Journal Articles

Open Access

Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

Xianliang Dai, Li Hua, Yihong Chen, Jiamei Wang, Jingyi Li, Feng Wu, Yanda Zhang, Jiyuan Su, Zonggui Wu, Chun Liang

Pages: 3-12 Published online on: 30 March 2018

Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)

Mengwen Zhou, Jing Luo, Huiming Zhang

Pages: 13-20 Published online on: 16 April 2018
Open Access

Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays

Hao Shen, Wei Wang, Bingbing Ni, Qiang Zou, Hua Lu, Zhanchao Wang

Pages: 21-30 Published online on: 27 March 2018
Open Access

Liuwei Dihuang, a traditional Chinese medicinal formula, inhibits proliferation and migration of vascular smooth muscle cells via modulation of estrogen receptors

Yayun Zhang, Xing Qian, Xin Sun, Chao Lin, Yi Jing, Yuan Yao, Zhi Ma, Meiyu Kuai, Ying Lu, Xueyun Kong, Qi Chen, Xiang Wu, Xuan Zhao, Yu Li, Huimin Bian

Pages: 31-40 Published online on: 16 April 2018
Open Access

Juglanin ameliorates UVB‑induced skin carcinogenesis via anti‑inflammatory and proapoptotic effects in vivo and in vitro

Gui‑Rong Hou, Kang Zeng, Hai‑Mei Lan, Qi Wang

Pages: 41-52 Published online on: 29 March 2018
Open Access

Generation of haploid spermatids from chicken embryonal primordial germ cells

Meng Ji, Shuang Tang, Wenhua Pei, Mingming Ning, Yuehui Ma, Xiangchen Li, Weijun Guan

Pages: 53-60 Published online on: 30 March 2018
Open Access

Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway

Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye

Pages: 61-70 Published online on: 22 March 2018
Open Access

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway

Lixian He, Zhou Zhou, Yi Shao, Zhen Yang, Shuangshuang Zhou, Xuexiang Zou, Ying Zhou, Gang Tan

Pages: 71-80 Published online on: 22 March 2018
Open Access

Gene microarray analysis of lncRNA and mRNA expression profiles in patients with high‑grade ovarian serous cancer

Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Xiangyu Wang, Lingzhi Wang, Yi Han

Pages: 91-104 Published online on: 23 March 2018
Open Access

Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer

Gui‑Feng Liu, Zong‑Qiang Wang, Shu‑Hua Zhang, Xue‑Feng Li, Lin Liu, Ying‑Ying Miao, Shao‑Nan Yu

Pages: 105-114 Published online on: 27 March 2018
Open Access

Tripterygium glycoside protects against puromycin amino nucleoside‑induced podocyte injury by upregulating autophagy

Jianguang Gong, Juan Jin, Li Zhao, Yiqiao Li, Yiwen Li, Qiang He

Pages: 115-122 Published online on: 29 March 2018
Open Access

Novel NADPH oxidase inhibitor VAS2870 suppresses TGF‑β‑dependent epithelial‑to‑mesenchymal transition in retinal pigment epithelial cells

Jing Yang, Jing Li, Qun Wang, Yao Xing, Zizhu Tan, Qianyan Kang

Pages: 123-130 Published online on: 03 April 2018
Open Access

Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/‌Akt‑dependent Tbx‑3 activation pathway

Minxia Ke, Quan He, Danping Hong, Ouyang Li, Mengyi  Zhu, Wen‑Bin Ou, Yulong He, Yuehong Wu

Pages: 131-140 Published online on: 03 April 2018
Open Access

miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3

Zhichun Liu, Jingwu Sun, Bin Liu, Mengjie Zhao, Entao Xing, Cunshu Dang

Pages: 141-148 Published online on: 20 April 2018
Open Access

Prognostic significance of microsatellite instability‑associated pathways and genes in gastric cancer

Xiaosheng Hang, Dapeng Li, Jianping Wang, Ge Wang

Pages: 149-160 Published online on: 26 April 2018
Open Access

Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor‑mediated angiogenesis

Qingfeng Ding, Peng Sun, Hao Zhou, Bowen Wan, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Jin Fan

Pages: 171-181 Published online on: 03 April 2018
Open Access

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E Jian Lee

Pages: 182-192 Published online on: 30 March 2018
Open Access

Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS

Hong-Mao Song, Xiang Li, Yuan-Yuan Liu, Wei-Ping Lu, Zhao-Hui Cui, Li Zhou, Di Yao, Hong-Man Zhang

Pages: 193-207 Published online on: 27 March 2018
Open Access

Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway

Wei Huang, Ming-Li Li, Ming-Yue Xia, Jian-Ying Shao

Pages: 208-218 Published online on: 22 March 2018
Open Access

Peroxisome proliferator-activated receptor-γ and its related pathway in bone marrow mesenchymal stem cell differentiation co-cultured with mechanically stretched ligament fibroblasts

Bing Zhao, Mengcai Hu, Huiyan Wu, Chenchen Ren, Juan Chen, Xiaodan Zhang, Shihong Cui

