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Article

Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA

  • Authors:
    • Liwei Li
    • Yue Song
    • Qing Liu
    • Xi Liu
    • Rui Wang
    • Chunsheng Kang
    • Qingyu Zhang
  • View Affiliations / Copyright

    Affiliations: Department of Gastroenterology, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China, Department of Gastroenterology, Tianjin Medical University Cancer Institute Hospital, Tianjin 300052, P.R. China, Department of Gastroenterology, Tianjin Nankai Hospital, Tianjin 300052, P.R. China, Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin 300052, P.R. China
  • Pages: 3629-3641
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ijmm.2018.3544
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Abstract

Gastric adenocarcinoma remains a life‑threatening disease, emphasizing the importance of gaining an improved understanding of signaling pathways involved in this disease, which can lead to the development of novel therapeutic methods targeting common molecular pathways shared across different types of gastric adenocarcinoma. The present study revealed phosphatase and tensin homolog deleted on chromosome 10 (PTEN) and aurora kinase A (AURKA) gene alterations, which were involved in changes in the phenotypes of gastric cancer cells, including increased proliferation by cell counting kit‑8 assay and invasion capacity by Transwell invasion assay, and predicted survival rates by KM Plotter database in gastric cancer. The present study investigated the association between PTEN and AURKA. Western blotting revealed that phosphorylated (p)-AURKA correlated with two target genes, PTEN and AURKA. The downregulation of PTEN by small interfering (si)RNA not only increased the expression of AURKA at the mRNA and protein levels by western blotting and by reverse transcription‑quantitative PCR, but also increased the expression of p‑AURKA by western blotting and immunofluorescence analysis. In addition, western blotting and reverse transcription‑quantitative PCR revealed that the downregulation of AURKA affected the expression level of PTEN. Furthermore, PTEN suppressed the malignant phenotypic changes of gastric adenocarcinoma cells by regulating the expression of AURKA inhibited by p‑AURKA, suggesting that p‑AURKA may be the key mediator of the PTEN‑associated activation of AURKA and may be key in maintaining the PTEN‑induced malignant state of gastric adenocarcinoma cells. This hypothesis was confirmed by western blotting, and changes were observed in the protein expression of p‑AURKA and AURKA under conditions in which cells were treated with either MLN8237 or si‑PTEN transfection only, or with si‑PTEN transfection and MLN8237. Knockdown of the expression of PTEN altered the expression of p‑AKT, p‑glycogen synthase kinase 3β and β‑catenin, which are genes that have been reported to be involved in the development of gastric adenocarcinoma. The present study confirmed that p‑AURKA is important in the development of gastric adenocarcinoma and revealed a novel functional link between PTEN, AURKA and p‑AURKA activation. The results also suggest a novel drug design strategy in targeting PTEN and AURKA for more specific gastric cancer cell death that spares normal cells.
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1 

Global Burden of Disease Cancer Collaboration; Fitzmaurice C, Allen C, Barber RM, Barregard L, Bhutta ZA, Brenner H, Dicker DJ, Chimed-Orchir O, Dandona R, Dandona L, et al: Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 32 cancer groups, 1990 to 2015: A systematic analysis for the global burden of disease study. JAMA Oncol. 3:524–548. 2017. View Article : Google Scholar

2 

SEER Cancer Statistics Factsheets: Stomach Cancer. National Cancer Institute; 2016

3 

Arrington AK, Nelson R, Patel SS, Luu C, Ko M, Garcia-Aguilar J and Kim J: Timing of chemotherapy and survival in patients with resectable gastric adenocarcinoma. World J Gastrointest Surg. 5:321–328. 2013. View Article : Google Scholar

4 

Sakar B, Karagol H, Gumus M, Basaran M, Kaytan E, Argon A, Ustuner Z, Bavbek SE, Bugra D and Aykan FN: Timing of death from tumor recurrence after curative gastrectomy for gastric cancer. Am J Clin Oncol. 27:205–209. 2004. View Article : Google Scholar : PubMed/NCBI

5 

Wagner AD, Unverzagt S, Grothe W, Kleber G, Grothey A, Haerting J and Fleig WE: Chemotherapy for advanced gastric cancer. Cochrane Database Syst Rev. Mar 17–2010.Epub ahead of print. View Article : Google Scholar : PubMed/NCBI

6 

Glover DM, Leibowitz MH, McLean DA and Parry H: Mutations in aurora prevent centrosome separation leading to the formation of monopolar spindles. Cell. 81:95–105. 1995. View Article : Google Scholar : PubMed/NCBI

