Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
May-2018 Volume 41 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
May-2018 Volume 41 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice

  • Authors:
    • Sarmila Nepali
    • Do‑Kuk Kim
    • Hoon‑Yeon Lee
    • Hyeon‑Hui Ki
    • Bo‑Ram Kim
    • Sung‑Woo Hwang
    • Min Park
    • Dae‑Ki Kim
    • Young‑Mi Lee
  • View Affiliations / Copyright

    Affiliations: Department of Immunology and Institute of Medical Sciences, Medical School, Chonbuk National University, Jeonju, Jeollabuk 54907, Republic of Korea, Department of Oriental Pharmacy, College of Pharmacy and Wonkwang‑Oriental Medicines Research Institute, Wonkwang University, Iksan, Jeollabuk 54538, Republic of Korea
  • Pages: 2952-2960
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ijmm.2018.3495
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The present study was undertaken to investigate the anti‑obesity effect of a 50% ethanol extract of Euphorbia supina (ESEE) in high‑fat‑diet (HFD)‑induced obese C57BL/6J mice. Mice were fed a HFD with or without ESEE (2, 10, or 50 mg/kg) or with Garcinia cambogia (positive control) for 6 weeks. ESEE supplementation significantly reduced body, epididymal white adipose tissue (eWAT), and organ weights (P<0.05). ESEE also reduced hepatic steatosis and improved serum lipid profiles. In addition, ESEE significantly reduced serum leptin levels and increased adiponectin levels, and significantly downregulated the mRNA and protein levels of proliferator‑activated receptor γ (PPARγ) and CCAAT/enhancer‑binding protein alpha (C/EPBα) in eWAT and liver tissues (all P<0.05). These results suggested that ESEE supplementation protects against HFD‑induced obesity by downregulating PPARγ and C/EPBα, and that ESEE may be beneficial for the prevention and treatment of obesity and associated diseases.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

View References

1 

Dorresteijn JA, Visseren FL and Spiering W: Mechanisms linking obesity to hypertension. Obes Rev. 13:17–26. 2012. View Article : Google Scholar

2 

McCarthy MI: Genomics, Type 2 diabetes, and obesity. N Engl J Med. 363:2339–2350. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Tzotzas T, Evangelou P and Kiortsis DN: Obesity, weight loss and conditional cardiovascular risk factors. Obes Rev. 12:e282–e289. 2011. View Article : Google Scholar

4 

Rocha VZ and Libby P: Obesity, inflammation, and atherosclerosis. Nat Rev Cardiol. 6:399–409. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Yeh WC, Cao Z, Classon M and McKnight SL: Cascade regulation of terminal adipocyte differentiation by three members of the C/EBP family of leucine zipper proteins. Genes Dev. 9:168–181. 1995. View Article : Google Scholar : PubMed/NCBI

6 

Poudel B, Nepali S, Xin M, Ki HH, Kim YH, Kim DK and Lee YM: Flavonoids from Triticum aestivum inhibit adipogenesis in 3T3-L1 cells by upregulating the insig pathway. Mol Med Rep. 12:3139–3145. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Han J, Farmer SR, Kirkland JL, Corkey BE, Yoon R, Pirtskhalava T, Ido Y and Guo W: Octanoate attenuates adipogenesis in 3T3-L1 preadipocytes. J Nutr. 132:904–910. 2002. View Article : Google Scholar : PubMed/NCBI

8 

Poudel B, Lim SW, Ki HH, Nepali S, Lee YM and Kim DK: Dioscin inhibits adipogenesis through the AMPK/MAPK pathway in 3T3-L1 cells and modulates fat accumulation in obese mice. Int J Mol Med. 34:1401–1408. 2014. View Article : Google Scholar : PubMed/NCBI

9 

Hanif MW and Kumar S: Pharmacological management of obesity. Expert Opin Pharmacother. 3:1711–1718. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Padwal RS and Majumdar SR: Drug treatments for obesity: Orlistat, sibutramine, and rimonabant. Lancet. 369:71–77. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Song MY, Lv N, Kim EK, Kwon KS, Yoo YB, Kim JH, Lee SW, Song JH, Lee JH, Lee SK, et al: Antiobesity activity of aqueous extracts of Rhizoma Dioscoreae Tokoronis on high-fat diet-induced obesity in mice. J Med Food. 12:304–309. 2009. View Article : Google Scholar : PubMed/NCBI

12 

Nugroho A, Rhim TJ, Choi MY, Choi JS, Kim YC, Kim MS and Park HJ: Simultaneous analysis and peroxynitrite-scavenging activity of galloylated flavonoid glycosides and ellagic acid in Euphorbia supina. Arch Pharm Res. 37:890–898. 2014. View Article : Google Scholar

