|
1
|
Vos T, Flaxman AD, Naghavi M, Lozano R,
Michaud C, Ezzati M, Shibuya K, Salomon JA, Abdalla S, Aboyans V,
et al: Years lived with disability (YLDs) for 1160 sequelae of 289
diseases and injuries 1990-2010: A systematic analysis for the
Global Burden of Disease Study 2010. Lancet. 380:2163–2196. 2012.
View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Hong J, Reed C, Novick D and Happich M:
Costs associated with treatment of chronic low back pain: An
analysis of the UK General Practice Research Database. Spine.
38:75–82. 2013. View Article : Google Scholar
|
|
3
|
Roberts S, Evans H, Trivedi J and Menage
J: Histology and pathology of the human intervertebral disc. J Bone
Joint Surg Am. 88(Suppl 2): 10–14. 2006.PubMed/NCBI
|
|
4
|
Battié MC, Videman T, Kaprio J, Gibbons
LE, Gill K, Manninen H, Saarela J and Peltonen L: The Twin Spine
Study: Contributions to a changing view of disc degeneration. Spine
J. 9:47–59. 2009. View Article : Google Scholar
|
|
5
|
Xing QJ, Liang QQ, Bian Q, Ding DF, Cui
XJ, Shi Q and Wang YJ: Leg amputation accelerates senescence of rat
lumbar intervertebral discs. Spine. 35:E1253–E1261. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
6
|
Wang D, Nasto LA, Roughley P, Leme AS,
Houghton AM, Usas A, Sowa G, Lee J, Niedernhofer L, Shapiro S, et
al: Spine degeneration in a murine model of chronic human tobacco
smokers. Osteoarthritis Cartilage. 20:896–905. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Stirling A, Worthington T, Rafiq M,
Lambert PA and Elliott TS: Association between sciatica and
Propionibacterium acnes. Lancet. 357:2024–2025. 2001. View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Park EY and Park JB: Dose- and
time-dependent effect of high glucose concentration on viability of
notochordal cells and expression of matrix degrading and fibrotic
enzymes. Int Orthop. 37:1179–1186. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Bartels EM, Fairbank JC, Winlove CP and
Urban JP: Oxygen and lactate concentrations measured in vivo in the
intervertebral discs of patients with scoliosis and back pain.
Spine. 23:1–7; discussion 8. 1998. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Urban JP, Smith S and Fairbank JC:
Nutrition of the intervertebral disc. Spine. 29:2700–2709. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Lee DC, Adams CS, Albert TJ, Shapiro IM,
Evans SM and Koch CJ: In situ oxygen utilization in the rat
intervertebral disc. J Anat. 210:294–303. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Risbud MV, Guttapalli A, Stokes DG,
Hawkins D, Danielson KG, Schaer TP, Albert TJ and Shapiro IM:
Nucleus pulposus cells express HIF-1 alpha under normoxic culture
conditions: A metabolic adaptation to the intervertebral disc
microenvironment. J Cell Biochem. 98:152–159. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Agrawal A, Guttapalli A, Narayan S, Albert
TJ, Shapiro IM and Risbud MV: Normoxic stabilization of HIF-1alpha
drives glycolytic metabolism and regulates aggrecan gene expression
in nucleus pulposus cells of the rat intervertebral disk. Am J
Physiol Cell Physiol. 293:C621–C631. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Ali R, Le Maitre CL, Richardson SM,
Hoyland JA and Freemont AJ: Connective tissue growth factor
expression in human intervertebral disc: implications for
angiogenesis in intervertebral disc degeneration. Biotech
Histochem. 83:239–245. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Furusawa N, Baba H, Miyoshi N, Maezawa Y,
Uchida K, Kokubo Y and Fukuda M: Herniation of cervical
intervertebral disc: Immunohistochemical examination and
measurement of nitric oxide production. Spine. 26:1110–1116. 2001.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Suzuki S, Fujita N, Hosogane N, Watanabe
K, Ishii K, Toyama Y, Takubo K, Horiuchi K, Miyamoto T, Nakamura M,
et al: Excessive reactive oxygen species are therapeutic targets
for intervertebral disc degeneration. Arthritis Res Ther.