7 

Nguyen AL and Schindler K: Specialize and divide (twice): Functions of three aurora kinase homologs in mammalian oocyte meiotic maturation. Trends Genet. 33:349–363. 2017. View Article : Google Scholar : PubMed/NCBI

8 

Sugimoto K, Urano T, Zushi H, Inoue K, Tasaka H, Tachibana M and Dotsu M: Molecular dynamics of Aurora-A kinase in living mitotic cells simultaneously visualized with histone H3 and nuclear membrane protein importinalpha. Cell Struct Funct. 27:457–467. 2002. View Article : Google Scholar

9 

Sen S, Zhou H, Zhang RD, Yoon DS, Vakar-Lopez F, Ito S, Jiang F, Johnston D, Grossman HB, Ruifrok AC, et al: Amplification/overexpression of a mitotic kinase gene in human bladder cancer. J Natl Cancer Inst. 94:1320–1329. 2002. View Article : Google Scholar : PubMed/NCBI

10 

Staff S, Isola J, Jumppanen M and Tanner M: Aurora-A gene is frequently amplified in basal-like breast cancer. Oncol Rep. 23:307–312. 2010.PubMed/NCBI

11 

Yang SB, Zhou XB, Zhu HX, Quan LP, Bai JF, He J, Gao YN, Cheng SJ and Xu NZ: Amplification and overexpression of Aurora-A in esophageal squamous cell carcinoma. Oncol Rep. 17:1083–1088. 2007.PubMed/NCBI

12 

Kamada K, Yamada Y, Hirao T, Fujimoto H, Takahama Y, Ueno M, Takayama T, Naito A, Hirao S and Nakajima Y: Amplification/overexpression of Aurora-A in human gastric carcinoma: Potential role in differentiated type gastric carcinogenesis. Oncol Rep. 12:593–599. 2004.

13 

Maehama T and Dixon JE: PTEN: A tumour suppressor that functions as a phospholipid phosphatase. Trends Cell Biol. 9:125–128. 1999. View Article : Google Scholar : PubMed/NCBI

14 

Ortega-Molina A and Serrano M: PTEN in cancer, metabolism, and aging. Trends Endocrinol Metab. 24:184–189. 2013. View Article : Google Scholar

15 

Maehama T and Dixon JE: The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylino-sitol 3,4,5-trisphosphate. J Biol Chem. 273:13375–13378. 1998. View Article : Google Scholar : PubMed/NCBI

16 

Manning BD and Cantley LC: AKT/PKB signaling: Navigating downstream. Cell. 129:1261–1274. 2007. View Article : Google Scholar : PubMed/NCBI

17 

VanderLaan PA, Rangachari D, Mockus SM, Spotlow V, Reddi HV, Malcolm J, Huberman MS, Joseph LJ, Kobayashi SS and Costa DB: Mutations in TP53, PIK3CA, PTEN and other genes in EGFR mutated lung cancers: Correlation with clinical outcomes. Lung Cancer. 106:17–21. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Smith IN and Briggs JM: Structural mutation analysis of PTEN and its genotype-phenotype correlations in endometriosis and cancer. Proteins. 84:1625–1643. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Liu JC, Wang DY, Egan SE and Zacksenhaus E: Common and distinct features of mammary tumors driven by Pten-deletion or activating Pik3ca mutation. Oncotarget. 7:9060–9068. 2016.PubMed/NCBI

20 

Mina S, Bohn BA, Simon R, Krohn A, Reeh M, Arnold D, Bokemeyer C, Sauter G, Izbicki JR, Marx A and Stahl PR: PTEN deletion is rare but often homogeneous in gastric cancer. J Clin Pathol. 65:693–698. 2012. View Article : Google Scholar : PubMed/NCBI

21 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta) C(T) method. Methods. 25:402–408. 2001. View Article : Google Scholar

22 

Wang J, Nikhil K, Viccaro K, Chang L, White J and Shah K: Phosphorylation-dependent regulation of ALDH1A1 by aurora kinase a: Insights on their synergistic relationship in pancreatic cancer. BMC Biol. 15:102017. View Article : Google Scholar : PubMed/NCBI

23 

Pitts TM, Bradshaw-Pierce EL, Bagby SM, Hyatt SL, Selby HM, Spreafico A, Tentler JJ, McPhillips K, Klauck PJ, Capasso A, et al: Antitumor activity of the aurora a selective kinase inhibitor, alisertib, against preclinical models of colorectal cancer. Oncotarget. 7:50290–50301. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Chen C, Song G, Xiang J, Zhang H, Zhao S and Zhan Y: AURKA promotes cancer metastasis by regulating epithelial-mesenchymal transition and cancer stem cell properties in hepatocellular carcinoma. Biochem Bioph Res Commun. 486:514–520. 2017. View Article : Google Scholar

