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Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment

  • Authors:
    • Yuanmin Li
    • Jingping Liu
    • Guangneng Liao
    • Jie Zhang
    • Younan Chen
    • Lan Li
    • Li Li
    • Fang Liu
    • Bo Chen
    • Gang Guo
    • Chengshi Wang
    • Lichuan Yang
    • Jingqiu Cheng
    • Yangrong Lu
  • View Affiliations / Copyright

    Affiliations: Key Laboratory of Transplant Engineering and Immunology, National Health and Family Planning Commission (NHFPC), West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China, Department of Nephrology, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2629-2639
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    Published online on: February 16, 2018
       https://doi.org/10.3892/ijmm.2018.3501
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Abstract

Diabetic nephropathy (DN) is a major complication of diabetes and represents the leading cause of end-stage renal disease. Mesenchymal stem cell (MSC) treatment has been demonstrated to be effective in DN models by reducing albuminuria and attenuating glomerular injury; however, limited in-depth understanding of the underlying mechanism and a lack of clinical trials hinders its clinical use. Additionally, most of these experimental studies were conducted on the advanced stage of nephropathy, which is difficult to reverse and consequently showed limited therapeutic efficacy. We sought to evaluate whether early intervention by MSCs has the potential to prevent DN onset and progression as well as protect kidney function when intravenously administered to rats with diabetes. Diabetes was induced in adult male SD rats by streptozotocin (STZ) injection (55 mg/kg, i.p.). The diabetic rats were injected with or without bone marrow-derived MSCs (5x106 per rat), via tail vein at 2, 4, 5 and 7 weeks after diabetes onset. Fasting blood glucose (FBG), blood urea nitrogen (BUN) and serum creatinine (Scr) levels in serum samples and glycosuria (GLU), microalbumin (MAU), and albumin to creatinine ratio (ACR) in urine samples were determined. Renal pathology and immunohistochemistry (IHC) for CD68, MCP-1, fibronectin (FN), transforming growth factor-β (TGF-β) and pro-inflammatory cytokines were also performed. Expression levels of the above factors as well as interleukin-10 (IL-10), and epidermal growth factor (EGF) were assessed by qPCR and multiplex bead-based suspension array system, respectively. Additionally, MSC tracing in vivo was performed. Ex vivo, peritoneal macrophages were co-cultured with MSCs, and expression of inflammatory cytokines was detected as well. MSC treatment profoundly suppressed renal macrophage infiltration and inflammatory cytokine secretion in diabetic rats, resulting in prominently improved kidney histology, systemic homeostasis, and animal survival, although no significant effect on hyperglycemia was observed. Engrafted MSCs were primarily localized in deteriorated areas of the kidney and immune organs 48 h after infusion. MSC treatment upregulated serum anti-inflammatory cytokines IL-10 and EGF. Ex vivo, MSCs inhibited lipopolysaccharide (LPS)-stimulated rat peritoneal macrophage activation via the downregulation of inflammatory-related cytokines such as IL-6, MCP-1, tumor necrosis factor-α (TNF-α) and IL-1β. Our results demonstrated that early intervention with MSCs prevented renal injury via immune regulation in diabetic rats, which restored the homeostasis of the immune microenvironment, contributing to the prevention of kidney dysfunction and glomerulosclerosis.
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View References

1 

Dronavalli S, Duka I and Bakris GL: The pathogenesis of diabetic nephropathy. Nat Clin Pract Endocrinol Metab. 4:444–452. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Maisonneuve P, Agodoa L, Gellert R, Stewart JH, Buccianti G, Lowenfels AB, Wolfe RA, Jones E, Disney APS, Briggs D, et al: Distribution of primary renal diseases leading to end-stage renal failure in the United States, Europe, and Australia/New Zealand: Results from an international comparative study. Am J Kidney Dis. 35:157–165. 2000. View Article : Google Scholar : PubMed/NCBI

3 

Chavers BM, Bilous RW, Ellis EN, Steffes MW and Mauer SM: Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria. N Engl J Med. 320:966–970. 1989. View Article : Google Scholar : PubMed/NCBI

4 

McCrary EB: The road to renal failure: An overview of diabetic nephropathy. Adv Nurse Pract. 16:61–63. 2008.

