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Article

Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells

  • Authors:
    • Bingxin Zhang
    • Zishen Zhao
    • Xiaoyin Meng
    • Hongguang Chen
    • Guojun Fu
    • Keliang Xie
  • View Affiliations / Copyright

    Affiliations: Department of Dermatology, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300193, P.R. China, Department of Dermatology, Cangzhou City People's Hospital, Cangzhou, Hebei 061000, P.R. China, Department of Gynaecology and Obstetrics, Tianjin Hospital, Tianjin 300211, P.R. China, Department of Anesthesiology, Tianjin Institute of Anesthesiology, General Hospital of Tianjin Medical University, Tianjin 300052, P.R. China
  • Pages: 3653-3661
    |
    Published online on: March 7, 2018
       https://doi.org/10.3892/ijmm.2018.3550
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Abstract

Chronic ultraviolet (UV) exposure-induced oxidative stress is associated with the pathogenesis of skin damage. However, the nuclear factor erythroid‑2‑related factor 2 (Nrf2) pathway is a critical factor in protecting cells against UVB‑induced injury through inhibiting oxidative stress. Furthermore, Nrf2 activation requires the involvement of the phosphoinositide-3 kinase (PI3K)/protein kinase B (AKT) pathway, which has a major role in survival of various cell types. Molecular hydrogen exerts protective effects on UV‑induced injury, but the underlying mechanisms have remained elusive. The present study assessed the protective effects of hydrogen against oxidative stress‑induced injury caused by UVB irradiation and investigated the molecular mechanisms. In vitro, UVB‑induced HaCaT cells were collected for the detection of reactive oxygen species, 8‑iso‑prostaglandin F2α, malondialdehyde via fluorescence spectrometry and ELISA; cell activity and cytotoxicity by MTT and lactate dehydrogenase assays, respectively. Additionally, the expression level of PI3K, Akt, Nrf2 and heme oxygenase‑1 (HO‑1) were investigated using western blot, etc. All of the results indicated that hydrogen decreased the levels of reactive oxygen species, 8‑iso‑prostaglandin F2α and malondialdehyde, and promoted the UVB exposure‑induced expression of PI3K, Akt, Nrf2 and heme oxygenase‑1 in HaCaT cells. Of note, PI3K inhibition partially reversed the effects of hydrogen on UVB‑induced HaCaT cells. Therefore, hydrogen effectively protects cells from UVB radiation‑induced oxidative stress by inhibiting Nrf2/HO‑1 activation through the PI3K/Akt signaling pathway.
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1 

Sharma SD and Katiyar SK: Dietary grape seed proanthocyanidins inhibit UVB-induced cyclooxygenase-2 expression and other inflammatory mediators in UVB-exposed skin and skin tumors of SKH-1 hairless mice. Pharm Res. 27:1092–1102. 2010. View Article : Google Scholar : PubMed/NCBI

2 

Helfrich YR, Sachs DL and Voorhees JJ: Overview of skin aging and photoaging. Dermatol Nurs. 20:177–183; quiz 184. 2008.PubMed/NCBI

3 

Bernstein EF, Chen YQ, Tamai K, Shepley KJ, Resnik KS, Zhang H, Tuan R, Mauviel A and Uitto J: Enhanced elastin and fibrillin gene expression in chronically photodamaged skin. J Invest Dermatol. 103:182–186. 1994. View Article : Google Scholar : PubMed/NCBI

4 

Avila Acevedo JG, Espinosa González AM, De Maria y Campos DM, Benitez Flores Jdel C, Hernández Delgado T, Flores Maya S, Campos Contreras J, Muñoz López JL and García Bores AM: Photoprotection of Buddleja cordata extract against UVB-induced skin damage in SKH-1 hairless mice. BMC Complement Altern Med. 14:2812014. View Article : Google Scholar : PubMed/NCBI

5 

de Gruijl FR: Photocarcinogenesis: UVA vs UVB. Methods Enzymol. 319:359–366. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Katiyar SK: Silymarin and skin cancer prevention: Anti- inflammatory, antioxidant and immunomodulatory effects (Review). Int J Oncol. 26:169–176. 2005.

