Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2018 Volume 41 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 41 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study

  • Authors:
    • Yanyun Li
    • Minjian Chen
    • Cuiping Liu
    • Yankai Xia
    • Bo Xu
    • Yanhui Hu
    • Ting Chen
    • Meiping Shen
    • Wei Tang
  • View Affiliations / Copyright

    Affiliations: Department of Endocrinology, Jiangyin People's Hospital, School of Medicine, Southeast University, Jiangyin, Jiangsu 214400, P.R. China, State Key Laboratory of Reproductive Medicine, Institute of Toxicology, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of General Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210036, P.R. China, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, P.R. China, Department of Science and Education Section, Maternity and Child Care Hospital of Nanjing, Nanjing, Jiangsu 210004, P.R. China
  • Pages: 3006-3014
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ijmm.2018.3494
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Papillary thyroid carcinoma (PTC) is the most common thyroid cancer. Nuclear magnetic resonance (NMR)‑based metabolomic technique is the gold standard in metabolite structural elucidation, and can provide different coverage of information compared with other metabolomic techniques. Here, we firstly conducted NMR based metabolomics study regarding detailed metabolic changes especially metabolic pathway changes related to PTC pathogenesis. 1H NMR-based metabolomic technique was adopted in conju­nction with multivariate analysis to analyze matched tumor and normal thyroid tissues obtained from 16 patients. The results were further annotated with Kyoto Encyclopedia of Genes and Genomes (KEGG), and Human Metabolome Database, and then were analyzed using modules of pathway analysis and enrichment analysis of MetaboAnalyst 3.0. Based on the analytical techniques, we established the models of principal component analysis (PCA), partial least squares-discriminant analysis (PLS-DA), and orthogonal partial least-squares discriminant analysis (OPLS‑DA) which could discriminate PTC from normal thyroid tissue, and found 15 robust differentiated metabolites from two OPLS-DA models. We identified 8 KEGG pathways and 3 pathways of small molecular pathway database which were significantly related to PTC by using pathway analysis and enrichment analysis, respectively, through which we identified metabolisms related to PTC including branched chain amino acid metabolism (leucine and valine), other amino acid metabolism (glycine and taurine), glycolysis (lactate), tricarboxylic acid cycle (citrate), choline metabolism (choline, ethanolamine and glycerolphosphocholine) and lipid metabolism (very-low‑density lipoprotein and low-density lipoprotein). In conclusion, the PTC was characterized with increased glycolysis and inhibited tricarboxylic acid cycle, increased oncogenic amino acids as well as abnormal choline and lipid metabolism. The findings in this study provide new insights into detailed metabolic changes of PTC, and hold great potential in the treatment of PTC.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Cheng LL, Burns MA, Taylor JL, He W, Halpern EF, McDougal WS and Wu CL: Metabolic characterization of human prostate cancer with tissue magnetic resonance spectroscopy. Cancer Res. 65:3030–3034. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Brindle JT, Antti H, Holmes E, Tranter G, Nicholson JK, Bethell HW, Clarke S, Schofield PM, McKilligin E, Mosedale DE, et al: Rapid and noninvasive diagnosis of the presence and severity of coronary heart disease using 1H-NMR-based metabonomics. Nat Med. 8:1439–1444. 2002. View Article : Google Scholar : PubMed/NCBI

4 

Sreekumar A, Poisson LM, Rajendiran TM, Khan AP, Cao Q, Yu J, Laxman B, Mehra R, Lonigro RJ, Li Y, et al: Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression. Nature. 457:910–914. 2009. View Article : Google Scholar : PubMed/NCBI

5 

El-Bacha T, Struchiner CJ, Cordeiro MT, Almeida FC, Marques ET Jr and Da Poian AT: 1H nuclear magnetic resonance metabolomics of plasma unveils liver dysfunction in dengue patients. J Virol. 90:7429–7443. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Shang X, Zhong X and Tian X: Metabolomics of papillary thyroid carcinoma tissues: potential biomarkers for diagnosis and promising targets for therapy. Tumour Biol. 37:11163–11175. 2016. View Article : Google Scholar : PubMed/NCBI

7 

Chen M, Shen M, Li Y, Liu C, Zhou K, Hu W, Xu B, Xia Y and Tang W: GC-MS-based metabolomic analysis of human papillary thyroid carcinoma tissue. Int J Mol Med. 36:1607–1614. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Pan Z and Raftery D: Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem. 387:525–527. 2007. View Article : Google Scholar

