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Article

3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway

  • Authors:
    • Yilin Zhao
    • Lijie Ma
    • Ruixuan Wang
    • Tingting Chen
    • Xueying Liu
    • Faguang Jin
  • View Affiliations / Copyright

    Affiliations: Department of Respiration, Tangdu Hospital, The Fourth Military Medical University, Xi'an, Shaanxi 710038, P.R. China, School of Accounting, Xijing University, Xi'an, Shaanxi 710032, P.R. China, Department of Medicinal Chemistry, School of Pharmacy, The Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China
  • Pages: 3493-3500
    |
    Published online on: March 1, 2018
       https://doi.org/10.3892/ijmm.2018.3528
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Abstract

The protecting effects of 3,5,4'-tri-O-acetylresveratrol (AC-Res) on seawater inhalation-induced acute respiratory distress syndrome (ARDS) by interfering with the activation of thioredoxin-1 (Trx-1) pathway were evaluated. Seawater inhalation-induced ARDS was assessed by magnitude of pulmonary edema and lung inflammation. Oxidative stress was tested by T-SOD activity and MDA content in lungs and cells. Besides, Trx-1, nuclear factor erythroid 2-related factor 2 (Nrf2) and Txnip expression were measured to explore how seawater induced oxidative stress and the mechanism by which AC-Res attenuated seawater inhalation-induced ARDS. The results showed that seawater inhalation increased wet-to-dry (W/D) ratios of lung tissues, enhanced secretion of tumor necrosis factor-α (TNF-α) and interleukin-1β (IL-1β), and disturbed the oxidative distress balance probably through interfering the activity of Trx-1 pathway. While treatment of AC-Res in vivo and Res in vitro reduced W/D ratios of lung tissues, decreased cytokines in lungs and maintained the oxidative stress balance through Trx-1 pathway. In conclusion, AC-Res treatment attenuated seawater inhalation induced ARDS via Trx-1 pathway.
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View References

1 

Koh Y: Update in acute respiratory distress syndrome. J Intensive Care. 2:22014. View Article : Google Scholar : PubMed/NCBI

2 

Organisation, World Health: Disease and injury regional mortality estimates for 2000-2011. Global summary estimates. 2015-1-20. 2013.

3 

Simcock AD: Treatment of near drowning - a review of 130 cases. Anaesthesia. 41:643–648. 1986. View Article : Google Scholar : PubMed/NCBI

4 

Gregorakos L, Markou N, Psalida V, Kanakaki M, Alexopoulou A, Sotiriou E, Damianos A and Myrianthefs P: Near-drowning: Clinical course of lung injury in adults. Lung. 187:93–97. 2009. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y, Zhang B, Xu DQ, Li WP, Xu M, Li JH, Xie XY, Fan QX, Liu W, Mu DG, et al: Tanshinone IIA attenuates seawater aspiration-induced lung injury by inhibiting macrophage migration inhibitory factor. Biol Pharm Bull. 34:1052–1057. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Yang T, Zhang A, Honeggar M, Kohan DE, Mizel D, Sanders K, Hoidal JR, Briggs JP and Schnermann JB: Hypertonic induction of COX-2 in collecting duct cells by reactive oxygen species of mitochondrial origin. J Biol Chem. 280:34966–34973. 2005. View Article : Google Scholar : PubMed/NCBI

7 

Yu HL, Zhao TF, Wu H, Pan YZ, Zhang Q, Wang KL, Zhang CC and Jin YP: Pinellia ternata lectin exerts a pro-inflammatory effect on macrophages by inducing the release of pro-inflammatory cytokines, the activation of the nuclear factor-κB signaling pathway and the overproduction of reactive oxygen species. Int J Mol Med. 36:1127–1135. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Lortz S, Gurgul-Convey E, Lenzen S and Tiedge M: Importance of mitochondrial superoxide dismutase expression in insulin-producing cells for the toxicity of reactive oxygen species and proinflammatory cytokines. Diabetologia. 48:1541–1548. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Liu Y, Qiu J, Wang Z, You W, Wu L, Ji C and Chen G: Dimethylfumarate alleviates early brain injury and secondary cognitive deficits after experimental subarachnoid hemorrhage via activation of Keap1-Nrf2-ARE system. J Neurosurg. 123:915–923. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Niso-Santano M, González-Polo RA, Bravo-San Pedro JM, Gómez-Sánchez R, Lastres-Becker I, Ortiz-Ortiz MA, Soler G, Morán JM, Cuadrado A and Fuentes JM; Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED): Activation of apoptosis signal-regulating kinase 1 is a key factor in paraquat-induced cell death: Modulation by the Nrf2/Trx axis. Free Radic Biol Med. 48:1370–1381. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Ogata FT, Batista WL, Sartori A, Gesteira TF, Masutani H, Arai RJ, Yodoi J, Stern A and Monteiro HP: Nitrosative/oxidative stress conditions regulate thioredoxin-interacting protein (TXNIP) expression and thioredoxin-1 (TRX-1) nuclear localization. PLoS One. 8:e845882013. View Article : Google Scholar :