7 

Sime S and Reeve VE: Protection from inflammation, immunosuppression and carcinogenesis induced by UV radiation in mice by topical Pycnogenol. Photochem Photobiol. 79:193–198. 2004. View Article : Google Scholar : PubMed/NCBI

8 

Narayanan DL, Saladi RN and Fox JL: Ultraviolet radiation and skin cancer. Int J Dermatol. 49:978–986. 2010. View Article : Google Scholar : PubMed/NCBI

9 

Lee SJ and Park JW: Enhancement of UVB radiation-mediated apoptosis by knockdown of cytosolic NADP+-dependent isocitrate dehydrogenase in HaCaT cells. BMB Rep. 47:209–214. 2014. View Article : Google Scholar :

10 

Lee KO, Kim SN and Kim YC: Anti-wrinkle effects of water extracts of teas in hairless mouse. Toxicol Res. 30:283–289. 2014. View Article : Google Scholar

11 

Palmer DM and Kitchin JS: Oxidative damage, skin aging, antioxidants and a novel antioxidant rating system. J Drugs Dermatol. 9:11–15. 2010.PubMed/NCBI

12 

Sklar LR, Almutawa F, Lim HW and Hamzavi I: Effects of ultraviolet radiation, visible light, and infrared radiation on erythema and pigmentation: A review. Photochem Photobiol Sci. 12:54–64. 2013. View Article : Google Scholar

13 

Vayalil PK, Mittal A, Hara Y, Elmets CA and Katiyar SK: Green tea polyphenols prevent ultraviolet light-induced oxidative damage and matrix metalloproteinases expression in mouse skin. J Invest Dermatol. 122:1480–1487. 2004. View Article : Google Scholar : PubMed/NCBI

14 

Verschooten L, Claerhout S, Van Laethem A, Agostinis P and Garmyn M: New strategies of photoprotection. Photochem Photobiol. 82:1016–1023. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Piao MJ, Kang KA, Kim KC, Chae S, Kim GO, Shin T, Kim HS and Hyun JW: Diphlorethohydroxycarmalol attenuated cell damage against UVB radiation via enhancing antioxidant effects and absorbing UVB ray in human HaCaT keratinocytes. Environ Toxicol Pharmacol. 36:680–688. 2013. View Article : Google Scholar : PubMed/NCBI

16 

Tao S, Justiniano R, Zhang DD and Wondrak GT: The Nrf2-inducers tanshinone I and dihydrotanshinone protect human skin cells and reconstructed human skin against solar simulated UV. Redox Biol. 1:532–541. 2013. View Article : Google Scholar : PubMed/NCBI

17 

Schäfer M, Dütsch S, auf dem Keller U, Navid F, Schwarz A, Johnson DA, Johnson JA and Werner S: Nrf2 establishes a glutathione-mediated gradient of UVB cytoprotection in the epidermis. Genes Dev. 24:1045–1058. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Saw CL, Huang MT, Liu Y, Khor TO, Conney AH and Kong AN: Impact of Nrf2 on UVB-induced skin inflammation/photo-protection and photoprotective effect of sulforaphane. Mol Carcinog. 50:479–486. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Kannan S and Jaiswal AK: Low and high dose UVB regulation of transcription factor NF-E2-related factor 2. Cancer Res. 66:8421–8429. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Zhong J and Li L: Skin-derived precursors against UVB-induced apoptosis via Bcl-2 and Nrf2 upregulation. Biomed Res Int. 2016.6894743:2016.

21 

Wang L, Chen Y, Sternberg P and Cai J: Essential roles of the PI3 kinase/Akt pathway in regulating Nrf2-dependent antioxidant functions in the RPE. Invest Ophthalmol Vis Sci. 49:1671–1678. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Lee YJ, Jeong HY, Kim YB, Lee YJ, Won SY, Shim JH, Cho MK, Nam HS and Lee SH: Reactive oxygen species and PI3K/Akt signaling play key roles in the induction of Nrf2-driven heme oxygenase-1 expression in sulforaphane-treated human mesothelioma MSTO-211H cells. Food Chem Toxicol. 50:116–123. 2012. View Article : Google Scholar

23 

Xu Y, Duan C, Kuang Z, Hao Y, Jeffries JL and Lau GW: Pseudomonas aeruginosa pyocyanin activates NRF2-ARE-mediated transcriptional response via the ROS-EGFR-PI3K-AKT/MEK-ERK MAP kinase signaling in pulmonary epithelial cells. PLoS One. 8:e725282013. View Article : Google Scholar : PubMed/NCBI

24 

Li KR, Yang SQ, Gong YQ, Yang H, Li XM, Zhao YX, Yao J, Jiang Q and Cao C: 3H-1,2-dithiole-3-thione protects retinal pigment epithelium cells against Ultra-violet radiation via activation of Akt-mTORC1-dependent Nrf2-HO-1 signaling. Sci Rep. 6:255252016. View Article : Google Scholar : PubMed/NCBI