17:3162015. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Dimozi A, Mavrogonatou E, Sklirou A and
Kletsas D: Oxidative stress inhibits the proliferation, induces
premature senescence and promotes a catabolic phenotype in human
nucleus pulposus intervertebral disc cells. Eur Cell Mater.
30:89–103. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Hou G, Lu H, Chen M, Yao H and Zhao H:
Oxidative stress participates in age-related changes in rat lumbar
intervertebral discs. Arch Gerontol Geriatr. 59:665–669. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Adams MA and Roughley PJ: What is
intervertebral disc degeneration, and what causes it? Spine.
31:2151–2161. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Ding F, Shao ZW and Xiong LM: Cell death
in intervertebral disc degeneration. Apoptosis. 18:777–785. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Nasto LA, Robinson AR, Ngo K, Clauson CL,
Dong Q, St Croix C, Sowa G, Pola E, Robbins PD, Kang J, et al:
Mitochondrial-derived reactive oxygen species (ROS) play a causal
role in aging-related intervertebral disc degeneration. J Orthop
Res. 31:1150–1157. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Chen JW, Ni BB, Zheng XF, Li B, Jiang SD
and Jiang LS: Hypoxia facilitates the survival of nucleus pulposus
cells in serum deprivation by downregulating excessive autophagy
through restricting ROS generation. Int J Biochem Cell Biol.
59:1–10. 2015. View Article : Google Scholar
|
|
23
|
Pan Q, Shai O, Lee LJ, Frey BJ and
Blencowe BJ: Deep surveying of alternative splicing complexity in
the human transcriptome by high-throughput sequencing. Nat Genet.
40:1413–1415. 2008. View
Article : Google Scholar : PubMed/NCBI
|
|
24
|
Black DL: Mechanisms of alternative
pre-messenger RNA splicing. Annu Rev Biochem. 72:291–336. 2003.
View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Blencowe BJ: Alternative splicing: New
insights from global analyses. Cell. 126:37–47. 2006. View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Lukong KE, Chang KW, Khandjian EW and
Richard S: RNA-binding proteins in human genetic disease. Trends
Genet. 24:416–425. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
27
|
Martinez-Contreras R, Cloutier P, Shkreta
L, Fisette JF, Revil T and Chabot B: hnRNP proteins and splicing
control. Adv Exp Med Biol. 623:123–147. 2007. View Article : Google Scholar
|
|
28
|
Ng B, Yang F, Huston DP, Yan Y, Yang Y,
Xiong Z, Peterson LE, Wang H and Yang XF: Increased noncanonical
splicing of autoantigen transcripts provides the structural basis
for expression of untolerized epitopes. J Allergy Clin Immunol.
114:1463–1470. 2004. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Anderson DG, Markova D, Adams SL, Pacifici
M, An HS and Zhang Y: Fibronectin splicing variants in human
intervertebral disc and association with disc degeneration. Spine.
35:1581–1588. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Hirose Y, Chiba K, Karasugi T, Nakajima M,
Kawaguchi Y, Mikami Y, Furuichi T, Mio F, Miyake A, Miyamoto T, et
al: A functional polymorphism in THBS2 that affects alternative
splicing and MMP binding is associated with lumbar-disc herniation.
Am J Hum Genet. 82:1122–1129. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Sztrolovics R, Grover J, Cs-Szabo G, Shi
SL, Zhang Y, Mort JS and Roughley PJ: The characterization of
versican and its message in human articular cartilage and
intervertebral disc. J Orthop Res. 20:257–266. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Purdom E, Simpson KM, Robinson MD, Conboy
JG, Lapuk AV and Speed TP: FIRMA: A method for detection of
alternative splicing from exon array data. Bioinformatics.
24:1707–1714. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Srinivasan K, Shiue L, Hayes JD, Centers
R, Fitzwater S, Loewen R, Edmondson LR, Bryant J, Smith M and
Rommelfanger C: Detection and measurement of alternative splicing
using splicing-sensitive microarrays. Methods. 37:345–359. 2005.
View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Clark TA, Sugnet CW and Ares M Jr:
Genomewide analysis of mRNA processing in yeast using
splicing-specific microarrays. Science. 296:907–910. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
35
|
Livak KJ and Schmittgen TD: Analysis of
relative gene expression data using real-time quantitative PCR and
the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001.