12 

Zhang C, Li Q, Kang L, Lei X, Zhai X, Zhao S, Zhang C and Dong W: Resveratrol inhibits hyperxia-induced cell apoptosis through up-regulating SIRT1 expression in HPAECs. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 31:590–595. 2015.In Chinese. PubMed/NCBI

13 

Kuno A, Tanno M and Horio Y: The effects of resveratrol and SIRT1 activation on dystrophic cardiomyopathy. Ann NY Acad Sci. 1348:46–54. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Tvrda E, Kovacik A, Tusimova E, Massanyi P and Lukac N: Resveratrol offers protection to oxidative stress induced by ferrous ascorbate in bovine spermatozoa. J Environ Sci Health A Tox Hazard Subst Environ Eng. 50:1440–1451. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Walle T, Hsieh F, DeLegge MH, Oatis JE Jr and Walle UK: High absorption but very low bioavailability of oral resveratrol in humans. Drug Metab Dispos. 32:1377–1382. 2004. View Article : Google Scholar : PubMed/NCBI

16 

Liang L, Liu X, Wang Q, Cheng S, Zhang S and Zhang M: Pharmacokinetics, tissue distribution and excretion study of resveratrol and its prodrug 3,5,4′-tri-O-acetylresveratrol in rats. Phytomedicine. 20:558–563. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Ma L, Zhao Y, Li B, Wang Q, Liu X, Chen X, Nan Y, Liang L, Chang R, Liang L, et al: 3,5,4′-Tri-O-acetylresveratrol attenuates seawater aspiration-induced lung injury by inhibiting activation of nuclear factor-kappa B and hypoxia-inducible factor-1α. Respir Physiol Neurobiol. 185:608–614. 2013. View Article : Google Scholar

18 

Ibsen LM and Koch T: Submersion and asphyxial injury. Crit Care Med. 30(Suppl 11): S402–S408. 2002. View Article : Google Scholar

19 

Janz DR and Ware LB: Biomarkers of ALI/ARDS: Pathogenesis, discovery, and relevance to clinical trials. Semin Respir Crit Care Med. 34:537–548. 2013. View Article : Google Scholar : PubMed/NCBI

20 

Ware LB: Autopsy in ARDS: Insights into natural history. Lancet Respir Med. 1:352–354. 2013. View Article : Google Scholar

21 

Tang PC, NG YF, Ho S, Gyda M and Chan SW: Resveratrol and cardiovascular health - promising therapeutic or hopeless illusion? Pharmacol Res. 90:88–115. 2014. View Article : Google Scholar : PubMed/NCBI

22 

Fu DG: Regulation of redox signalling and autophagy during cardiovascular diseases-role of resveratrol. Eur Rev Med Pharmacol Sci. 19:1530–1536. 2015.PubMed/NCBI

23 

Ma L, Li W, Wang R, Nan Y, Wang Q, Liu W and Jin F: Resveratrol enhanced anticancer effects of cisplatin on non-small cell lung cancer cell lines by inducing mitochondrial dysfunction and cell apoptosis. Int J Oncol. 47:1460–1468. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Empl MT, Albers M, Wang S and Steinberg P: The resveratrol tetramer r-viniferin Induces a cell cycle arrest followed by apoptosis in the prostate cancer cell line LNCaP. Phytother Res. 29:1640–1645. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Kjær TN, Thorsen K, Jessen N, Stenderup K and Pedersen SB: Resveratrol ameliorates imiquimod-induced psoriasis-like skin inflammation in mice. PLoS One. 10:e01265992015. View Article : Google Scholar : PubMed/NCBI