25 

Zhang H, Liu YY, Jiang Q, Li KR, Zhao YX, Cao C and Yao J: Salvianolic acid A protects RPE cells against oxidative stress through activation of Nrf2/HO-1 signaling. Free Radic Biol Med. 69:219–228. 2014. View Article : Google Scholar : PubMed/NCBI

26 

Rodriguez KJ, Wong HK, Oddos T, Southall M, Frei B and Kaur S: A purified feverfew extract protects from oxidative damage by inducing DNA repair in skin cells via a PI3-kinase-dependent Nrf2/ARE pathway. J Dermatol Sci. 72:304–310. 2013. View Article : Google Scholar : PubMed/NCBI

27 

Chen H, Xie K, Han H, Li Y, Liu L, Yang T and Yu Y: Molecular hydrogen protects mice against polymicrobial sepsis by ameliorating endothelial dysfunction via an Nrf2/HO-1 signaling pathway. Int Immunopharmacol. 28:643–654. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Li DZ, Zhang QX, Dong XX, Li HD and Ma X: Treatment with hydrogen molecules prevents RANKL-induced osteoclast differentiation associated with inhibition of ROS formation and inactivation of MAPK, AKT and NF-kappa B pathways in murine RAW264.7 cells. J Bone Miner Metab. 32:494–504. 2014. View Article : Google Scholar

29 

Hong Y, Shao A, Wang J, Chen S, Wu H, McBride DW, Wu Q, Sun X and Zhang J: Neuroprotective effect of hydrogen-rich saline against neurologic damage and apoptosis in early brain injury following subarachnoid hemorrhage: Possible role of the Akt/GSK3beta signaling pathway. PLoS One. 9:e962122014. View Article : Google Scholar

30 

Yu P, Wang Z, Sun X, Chen X, Zeng S, Chen L and Li S: Hydrogen-rich medium protects human skin fibroblasts from high glucose or mannitol induced oxidative damage. Biochem Biophys Res Commun. 409:350–355. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Mei K, Zhao S, Qian L, Li B, Ni J and Cai J: Hydrogen protects rats from dermatitis caused by local radiation. J Dermatolog Treat. 25:182–188. 2014. View Article : Google Scholar

32 

Ishibashi T, Ichikawa M, Sato B, Shibata S, Hara Y, Naritomi Y, Okazaki K, Nakashima Y, Iwamoto Y, Koyanagi S, et al: Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Mol Med Rep. 12:2757–2764. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Meng CY: Effect of hydrogen-rich saline on allergic contact dermatitis in mice. Chin J Dermatol. 46:275–278. 2013.

34 

Zhang BX: Hydrogen-rich liquid down-regulates the expressions of inflammatory facmrs by ultraviolet B-induced human HaCaT keratinocytes through the autophagy pathway. Chin J Dermatol. 49:123–127. 2016.In Chinese.

35 

Xing WB, Fu GJ, Ye WJ, Qin LY, Chen HG, Meng XY and Meng CY: Effects of hydrogen on ultraviolet B-induced oxidative damage to skin fibroblasts. Chin J Dermatol. 46:424–426. 2013.

36 

Chen HG, Xie KL, Han HZ, Wang WN, Liu DQ, Wang GL and Yu YH: Heme oxygenase-1 mediates the anti-inflammatory effect of molecular hydrogen in LPS-stimulated RAW 264.7 macrophages. Int J Surg. 11:1060–1066. 2013. View Article : Google Scholar : PubMed/NCBI

37 

Tongqiang L, Shaopeng L, Xiaofang Y, Nana S, Xialian X, Jiachang H, Ting Z and Xiaoqiang D: Salvianolic acid B prevents iodinated contrast media-induced acute renal injury in rats via the PI3K/Akt/Nrf2 pathway. Oxid Med Cell Longev. 2016:70794872016. View Article : Google Scholar : PubMed/NCBI

38 

Song JL and Gao Y: Protective effects of lindera coreana on UVB-induced oxidative stress in human HaCaT keratinocytes. Iran J Pharm Res. 13:1369–1378. 2014.

