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RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways

  • Authors:
    • Jun Yang
    • Chaojun Yang
    • Jian Yang
    • Jiawang Ding
    • Xinxin Li
    • Qinqin Yu
    • Xin Guo
    • Zhixing Fan
    • Huibo Wang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, The First College of Clinical Medical Sciences, China Three Gorges University, Yichang, Hubei 443000, P.R. China, Institute of Cardiovascular Diseases, China Three Gorges University, Yichang, Hubei 443000, P.R. China
    Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3287-3295
    |
    Published online on: March 6, 2018
       https://doi.org/10.3892/ijmm.2018.3538
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Abstract

The Toll-like receptor 4 (TLR4) signal pathway- induced inflammation is considered to be a crucial link to myocardial ischemia reperfusion injury (MIRI). Our previous study proved that radioprotective 105 kDa protein (RP105), a negative regulator of TLR4, performed a protective role in MIRI by anti-apoptosis approach. However, the mechanism of RP105 cardioprotection of anti-inflammation is still unclear. This study aimed to explore the underlying mechanism of RP105 anti-inflammation effect in MIRI. We established a rat model of MIRI induced by ligation of the left anterior descending coronary artery for 30 min followed by 2 h reperfusion. Animals were pre-infected with Ad-EGFP-RP105, Ad-EGFP or saline at the apex of the heart. All rats were sacrificed to collect blood samples and myocardial tissue and assessed by immunofluorescence, blood biochemical analysis, Evans blue/triphenyltetrazolium chloride (TTC), hematoxylin and eosin (H&E) staining, enzyme-linked immuno sorbent assay (ELISA), western blot analysis, quantitative PCR and electrophoretic mobility shift assay (EMSA). RP105 overexpression with adenovirus vectors reduced serum myocardial enzyme (CK-MB and LDH) activities, decreased myocardial infarct size, mitigated inflammatory factors interferon-β and tumor necrosis factor-α during MIRI. We also found that Ad-RP105 group exerted distinct repression of TLR4/TRIF signal pathway related proteins and mRNAs (TRIF, TBK-1, IRF3 and p-IRF3) with a low transcriptional activity of IRF3. These findings first expounded that RP105 could alleviate the ischemia reperfusion induced inflammatory status in heart via inhibiting TLR4/TRIF signaling pathway and provided a theoretical foundation of RP105 gene in MIRI.
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1 

Go AS, Mozaffarian D, Roger VL, Benjamin EJ, Berry JD, Blaha MJ, Dai S, Ford ES, Fox CS, Franco S, et al American Heart Association Statistics Committee and Stroke Statistics Subcommittee: Executive summary: Heart disease and stroke statistics - 2014 update: a report from the American Heart Association. Circulation. 129:399–410. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Fang Y and Hu J: Toll-like receptor and its roles in myocardial ischemic/reperfusion injury. Med Sci Monit. 17:RA100–RA109. 2011. View Article : Google Scholar : PubMed/NCBI

3 

Yang M, Chen J, Zhao J and Meng M: Etanercept attenuates myocardial ischemia/reperfusion injury by decreasing inflammation and oxidative stress. PLoS One. 9:e1080242014. View Article : Google Scholar : PubMed/NCBI

4 

Ma HJ, Li Q, Ma HJ, Guan Y, Shi M, Yang J, Li DP and Zhang Y: Chronic intermittent hypobaric hypoxia ameliorates ischemia/reperfusion-induced calcium overload in heart via Na/Ca2 exchanger in developing rats. Cell Physiol Biochem. 34:313–324. 2014. View Article : Google Scholar

5 

Ilczuk T, Wasiutynski A, Wilczek E and Gornicka B: The study of the protein complement in myocardial infarction. Immunol Lett. 162:262–268. 2014. View Article : Google Scholar : PubMed/NCBI

6 

Xu J, Qin X, Cai X, Yang L, Xing Y, Li J, Zhang L, Tang Y, Liu J, Zhang X, et al: Mitochondrial JNK activation triggers autophagy and apoptosis and aggravates myocardial injury following ischemia/reperfusion. Biochim Biophys Acta. 1852:262–270. 2015. View Article : Google Scholar

