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Article Open Access

Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells

  • Authors:
    • Ling-Zhi Ding
    • Xiao Teng
    • Zhao-Bo Zhang
    • Chang-Jun Zheng
    • Shi-Hong Chen
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Taizhou Central Hospital, Taizhou, Zhejiang 318000, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2517-2526
    |
    Published online on: February 20, 2018
       https://doi.org/10.3892/ijmm.2018.3506
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Abstract

Mangiferin is a xanthone glucoside, which possesses antioxidant, antiviral, antitumor and anti-inflammatory functions, and is associated with gene regulation. However, it remains unknown whether mangiferin protects osteoblasts, such as the MC3T3-E1 cell line, against glucocorticoid-induced damage. In the present study, MC3T3-E1 cells were treated with dexamethasone (Dex), which is a well-known synthetic glucocorticoid, in order to establish a glucocorticoid-induced cell injury model. After Dex and/or mangiferin treatment, cell viability, apoptosis and reactive oxygen species (ROS) production was measured by Cell Counting kit-8 (CCK-8) and flow cytometry, respectively, and the concentration of tumor necrosis factor (TNF)-α, interleukin (IL)-6 and macrophage colony-stimulating factor (M-CSF) was measured by ELISA. The expression of bone morphogenetic protein 2 (BMP2), phosphorylated‑SMAD family member 1 (p-Smad-1), t-Smad-1, osterix (OSX), osteocalcin (OCN), osteoprotegerin (OPG), receptor activator of nuclear factor-κB (RANK), RANK ligand (RANKL), B‑cell lymphoma 2 (Bcl-2) and Bcl‑2‑associated X protein (Bax) was measured by real-time PCR and/or western blot analysis. The results indicated that pretreatment of MC3T3-E1 cells with mangiferin for 3 h prior to exposure to Dex for 48 h significantly attenuated Dex-induced injury and inflammation, as demonstrated by increased cell viability, and decreases in apoptosis, ROS generation, and the secretion of TNF-α, IL-6 and M-CSF. In addition, pretreatment with mangiferin markedly reduced Dex-induced BMP2 and p‑Smad-1 downregulation, and corrected the expression of differentiation‑ and apoptosis‑associated markers, including alkaline phosphatase, OSX, OCN, OPG, RANK, RANKL, Bcl-2 and Bax, which were altered by Dex treatment. Similar to the protective effects of mangiferin, overexpression of BMP2 suppressed not only Dex-induced cytotoxicity, but also ROS generation, and the secretion of TNF-α, IL-6 and M-CSF. In conclusion, the results of the present study are the first, to the best of our knowledge, to demonstrate that mangiferin protects MC3T3-E1 cells against Dex-induced apoptosis and oxidative stress by activating the BMP2/Smad-1 signaling pathway.
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View References

1 

Ang E, Liu Q, Qi M, Liu HG, Yang X, Chen H, Zheng MH and Xu J: Mangiferin attenuates osteoclastogenesis, bone resorption, and RANKL-induced activation of NF-κB and ERK. J Cell Biochem. 112:89–97. 2011. View Article : Google Scholar

2 

Bar-Shavit Z: The osteoclast: a multinucleated, hematopoietic-origin, bone-resorbing osteoimmune cell. J Cell Biochem. 102:1130–1139. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Whittier X and Saag KG: Glucocorticoid-induced osteoporosis. Rheum Dis Clin North Am. 42:177–189. 2016. View Article : Google Scholar

4 

Wang Y, Liu J, Pang Q and Tao D: Alpinumisoflavone protects against glucocorticoid-induced osteoporosis through suppressing the apoptosis of osteoblastic and osteocytic cells. Biomed Pharmacother. 96:993–999. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Boyce BF and Xing L: Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys. 473:139–146. 2008. View Article : Google Scholar : PubMed/NCBI

6 

Fujita K and Janz S: Attenuation of WNT signaling by DKK-1 and -2 regulates BMP2-induced osteoblast differentiation and expression of OPG, RANKL and M-CSF. Mol Cancer. 6:712007. View Article : Google Scholar : PubMed/NCBI

7 

Ross FP: M-CSF, c-Fms, and signaling in osteoclasts and their precursors. Ann N Y Acad Sci. 1068:110–116. 2006. View Article : Google Scholar : PubMed/NCBI

8 

Yamaguchi Y, Sakai E, Sakamoto H, Fumimoto R, Fukuma Y, Nishishita K, Okamoto K and Tsukuba T: Inhibitory effects of tert-butylhydroquinone on osteoclast differentiation via up-regulation of heme oxygenase-1 and down-regulation of HMGB1 release and NFATc1 expression. J Appl Toxicol. 34:49–56. 2014. View Article : Google Scholar

9 

Boyce BF and Xing L: Biology of RANK, RANKL, and osteoprotegerin. Arthritis Res Ther. 9(Suppl 1): S12007. View Article : Google Scholar : PubMed/NCBI

