Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
July-2018 Volume 42 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
July-2018 Volume 42 Issue 1

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway

  • Authors:
    • Lixian He
    • Zhou Zhou
    • Yi Shao
    • Zhen Yang
    • Shuangshuang Zhou
    • Xuexiang Zou
    • Ying Zhou
    • Gang Tan
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China, Medical College, University of South China, Hengyang, Hunan 421001, P.R. China, Department of Ophthalmology, The First Affiliated Hospital of Nanchang University, Jiangxi Province Clinical Ophthalmology Institute, Nanchang, Jiangxi 330006, P.R. China, Department of Cardiology, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China
    Copyright: © He et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 71-80
    |
    Published online on: March 22, 2018
       https://doi.org/10.3892/ijmm.2018.3580
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Bradykinin (BK) has been demonstrated to induce proliferation in several types of cell in ex vivo corneas. However, the mechanisms underlying the action of BK on corneal endothelial cells (CECs) remain largely unknown. The present study aimed to investigate the effect of BK on rabbit corneal endothelial cell (RCEC) proliferation, and assess the involvement of the zonula occludens‑1(ZO‑1)/ZO‑1associated nucleic acid binding protein (ZONAB) pathway. Cell proliferation and cell cycle distribution was analyzed following treatment with BK (0.01, 0.1,1.0 or 10.0 µM) for the indicated time intervals (24, 48, 72 and 96 h), or following BK treatment combined with transfection of ZONAB‑small interfering (si)RNA for 72 h. In addition, the expression of tight junction ZO‑1, nuclear ZONAB, proliferating cell nuclear antigen(PCNA) and cyclin D1 were evaluated using western blotting or immunofluorescence. BK treatment was demonstrated to induce time‑ and concentration‑dependent cell proliferation and cell cycle progression, along with the upregulation of tight junction ZO‑1 and nuclear ZONAB, as well as PCNA and cyclin D1 protein expression. Furthermore, knockdown with ZONAB‑siRNA inhibited cell proliferation, induced cell cycle arrest and downregulated PCNA and cyclin D1 protein expression. ZONAB knockdown therefore successfully reversed the increase in proliferation induced by BK treatment. Taken together, these results suggested that BK stimulated RCEC proliferation, potentially via the ZO‑1/ZONAB pathway. The signaling paradigm disclosed in the present study potentially serves as an important therapeutic target for cornea regeneration and transplantation.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Waring GO, Bourne WM, Edelhauser HF and Kenyon KR: The corneal endothelium. Normal and pathologic structure and function. Ophthalmology. 89:531–590. 1982. View Article : Google Scholar : PubMed/NCBI

2 

Joyce NC: Proliferative capacity of the corneal endothelium. Prog Retin Eye Res. 22:359–389. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Bourne WM, Nelson LR and Hodge DO: Central corneal endothelial cell changes over a ten-year period. Invest Ophthalmol Vis Sci. 38:779–782. 1997.PubMed/NCBI

4 

Saxena R, Boekhoorn SS, Mulder PG, Noordzij B, van Rij G and Luyten GP: Long-term follow-up of endothelial cell change after Artisan phakic intraocular lens implantation. Ophthalmology. 115:608–613. 2008. View Article : Google Scholar

5 

Kashuba E, Bailey J, Allsup D and Cawkwell L: The kinin-kallikrein system: Physiological roles, pathophysiology and its relationship to cancer biomarkers. Biomarkers. 18:279–296. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Khan MM, Bradford HN, Isordia-Salas I, Liu Y, Wu Y, Espinola RG, Ghebrehiwet B and Colman RW: High-molecular-weight kininogen fragments stimulate the secretion of cytokines and chemokines through uPAR, Mac-1, and gC1qR in monocytes. Arterioscler Thromb Vasc Biol. 26:2260–2266. 2006. View Article : Google Scholar : PubMed/NCBI

7 

Levy D and Zochodne DW: Increased mRNA expression of the B1 and B2 bradykinin receptors and antinociceptive effects of their antagonists in an animal model of neuropathic pain. Pain. 86:265–271. 2000. View Article : Google Scholar : PubMed/NCBI

8 

Huang SC, Chien C, Hsiao L, Wang C, Chiu C, Liang K and Yang CM: Mechanisms of bradykinin-mediated Ca2+ signaling in canine cultured corneal epithelial cells. CellSignal. 13:565–574. 2001.

9 

Wiernas TK, Davis TL, Griffin BW and Sharif NA: Effects of bradykinin on signal transduction, cell proliferation, and cytokine, prostaglandin E2 and collagenase-1 release from human corneal epithelial cells. Br J Pharmacol. 123:1127–1137. 1998. View Article : Google Scholar : PubMed/NCBI

10 

Cheng CY, Huang SC, Hsiao LD, Sun CC, Jou MJ and Yang CM: Bradykinin-stimulated P42/44 MAPK activation associated with cell proliferation in corneal keratocytes. CellSignal. 16:535–549. 2004.

