the invasion and proliferation were obviously suppressed. Furthermore, LMO3 knockdown suppressed the phosphorylation of Akt, mammalian target of rapamycin (mTOR) and glycogen synthase kinase (GSK)3β signaling. An inhibitor of mTOR, dactolisib, abrogated recombinant LMO3 protein-induced GC cell invasion and proliferation, while an inhibitor of GSK3β, CHIR-98014, only abrogated rLMO3 protein-induced proliferation. These results suggested that LMO3 promotes GC cell invasion and proliferation mainly through Akt/mTOR and Akt/GSK3β signaling. LMO3 may serve as a potential therapeutic target for GC in the future.
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May-2018
Volume 41 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Qiu Y, Jiang N, Zhou Y, Yu K, Gong H and Liao G: LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling. Int J Mol Med 41: 2755-2763, 2018
APA
Qiu, Y., Jiang, N., Zhou, Y., Yu, K., Gong, H., & Liao, G. (2018). LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling. International Journal of Molecular Medicine, 41, 2755-2763. https://doi.org/10.3892/ijmm.2018.3476
MLA
Qiu, Y., Jiang, N., Zhou, Y., Yu, K., Gong, H., Liao, G."LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling". International Journal of Molecular Medicine 41.5 (2018): 2755-2763.
Chicago
Qiu, Y., Jiang, N., Zhou, Y., Yu, K., Gong, H., Liao, G."LMO3 promotes gastric cancer cell invasion and proliferation through Akt-mTOR and Akt-GSK3β signaling". International Journal of Molecular Medicine 41, no. 5 (2018): 2755-2763. https://doi.org/10.3892/ijmm.2018.3476