5 

Schena FP and Gesualdo L: Pathogenetic mechanisms of diabetic nephropathy. J Am Soc Nephrol. 16(Suppl 1): S30–S33. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Navarro-González JF, Mora-Fernández C, Muros de Fuentes M and García-Pérez J: Inflammatory molecules and pathways in the pathogenesis of diabetic nephropathy. Nat Rev Nephrol. 7:327–340. 2011. View Article : Google Scholar : PubMed/NCBI

7 

Navarro-González JF and Mora-Fernández C: The role of inflammatory cytokines in diabetic nephropathy. J Am Soc Nephrol. 19:433–442. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Cho DI, Kim MR, Jeong HY, Jeong HC, Jeong MH, Yoon SH, Kim YS and Ahn Y: Mesenchymal stem cells reciprocally regulate the M1/M2 balance in mouse bone marrow-derived macrophages. Exp Mol Med. 46:e702014. View Article : Google Scholar : PubMed/NCBI

9 

Nguyen D, Ping F, Mu W, Hill P, Atkins RC and Chadban SJ: Macrophage accumulation in human progressive diabetic nephropathy. Nephrology (Carlton). 11:226–231. 2006. View Article : Google Scholar

10 

Chow F, Ozols E, Nikolic-Paterson DJ, Atkins RC and Tesch GH: Macrophages in mouse type 2 diabetic nephropathy: Correlation with diabetic state and progressive renal injury. Kidney Int. 65:116–128. 2004. View Article : Google Scholar

11 

Cao Q, Wang Y, Zheng D, Sun Y, Wang Y, Lee VWS, Zheng G, Tan TK, Ince J, Alexander SI, et al: IL-10/TGF-β-modified macrophages induce regulatory T cells and protect against adriamycin nephrosis. J Am Soc Nephrol. 21:933–942. 2010. View Article : Google Scholar : PubMed/NCBI

12 

Prockop DJ and Oh JY: Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation. Mol Ther. 20:14–20. 2012. View Article : Google Scholar :

13 

Chow FY, Nikolic-Paterson DJ, Atkins RC and Tesch GH: Macrophages in streptozotocin-induced diabetic nephropathy: potential role in renal fibrosis. Nephrol Dial Transplant. 19:2987–2996. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Wang S, Li Y, Zhao J, Zhang J and Huang Y: Mesenchymal stem cells ameliorate podocyte injury and proteinuria in a type 1 diabetic nephropathy rat model. Biol Blood Marrow Transplant. 19:538–546. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Singer NG and Caplan AI: Mesenchymal stem cells: Mechanisms of inflammation. Annu Rev Pathol. 6:457–478. 2011. View Article : Google Scholar

16 

Volarevic V, Arsenijevic N, Lukic ML and Stojkovic M: Concise review: Mesenchymal stem cell treatment of the complications of diabetes mellitus. Stem Cells. 29:5–10. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Lee RH, Seo MJ, Reger RL, Spees JL, Pulin AA, Olson SD and Prockop DJ: Multipotent stromal cells from human marrow home to and promote repair of pancreatic islets and renal glomeruli in diabetic NOD/scid mice. Proc Natl Acad Sci USA. 103:17438–17443. 2006. View Article : Google Scholar :

18 

Tögel F, Hu Z, Weiss K, Isaac J, Lange C and Westenfelder C: Administered mesenchymal stem cells protect against ischemic acute renal failure through differentiation-independent mechanisms. Am J Physiol Renal Physiol. 289:F31–F42. 2005. View Article : Google Scholar : PubMed/NCBI

19 

Tögel F, Weiss K, Yang Y, Hu Z, Zhang P and Westenfelder C: Vasculotropic, paracrine actions of infused mesenchymal stem cells are important to the recovery from acute kidney injury. Am J Physiol Renal Physiol. 292:F1626–F1635. 2007. View Article : Google Scholar : PubMed/NCBI

20 

Ezquer FE, Ezquer ME, Parrau DB, Carpio D, Yañez AJ and Conget PA: Systemic administration of multipotent mesenchymal stromal cells reverts hyperglycemia and prevents nephropathy in type 1 diabetic mice. Biol Blood Marrow Transplant. 14:631–640. 2008. View Article : Google Scholar : PubMed/NCBI

21 

Semedo P, Palasio CG, Oliveira CD, Feitoza CQ, Gonçalves GM, Cenedeze MA, Wang PMH, Teixeira VPA, Reis MA, Pacheco-Silva A, et al: Early modulation of inflammation by mesenchymal stem cell after acute kidney injury. Int Immunopharmacol. 9:677–682. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Semedo P, Correa-Costa M, Antonio Cenedeze M, Maria Avancini Costa Malheiros D, Antonia dos Reis M, Shimizu MH, Seguro AC, Pacheco-Silva A, Saraiva Camara NO and Olsen N: Mesenchymal stem cells attenuate renal fibrosis through immune modulation and remodeling properties in a rat remnant kidney model. Stem Cells. 27:3063–3073. 2009.PubMed/NCBI

23 

Park JH, Hwang I, Hwang SH, Han H and Ha H: Human umbilical cord blood-derived mesenchymal stem cells prevent diabetic renal injury through paracrine action. Diabetes Res Clin Pract. 98:465–473. 2012. View Article : Google Scholar : PubMed/NCBI