26 

Kimbrough CW, Lakshmanan J, Matheson PJ, Woeste M, Gentile A, Benns MV, Zhang B, Smith JW and Harbrecht BG: Resveratrol decreases nitric oxide production by hepatocytes during inflammation. Surgery. 158:1095–1101. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Guo S, Yao Q, Ke Z, Chen H, Wu J and Liu C: Resveratrol attenuates high glucose-induced oxidative stress and cardiomyocyte apoptosis through AMPK. Mol Cell Endocrinol. 412:85–94. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Ates O, Cayli SR, Yucel N, Altinoz E, Kocak A, Durak MA, Turkoz Y and Yologlu S: Central nervous system protection by resveratrol in streptozotocin-induced diabetic rats. J Clin Neurosci. 14:256–260. 2007. View Article : Google Scholar : PubMed/NCBI

29 

Venturini CD, Merlo S, Souto AA, Fernandes MC, Gomez R and Rhoden CR: Resveratrol and red wine function as antioxidants in the nervous system without cellular proliferative effects during experimental diabetes. Oxid Med Cell Longev. 3:434–441. 2010. View Article : Google Scholar

30 

Chen X, He H, Wang G, Yang B, Ren W, Ma L and Yu Q: Stereospecific determination of cis- and trans-resveratrol in rat plasma by HPLC: Application to pharmacokinetic studies. Biomed Chromatogr. 21:257–265. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Koide K, Osman S, garner AL, Song F, Dixon T, Greenberger JS and Epperly MW: The use of 3,5,4′-tri-O-acetylresveratrol as a potential pro-drug for resveratrol protects mice from γ-irradiation-induced death. ACS Med Chem Lett. 2:270–274. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Forsgren P, Modig J, Gerdin B, Axelsson B and Dahlbäck M: Intrapulmonary deposition of aerosolized Evans blue dye and liposomes in an experimental porcine model of early ARDS. Ups J Med Sci. 95:117–136. 1990. View Article : Google Scholar : PubMed/NCBI

33 

Liu H, Zhang D, Zhao B and Zhao J: Superoxide anion, the main species of ROS in the development of ARDS induced by oleic acid. Free Radic Res. 38:1281–1287. 2004. View Article : Google Scholar

34 

Kovac S, Angelova PR, Holmström KM, Zhang Y, Dinkova-Kostova AT and Abramov AY: Nrf2 regulates ROS production by mitochondria and NADPH oxidase. Biochim Biophys Acta. 1850:794–801. 2015. View Article : Google Scholar :

35 

Yu M, Geiger B, Deeb N and Rothschild MF: Investigation of TXNIP (thioredoxin-interacting protein) and TRX (thioredoxin) genes for growth-related traits in pigs. Mamm genome. 18:197–209. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhao Y, Ma L, Wang R, Chen T, Liu X and Jin F: 3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway. Int J Mol Med 41: 3493-3500, 2018.
APA
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., & Jin, F. (2018). 3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway. International Journal of Molecular Medicine, 41, 3493-3500. https://doi.org/10.3892/ijmm.2018.3528
MLA
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., Jin, F."3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway". International Journal of Molecular Medicine 41.6 (2018): 3493-3500.
Chicago
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., Jin, F."3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3493-3500. https://doi.org/10.3892/ijmm.2018.3528
Copy and paste a formatted citation
x
Spandidos Publications style
Zhao Y, Ma L, Wang R, Chen T, Liu X and Jin F: 3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway. Int J Mol Med 41: 3493-3500, 2018.
APA
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., & Jin, F. (2018). 3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway. International Journal of Molecular Medicine, 41, 3493-3500. https://doi.org/10.3892/ijmm.2018.3528
MLA
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., Jin, F."3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway". International Journal of Molecular Medicine 41.6 (2018): 3493-3500.
Chicago
Zhao, Y., Ma, L., Wang, R., Chen, T., Liu, X., Jin, F."3,5,4'-Tri-O-acetylresveratrol attenuates seawater inhalation-induced acute respiratory distress syndrome via thioredoxin 1 pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3493-3500. https://doi.org/10.3892/ijmm.2018.3528
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