9 

Jordan KW, Adkins CB, Cheng LL and Faquin WC: Application of magnetic-resonance-spectroscopy-based metabolomics to the fine-needle aspiration diagnosis of papillary thyroid carcinoma. Acta Cytol. 55:584–589. 2011. View Article : Google Scholar

10 

Miccoli P, Torregrossa L, Shintu L, Magalhaes A, Chandran J, Tintaru A, Ugolini C, Minuto MN, Miccoli M, Basolo F, et al: Metabolomics approach to thyroid nodules: a high-resolution magic-angle spinning nuclear magnetic resonance-based study. Surgery. 152:1118–1124. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Deja S, Dawiskiba T, Balcerzak W, Orczyk-Pawiłowicz M, Głód M, Pawełka D and Młynarz P: Follicular adenomas exhibit a unique metabolic profile. 1H NMR studies of thyroid lesions. PLoS One. 8:e846372013. View Article : Google Scholar

12 

DeLellis RA, Lloyd RV, Heitz PU and Eng C: Organization Classification of Tumours Pathology and Genetics of Tumours of Endocrine Organs. 8. 3rd edition. IARC Press; Lyon: 2004

13 

Jordan KW, Nordenstam J, Lauwers GY, Rothenberger DA, Alavi K, Garwood M and Cheng LL: Metabolomic characterization of human rectal adenocarcinoma with intact tissue magnetic resonance spectroscopy. Dis Colon Rectum. 52:520–525. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Du J, Yuan Z, Ma Z, Song J, Xie X and Chen Y: KEGG-PATH: Kyoto Encyclopedia of Genes and Genomes-based pathway analysis using a path analysis model. Mol Biosyst. 10:2441–2447. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Wishart DS, Jewison T, Guo AC, Wilson M, Knox C, Liu Y, Djoumbou Y, Mandal R, Aziat F, Dong E, et al: HMDB 3.0 - the Human Metabolome Database in 2013. Nucleic Acids Res. 41:D801–D807. 2013. View Article : Google Scholar

16 

Xia J, Sinelnikov IV, Han B and Wishart DS: Metabo-Analyst 3.0 - making metabolomics more meaningful. Nucleic Acids Res. 43:W251–W257. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Frolkis A, Knox C, Lim E, Jewison T, Law V, Hau DD, Liu P, Gautam B, Ly S, Guo AC, et al: SMPDB: The Small Molecule Pathway Database. Nucleic Acids Res. 38(Suppl 1): D480–D487. 2010. View Article : Google Scholar :

18 

Anthony ML, Rose VS, Nicholson JK and Lindon JC: Classification of toxin-induced changes in 1H NMR spectra of urine using an artificial neural network. J Pharm Biomed Anal. 13:205–211. 1995. View Article : Google Scholar : PubMed/NCBI

19 

Lamour SD, Straschil U, Saric J and Delves MJ: Changes in metabolic phenotypes of Plasmodium falciparum in vitro cultures during gametocyte development. Malar J. 13:468–478. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Bahety P, Tan YM, Hong Y, Zhang L, Chan EC and Ee PL: Metabotyping of docosahexaenoic acid - treated Alzheimer's disease cell model. PLoS One. 9:e901232014. View Article : Google Scholar : PubMed/NCBI

21 

Wang Z, Klipfell E, Bennett BJ, Koeth R, Levison BS, Dugar B, Feldstein AE, Britt EB, Fu X, Chung YM, et al: Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease. Nature. 472:57–63. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, et al: Detrimental effects of adenosine signaling in sickle cell disease. Nat Med. 17:79–86. 2011. View Article : Google Scholar

23 

Wang TJ, Larson MG, Vasan RS, Cheng S, Rhee EP, McCabe E, Lewis GD, Fox CS, Jacques PF, Fernandez C, et al: Metabolite profiles and the risk of developing diabetes. Nat Med. 17:448–453. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Chen M, Zhou K, Chen X, Qiao S, Hu Y, Xu B, Xu B, Han X, Tang R, Mao Z, et al: Metabolomic analysis reveals metabolic changes caused by bisphenol A in rats. Toxicol Sci. 138:256–267. 2014. View Article : Google Scholar : PubMed/NCBI

