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The antitumor activity screening of chemical constituents from Camellia nitidissima Chi

  • Authors:
    • Xiaoying Hou
    • Hongzhi Du
    • Rui Yang
    • Jing Qi
    • Yue Huang
    • Shuyun Feng
    • Yao Wu
    • Sensen Lin
    • Zhixin Liu
    • Ai-Qun Jia
    • Shengtao Yuan
    • Li Sun
  • View Affiliations / Copyright

    Affiliations: Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, P.R. China, Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing, Jiangsu 210009, P.R. China, Guangxi Gui RenTang Co., Ltd., Fangchenggang 538021, P.R. China
    Copyright: © Hou et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2793-2801
    |
    Published online on: February 16, 2018
       https://doi.org/10.3892/ijmm.2018.3502
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Abstract

Chemotherapy is the preferred and most common treatment for cancer in clinical practice. An increasing number of researchers all over the world are focusing on natural medicines to find new antitumor drugs, and several reports have shown that Camellia nitidissima (C. nitidissima) Chi could reduce blood-lipid, decrease blood pressure, resist oxidation, prevent carcinogenesis and inhibit tumors. Therefore, the pharmacodynamics of the chemical constituents in C. nitidissima need to be investigated further. In the present study, 16 chemical constituents were isolated from the leaves of C. nitidissima, of which 6 compounds are reported to be found in this plant for the first time. Furthermore, all these phytochemicals were screened for antitumor activity on 4 common cancer cell lines, while compound 3, one oleanane-type triterpene, exhibited the most potential antitumor effects. Interestingly, to our knowledge, this was the first report that compound 3 inhibits cancer cells. Compound 3 inhibited EGFR-mutant lung cancer cell line, NCI-H1975 via apoptosis effect, with an IC50 of 13.37±2.05 µM at 48 h. Based on the data, compound 3 showed potential for antitumor drug development, suggesting the scientific basis for the antitumor activity of C. nitidissima.
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Copy and paste a formatted citation
Spandidos Publications style
Hou X, Du H, Yang R, Qi J, Huang Y, Feng S, Wu Y, Lin S, Liu Z, Jia A, Jia A, et al: The antitumor activity screening of chemical constituents from Camellia nitidissima Chi. Int J Mol Med 41: 2793-2801, 2018.
APA
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S. ... Sun, L. (2018). The antitumor activity screening of chemical constituents from Camellia nitidissima Chi. International Journal of Molecular Medicine, 41, 2793-2801. https://doi.org/10.3892/ijmm.2018.3502
MLA
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S., Wu, Y., Lin, S., Liu, Z., Jia, A., Yuan, S., Sun, L."The antitumor activity screening of chemical constituents from Camellia nitidissima Chi". International Journal of Molecular Medicine 41.5 (2018): 2793-2801.
Chicago
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S., Wu, Y., Lin, S., Liu, Z., Jia, A., Yuan, S., Sun, L."The antitumor activity screening of chemical constituents from Camellia nitidissima Chi". International Journal of Molecular Medicine 41, no. 5 (2018): 2793-2801. https://doi.org/10.3892/ijmm.2018.3502
Copy and paste a formatted citation
x
Spandidos Publications style
Hou X, Du H, Yang R, Qi J, Huang Y, Feng S, Wu Y, Lin S, Liu Z, Jia A, Jia A, et al: The antitumor activity screening of chemical constituents from Camellia nitidissima Chi. Int J Mol Med 41: 2793-2801, 2018.
APA
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S. ... Sun, L. (2018). The antitumor activity screening of chemical constituents from Camellia nitidissima Chi. International Journal of Molecular Medicine, 41, 2793-2801. https://doi.org/10.3892/ijmm.2018.3502
MLA
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S., Wu, Y., Lin, S., Liu, Z., Jia, A., Yuan, S., Sun, L."The antitumor activity screening of chemical constituents from Camellia nitidissima Chi". International Journal of Molecular Medicine 41.5 (2018): 2793-2801.
Chicago
Hou, X., Du, H., Yang, R., Qi, J., Huang, Y., Feng, S., Wu, Y., Lin, S., Liu, Z., Jia, A., Yuan, S., Sun, L."The antitumor activity screening of chemical constituents from Camellia nitidissima Chi". International Journal of Molecular Medicine 41, no. 5 (2018): 2793-2801. https://doi.org/10.3892/ijmm.2018.3502
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