25 

Katsha A, Arras J, Soutto M, Belkhiri A and El-Rifai W: AURKA regulates JAK2-STAT3 activity in human gastric and esophageal cancers. Mol Oncol. 8:1419–1428. 2014. View Article : Google Scholar : PubMed/NCBI

26 

You D, Xin J, Volk A, Wei W, Schmidt R, Scurti G, Nand S, Breuer EK, Kuo PC, Breslin P, et al: FAK mediates a compensatory survival signal parallel to I3K-AKT in PTEN-null T-ALL Cells. Cell Rep. 10:2055–2068. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Yang LY, He CY, Chen XH, Su LP, Liu BY and Zhang H: Aurora kinase a revives dormant laryngeal squamous cell carcinoma cells via FAK/PI3K/Akt pathway activation. Oncotarget. 7:48346–4859. 2016.PubMed/NCBI

28 

Wang Y, Chen B, Wang Z, Zhang W, Hao K, Chen Y, Li K, Wang T, Xie Y, Huang Z and Tong X: Marsdenia tenacissimae extraction (MTE) inhibits the proliferation and induces the apoptosis of human acute T cell leukemia cells through inactivating PI3K/AKT/mTOR signaling pathway via PTEN enhancement. Oncotarget. 7:82851–82863. 2016.PubMed/NCBI

29 

Li JP, Yang YX, Liu QL, Pan ST, He ZX, Zhang X, Yang T, Chen XW, Wang D, Qiu JX and Zhou SF: The investigational aurora kinase a inhibitor alisertib (MLN8237) induces cell cycle G2/M arrest, apoptosis, and autophagy via p38 MAPK and Akt/mTOR signaling pathways in human breast cancer cells. Drug Des Devel Ther. 9:1627–1652. 2015.PubMed/NCBI

30 

Jiang X and Li H: Overexpression of LRIG1 regulates PTEN via MAPK/MEK signaling pathway in esophageal squamous cell carcinoma. Exp Ther Med. 12:2045–2052. 2016. View Article : Google Scholar : PubMed/NCBI

31 

Puig-Butille JA, Vinyals A, Ferreres JR, Aguilera P, Cabré E, Tell-Martí G, Marcoval J, Mateo F, Palomero L, Badenas C, et al: AURKA overexpression is driven by FOXM1 and MAPK/ERK activation in melanoma cells harboring BRAF or NRAS mutations: Impact on melanoma prognosis and therapy. J Invest Dermatol. 137:1297–1310. 2017. View Article : Google Scholar : PubMed/NCBI

32 

Zorba A, Buosi V, Kutter S, Kern N, Pontiggia F, Cho YJ and Kern D: Molecular mechanism of aurora a kinase autophosphorylation and its allosteric activation by TPX2. Elife. 3:e026672014. View Article : Google Scholar : PubMed/NCBI

33 

Shu LP, Zhou ZW, Zi D, He ZX and Zhou SF: A SILAC-based proteomics elicits the molecular interactome of alisertib (MLN8237) in human erythroleukemia K562 cells. Am J Transl Res. 7:2442–2461. 2015.

34 

Narbonne P, Maddox PS and Labbe JC: DAF-18/PTEN signals through AAK-1/AMPK to inhibit MPK-1/MAPK in feedback control of germline stem cell proliferation. PLoS Genet. 13:e10067382017. View Article : Google Scholar : PubMed/NCBI

35 

Benitez JA, Ma J, D'Antonio M, Boyer A, Camargo MF, Zanca C, Kelly S, Khodadadi-Jamayran A, Jameson NM, Andersen M, et al: PTEN regulates glioblastoma oncogenesis through chromatin-associated complexes of DAXX and histone H3.3. Nat Commun. 8:152232017. View Article : Google Scholar : PubMed/NCBI

36 

de la Rosa J, Weber J, Friedrich MJ, Li Y, Rad L, Ponstingl H, Liang Q, de Quirós SB, Noorani I, Metzakopian E, et al: A single-copy sleeping beauty transposon mutagenesis screen identifies new PTEN-cooperating tumor suppressor genes. Nat Genet. 49:730–741. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Shah MA: Gastrointestinal cancer targeted therapies in gastric cancer-the dawn of a new era. Nat Rev Clin Oncol. 11:10–11. 2014. View Article : Google Scholar