13 

Han MH, Lee WS, Nagappan A, Kim HJ, Park C, Kim GY, Hong SH, Kim ND, Kim G, Ryu CH, et al: Polyphenols from Korean prostrate spurge Eurphorbia supine induce apoptosis through the Fas-associated extrinsic pathway and activation of ERK in human leukemic U937 cells. Oncol Rep. 36:99–107. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Dhanalakshmi C, Manivasagam T, Nataraj J, Justin Thenmozhi A and Essa MM: Neurosupportive role of vanillin, a natural phenolic compound, on rotenone induced neurotoxicity in SH-SY5Y neuroblastoma cells. Evid Based Complement Alternat Med. 2015:6260282015. View Article : Google Scholar : PubMed/NCBI

15 

Song Y, Jeong SW, Lee WS, Park S, Kim YH, Kim GS, Lee SJ, Jin JS, Kim CY, Lee JE, et al: Determination of polyphenol components of Korean prostrate spurge (Euphorbia supina) by using liquid chromatography-tandem mass spectrometry: Overall contribution to antioxidant activity. J Anal Methods Chem. 2014:4186902014. View Article : Google Scholar : PubMed/NCBI

16 

Ko YS, Lee WS, Joo YN, Choi YH, Kim GS, Jung JM, Ryu CH, Shin SC and Kim HJ: Polyphenol mixtures of Euphorbia supina the inhibit invasion and metastasis of highly metastatic breast cancer MDA-MB-231 cells. Oncol Rep. 34:3035–3042. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Im JY, Ki HH, Xin M, Kwon SU, Kim YH, Kim DK, Hong SP, Jin JS and Lee YM: Anti-obesity effect of Triticum aestivum sprouts extract in high-fat-diet-induced obese mice. Biosci Biotechnol Biochem. 79:1133–1140. 2015. View Article : Google Scholar

18 

Nepali S, Ki HH, Lee JH, Lee HY, Lee YM and Kim DK: Wheatgrass derived polysaccharide has anti-inflammatory, anti-oxidative and anti-apoptotic effects on LPS-induced hepatic injury in mice. Phytother Res. 31:1107–1116. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Nepali S, Ki HH, Lee JH, Cha JH, Lee YM and Kim DK: Triticum aestivum sprout-derived polysaccharide exerts hepatoprotective effects against ethanol-induced liver damage by enhancing the antioxidant system in mice. Int J Mole Med. 40:1243–1252. 2017. View Article : Google Scholar

20 

Friedewald WT, Levy RI and Fredrickson DS: Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 18:499–502. 1972.PubMed/NCBI

21 

Nepali S, Son JS, Poudel B, Lee JH, Lee YM and Kim DK: Luteolin is a bioflavonoid that attenuates adipocyte-derived inflammatory responses via suppression of nuclear factor-κB/mitogen-activated protein kinases pathway. Pharmacogn Mag. 11:627–635. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Perez Gutierrez RM, Madrigales Ahuatzi D, Horcacitas Mdel C, Garcia Baez E, Cruz Victoria T and Mota-Flores JM: Ameliorative effect of hexane extract of Phalaris canariensis on high fat diet-induced obese and streptozotocin-induced diabetic mice. Evid Based Complement Alternat Med. 2014:1459012014. View Article : Google Scholar : PubMed/NCBI

23 

Sung J, Jeong HS and Lee J: Effect of the Capsicoside G-rich Fraction from Pepper (Capsicum annuum L.) seeds on high-fat diet-induced obesity in mice. Phytother Res. 30:1848–1855. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Haque M and Sanyal AJ: The metabolic abnormalities associated with non-alcoholic fatty liver disease. Best Pract Res Clin Gastroenterol. 16:709–731. 2002. View Article : Google Scholar : PubMed/NCBI

25 

Reddy JK and Rao MS: Lipid metabolism and liver inflammation. II. Fatty liver disease and fatty acid oxidation. Am J Physiol Gastrointest Liver Physiol. 290:G852–G858. 2006. View Article : Google Scholar : PubMed/NCBI

26 

Jang MK, Yun YR, Kim JH, Park MH and Jung MH: Gomisin N inhibits adipogenesis and prevents high-fat diet-induced obesity. Sci Rep. 7:403452017. View Article : Google Scholar : PubMed/NCBI

27 

Maffei M, Halaas J, Ravussin E, Pratley RE, Lee GH, Zhang Y, Fei H, Kim S, Lallone R, Ranganathan S, et al: Leptin levels in human and rodent: Measurement of plasma leptin and ob RNA in obese and weight-reduced subjects. Nat Med. 1:1155–1161. 1995. View Article : Google Scholar : PubMed/NCBI