39 

Drouin R and Therrien JP: UVB-induced cyclobutane pyrimidine dimer frequency correlates with skin cancer mutational hotspots in p53. Photochem Photobiol. 66:719–726. 1997. View Article : Google Scholar

40 

Podhaisky HP, Riemschneider S and Wohlrab W: UV light and oxidative damage of the skin. Pharmazie. 57:30–33. 2002.PubMed/NCBI

41 

Sander CS, Chang H, Salzmann S, Müller CS, Ekanayake-Mudiyanselage S, Elsner P and Thiele JJ: Photoaging is associated with protein oxidation in human skin in vivo. J Invest Dermatol. 118:618–625. 2002. View Article : Google Scholar : PubMed/NCBI

42 

Beauchamp MC, Letendre E and Renier G: Macrophage lipoprotein lipase expression is increased in patients with heterozygous familial hypercholesterolemia. J Lipid Res. 43:215–222. 2002.PubMed/NCBI

43 

Bai K, Xu W, Zhang J, Kou T, Niu Y, Wan X, Zhang L, Wang C and Wang T: Assessment of free radical scavenging activity of dimethylglycine sodium salt and its role in providing protection against lipopolysaccharide-induced oxidative stress in mice. PLoS One. 11:e1553932016. View Article : Google Scholar

44 

Ohsawa I, Ishikawa M, Takahashi K, Watanabe M, Nishimaki K, Yamagata K, Katsura K, Katayama Y, Asoh S and Ohta S: Hydrogen acts as a therapeutic antioxidant by selectively reducing cytotoxic oxygen radicals. Nat Med. 13:688–694. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Shi Q, Liao KS, Zhao KL, Wang WX, Zuo T, Deng WH, Chen C, Yu J, Guo WY, He XB, et al: Hydrogen-rich saline attenuates acute renal injury in sodium taurocholate-induced severe acute pancreatitis by inhibiting ROS and NF-kB pathway. Mediators Inflamm. 2015:6850432015. View Article : Google Scholar

46 

Done AJ and Traustadóttir T: Nrf2 mediates redox adaptations to exercise. Redox Biol. 10:191–199. 2016. View Article : Google Scholar : PubMed/NCBI

47 

Shih PH, Yeh CT and Yen GC: Anthocyanins induce the activation of phase II enzymes through the antioxidant response element pathway against oxidative stress-induced apoptosis. J Agric Food Chem. 55:9427–9435. 2007. View Article : Google Scholar : PubMed/NCBI

48 

Uchi H, Yasumatsu M, Morino-Koga S, Mitoma C and Furue M: Inhibition of aryl hydrocarbon receptor signaling and induction of NRF2-mediated antioxidant activity by cinnamaldehyde in human keratinocytes. J Dermatol Sci. 85:36–43. 2017. View Article : Google Scholar

49 

Sun Z, Park SY, Hwang E, Zhang M, Seo SA, Lin P and Yi TH: Thymus vulgaris alleviates UVB irradiation induced skin damage via inhibition of MAPK/AP-1 and activation of Nrf2-ARE antioxidant system. J Cell Mol Med. 21:336–348. 2017. View Article : Google Scholar

50 

Shan Y, Wei Z, Tao L, Wang S, Zhang F, Shen C, Wu H, Liu Z, Zhu P, Wang A, et al: Prophylaxis of Diallyl disulfide on skin carcinogenic model via p21-dependent Nrf2 stabilization. Sci Rep. 6:356762016. View Article : Google Scholar : PubMed/NCBI

51 

Ji C, Huang JW, Xu QY, Zhang J, Lin MT, Tu Y, He L, Bi ZG and Cheng B: Gremlin inhibits UV-induced skin cell damages via activating VEGFR2-Nrf2 signaling. Oncotarget. 7:84748–84757. 2016. View Article : Google Scholar : PubMed/NCBI

52 

Yuan XY, Pang XW, Zhang GQ and Guo JY: Salidroside's protection against UVB-mediated oxidative damage and apoptosis is associated with the upregulation of Nrf2 expression. Photomed Laser Surg. 35:49–56. 2017. View Article : Google Scholar

53 

Xie K, Liu L, Yu Y and Wang G: Hydrogen gas presents a promising therapeutic strategy for sepsis. Biomed Res Int. 2014:8076352014. View Article : Google Scholar : PubMed/NCBI

54 

Diao M, Zhang S, Wu L, Huan L, Huang F, Cui Y and Lin Z: Hydrogen gas inhalation attenuates seawater instillation-induced acute lung injury via the Nrf2 pathway in rabbits. Inflammation. 39:2029–2039. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Tamaki N, Orihuela-Campos RC, Fukui M and Ito HO: Hydrogen-rich water intake accelerates oral palatal wound healing via activation of the Nrf2/antioxidant defense pathways in a rat model. Oxid Med Cell Longev. 2016:56790402016. View Article : Google Scholar : PubMed/NCBI

56 

Yu J, Zhang W, Zhang R, Jiang G, Tang H, Ruan X, Ren P and Lu B: Molecular hydrogen attenuates hypoxia/reoxygenation injury of intrahepatic cholangiocytes by activating Nrf2 expression. Toxicol Lett. 238:11–19. 2015. View Article : Google Scholar : PubMed/NCBI

