MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway

  • Authors:
    • Yun Zhang
    • Shaochen Xu
    • Eric Huang
    • Haichao Zhou
    • Bing Li
    • Chenni Shao
    • Yunfeng Yang
  • View Affiliations

  • Published online on: March 9, 2018     https://doi.org/10.3892/ijmm.2018.3551
  • Pages: 3699-3708
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Abstract

The function of microRNA‑130a in development and progression of osteoarthritis was determined. In osteoarthritis patients, the serum levels of microRNA‑130a were decreased, compared with normal group. Overexpression of microRNA‑130a increased cell proliferation and decreased apoptosis of chondrocytes, and downregulation of microRNA‑130a also decreased cell proliferation and induced apoptosis in chondrocytes. Downregulation of microRNA‑130a promoted Bax and caspase‑3/9 protein expression, increased inflammation divisors and suppressed the PTEN/PI3K/Akt signaling pathway. PTEN inhibitor, VO‑Ohpic trihydrate increased the destructive effect of microRNA‑130a on cell proliferation of chondrocytes. PI3K inhibitor, wortmannin also increased the destructive effect of microRNA‑130a on osteoarthritis. In conclusion, microRNA‑130a is an important regulator of osteoarthritis in chondrocytes through PTEN/PI3K/Akt signaling pathway.
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June-2018
Volume 41 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhang Y, Xu S, Huang E, Zhou H, Li B, Shao C and Yang Y: MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. Int J Mol Med 41: 3699-3708, 2018
APA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., & Yang, Y. (2018). MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 41, 3699-3708. https://doi.org/10.3892/ijmm.2018.3551
MLA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41.6 (2018): 3699-3708.
Chicago
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3699-3708. https://doi.org/10.3892/ijmm.2018.3551