11 

Cheng CY, Tseng HC and Yang CM: Bradykinin-mediated cell proliferation depends on transactivation of EGF receptor in corneal fibroblasts. J Cell Physiol. 227:1367–1381. 2012. View Article : Google Scholar

12 

Yang SW, Lee WK, Lee EJ, Kim KY, Lim Y, Lee KH, Rha HK and Hahn TW: Effect of bradykinin on cultured bovine corneal endothelial cells. Ophthalmologica. 215:303–308. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Webb JG: The kallikrein/kinin system in ocular function. J Ocul Pharmacol Ther. 27:539–543. 2011. View Article : Google Scholar : PubMed/NCBI

14 

Balda MS and Matter K: Tight junctions and the regulation of gene expression. Biochim Biophys Acta. 1788:761–767. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Terry S, Nie M, Matter K and Balda MS: Rho signaling and tight junction functions. Physiology. 25:16–26. 2010. View Article : Google Scholar : PubMed/NCBI

16 

Balda MS and Matter K: The tight junction protein ZO-1 and an interacting transcription factor regulate ErbB-2 expression. EMBO J. 19:2024–2033. 2000. View Article : Google Scholar : PubMed/NCBI

17 

Balda MS, Garrett MD and Matter K: The ZO-1-associated Y-box factor ZONAB regulates epithelial cell proliferation and cell density. J Cell Bio1. 160:423–432. 2003. View Article : Google Scholar

18 

Lima WR, Parreira KS, Devuyst O, Caplanusi A, N'kuli F, Marien B, Van Der Smissen P, Alves PM, Verroust P, Christensen EI, et al: ZONAB promotes proliferation and represses differentiation of proximal tubule epithelial cells. J Am Soc Nephrol. 21:478–488. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Sourisseau T, Georgiadis A, Tsapara A, Ali RR, Pestell R, Matter K and Balda MS: Regulation of PCNA and cyclin D1 expression and epithelial morphogenesis by the ZO-1-regulated transcription factor ZONAB/DbpA. Mol Cell Biol. 26:2387–2398. 2006. View Article : Google Scholar : PubMed/NCBI

20 

Georgiadis A, Tschemutter M, Bainbridge JW, Balaggan KS, Mowat F, West EL, Munro PM, Thrasher AJ, Matter K, Balda MS, et al: The tight junction associated signaling proteins ZO-1 and ZONAB regulate retinal pigment epithelium homeostasis in mice. PloS One. 5:e157302010. View Article : Google Scholar

21 

U.S. Office of Science and Technology Policy: Technology, Laboratory animal welfare: U.S. government principles for the utilization andcare of vertebrate animals used in testing, research and training; notice. Fed Regist. 50:20864–20865. 1985.

22 

Kay P, Nimni ME and Smith RE: Stability of collagen phenotype in morphologically modulated rabbit corneal endothelial cells. Invest Ophthalmol Vis Sci. 25:495–501. 1984.PubMed/NCBI

23 

Kim TY, Kim WI, Smith RE and Kay ED: Role of p27Kip1 in cAMP- and TGF-β2-mediated antiproliferation in rabbit corneal endothelial cells. Invest Ophthalmol Vis Sci. 42:3142–3149. 2001.PubMed/NCBI

24 

Schäfer J, Höbel S, Bakowsky U and Aigner A: Liposome-polyethylenimine complexes for enhanced DNA and siRNA delivery. Biomaterials. 31:6892–6900. 2010. View Article : Google Scholar : PubMed/NCBI

25 

Park SY, Jeong MS, Han CW, Yu HS and Jang SB: Structural and functional insight into proliferating cell nuclear antigen. J Microbiol Biotechnol. 28:637–647. 2016. View Article : Google Scholar

26 

Qie S and Diehl JA: Cyclin D1, cancer progression, and opportunities in cancer treatment. J Mol Med). 94:1313–1326. 2016. View Article : Google Scholar

27 

Wiernas TK, Griffin BW and Sharif NA: The expression of functionally-coupled B2-bradykinin receptors in human corneal epithelial cells and their pharmacological characterization with agonists and antagonists. Br J Pharmacol. 121:649–656. 1997. View Article : Google Scholar : PubMed/NCBI

28 

Kuznetsova TP, Chesnokova NB and Paskhina TS: Activity of tissue and plasma kallikrein and level of their precursors in eye tissue structures and media of healthy rabbits. Vopr Med Khim. 37:79–82. 1991.In Russian. PubMed/NCBI