57 

Nguyen CN, Kim HE and Lee SG: Caffeoylserotonin protects human keratinocyte HaCaT cells against H2O2-induced oxidative stress and apoptosis through upregulation of HO-1 expression via activation of the PI3K/Akt/Nrf2 pathway. Phytother Res. 27:1810–1818. 2013. View Article : Google Scholar : PubMed/NCBI

58 

Hermida MA, Dinesh Kumar J and Leslie NR: GSK3 and its interactions with the PI3K/AKT/mTOR signalling network. Adv Biol Regul. 65:5–15. 2017. View Article : Google Scholar : PubMed/NCBI

59 

Follo MY, Manzoli L, Poli A, McCubrey JA and Cocco L: PLC and PI3K/Akt/mTOR signalling in disease and cancer. Adv Biol Regul. 57:10–16. 2015. View Article : Google Scholar

60 

Jhanwar-Uniyal M, Amin AG, Cooper JB, Das K, Schmidt MH and Murali R: Discrete signaling mechanisms of mTORC1 and mTORC2: Connected yet apart in cellular and molecular aspects. Adv Biol Regul. 64:39–48. 2017. View Article : Google Scholar : PubMed/NCBI

61 

Ricciardi MR, Mirabilii S, Licchetta R, Piedimonte M and Tafuri A: Targeting the Akt, GSK-3, Bcl-2 axis in acute myeloid leukemia. Adv Biol Regul. 65:36–58. 2017. View Article : Google Scholar : PubMed/NCBI

62 

Jayasooriya RG, Lee KT, Choi YH, Moon SK, Kim WJ and Kim GY: Antagonistic effects of acetylshikonin on LPS-induced NO and PGE2 production in BV2 microglial cells via inhibition of ROS/PI3K/Akt-mediated NF-κB signaling and activation of Nrf2-dependent HO-1. In Vitro Cell Dev Biol Anim. 51:975–986. 2015. View Article : Google Scholar : PubMed/NCBI

63 

Ryu MJ, Kang KA, Piao MJ, Kim KC, Zheng J, Yao CW, Cha JW, Chung HS, Kim SC, Jung E, et al: 7,8-Dihydroxyflavone protects human keratinocytes against oxidative stress-induced cell damage via the ERK and PI3K/Akt-mediated Nrf2/HO-1 signaling pathways. Int J Mol Med. 33:964–970. 2014. View Article : Google Scholar : PubMed/NCBI

64 

Seo SH and Jeong GS: Fisetin inhibits TNF-α-induced inflammatory action and hydrogen peroxide-induced oxidative damage in human keratinocyte HaCaT cells through PI3K/AKT/Nrf-2-mediated heme oxygenase-1 expression. Int Immunopharmacol. 29:246–253. 2015. View Article : Google Scholar : PubMed/NCBI

65 

Li H, Chen O, Ye Z, Zhang R, Hu H, Zhang N, Huang J, Liu W and Sun X: Inhalation of high concentrations of hydrogen ameliorates liver ischemia/reperfusion injury through A2A receptor mediated PI3K-Akt pathway. Biochem Pharmacol. 130:83–92. 2017. View Article : Google Scholar : PubMed/NCBI

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Zhang B, Zhao Z, Meng X, Chen H, Fu G and Xie K: Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. Int J Mol Med 41: 3653-3661, 2018.
APA
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., & Xie, K. (2018). Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. International Journal of Molecular Medicine, 41, 3653-3661. https://doi.org/10.3892/ijmm.2018.3550
MLA
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., Xie, K."Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells". International Journal of Molecular Medicine 41.6 (2018): 3653-3661.
Chicago
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., Xie, K."Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells". International Journal of Molecular Medicine 41, no. 6 (2018): 3653-3661. https://doi.org/10.3892/ijmm.2018.3550
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang B, Zhao Z, Meng X, Chen H, Fu G and Xie K: Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. Int J Mol Med 41: 3653-3661, 2018.
APA
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., & Xie, K. (2018). Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells. International Journal of Molecular Medicine, 41, 3653-3661. https://doi.org/10.3892/ijmm.2018.3550
MLA
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., Xie, K."Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells". International Journal of Molecular Medicine 41.6 (2018): 3653-3661.
Chicago
Zhang, B., Zhao, Z., Meng, X., Chen, H., Fu, G., Xie, K."Hydrogen ameliorates oxidative stress via PI3K-Akt signaling pathway in UVB-induced HaCaT cells". International Journal of Molecular Medicine 41, no. 6 (2018): 3653-3661. https://doi.org/10.3892/ijmm.2018.3550
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