28 

Combs TP, Berg AH, Obici S, Scherer PE and Rossetti L: Endogenous glucose production is inhibited by the adipose-derived protein Acrp 30. J Clin Invest. 108:1875–1881. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Pajvani UB and Scherer PE: Adiponectin: Systemic contributor to insulin sensitivity. Curr Diab Rep. 3:207–213. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Soukas A, Socci ND, Saatkamp BD, Novelli S and Friedman JM: Distinct transcriptional profiles of adipogenesis in vivo and in vitro. J Biol Chem. 276:34167–34174. 2001. View Article : Google Scholar : PubMed/NCBI

31 

Schoonjans K, Staels B and Auwerx J: The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation. Biochim Biophys Acta. 1302:93–109. 1996. View Article : Google Scholar : PubMed/NCBI

32 

Rosen ED, Walkey CJ, Puigserver P and Spiegelman BM: Transcriptional regulation of adipogenesis. Genes Dev. 14:1293–1307. 2000.PubMed/NCBI

33 

Wu Z, Xie Y, Bucher NL and Farmer SR: Conditional ectopic expression of C/EBP beta in NIH-3T3 cells induced PPAR gamma and stimulates adipogenesis. Genes Dev. 9:2350–2363. 1995. View Article : Google Scholar : PubMed/NCBI

34 

Choi KM, Lee YS, Shin DM, Lee S, Yoo KS, Lee MK, Lee JH, Kim SY, Lee YM, Hong JT, et al: Green tomato extract attenuates high-fat-diet-induced obesity through activation of the AMPK pathway in C57BL/6 mice. J Nutr Biochem. 24:335–342. 2013. View Article : Google Scholar

35 

Li HR, Liu J, Zhang SL, Luo T, Wu F, Dong JH, Guo YJ and Zhao L: Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways. BMC Complement Alter Med. 17:182017. View Article : Google Scholar

36 

Attar R, Cincin ZB, Bireller ES and Cakmakoglu B: Apoptotic and genomic effects of corilagin on SKOV3 ovarian cancer cell line. Oncol Targets Ther. 10:1941–1946. 2017. View Article : Google Scholar

37 

Liu FC, Chaudry IH and Yu HP: Hepatoprotective effects of corilagin following hemorrhagic shock are through Akt-dependent pathway. Shock. 47:346–351. 2017. View Article : Google Scholar :

38 

Yoshimura Y, Nishii S, Zaima N, Moriyama T and Kawamura Y: Ellagic acid improves hepatic steatosis and serum lipid composition through reduction of serum resistin levels and transcriptional activation of hepatic ppara in obese, diabetic KK-A(y) mice. Biochem Biophys Res Commun. 434:486–491. 2013. View Article : Google Scholar : PubMed/NCBI

39 

Panchal SK, Ward L and Brown L: Ellagic acid attenuates high-carbohydrate, high-fat diet-induced metabolic syndrome in rats. Eur J Nutr. 52:559–568. 2013. View Article : Google Scholar

40 

Woo MS, Choi HS, Seo MJ, Jeon HJ and Lee BY: Ellagic acid suppresses lipid accumulation by suppressing early adipogenic events and cell cycle arrest. Phytother Res. 29:398–406. 2015. View Article : Google Scholar

41 

Sung YY, Yoon T, Yang WK, Kim SJ and Kim HK: Anti-obesity effects of Geranium thunbergii extract via improvement of lipid metabolism in high-fat diet-induced obese mice. Mol Med Rep. 4:1107–1113. 2011.PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Nepali S, Kim DK, Lee HY, Ki HH, Kim BR, Hwang SW, Park M, Kim DK and Lee YM: Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. Int J Mol Med 41: 2952-2960, 2018.
APA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S. ... Lee, Y. (2018). Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. International Journal of Molecular Medicine, 41, 2952-2960. https://doi.org/10.3892/ijmm.2018.3495
MLA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41.5 (2018): 2952-2960.
Chicago
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41, no. 5 (2018): 2952-2960. https://doi.org/10.3892/ijmm.2018.3495
Copy and paste a formatted citation
x
Spandidos Publications style
Nepali S, Kim DK, Lee HY, Ki HH, Kim BR, Hwang SW, Park M, Kim DK and Lee YM: Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. Int J Mol Med 41: 2952-2960, 2018.
APA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S. ... Lee, Y. (2018). Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice. International Journal of Molecular Medicine, 41, 2952-2960. https://doi.org/10.3892/ijmm.2018.3495
MLA
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41.5 (2018): 2952-2960.
Chicago
Nepali, S., Kim, D., Lee, H., Ki, H., Kim, B., Hwang, S., Park, M., Kim, D., Lee, Y."Euphorbia supina extract results in inhibition of high‑fat‑diet‑induced obesity in mice". International Journal of Molecular Medicine 41, no. 5 (2018): 2952-2960. https://doi.org/10.3892/ijmm.2018.3495
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team