7 

Kim MY, Lim SH and Lee J: Intake of hot water-extracted apple protects against myocardial injury by inhibiting apoptosis in an ischemia/reperfusion rat model. Nutr Res. 34:951–960. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Frangogiannis NG, Smith CW and Entman ML: The inflammatory response in myocardial infarction. Cardiovasc Res. 53:31–47. 2002. View Article : Google Scholar

9 

Chao W: Toll-like receptor signaling: A critical modulator of cell survival and ischemic injury in the heart. Am J Physiol Heart Circ Physiol. 296:H1–H12. 2009. View Article : Google Scholar :

10 

Ding HS, Yang J, Gong FL, Yang J, Ding JW, Li S and Jiang YR: High mobility group [corrected] box 1 mediates neutrophil recruitment in myocardial ischemia-reperfusion injury through toll like receptor 4-related pathway. Gene. 509:149–153. 2012. View Article : Google Scholar : PubMed/NCBI

11 

Akira S, Uematsu S and Takeuchi O: Pathogen recognition and innate immunity. Cell. 124:783–801. 2006. View Article : Google Scholar : PubMed/NCBI

12 

Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, et al: Inhibition of TLR-4/MD-2 signaling by RP105/MD-1. J Endotoxin Res. 11:363–368. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Divanovic S, Trompette A, Atabani SF, Madan R, Golenbock DT, visintin A, Finberg RW, Tarakhovsky A, Vogel SN, Belkaid Y, et al: Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105. Nat Immunol. 6:571–578. 2005. View Article : Google Scholar : PubMed/NCBI

14 

Wezel A, van der velden D, Maassen JM, Lagraauw HM, de vries MR, Karper JC, Kuiper J, Bot I and Quax PH: RP105 deficiency attenuates early atherosclerosis via decreased monocyte influx in a CCR2 dependent manner. Atherosclerosis. 238:132–139. 2015. View Article : Google Scholar

15 

Ohto U, Miyake K and Shimizu T: Crystal structures of mouse and human RP105/MD-1 complexes reveal unique dimer organization of the toll-like receptor family. J Mol Biol. 413:815–825. 2011. View Article : Google Scholar : PubMed/NCBI

16 

Kimoto M, Nagasawa K and Miyake K: Role of TLR4/MD-2 and RP105/MD-1 in innate recognition of lipopolysaccharide. Scand J Infect Dis. 35:568–572. 2003. View Article : Google Scholar : PubMed/NCBI

17 

Yang J1, Guo X, Yang J, Ding JW, Li S, Yang R, Fan ZX and Yang CJ: RP105 protects against apoptosis in ischemia/reperfusion-induced myocardial damage in rats by suppressing TLR4-mediated signaling pathways. Cell Physiol Biochem. 36:2137–2148. 2015. View Article : Google Scholar : PubMed/NCBI

18 

Yang J, Chen L, Yang J, Ding J, Li S, Wu H, Zhang J, Fan Z, Dong W and Li X: MicroRNA-22 targeting CBP protects against myocardial ischemia-reperfusion injury through anti-apoptosis in rats. Mol Biol Rep. 41:555–561. 2014. View Article : Google Scholar

19 

vilahur G and Badimon L: Ischemia/reperfusion activates myocardial innate immune response: The key role of the toll-like receptor. Front Physiol. 5:4962014. View Article : Google Scholar

20 

Miyake K, Yamashita Y, Hitoshi Y, Takatsu K and Kimoto M: Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: Unresponsiveness of X-linked immunodeficient B cells. J Exp Med. 180:1217–1224. 1994. View Article : Google Scholar : PubMed/NCBI

21 

Ogata H, Su I, Miyake K, Nagai Y, Akashi S, Mecklenbräuker I, Rajewsky K, Kimoto M and Tarakhovsky A: The toll-like receptor protein RP105 regulates lipopolysaccharide signaling in B cells. J Exp Med. 192:23–29. 2000. View Article : Google Scholar : PubMed/NCBI

22 

Bastiaansen AJ, Karper JC, Wezel A, de Boer HC, Welten SM, de Jong RC, Peters EA, de vries MR, van Oeveren-Rietdijk AM, van Zonneveld AJ, et al: TLR4 accessory molecule RP105 (CD180) regulates monocyte-driven arteriogenesis in a murine hind limb ischemia model. PLoS One. 9:e998822014. View Article : Google Scholar : PubMed/NCBI

