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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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May-2018 Volume 41 Issue 5

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International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

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International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

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Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

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Article

The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway

  • Authors:
    • Yan Wang
    • Caifu Luan
    • Guili Zhang
    • Chengming Sun
  • View Affiliations / Copyright

    Affiliations: Clinical Laboratory, Shanghai Pudong New District Zhoupu Hospital, Shanghai 201318, P.R. China, Clinical Laboratory, Yantai Yuhuangding Hospital, Yantai, Shandong 370600, P.R. China
  • Pages: 2935-2942
    |
    Published online on: February 23, 2018
       https://doi.org/10.3892/ijmm.2018.3510
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Abstract

cMaf is a leucine-zipper transcription factor that is involved in cell differentiation, oncogenic transformation, and human diseases; however, the functions of cMaf in inflammatory responses in macrophages are still not fully understood. Western blot analysis showed that cMaf expression was induced by lipopolysaccharide (LPS) stimulation in mouse macrophages. An enzyme-linked immunosorbent assay was performed to detect the level of expression of inflammatory cytokines after knockdown of cMaf expression in macrophages using a small interfering RNA (siRNA). Signaling pathway inhibitor analyses indicated that extracellular signal-related kinase and phosphoinositide 3-kinase contribute to mammalian target of rapamycin phosphorylation (mTOR), which controls cMaf expression at the translational level by regulating the expression of eIF4E-binding protein 1 and S6 ribosomal kinase 1 in response to Toll-like receptor 4 signaling. Histopathological findings of the lung and a survival analysis showed that mice transplanted with cMaf-knockdown macrophages were more susceptible to LPS challenge. Taken together, our study revealed that the control of cMaf expression at the translational level by mTOR regulated the expression of inflammatory genes in response to LPS challenge. Moreover, cMaf protected mice from septic shock indicating that cMaf may improve host fitness, thereby enabling the survival of certain infectious diseases.
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1 

Beutler B: Inferences, questions and possibilities in Toll-like receptor signalling. Nature. 430:257–263. 2004. View Article : Google Scholar : PubMed/NCBI

2 

Murray PJ and Smale ST: Restraint of inflammatory signaling by interdependent strata of negative regulatory pathways. Nat Immunol. 13:916–924. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Liew FY, Xu D, Brint EK and O'Neill LA: Negative regulation of Toll-like receptor-mediated immune responses. Nat Rev Immunol. 5:446–458. 2005. View Article : Google Scholar : PubMed/NCBI

4 

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, et al: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. 13:1045–1054. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Cohen P: Immune diseases caused by mutations in kinases and components of the ubiquitin system. Nat Immunol. 15:521–529. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Lu YC, Yeh WC and Ohashi PS: LPS/TLR4 signal transduction pathway. Cytokine. 42:145–151. 2008. View Article : Google Scholar : PubMed/NCBI

7 

Sun SC: Deubiquitylation and regulation of the immune response. Nat Rev Immunol. 8:501–511. 2008. View Article : Google Scholar : PubMed/NCBI

8 

Katsuoka F and Yamamoto M: Small Maf proteins (MafF, MafG, MafK): History, structure and function. Gene. 586:197–205. 2016. View Article : Google Scholar : PubMed/NCBI

9 

Tsuchiya M, Misaka R, Nitta K and Tsuchiya K: Transcriptional factors, Mafs and their biological roles. World J Diabetes. 6:175–183. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Kataoka K: Multiple mechanisms and functions of maf transcription factors in the regulation of tissue-specific genes. J Biochem. 141:775–781. 2007. View Article : Google Scholar : PubMed/NCBI

11 

Sumiya Y, Ishikawa M, Inoue T, Inui T, Kuchiike D, Kubo K, Uto Y and Nishikata T: Macrophage activation mechanisms in human monocytic cell line-derived macrophages. Anticancer Res. 35:4447–4451. 2015.PubMed/NCBI

12 

Sato K, Miyoshi F, Yokota K, Araki Y, Asanuma Y, Akiyama Y, Yoh K, Takahashi S, Aburatani H and Mimura T: Marked induction of c-Maf protein during Th17 cell differentiation and its implication in memory Th cell development. J Biol Chem. 286:14963–14971. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Xu J, Yang Y, Qiu G, Lal G, Wu Z, Levy DE, Ochando JC, Bromberg JS and Ding Y: c-Maf regulates IL-10 expression during Th17 polarization. J Immunol. 182:6226–6236. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Zhang Y, Zhang Y, Gu W and Sun B: TH1/TH2 cell differentiation and molecular signals. Adv Exp Med Biol. 841:15–44. 2014. View Article : Google Scholar : PubMed/NCBI

