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Article Open Access

Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro

  • Authors:
    • Wen Kang
    • Xiao Zheng
    • Ping Wang
    • Shanyu Guo
  • View Affiliations / Copyright

    Affiliations: Department of General Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China, Department of Pathology, College of Basic Medical Sciences, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China
    Copyright: © Kang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3157-3166
    |
    Published online on: March 5, 2018
       https://doi.org/10.3892/ijmm.2018.3532
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Abstract

During the pathogenesis of gastric cancer, Akt signaling is considered as a pivotal inducer of gastric cancer development. Here we report the identification of anticancer activities of deguelin, a natural agent that inhibits Akt signaling. When applied to MGC-803 and MKN-45 cells, deguelin suppressed the proliferation and arrested cell cycle by p21-mediated inhibition of cyclin E. We further present in vitro evidence that deguelin promoted apoptosis of cancer cells by decreasing the phospho-Akt signaling and affecting expression of the apoptosis-associated genes Bax and Bcl-2. Additionally, deguelin was found to suppress the migration and invasion of gastric cancer cells. Taken together, these results indicated that deguelin exerted anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro.
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Copy and paste a formatted citation
Spandidos Publications style
Kang W, Zheng X, Wang P and Guo S: Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. Int J Mol Med 41: 3157-3166, 2018.
APA
Kang, W., Zheng, X., Wang, P., & Guo, S. (2018). Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. International Journal of Molecular Medicine, 41, 3157-3166. https://doi.org/10.3892/ijmm.2018.3532
MLA
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41.6 (2018): 3157-3166.
Chicago
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41, no. 6 (2018): 3157-3166. https://doi.org/10.3892/ijmm.2018.3532
Copy and paste a formatted citation
x
Spandidos Publications style
Kang W, Zheng X, Wang P and Guo S: Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. Int J Mol Med 41: 3157-3166, 2018.
APA
Kang, W., Zheng, X., Wang, P., & Guo, S. (2018). Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro. International Journal of Molecular Medicine, 41, 3157-3166. https://doi.org/10.3892/ijmm.2018.3532
MLA
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41.6 (2018): 3157-3166.
Chicago
Kang, W., Zheng, X., Wang, P., Guo, S."Deguelin exerts anticancer activity of human gastric cancer MGC-803 and MKN-45 cells in vitro". International Journal of Molecular Medicine 41, no. 6 (2018): 3157-3166. https://doi.org/10.3892/ijmm.2018.3532
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