23 

Hoebe K, Du X, Georgel P, Janssen E, Tabeta K, Kim SO, Goode J, Lin P, Mann N, Mudd S, et al: Identification of Lps2 as a key transducer of MyD88-independent TIR signalling. Nature. 424:743–748. 2003. View Article : Google Scholar : PubMed/NCBI

24 

Akashi S1, Shimazu R, Ogata H, Nagai Y, Takeda K, Kimoto M and Miyake K: Cutting edge: cell surface expression and lipopolysaccharide signaling via the toll-like receptor 4-MD-2 complex on mouse peritoneal macrophages. J Immunol. 164:3471–3475. 2000. View Article : Google Scholar : PubMed/NCBI

25 

Louwe MC, Karper JC, de vries MR, Nossent AY, Bastiaansen AJ, van der Hoorn JW, Willems van Dijk K, Rensen PC, Steendijk P, Smit JW, et al: RP105 deficiency aggravates cardiac dysfunction after myocardial infarction in mice. Int J Cardiol. 176:788–793. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Liu S, Cai X, Wu J, Cong Q, Chen X, Li T, Du F, Ren J, Wu YT, Grishin NV, et al: Phosphorylation of innate immune adaptor proteins MAvS, STING, and TRIF induces IRF3 activation. Science. 347:aaa26302015. View Article : Google Scholar : PubMed/NCBI

27 

Covert MW, Leung TH, Gaston JE and Baltimore D: Achieving stability of lipopolysaccharide-induced NF-kappaB activation. Science. 309:1854–1857. 2005. View Article : Google Scholar : PubMed/NCBI

28 

Fitzgerald KA, McWhirter SM, Faia KL, Rowe DC, Latz E, Golenbock DT, Coyle AJ, Liao SM and Maniatis T: IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol. 4:491–496. 2003. View Article : Google Scholar : PubMed/NCBI

29 

Kagan JC, Su T, Horng T, Chow A, Akira S and Medzhitov R: TRAM couples endocytosis of Toll-like receptor 4 to the induction of interferon-beta. Nat Immunol. 9:361–368. 2008. View Article : Google Scholar : PubMed/NCBI

30 

O'Neill LA and Bowie AG: The family of five: TIR-domain-containing adaptors in Toll-like receptor signalling. Nat Rev Immunol. 7:353–364. 2007. View Article : Google Scholar : PubMed/NCBI

31 

Bowie AG and Haga IR: The role of Toll-like receptors in the host response to viruses. Mol Immunol. 42:859–867. 2005. View Article : Google Scholar : PubMed/NCBI

32 

Perry AK, Chen G, Zheng D, Tang H and Cheng G: The host type I interferon response to viral and bacterial infections. Cell Res. 15:407–422. 2005. View Article : Google Scholar : PubMed/NCBI

33 

Toshchakov V, Jones BW, Perera PY, Thomas K, Cody MJ, Zhang S, Williams BR, Major J, Hamilton TA, Fenton MJ, et al: TLR4, but not TLR2, mediates IFN-beta-induced STAT1alpha/beta-dependent gene expression in macrophages. Nat Immunol. 3:392–398. 2002. View Article : Google Scholar : PubMed/NCBI

34 

Samavati L, Rastogi R, Du W, Hüttemann M, Fite A and Franchi L: STAT3 tyrosine phosphorylation is critical for interleukin 1 beta and interleukin-6 production in response to lipopolysaccharide and live bacteria. Mol Immunol. 46:1867–1877. 2009. View Article : Google Scholar : PubMed/NCBI

35 

Hui KP1, Lee SM, Cheung CY, Ng IH, Poon LL, Guan Y, Ip NY, Lau AS and Peiris JS: Induction of proinflammatory cytokines in primary human macrophages by influenza A virus (H5N1) is selectively regulated by IFN regulatory factor 3 and p38 MAPK. J Immunol. 182:1088–1098. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Kang JW, Koh EJ and Lee SM: Melatonin protects liver against ischemia and reperfusion injury through inhibition of toll-like receptor signaling pathway. J Pineal Res. 50:403–411. 2011. View Article : Google Scholar : PubMed/NCBI

