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International Journal of Molecular Medicine
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June-2018 Volume 41 Issue 6

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Article

MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway

  • Authors:
    • Yun Zhang
    • Shaochen Xu
    • Eric Huang
    • Haichao Zhou
    • Bing Li
    • Chenni Shao
    • Yunfeng Yang
  • View Affiliations / Copyright

    Affiliations: Department of Orthopaedics, Shanghai Tongji Hospital, Shanghai 200065, P.R. China, Shanghai Jiading Nanxiang Hospital, Shanghai 200065, P.R. China
  • Pages: 3699-3708
    |
    Published online on: March 9, 2018
       https://doi.org/10.3892/ijmm.2018.3551
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Abstract

The function of microRNA‑130a in development and progression of osteoarthritis was determined. In osteoarthritis patients, the serum levels of microRNA‑130a were decreased, compared with normal group. Overexpression of microRNA‑130a increased cell proliferation and decreased apoptosis of chondrocytes, and downregulation of microRNA‑130a also decreased cell proliferation and induced apoptosis in chondrocytes. Downregulation of microRNA‑130a promoted Bax and caspase‑3/9 protein expression, increased inflammation divisors and suppressed the PTEN/PI3K/Akt signaling pathway. PTEN inhibitor, VO‑Ohpic trihydrate increased the destructive effect of microRNA‑130a on cell proliferation of chondrocytes. PI3K inhibitor, wortmannin also increased the destructive effect of microRNA‑130a on osteoarthritis. In conclusion, microRNA‑130a is an important regulator of osteoarthritis in chondrocytes through PTEN/PI3K/Akt signaling pathway.
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1 

Wallenstein GV, Kanik KS, Wilkinson B, Cohen S, Cutolo M, Fleishmann R, Genovese MC, Gomez Reino J, Gruben D, Kremer J, et al: Effects of the oral Janus kinase inhibitor tofacitinib on patient-reported outcomes in patients with active rheumatoid arthritis: Results of two phase 2 randomised controlled trials. Clin Exp Rheumatol. 34:430–442. 2016.PubMed/NCBI

2 

Izumi K, Kaneko Y, Hashizume M, Yoshimoto K and Takeuchi T: Baseline serum osteopontin levels predict the clinical effectiveness of tocilizumab but not infliximab in biologic-naïve patients with rheumatoid arthritis: A single-center prospective study at 1 year (the Keio First-Bio Cohort study). PLoS One. 10:e01454682015. View Article : Google Scholar

3 

Xu Y, Zhu Q, Song J, Liu H, Miao Y, Yang F, Wang F, Cheng W, Xi Y, Niu X, et al: Regulatory effect of iguratimod on the balance of Th subsets and inhibition of inflammatory cytokines in patients with rheumatoid arthritis. Mediators Inflamm. 2015:3560402015. View Article : Google Scholar : PubMed/NCBI

4 

Durez P, Vandepapeliere P, Miranda P, Toncheva A, Berman A, Kehler T, Mociran E, Fautrel B, Mariette X, Dhellin O, et al: Therapeutic vaccination with TNF-Kinoid in TNF antagonist- resistant rheumatoid arthritis: A phase II randomized, controlled clinical trial. PLoS One. 9:e1134652014. View Article : Google Scholar

5 

Genovese MC, Kremer J, Zamani O, Ludivico C, Krogulec M, Xie L, Beattie SD, Koch AE, Cardillo TE, Rooney TP, et al: Baricitinib in patients with refractory rheumatoid arthritis. N Engl J Med. 374:1243–1252. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Maeda Y, Farina NH, Matzelle MM, Fanning PJ, Lian JB and Gravallese EM: Synovium-derived microRNAs regulate bone pathways in rheumatoid arthritis. J Bone Miner Res. 32:461–472. 2017. View Article : Google Scholar :