38 

Shagisultanova E, Dunbrack RL Jr and Golemis EA: Issues in interpreting the in vivo activity of Aurora-A. Expert Opin Ther Targets. 19:187–200. 2015. View Article : Google Scholar

39 

Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW and Ouchi T: BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 279:19643–19648. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Kashatus DF, Lim KH, Brady DC, Pershing NL, Cox AD and Counter CM: RALA and RALBP1 regulate mitochondrial fission at mitosis. Nat Cell Biol. 13:1108–1115. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Zhang K, Chen J, Chen D, Huang J, Feng B, Han S, Chen Y, Song H, De W, Zhu Z, et al: Aurora-A promotes chemoresistance in hepatocelluar carcinoma by targeting NF-kappaB/microRNA-21/PTEN signaling pathway. Oncotarget. 5:12916–12935. 2014.PubMed/NCBI

42 

Kwon YW, Kim IJ, Wu D, Lu J, Stock WA Jr, Liu Y, Huang Y, Kang HC, DelRosario R, Jen KY, et al: Pten regulates Aurora-A and cooperates with Fbxw7 in modulating radiation-induced tumor development. Mol Cancer Res. 10:834–844. 2012. View Article : Google Scholar : PubMed/NCBI

43 

Cirak Y, Furuncuoglu Y, Yapicier O, Aksu A and Cubukcu E: Aurora A overexpression in breast cancer patients induces taxane resistance and results in worse prognosis. J BUON. 20:1414–1419. 2015.

44 

Mignogna C, Staropoli N, Botta C, De Marco C, Rizzuto A, Morelli M, Di Cello A, Franco R, Camastra C, Presta I, et al: Aurora Kinase A expression predicts platinum-resistance and adverse outcome in high-grade serous ovarian carcinoma patients. J Ovarian Res. 9:312016. View Article : Google Scholar : PubMed/NCBI

45 

Xu J, Yue CF, Zhou WH, Qian YM, Zhang Y, Wang SW, Liu AW and Liu Q: Aurora-A contributes to cisplatin resistance and lymphatic metastasis in non-small cell lung cancer and predicts poor prognosis. J Transl Med. 12:2002014. View Article : Google Scholar : PubMed/NCBI

46 

Kitano S, Shiraishi N, Uyama I, Sugihara K and Tanigawa N; Japanese Laparoscopic Surgery Study G: A multicenter study on oncologic outcome of laparoscopic gastrectomy for early cancer in Japan. Ann Surg. 245:68–72. 2007. View Article : Google Scholar : PubMed/NCBI

47 

Yang SY, Roh KH, Kim YN, Cho M, Lim SH, Son T, Hyung WJ and Kim HI: Surgical outcomes after open, laparoscopic, and robotic gastrectomy for gastric cancer. Ann Surg Oncol. 24:1770–1777. 2017. View Article : Google Scholar : PubMed/NCBI

48 

Choi YY, Noh SH and Cheong JH: Evolution of gastric cancer treatment: From the golden age of surgery to an era of precision medicine. Yonsei Med J. 56:1177–1185. 2015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li L, Song Y, Liu Q, Liu X, Wang R, Kang C and Zhang Q: Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA. Int J Mol Med 41: 3629-3641, 2018.
APA
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., & Zhang, Q. (2018). Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA. International Journal of Molecular Medicine, 41, 3629-3641. https://doi.org/10.3892/ijmm.2018.3544
MLA
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., Zhang, Q."Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA". International Journal of Molecular Medicine 41.6 (2018): 3629-3641.
Chicago
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., Zhang, Q."Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA". International Journal of Molecular Medicine 41, no. 6 (2018): 3629-3641. https://doi.org/10.3892/ijmm.2018.3544
Copy and paste a formatted citation
x
Spandidos Publications style
Li L, Song Y, Liu Q, Liu X, Wang R, Kang C and Zhang Q: Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA. Int J Mol Med 41: 3629-3641, 2018.
APA
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., & Zhang, Q. (2018). Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA. International Journal of Molecular Medicine, 41, 3629-3641. https://doi.org/10.3892/ijmm.2018.3544
MLA
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., Zhang, Q."Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA". International Journal of Molecular Medicine 41.6 (2018): 3629-3641.
Chicago
Li, L., Song, Y., Liu, Q., Liu, X., Wang, R., Kang, C., Zhang, Q."Low expression of PTEN is essential for maintenance of a malignant state in human gastric adenocarcinoma via upregulation of p‑AURKA mediated by activation of AURKA". International Journal of Molecular Medicine 41, no. 6 (2018): 3629-3641. https://doi.org/10.3892/ijmm.2018.3544
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