10 

Xue L, Jiao L, Wang Y, Nie Y, Han T, Jiang Y, Rahman K, Zhang Q and Qin L: Effects and interaction of icariin, curculigoside, and berberine in er-xian decoction, a traditional chinese medicinal formula, on osteoclastic bone resorption. Evid Based Complement Alternat Med. 2012:4908432012. View Article : Google Scholar : PubMed/NCBI

11 

Cancedda R, Giannoni P and Mastrogiacomo M: A tissue engineering approach to bone repair in large animal models and in clinical practice. Biomaterials. 28:4240–4250. 2007. View Article : Google Scholar : PubMed/NCBI

12 

Bishop GB and Einhorn TA: Current and future clinical applications of bone morphogenetic proteins in orthopaedic trauma surgery. Int Orthop. 31:721–727. 2007. View Article : Google Scholar : PubMed/NCBI

13 

Langenfeld EM, Kong Y and Langenfeld J: Bone morphogenetic protein 2 stimulation of tumor growth involves the activation of Smad-1/5. Oncogene. 25:685–692. 2006. View Article : Google Scholar

14 

Tang CH, Yang RS, Chien MY, Chen CC and Fu WM: Enhancement of bone morphogenetic protein-2 expression and bone formation by coumarin derivatives via p38 and ERK-dependent pathway in osteoblasts. Eur J Pharmacol. 579:40–49. 2008. View Article : Google Scholar

15 

Wilkinson AS, Monteith GR, Shaw PN, Lin C-N, Gidley MJ and Roberts-Thomson SJ: Effects of the mango components mangiferin and quercetin and the putative mangiferin metabolite norathyriol on the transactivation of peroxisome proliferator-activated receptor isoforms. J Agric Food Chem. 56:3037–3042. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Campos-Esparza MR, Sánchez-Gómez MV and Matute C: Molecular mechanisms of neuroprotection by two natural antioxidant polyphenols. Cell Calcium. 45:358–368. 2009. View Article : Google Scholar : PubMed/NCBI

17 

Rajendran P, Ekambaram G and Sakthisekaran D: Protective role of mangiferin against benzo(a)pyrene induced lung carcinogenesis in experimental animals. Biol Pharm Bull. 31:1053–1058. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Luo Y, Fu C, Wang Z, Zhang Z, Wang H and Liu Y: Mangiferin attenuates contusive spinal cord injury in rats through the regulation of oxidative stress, inflammation and the Bcl-2 and Bax pathway. Mol Med Rep. 12:7132–7138. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Zhang YH, Wang Y, Yusufali AH, Ashby F, Zhang D, Yin ZF, Aslanidi GV, Srivastava A, Ling CQ and Ling C: Cytotoxic genes from traditional Chinese medicine inhibit tumor growth both in vitro and in vivo. J Integr Med. 12:483–494. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Owen TA, Aronow M, Shalhoub V, Barone LM, Wilming L, Tassinari MS, Kennedy MB, Pockwinse S, Lian JB and Stein GS: Progressive development of the rat osteoblast phenotype in vitro: reciprocal relationships in expression of genes associated with osteoblast proliferation and differentiation during formation of the bone extracellular matrix. J Cell Physiol. 143:420–430. 1990. View Article : Google Scholar : PubMed/NCBI

21 

Bradford MM: A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem. 72:248–254. 1976. View Article : Google Scholar : PubMed/NCBI

22 

Sun M, Xia R, Jin F, Xu T, Liu Z, De W and Liu X: Downregulated long noncoding RNA MEG3 is associated with poor prognosis and promotes cell proliferation in gastric cancer. Tumour Biol. 35:1065–1073. 2014. View Article : Google Scholar

23 

Walker BR: Glucocorticoids and cardiovascular disease. Eur J Endocrinol. 157:545–559. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Green KN, Billings LM, Roozendaal B, McGaugh JL and LaFerla FM: Glucocorticoids increase amyloid-β and tau pathology in a mouse model of Alzheimer's disease. J Neurosci. 26:9047–9056. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Vegiopoulos A and Herzig S: Glucocorticoids, metabolism and metabolic diseases. Mol Cell Endocrinol. 275:43–61. 2007. View Article : Google Scholar : PubMed/NCBI

26 

Sato H, Takahashi T, Sumitani K, Takatsu H and Urano S: Glucocorticoid generates ROS to induce oxidative injury in the hippocampus, leading to impairment of cognitive function of rats. J Clin Biochem Nutr. 47:224–232. 2010. View Article : Google Scholar : PubMed/NCBI

27 

Hurson CJ, Butler JS, Keating DT, Murray DW, Sadlier DM, O'Byrne JM and Doran PP: Gene expression analysis in human osteoblasts exposed to dexamethasone identifies altered developmental pathways as putative drivers of osteoporosis. BMC Musculoskelet Disord. 8:122007. View Article : Google Scholar : PubMed/NCBI