24 

Nakajima H, Uchida K, Guerrero AR, Watanabe S, Sugita D, Takeura N, Yoshida A, Long G, Wright KT, Johnson WEB, et al: Transplantation of mesenchymal stem cells promotes an alternative pathway of macrophage activation and functional recovery after spinal cord injury. J Neurotrauma. 29:1614–1625. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Jiang TS, Cai L, Ji WY, Hui YN, Wang YS, Hu D and Zhu J: Reconstruction of the corneal epithelium with induced marrow mesenchymal stem cells in rats. Mol Vis. 16:1304–1316. 2010.PubMed/NCBI

26 

Mafi P: Adult mesenchymal stem cells and cell surface characterization - a systematic review of the literature. Open Orthop J. 5(Suppl 2): 253–260. 2011. View Article : Google Scholar

27 

Zhang X, Goncalves R and Mosser DM: The isolation and characterization of murine macrophages. Curr Protoc Immunol. Chapter: Unit-14.1. 2008. View Article : Google Scholar

28 

Wang Y, Wang Y, Feng X, Bao S, Yi S, Kairaitis L, Tay YC, Rangan GK and Harris DC: Depletion of CD4(+) T cells aggravates glomerular and interstitial injury in murine adriamycin nephropathy. Kidney Int. 59:975–984. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Kim J and Hematti P: Mesenchymal stem cell-educated macrophages: A novel type of alternatively activated macrophages. Exp Hematol. 37:1445–1453. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Tesch GH and Allen TJ: Rodent models of streptozotocin-induced diabetic nephropathy. Nephrology (Carlton). 12:261–266. 2007. View Article : Google Scholar

31 

Liu CX, Hu Q, Wang Y, Zhang W, Ma ZY, Feng JB, Wang R, Wang XP, Dong B, Gao F, et al: Angiotensin-converting enzyme (ACE) 2 overexpression ameliorates glomerular injury in a rat model of diabetic nephropathy: A comparison with ACE inhibition. Mol Med. 17:59–69. 2011.

32 

Lv SS, Liu G, Wang JP, Wang WW, Cheng J, Sun AL, Liu HY, Nie HB, Su MR and Guan GJ: Mesenchymal stem cells transplantation ameliorates glomerular injury in streptozotocin-induced diabetic nephropathy in rats via inhibiting macrophage infiltration. Int Immunopharmacol. 17:275–282. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Lv S, Cheng J, Sun A, Li J, Wang W, Guan G, Liu G and Su M: Mesenchymal stem cells transplantation ameliorates glomerular injury in streptozotocin-induced diabetic nephropathy in rats via inhibiting oxidative stress. Diabetes Res Clin Pract. 104:143–154. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Tesch GH: MCP-1/CCL2: A new diagnostic marker and therapeutic target for progressive renal injury in diabetic nephropathy. Am J Physiol Renal Physiol. 294:F697–F701. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Brady HR: Leukocyte adhesion molecules and kidney diseases. Kidney Int. 45:1285–1300. 1994. View Article : Google Scholar : PubMed/NCBI

36 

Duffield JS, Erwig L-P, Wei X, Liew FY, Rees AJ and Savill JS: Activated macrophages direct apoptosis and suppress mitosis of mesangial cells. J Immunol. 164:2110–2119. 2000. View Article : Google Scholar : PubMed/NCBI

37 

Chow FY, Nikolic-Paterson DJ, Ozols E, Atkins RC and Tesch GH: Intercellular adhesion molecule-1 deficiency is protective against nephropathy in type 2 diabetic db/db mice. J Am Soc Nephrol. 16:1711–1722. 2005. View Article : Google Scholar : PubMed/NCBI

38 

Banba N, Nakamura T, Matsumura M, Kuroda H, Hattori Y and Kasai K: Possible relationship of monocyte chemoattractant protein-1 with diabetic nephropathy. Kidney Int. 58:684–690. 2000. View Article : Google Scholar : PubMed/NCBI

39 

Santos JC, de Brito CA, Futata EA, Azor MH, Orii NM, Maruta CW, Rivitti EA, Duarte AJS and Sato MN: Upregulation of chemokine C-C ligand 2 (CCL2) and C-X-C chemokine 8 (CXCL8) expression by monocytes in chronic idiopathic urticaria. Clin Exp Immunol. 167:129–136. 2012. View Article : Google Scholar :

40 

Li W, Zhang Q, Wang M, Wu H, Mao F, Zhang B, Ji R, Gao S, Sun Z, Zhu W, et al: Macrophages are involved in the protective role of human umbilical cord-derived stromal cells in renal ischemia-reperfusion injury. Stem Cell Res (Amst). 10:405–416. 2013. View Article : Google Scholar