7 

Krintel SB, Dehlendorff C, Hetland ML, Hørslev-Petersen K, Andersen KK, Junker P, Pødenphant J, Ellingsen T, Ahlquist P, Lindegaard HM, et al: Prediction of treatment response to adalimumab: A double-blind placebo-controlled study of circulating microRNA in patients with early rheumatoid arthritis. Pharmacogenomics J. 16:141–146. 2016. View Article : Google Scholar

8 

Abou-Zeid A, Saad M and Soliman E: MicroRNA 146a expression in rheumatoid arthritis: Association with tumor necrosis factor-alpha and disease activity. Genet Test Mol Biomarkers. 15:807–812. 2011. View Article : Google Scholar : PubMed/NCBI

9 

Yang G, Wu D, Zeng G, Jiang O, Yuan P, Huang S, Zhu J, Tian J, Weng Y and Rao Z: Correlation between miR-126 expression and DNA hypomethylation of CD4+ T cells in rheumatoid arthritis patients. Int J Clin Exp Pathol. 8:8929–8936. 2015.

10 

Jiang Y and Wang L: Role of histone deacetylase 3 in ankylosing spondylitis via negative feedback loop with microRNA-130a and enhancement of tumor necrosis factor-1α expression in peripheral blood mononuclear cells. Mol Med Rep. 13:35–40. 2016. View Article : Google Scholar

11 

Li ZC, Han N, Li X, Li G, Liu YZ, Sun GX, Wang Y, Chen GT and Li GF: Decreased expression of microRNA-130a correlates with TNF-α in the development of osteoarthritis. Int J Clin Exp Pathol. 8:2555–2564. 2015.

12 

Kuuliala K, Kuuliala A, Hämäläinen M, Koivuniemi R, Kautiainen H, Moilanen E, Repo H and Leirisalo-Repo M: Impaired Akt phosphorylation in monocytes of patients with rheumatoid arthritis. Scand J Immunol. 85:155–161. 2017. View Article : Google Scholar

13 

Zhang W, Du Z, Zhu J, Yu J and Xu Y: Sprouty2 suppresses the inflammatory responses in rheumatoid arthritis fibroblast-like synoviocytes through regulating the Raf/ERK and PTEN/AKT signals. Mol Immunol. 67:532–539. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Wang CR, Shiau AL, Chen SY, Lin LL, Tai MH, Shieh GS, Lin PR, Yo YT, Lee CH, Kuo SM, et al: Amelioration of collagen-induced arthritis in rats by adenovirus-mediated PTEN gene transfer. Arthritis Rheum. 58:1650–1656. 2008. View Article : Google Scholar

15 

Malemud CJ: The PI3K/Akt/PTEN/mTOR pathway: A fruitful target for inducing cell death in rheumatoid arthritis? Future Med Chem. 7:1137–1147. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Østergaard M, Jacobsson LT, Schaufelberger C, Hansen MS, Bijlsma JW, Dudek A, Rell-Bakalarska M, Staelens F, Haake R, Sundman-Engberg B, et al: MRI assessment of early response to certolizumab pegol in rheumatoid arthritis: A randomised, double-blind, placebo-controlled phase IIIb study applying MRI at weeks 0, 1, 2, 4, 8 and 16. Ann Rheum Dis. 74:1156–1163. 2015. View Article : Google Scholar :

17 

Zhu Q, Huang J, Wang SZ, Qin ZH and Lin F: Cobrotoxin extracted from Naja atra venom relieves arthritis symptoms through anti-inflammation and immunosuppression effects in rat arthritis model. J Ethnopharmacol. 194:1087–1095. 2016. View Article : Google Scholar : PubMed/NCBI

18 

McWilliams DF, Ferguson E, Young A, Kiely PD and Walsh DA: Discordant inflammation and pain in early and established rheumatoid arthritis: Latent Class Analysis of Early Rheumatoid Arthritis Network and British Society for Rheumatology Biologics Register data. Arthritis Res Ther. 18:2952016. View Article : Google Scholar :