28 

Lin H, Lan J, Guan M, Sheng F and Zhang H: Spectroscopic investigation of interaction between mangiferin and bovine serum albumin. Spectrochim Acta A Mol Biomol Spectrosc. 73:936–941. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Holtorf HL, Jansen JA and Mikos AG: Flow perfusion culture induces the osteoblastic differentiation of marrow stroma cell-scaffold constructs in the absence of dexamethasone. J Biomed Mater Res A. 72:326–334. 2005. View Article : Google Scholar : PubMed/NCBI

30 

Vali B, Rao LG and El-Sohemy A: Epigallocatechin-3-gallate increases the formation of mineralized bone nodules by human osteoblast-like cells. J Nutr Biochem. 18:341–347. 2007. View Article : Google Scholar

31 

Iu MF, Kaji H, Sowa H, Naito J, Sugimoto T and Chihara K: Dexamethasone suppresses Smad3 pathway in osteoblastic cells. J Endocrinol. 185:131–138. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Mori K, Shioi A, Jono S, Nishizawa Y and Morii H: Dexamethasone enhances in vitro vascular calcification by promoting osteoblastic differentiation of vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 19:2112–2118. 1999. View Article : Google Scholar : PubMed/NCBI

33 

Liu H, Yang X, Zhang Y, Dighe A, Li X and Cui Q: Fullerol antagonizes dexamethasone-induced oxidative stress and adipogenesis while enhancing osteogenesis in a cloned bone marrow mesenchymal stem cell. J Orthop Res. 30:1051–1057. 2012. View Article : Google Scholar : PubMed/NCBI

34 

Sánchez GM, Re L, Giuliani A, Núñez-Sellés AJ, Davison GP and León-Fernández OS: Protective effects of Mangifera indica L. extract, mangiferin and selected antioxidants against TPA-induced biomolecules oxidation and peritoneal macrophage activation in mice. Pharmacol Res. 42:565–573. 2000. View Article : Google Scholar : PubMed/NCBI

35 

Kudo O, Fujikawa Y, Itonaga I, Sabokbar A, Torisu T and Athanasou NA: Proinflammatory cytokine (TNFalpha/IL-1α) induction of human osteoclast formation. J Pathol. 198:220–227. 2002. View Article : Google Scholar : PubMed/NCBI

36 

Kudo O, Sabokbar A, Pocock A, Itonaga I, Fujikawa Y and Athanasou NA: Interleukin-6 and interleukin-11 support human osteoclast formation by a RANKL-independent mechanism. Bone. 32:1–7. 2003. View Article : Google Scholar : PubMed/NCBI

37 

Styrkarsdottir U, Cazier JB, Kong A, Rolfsson O, Larsen H, Bjarnadottir E, Johannsdottir VD, Sigurdardottir MS, Bagger Y, Christiansen C, et al: Linkage of osteoporosis to chromosome 20p12 and association to BMP2. PLoS Biol. 1:e692003. View Article : Google Scholar : PubMed/NCBI

38 

Chen JR, Shankar K, Nagarajan S, Badger TM and Ronis MJ: Protective effects of estradiol on ethanol-induced bone loss involve inhibition of reactive oxygen species generation in osteoblasts and downstream activation of the extracellular signal-regulated kinase/signal transducer and activator of transcription 3/receptor activator of nuclear factor-kappaB ligand signaling cascade. J Pharmacol Exp Ther. 324:50–59. 2008. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Ding L, Teng X, Zhang Z, Zheng C and Chen S: Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells. Int J Mol Med 41: 2517-2526, 2018.
APA
Ding, L., Teng, X., Zhang, Z., Zheng, C., & Chen, S. (2018). Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells. International Journal of Molecular Medicine, 41, 2517-2526. https://doi.org/10.3892/ijmm.2018.3506
MLA
Ding, L., Teng, X., Zhang, Z., Zheng, C., Chen, S."Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells". International Journal of Molecular Medicine 41.5 (2018): 2517-2526.
Chicago
Ding, L., Teng, X., Zhang, Z., Zheng, C., Chen, S."Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells". International Journal of Molecular Medicine 41, no. 5 (2018): 2517-2526. https://doi.org/10.3892/ijmm.2018.3506
Copy and paste a formatted citation
x
Spandidos Publications style
Ding L, Teng X, Zhang Z, Zheng C and Chen S: Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells. Int J Mol Med 41: 2517-2526, 2018.
APA
Ding, L., Teng, X., Zhang, Z., Zheng, C., & Chen, S. (2018). Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells. International Journal of Molecular Medicine, 41, 2517-2526. https://doi.org/10.3892/ijmm.2018.3506
MLA
Ding, L., Teng, X., Zhang, Z., Zheng, C., Chen, S."Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells". International Journal of Molecular Medicine 41.5 (2018): 2517-2526.
Chicago
Ding, L., Teng, X., Zhang, Z., Zheng, C., Chen, S."Mangiferin inhibits apoptosis and oxidative stress via BMP2/Smad-1 signaling in dexamethasone-induced MC3T3-E1 cells". International Journal of Molecular Medicine 41, no. 5 (2018): 2517-2526. https://doi.org/10.3892/ijmm.2018.3506
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