15 

Rutz S, Noubade R, Eidenschenk C, Ota N, Zeng W, Zheng Y, Hackney J, Ding J, Singh H and Ouyang W: Transcription factor c-Maf mediates the TGF-β-dependent suppression of IL-22 production in T(H)17 cells. Nat Immunol. 12:1238–1245. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Cao S, Liu J, Song L and Ma X: The protooncogene c-Maf is an essential transcription factor for IL-10 gene expression in macrophages. J Immunol. 174:3484–3492. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Ma XM and Blenis J: Molecular mechanisms of mTOR-mediated translational control. Nat Rev Mol Cell Biol. 10:307–318. 2009. View Article : Google Scholar : PubMed/NCBI

18 

Weichhart T, Hengstschläger M and Linke M: Regulation of innate immune cell function by mTOR. Nat Rev Immunol. 15:599–614. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Cheng SC, Quintin J, Cramer RA, Shepardson KM, Saeed S, Kumar V, Giamarellos-Bourboulis EJ, Martens JH, Rao NA, Aghajanirefah A, et al: mTOR- and HIF-1α-mediated aerobic glycolysis as metabolic basis for trained immunity. Science. 345:1250684. 2014. View Article : Google Scholar

20 

Laplante M and Sabatini DM: mTOR signaling in growth control and disease. Cell. 149:274–293. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Dazert E and Hall MN: mTOR signaling in disease. Curr Opin Cell Biol. 23:744–755. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Lewis CA, Griffiths B, Santos CR, Pende M and Schulze A: Regulation of the SREBP transcription factors by mTORC1. Biochem Soc Trans. 39:495–499. 2011. View Article : Google Scholar : PubMed/NCBI

23 

Jiao S, Zhang Z, Li C, Huang M, Shi Z, Wang Y, Song X, Liu H, Li C, Chen M, et al: The kinase MST4 limits inflammatory responses through direct phosphorylation of the adaptor TRAF6. Nat Immunol. 16:246–257. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Daassi D, Hamada M, Jeon H, Imamura Y, Nhu Tran MT and Takahashi S: Differential expression patterns of MafB and c-Maf in macrophages in vivo and in vitro. Biochem Biophys Res Commun. 473:118–124. 2016. View Article : Google Scholar : PubMed/NCBI

25 

Lucas M, Zhang X, Prasanna V and Mosser DM: ERK activation following macrophage FcgammaR ligation leads to chromatin modifications at the IL-10 locus. J Immunol. 175:469–477. 2005. View Article : Google Scholar : PubMed/NCBI

26 

Benkhart EM, Siedlar M, Wedel A, Werner T and Ziegler-Heitbrock HW: Role of Stat3 in lipopolysaccharide-induced IL-10 gene expression. J Immunol. 165:1612–1617. 2000. View Article : Google Scholar : PubMed/NCBI

27 

Staples KJ, Smallie T, Williams LM, Foey A, Burke B, Foxwell BM and Ziegler-Heitbrock L: IL-10 induces IL-10 in primary human monocyte-derived macrophages via the transcription factor Stat3. J Immunol. 178:4779–4785. 2007. View Article : Google Scholar : PubMed/NCBI

28 

Yu H, Pardoll D and Jove R: STATs in cancer inflammation and immunity: A leading role for STAT3. Nat Rev Cancer. 9:798–809. 2009. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang Y, Luan C, Zhang G and Sun C: The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway. Int J Mol Med 41: 2935-2942, 2018.
APA
Wang, Y., Luan, C., Zhang, G., & Sun, C. (2018). The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway. International Journal of Molecular Medicine, 41, 2935-2942. https://doi.org/10.3892/ijmm.2018.3510
MLA
Wang, Y., Luan, C., Zhang, G., Sun, C."The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway". International Journal of Molecular Medicine 41.5 (2018): 2935-2942.
Chicago
Wang, Y., Luan, C., Zhang, G., Sun, C."The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway". International Journal of Molecular Medicine 41, no. 5 (2018): 2935-2942. https://doi.org/10.3892/ijmm.2018.3510
Copy and paste a formatted citation
x
Spandidos Publications style
Wang Y, Luan C, Zhang G and Sun C: The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway. Int J Mol Med 41: 2935-2942, 2018.
APA
Wang, Y., Luan, C., Zhang, G., & Sun, C. (2018). The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway. International Journal of Molecular Medicine, 41, 2935-2942. https://doi.org/10.3892/ijmm.2018.3510
MLA
Wang, Y., Luan, C., Zhang, G., Sun, C."The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway". International Journal of Molecular Medicine 41.5 (2018): 2935-2942.
Chicago
Wang, Y., Luan, C., Zhang, G., Sun, C."The transcription factor cMaf is targeted by mTOR, and regulates the inflammatory response via the TLR4 signaling pathway". International Journal of Molecular Medicine 41, no. 5 (2018): 2935-2942. https://doi.org/10.3892/ijmm.2018.3510
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