View Article : Google Scholar
|
|
36
|
Sakai D and Andersson GB: Stem cell
therapy for intervertebral disc regeneration: Obstacles and
solutions. Nat Rev Rheumatol. 11:243–256. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Vo NV, Hartman RA, Yurube T, Jacobs LJ,
Sowa GA and Kang JD: Expression and regulation of
metalloproteinases and their inhibitors in intervertebral disc
aging and degeneration. Spine J. 13:331–341. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Feng C, Liu H, Yang Y, Huang B and Zhou Y:
Growth and differentiation factor-5 contributes to the structural
and functional maintenance of the intervertebral disc. Cell Physiol
Biochem. 35:1–16. 2015. View Article : Google Scholar
|
|
39
|
Shen C, Yan J, Jiang LS and Dai LY:
Autophagy in rat annulus fibrosus cells: Evidence and possible
implications. Arthritis Res Ther. 13:R1322011. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Chen JW, Ni BB, Li B, Yang YH, Jiang SD
and Jiang LS: The responses of autophagy and apoptosis to oxidative
stress in nucleus pulposus cells: implications for disc
degeneration. Cell Physiol Biochem. 34:1175–1189. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Jiang L, Jin Y, Wang H, Jiang Y and Dong
J: Glucosamine protects nucleus pulposus cells and induces
autophagy via the mTOR-dependent pathway. J Orthop Res.
32:1532–1542. 2014. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Binch AL, Cole AA, Breakwell LM, Michael
AL, Chiverton N, Creemers LB, Cross AK and Le Maitre CL: Nerves are
more abundant than blood vessels in the degenerate human
intervertebral disc. Arthritis Res Ther. 17:3702015. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Binch AL, Cole AA, Breakwell LM, Michael
AL, Chiverton N, Cross AK and Le Maitre CL: Expression and
regulation of neurotrophic and angiogenic factors during human
intervertebral disc degeneration. Arthritis Res Ther. 16:4162014.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Takae R, Matsunaga S, Origuchi N, Yamamoto
T, Morimoto N, Suzuki S and Sakou T: Immunolocalization of bone
morphogenetic protein and its receptors in degeneration of
intervertebral disc. Spine. 24:1397–1401. 1999. View Article : Google Scholar : PubMed/NCBI
|
|
45
|
Nakase T, Ariga K, Miyamoto S, Okuda S,
Tomita T, Iwasaki M, Yonenobu K and Yoshikawa H: Distribution of
genes for bone morphogenetic protein-4, -6, growth differentiation
factor-5, and bone morphogenetic protein receptors in the process
of experimental spondylosis in mice. J Neurosurg. 94(Suppl 1):
68–75. 2001.PubMed/NCBI
|
|
46
|
Haro H, Kato T, Komori H, Osada M and
Shinomiya K: Vascular endothelial growth factor (VEGF)-induced
angiogenesis in herniated disc resorption. J Orthop Res.
20:409–415. 2002. View Article : Google Scholar : PubMed/NCBI
|
|
47
|
Gawri R, Rosenzweig DH, Krock E, Ouellet
JA, Stone LS, Quinn TM and Haglund L: High mechanical strain of
primary intervertebral disc cells promotes secretion of
inflammatory factors associated with disc degeneration and pain.
Arthritis Res Ther. 16:R212014. View
Article : Google Scholar : PubMed/NCBI
|
|
48
|
Lee JM, Song JY, Baek M, Jung HY, Kang H,
Han IB, Kwon YD and Shin DE: Interleukin-1β induces angiogenesis
and innervation in human intervertebral disc degeneration. J Orthop
Res. 29:265–269. 2011. View Article : Google Scholar
|
|
49
|
Sahoo S, Meijles DN and Pagano PJ: NADPH
oxidases: key modulators in aging and age-related cardiovascular
diseases? Clin Sci (Lond). 130:317–335. 2016. View Article : Google Scholar
|
|
50
|
Weyemi U, Lagente-Chevallier O, Boufraqech
M, Prenois F, Courtin F, Caillou B, Talbot M, Dardalhon M, Al
Ghuzlan A, Bidart JM, et al: ROS-generating NADPH oxidase NOX4 is a
critical mediator in oncogenic H-Ras-induced DNA damage and
subsequent senescence. Oncogene. 31:1117–1129. 2012. View Article : Google Scholar :
|