37 

Kang JW and Lee SM: Melatonin inhibits type 1 interferon signaling of toll-like receptor 4 via heme oxygenase-1 induction in hepatic ischemia/reperfusion. J Pineal Res. 53:67–76. 2012. View Article : Google Scholar : PubMed/NCBI

38 

Huang HF, Zeng Z, Wang KH, Zhang HY, Wang S, Zhou WX, Wang ZB, Xu WG and Duan J: Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol. 21:2937–2948. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Mahmoud MF, Gamal S and El-Fayoumi HM: Limonin attenuates hepatocellular injury following liver ischemia and reperfusion in rats via toll-like receptor dependent pathway. Eur J Pharmacol. 740:676–682. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Dvoriantchikova G, Santos AR, Danek D, Dvoriantchikova X and Ivanov D: The TIR-domain-containing adapter inducing interferon-β-dependent signaling cascade plays a crucial role in ischemia-reperfusion-induced retinal injury, whereas the contribution of the myeloid differentiation primary response 88-dependent signaling cascade is not as pivotal. Eur J Neurosci. 40:2502–2512. 2014. View Article : Google Scholar : PubMed/NCBI

41 

Wang J, He GZ, Wang YK, Zhu QK, Chen W and Guo T: TLR4-HMGB1-, MyD88- and TRIF-dependent signaling in mouse intestinal ischemia/reperfusion injury. World J Gastroenterol. 21:8314–8325. 2015. View Article : Google Scholar : PubMed/NCBI

42 

Lyon AR, Sato M, Hajjar RJ, Samulski RJ and Harding SE: Gene therapy: Targeting the myocardium. Heart. 94:89–99. 2008. View Article : Google Scholar

43 

Mason D, Chen YZ, Krishnan HV and Sant S: Cardiac gene therapy: Recent advances and future directions. J Control Release. 215:101–111. 2015. View Article : Google Scholar : PubMed/NCBI

44 

Yang ZJ, Xu SL, Chen B, Zhang SL, Zhang YL, Wei W, Ma DC, Wang LS, Zhu TB, Li CJ, et al: Hepatocyte growth factor plays a critical role in the regulation of cytokine production and induction of endothelial progenitor cell mobilization: A pilot gene therapy study in patients with coronary heart disease. Clin Exp Pharmacol Physiol. 36:790–796. 2009. View Article : Google Scholar : PubMed/NCBI

45 

Sasano T, Kikuchi K, McDonald AD, Lai S and Donahue JK: Targeted high-efficiency, homogeneous myocardial gene transfer. J Mol Cell Cardiol. 42:954–961. 2007. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yang J, Yang C, Yang J, Ding J, Li X, Yu Q, Guo X, Fan Z and Wang H: RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways. Int J Mol Med 41: 3287-3295, 2018.
APA
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q. ... Wang, H. (2018). RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways. International Journal of Molecular Medicine, 41, 3287-3295. https://doi.org/10.3892/ijmm.2018.3538
MLA
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q., Guo, X., Fan, Z., Wang, H."RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways". International Journal of Molecular Medicine 41.6 (2018): 3287-3295.
Chicago
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q., Guo, X., Fan, Z., Wang, H."RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways". International Journal of Molecular Medicine 41, no. 6 (2018): 3287-3295. https://doi.org/10.3892/ijmm.2018.3538
Copy and paste a formatted citation
x
Spandidos Publications style
Yang J, Yang C, Yang J, Ding J, Li X, Yu Q, Guo X, Fan Z and Wang H: RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways. Int J Mol Med 41: 3287-3295, 2018.
APA
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q. ... Wang, H. (2018). RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways. International Journal of Molecular Medicine, 41, 3287-3295. https://doi.org/10.3892/ijmm.2018.3538
MLA
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q., Guo, X., Fan, Z., Wang, H."RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways". International Journal of Molecular Medicine 41.6 (2018): 3287-3295.
Chicago
Yang, J., Yang, C., Yang, J., Ding, J., Li, X., Yu, Q., Guo, X., Fan, Z., Wang, H."RP105 alleviates myocardial ischemia reperfusion injury via inhibiting TLR4/TRIF signaling pathways". International Journal of Molecular Medicine 41, no. 6 (2018): 3287-3295. https://doi.org/10.3892/ijmm.2018.3538
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