19 

Zumbrennen-Bullough KB, Wu Q, Core AB, Canali S, Chen W, Theurl I, Meynard D and Babitt JL: MicroRNA-130a is up-regulated in mouse liver by iron deficiency and targets the bone morphogenetic protein (BMP) receptor ALK2 to attenuate BMP signaling and hepcidin transcription. J Biol Chem. 289:23796–23808. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Jia Q, Cheng W, Yue Y, Hu Y, Zhang J, Pan X, Xu Z and Zhang P: Cucurbitacin E inhibits TNF-α-induced inflammatory cytokine production in human synoviocyte MH7A cells via suppression of PI3K/Akt/NF-κB pathways. Int Immunopharmacol. 29:884–890. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Tang TT, Song Y, Ding YJ, Liao YH, Yu X, Du R, Xiao H, Yuan J, Zhou ZH, Liao MY, et al: Atorvastatin upregulates regulatory T cells and reduces clinical disease activity in patients with rheumatoid arthritis. J Lipid Res. 52:1023–1032. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Gao J, Zhou XL, Kong RN, Ji LM, He LL and Zhao DB: microRNA-126 targeting PIK3R2 promotes rheumatoid arthritis synovial fibro-blasts proliferation and resistance to apoptosis by regulating PI3K/AKT pathway. Exp Mol Pathol. 100:192–198. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Zhu X, Song Y, Huo R, Zhang J, Sun S, He Y, Gao H, Zhang M, Sun X, Zhai T, et al: Cyr61 participates in the pathogenesis of rheumatoid arthritis by promoting proIL-1β production by fibroblast-like synoviocytes through an AKT-dependent NF-κB signaling pathway. Clin Immunol. 157:187–197. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Lu C, Wang X, Ha T, Hu Y, Liu L, Zhang X, Yu H, Miao J, Kao R, Kalbfleisch J, et al: Attenuation of cardiac dysfunction and remodeling of myocardial infarction by microRNA-130a are mediated by suppression of PTEN and activation of PI3K dependent signaling. J Mol Cell Cardiol. 89:87–97. 2015. View Article : Google Scholar : PubMed/NCBI

25 

Lee SH, Park JS, Byun JK, Jhun J, Jung K, Seo HB, Moon YM, Kim HY, Park SH and Cho ML: PTEN ameliorates autoimmune arthritis through down-regulating STAT3 activation with reciprocal balance of Th17 and Tregs. Sci Rep. 6:346172016. View Article : Google Scholar : PubMed/NCBI

26 

Song CL, Liu B, Shi YF, Liu N, Yan YY, Zhang JC, Xue X, Wang JP, Zhao Z, Liu JG, et al: MicroRNA-130a alleviates human coronary artery endothelial cell injury and inflammatory responses by targeting PTEN via activating PI3K/Akt/eNOS signaling pathway. Oncotarget. 7:71922–71936. 2016. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Zhang Y, Xu S, Huang E, Zhou H, Li B, Shao C and Yang Y: MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. Int J Mol Med 41: 3699-3708, 2018.
APA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., & Yang, Y. (2018). MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 41, 3699-3708. https://doi.org/10.3892/ijmm.2018.3551
MLA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41.6 (2018): 3699-3708.
Chicago
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3699-3708. https://doi.org/10.3892/ijmm.2018.3551
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang Y, Xu S, Huang E, Zhou H, Li B, Shao C and Yang Y: MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. Int J Mol Med 41: 3699-3708, 2018.
APA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., & Yang, Y. (2018). MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway. International Journal of Molecular Medicine, 41, 3699-3708. https://doi.org/10.3892/ijmm.2018.3551
MLA
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41.6 (2018): 3699-3708.
Chicago
Zhang, Y., Xu, S., Huang, E., Zhou, H., Li, B., Shao, C., Yang, Y."MicroRNA-130a regulates chondrocyte proliferation and alleviates osteoarthritis through PTEN/PI3K/Akt signaling pathway". International Journal of Molecular Medicine 41, no. 6 (2018): 3699-3708. https://doi.org/10.3892/ijmm.2018.3551
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