41 

Villanueva S, Ewertz E, Carrión F, Tapia A, Vergara C, Céspedes C, Sáez PJ, Luz P, Irarrázabal C, Carreño JE, et al: Mesenchymal stem cell injection ameliorates chronic renal failure in a rat model. Clin Sci (Lond). 121:489–499. 2011. View Article : Google Scholar

42 

Ezquer F, Giraud-Billoud M, Carpio D, Cabezas F, Conget P and Ezquer M: Proregenerative microenvironment triggered by donor mesenchymal stem cells preserves renal function and structure in mice with severe diabetes mellitus. Biomed Res Int. 2015:1647032015. View Article : Google Scholar : PubMed/NCBI

43 

Bi B, Schmitt R, Israilova M, Nishio H and Cantley LG: Stromal cells protect against acute tubular injury via an endocrine effect. J Am Soc Nephrol. 18:2486–2496. 2007. View Article : Google Scholar : PubMed/NCBI

44 

Zhang A, Wang Y, Ye Z, Xie H, Zhou L and Zheng S: Mechanism of TNF-α-induced migration and hepatocyte growth factor production in human mesenchymal stem cells. J Cell Biochem. 111:469–475. 2010. View Article : Google Scholar : PubMed/NCBI

45 

Kim YH, Ryu JM, Lee YJ and Han HJ: Fibronectin synthesis by high glucose level mediated proliferation of mouse embryonic stem cells: Involvement of ANG II and TGF-β1. J Cell Physiol. 223:397–407. 2010.PubMed/NCBI

46 

Wise AF and Ricardo SD: Mesenchymal stem cells in kidney inflammation and repair. Nephrology (Carlton). 17:1–10. 2012. View Article : Google Scholar

47 

Rasmusson I: Immune modulation by mesenchymal stem cells. Exp Cell Res. 312:2169–2179. 2006. View Article : Google Scholar : PubMed/NCBI

48 

Meisel R, Zibert A, Laryea M, Göbel U, Däubener W and Dilloo D: Human bone marrow stromal cells inhibit allogeneic T-cell responses by indoleamine 2,3-dioxygenase-mediated tryptophan degradation. Blood. 103:4619–4621. 2004. View Article : Google Scholar : PubMed/NCBI

49 

Tipnis S, Viswanathan C and Majumdar AS: Immunosuppressive properties of human umbilical cord-derived mesenchymal stem cells: Role of B7-H1 and IDO. Immunol Cell Biol. 88:795–806. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li Y, Liu J, Liao G, Zhang J, Chen Y, Li L, Li L, Liu F, Chen B, Guo G, Guo G, et al: Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment. Int J Mol Med 41: 2629-2639, 2018.
APA
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L. ... Lu, Y. (2018). Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment. International Journal of Molecular Medicine, 41, 2629-2639. https://doi.org/10.3892/ijmm.2018.3501
MLA
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L., Li, L., Liu, F., Chen, B., Guo, G., Wang, C., Yang, L., Cheng, J., Lu, Y."Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment". International Journal of Molecular Medicine 41.5 (2018): 2629-2639.
Chicago
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L., Li, L., Liu, F., Chen, B., Guo, G., Wang, C., Yang, L., Cheng, J., Lu, Y."Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment". International Journal of Molecular Medicine 41, no. 5 (2018): 2629-2639. https://doi.org/10.3892/ijmm.2018.3501
Copy and paste a formatted citation
x
Spandidos Publications style
Li Y, Liu J, Liao G, Zhang J, Chen Y, Li L, Li L, Liu F, Chen B, Guo G, Guo G, et al: Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment. Int J Mol Med 41: 2629-2639, 2018.
APA
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L. ... Lu, Y. (2018). Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment. International Journal of Molecular Medicine, 41, 2629-2639. https://doi.org/10.3892/ijmm.2018.3501
MLA
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L., Li, L., Liu, F., Chen, B., Guo, G., Wang, C., Yang, L., Cheng, J., Lu, Y."Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment". International Journal of Molecular Medicine 41.5 (2018): 2629-2639.
Chicago
Li, Y., Liu, J., Liao, G., Zhang, J., Chen, Y., Li, L., Li, L., Liu, F., Chen, B., Guo, G., Wang, C., Yang, L., Cheng, J., Lu, Y."Early intervention with mesenchymal stem cells prevents nephropathy in diabetic rats by ameliorating the inflammatory microenvironment". International Journal of Molecular Medicine 41, no. 5 (2018): 2629-2639. https://doi.org/10.3892/ijmm.2018.3501
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