Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

  • Authors:
    • Sarmila Nepali
    • Do‑Kuk Kim
    • Hoon‑Yeon Lee
    • Hyeon‑Hui Ki
    • Bo‑Ram Kim
    • Sung‑Woo Hwang
    • Min Park
    • Dae‑Ki Kim
    • Young‑Mi Lee
  • View Affiliations

  • Published online on: February 16, 2018     https://doi.org/10.3892/ijmm.2018.3495
  • Pages: 2952-2960
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Abstract

The present study was undertaken to investigate the anti‑obesity effect of a 50% ethanol extract of Euphorbia supina (ESEE) in high‑fat‑diet (HFD)‑induced obese C57BL/6J mice. Mice were fed a HFD with or without ESEE (2, 10, or 50 mg/kg) or with Garcinia cambogia (positive control) for 6 weeks. ESEE supplementation significantly reduced body, epididymal white adipose tissue (eWAT), and organ weights (P<0.05). ESEE also reduced hepatic steatosis and improved serum lipid profiles. In addition, ESEE significantly reduced serum leptin levels and increased adiponectin levels, and significantly downregulated the mRNA and protein levels of proliferator‑activated receptor γ (PPARγ) and CCAAT/enhancer‑binding protein alpha (C/EPBα) in eWAT and liver tissues (all P<0.05). These results suggested that ESEE supplementation protects against HFD‑induced obesity by downregulating PPARγ and C/EPBα, and that ESEE may be beneficial for the prevention and treatment of obesity and associated diseases.
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May-2018
Volume 41 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Nepali S, Kim DK, Lee HY, Ki HH, Kim BR, Hwang SW, Park M, Kim DK and Lee YM: Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. Int J Mol Med 41: 2952-2960, 2018
APA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S. ... Lee, Y. (2018). Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. International Journal of Molecular Medicine, 41, 2952-2960. https://doi.org/10.3892/ijmm.2018.3495
MLA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41.5 (2018): 2952-2960.
Chicago
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41, no. 5 (2018): 2952-2960. https://doi.org/10.3892/ijmm.2018.3495