25 

Tessem MB, Selnaes KM, Sjursen W, Tranø G, Giskeødegård GF, Bathen TF, Gribbestad IS and Hofsli E: Discrimination of patients with microsatellite instability colon cancer using 1H HR MAS MR spectroscopy and chemometric analysis. J Proteome Res. 9:3664–3670. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Tessem MB, Swanson MG, Keshari KR, Albers MJ, Joun D, Tabatabai ZL, Simko JP, Shinohara K, Nelson SJ, Vigneron DB, et al: Evaluation of lactate and alanine as metabolic biomarkers of prostate cancer using 1H HR-MAS spectroscopy of biopsy tissues. Magn Reson Med. 60:510–516. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Koppenol WH, Bounds PL and Dang CV: Otto Warburg's contributions to current concepts of cancer metabolism. Nat Rev Cancer. 11:325–337. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Cai Z, Zhao JS, Li JJ, Peng DN, Wang XY, Chen TL, Qiu YP, Chen PP, Li WJ, Xu LY, et al: A combined proteomics and metabolomics profiling of gastric cardia cancer reveals characteristic dysregulations in glucose metabolism. Mol Cell Proteomics. 9:2617–2628. 2010. View Article : Google Scholar : PubMed/NCBI

29 

Newgard CB, An J, Bain JR, Muehlbauer MJ, Stevens RD, Lien LF, Haqq AM, Shah SH, Arlotto M, Slentz CA, et al: A branched-chain amino acid-related metabolic signature that differentiates obese and lean humans and contributes to insulin resistance. Cell Metab. 9:311–326. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Cheng SP, Chi CW, Tzen CY, Yang TL, Lee JJ, Liu TP and Liu CL: Clinicopathologic significance of leptin and leptin receptor expressions in papillary thyroid carcinoma. Surgery. 147:847–853. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Nishio Y, Kakizoe T, Ohtani M, Sato S, Sugimura T and Fukushima S: L-isoleucine and L-leucine: tumor promoters of bladder cancer in rats. Science. 231:843–845. 1986. View Article : Google Scholar : PubMed/NCBI

32 

Jain M, Nilsson R, Sharma S, Madhusudhan N, Kitami T, Souza AL, Kafri R, Kirschner MW, Clish CB and Mootha VK: Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation. Science. 336:1040–1044. 2012. View Article : Google Scholar : PubMed/NCBI

33 

Srivastava S, Roy R, Singh S, Kumar P, Dalela D, Sankhwar SN, Goel A and Sonkar AA: Taurine - a possible fingerprint biomarker in non-muscle invasive bladder cancer: a pilot study by 1H NMR spectroscopy. Cancer Biomark. 6:11–20. 2010. View Article : Google Scholar

34 

Katz-Brull R, Seger D, Rivenson-Segal D, Rushkin E and Degani H: Metabolic markers of breast cancer: enhanced choline metabolism and reduced choline-ether-phospholipid synthesis. Cancer Res. 62:1966–1970. 2002.PubMed/NCBI

35 

Venkataraman GM, Yatin M, Marcinek R and Ain KB: Restoration of iodide uptake in dedifferentiated thyroid carcinoma: relationship to human Na+/I− symporter gene methylation status. J Clin Endocrinol Metab. 84:2449–2457. 1999.PubMed/NCBI

36 

Halton JM, Nazir DJ, McQueen MJ and Barr RD: Blood lipid profiles in children with acute lymphoblastic leukemia. Cancer. 83:379–384. 1998. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Li Y, Chen M, Liu C, Xia Y, Xu B, Hu Y, Chen T, Shen M and Tang W: Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study. Int J Mol Med 41: 3006-3014, 2018.
APA
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y. ... Tang, W. (2018). Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study. International Journal of Molecular Medicine, 41, 3006-3014. https://doi.org/10.3892/ijmm.2018.3494
MLA
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y., Chen, T., Shen, M., Tang, W."Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study". International Journal of Molecular Medicine 41.5 (2018): 3006-3014.
Chicago
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y., Chen, T., Shen, M., Tang, W."Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study". International Journal of Molecular Medicine 41, no. 5 (2018): 3006-3014. https://doi.org/10.3892/ijmm.2018.3494
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Chen M, Liu C, Xia Y, Xu B, Hu Y, Chen T, Shen M and Tang W: Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study. Int J Mol Med 41: 3006-3014, 2018.
APA
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y. ... Tang, W. (2018). Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study. International Journal of Molecular Medicine, 41, 3006-3014. https://doi.org/10.3892/ijmm.2018.3494
MLA
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y., Chen, T., Shen, M., Tang, W."Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study". International Journal of Molecular Medicine 41.5 (2018): 3006-3014.
Chicago
Li, Y., Chen, M., Liu, C., Xia, Y., Xu, B., Hu, Y., Chen, T., Shen, M., Tang, W."Metabolic changes associated with papillary thyroid carcinoma: A nuclear magnetic resonance-based metabolomics study". International Journal of Molecular Medicine 41, no. 5 (2018): 3006-3014. https://doi.org/10.3892/ijmm.2018.3494
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team