29 

Ma JX, Song Q, Hatcher HC, Crouch RK, Chao L and Chao J: Expression and cellular localization of the kallikrein-kinin system in human ocular tissues. Exp Eye Res. 63:19–26. 1996. View Article : Google Scholar : PubMed/NCBI

30 

Leeb-Lundberg LM: Bradykinin specificity and signaling at GPR100 and B2 kinin receptors. Br J Pharmacol. 143:931–932. 2004. View Article : Google Scholar : PubMed/NCBI

31 

Dixon BS, Sharma RV, Dickerson T and Fortune J: Bradykinin and angiotensin II: Activation of protein kinase C in arterial smooth muscle. Am J Physiol. 266:C1406–1420. 1994. View Article : Google Scholar : PubMed/NCBI

32 

Mio T, Liu X, Toews ML, Adachi Y, Romberger DJ, Spurzem JR and Rennard SI: Bradykinin augments fibroblast-mediated contraction of released collagen gels. Am J Physiol Lung Cell Mol Physiol. 281:L164–L171. 2001. View Article : Google Scholar : PubMed/NCBI

33 

Bernier SG, Haldar S and Michel T: Bradykinin-regulated interactions of the mitogen-activated protein kinase pathway with the endothelial nitric-oxide synthase. J Biol Chem. 275:30707–30715. 2000. View Article : Google Scholar : PubMed/NCBI

34 

Yang CM, Lin MI, Hsieh HL, Sun CC, Ma YH and Hsiao LD: Bradykinin-induced p42/44 MAPK phosphorylation and cell proliferation via Src, EGF receptors, and PI3-K/Akt in vascular smooth muscle cells. J Cell Physiol. 203:538–546. 2005. View Article : Google Scholar

35 

Arakawa Y, Kajino K, Kano S, Tobita H, Hayashi J, Yasen M, Moriyama M, Arakawa Y and Hino O: Transcription of dbpA, a Y box binding protein, is positively regulated by E2F1: Implications in hepatocarcinogenesis. Biochem Biophys Res Commun. 322:297–302. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Jayagopal A, Yang JL, Haselton FR and Chang MS: Tight junction-associated signaling pathways modulate cell proliferation in uveal melanoma. Invest Ophthalmol Vis Sci. 52:588–593. 2011. View Article : Google Scholar :

37 

Kampik D, Basche M, Georgiadis A, Luhmann UF, Smith AJ, Larkin F and Ali RR: Lentivirus mediated interference with the ZO-1/ZONAB pathway induces cell cycle progression in human corneal endothelial cells. Invest Ophthalmol Vis Sci. 53:60042012.

38 

Spadaro D, Tapia R, Jond L, Sudol M, Fanning AS and Citi S: ZO proteins redundantly regulate the transcription factor DbpA/ZONAB. J Biol Chem. 289:22500–22511. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Qiao X, Roth I, Féraille E and Hasler U: Different effects of ZO-1, ZO-2 and ZO-3 silencing on kidney collecting duct principal cell proliferation and adhesion. Cell Cycle. 13:3059–3075. 2014. View Article : Google Scholar

40 

Willott E, Balda MS, Fanning AS, Jameson B, Van Itallie C and Anderson JM: The tight junction protein ZO-1 is homologous to the Drosophila discs-large tumor suppressor protein of septate junctions. Proc Natl Acad Sci USA. 90:7834–7838. 1993. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
He L, Zhou Z, Shao Y, Yang Z, Zhou S, Zou X, Zhou Y and Tan G: Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway. Int J Mol Med 42: 71-80, 2018.
APA
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X. ... Tan, G. (2018). Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway. International Journal of Molecular Medicine, 42, 71-80. https://doi.org/10.3892/ijmm.2018.3580
MLA
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X., Zhou, Y., Tan, G."Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway". International Journal of Molecular Medicine 42.1 (2018): 71-80.
Chicago
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X., Zhou, Y., Tan, G."Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway". International Journal of Molecular Medicine 42, no. 1 (2018): 71-80. https://doi.org/10.3892/ijmm.2018.3580
Copy and paste a formatted citation
x
Spandidos Publications style
He L, Zhou Z, Shao Y, Yang Z, Zhou S, Zou X, Zhou Y and Tan G: Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway. Int J Mol Med 42: 71-80, 2018.
APA
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X. ... Tan, G. (2018). Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway. International Journal of Molecular Medicine, 42, 71-80. https://doi.org/10.3892/ijmm.2018.3580
MLA
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X., Zhou, Y., Tan, G."Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway". International Journal of Molecular Medicine 42.1 (2018): 71-80.
Chicago
He, L., Zhou, Z., Shao, Y., Yang, Z., Zhou, S., Zou, X., Zhou, Y., Tan, G."Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway". International Journal of Molecular Medicine 42, no. 1 (2018): 71-80. https://doi.org/10.3892/ijmm.2018.3580
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team