Pages: 219-227 Published online on: 20 March 2018
Open Access

miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells

Fei Zhu, Qiong Wu, Zhen Ni, Chao Lei, Ting Li, Yongquan Shi

Pages: 228-236 Published online on: 22 March 2018
Open Access

Fisetin administration improves LPS-induced acute otitis media in mouse in vivo

Peng Li, Dan Chen, Yang Huang

Pages: 237-247 Published online on: 22 March 2018
Open Access

A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families

Shuo Yu, Cui Mao, Jinyi Yu, Xin Qi, Jing Wang, Hong Lu

Pages: 259-269 Published online on: 29 March 2018
Open Access

Hypoxia induces endothelial‑mesenchymal transition in pulmonary vascular remodeling

Bo Zhang, Wen Niu, Hai‑Ying Dong, Man‑Ling Liu, Ying Luo, Zhi‑Chao Li

Pages: 270-278 Published online on: 22 March 2018
Open Access

Deregulation of microRNA‑31a‑5p is involved in the development of primary hypertension by suppressing apoptosis of pulmonary artery smooth muscle cells via targeting TP53

Qiang Feng, Tao Tian, Junfeng Liu, Li Zhang, Jiangang Qi, Xiaojuan Lin

Pages: 290-298 Published online on: 29 March 2018
Open Access

Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice

Jia‑Li Zhang, Xue‑Min Qiu, Na Zhang, Wei Tang, Hans‑Jürgen Gober, Da‑Jin Li, Ling Wang

Pages: 299-308 Published online on: 26 April 2018
Open Access

Imaging of immunogold labeling in cells and tissues by helium ion microscopy

Chikara Sato, Mari Sato, Shinichi Ogawa

Pages: 309-321 Published online on: 30 March 2018
Open Access

Low‑intensity pulsed ultrasound promotes periodontal ligament stem cell migration through TWIST1‑mediated SDF‑1 expression

Yunji Wang, Jie Li, Ye Qiu, Bo Hu, Jin Chen, Tiwei Fu, Pengfei Zhou, Jinlin Song

Pages: 322-330 Published online on: 27 March 2018
Open Access

Poligoni Multiflori Radix enhances osteoblast formation and reduces osteoclast differentiation

Sang‑Yong Han, Kyung‑Hee Lee, Yun‑Kyung Kim

Pages: 331-345 Published online on: 30 March 2018
Open Access

PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells

Chunhui Wang, Jianghong Qu, Siyuan Yan, Quan Gao, Sibin Hao, Dongsheng Zhou

Pages: 359-367 Published online on: 29 March 2018
Open Access

Inflammatory genes are novel prognostic biomarkers for colorectal cancer

Hao Jiang, Li Dong, Fangyan Gong, Yuping Gu, Henghun Zhang, Dong Fan, Zhiguo Sun

Pages: 368-380 Published online on: 18 April 2018
Open Access

miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10

Naixin Ding, Xiujin Sun, Tingting Wang, Lei Huang, Jing Wen, Yiqin Zhou

Pages: 381-391 Published online on: 24 April 2018
Open Access

FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma

Eva Skarmoutsou, Valentina Bevelacqua, Fabio D' Amico, Angela Russo, Demetrios   A. Spandidos, Aurora Scalisi, Grazia Malaponte, Claudio Guarneri

Pages: 392-404 Published online on: 04 April 2018
Open Access

Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging

Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N. Tzatzarakis, Christina Tsitsimpikou, Polychronis D. Stivaktakis, Dimitrios Tsoukalas, Demetrios A. Spandidos, Aristides M. Tsatsakis, Buket Alpertunga

Pages: 405-413 Published online on: 26 April 2018

Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression Corrigendum in /10.3892/ijmm.2019.4119

Ali Kadivar, Mohamed Ibrahim Noordin, Arya Aditya, Behnam Kamalidehghan, Ehsan Taghizadeh Davoudi, Reihaneh Sedghi, Hamid Akbari Javar

Pages: 414-424 Published online on: 27 March 2018

Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines

Abudubari Sikandan, Takahisa Shinomiya, Yukitoshi Nagahara

Pages: 425-434 Published online on: 02 April 2018

Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs

Yehui Shi, Yongsheng Jia, Weipeng Zhao, Liyan Zhou, Xiaojuan Xie, Zhongsheng Tong

Pages: 435-442 Published online on: 03 April 2018

Genome-wide analysis of DNA methylation in human peripheral leukocytes identifies potential biomarkers of nonalcoholic fatty liver disease

Rui-Nan Zhang, Qin Pan, Rui-Dan Zheng, Yu-Qiang Mi, Feng Shen, Da Zhou, Guang-Yu Chen, Chan-Yan Zhu, Jian-Gao Fan

Pages: 443-452 Published online on: 22 March 2018

miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway

Hongtao Hu, Shuang Hu, Shen Xu, Yue Gao, Fang Zeng, Hua Shui

Pages: 453-460 Published online on: 22 March 2018

TWIST1 upregulates miR-214 to promote epithelial-to-mesenchymal transition and metastasis in lung adenocarcinoma

Chao Liu, Jing Luo, Yue-Tao Zhao, Zhong-Yu Wang, Jie Zhou, Shuo Huang, Jia-Ni Huang, Hai-Xia Long, Bo Zhu

Pages: 461-470 Published online on: 17 April 2018

Plasma cholesterol lowering in an AngII‑infused atherosclerotic mouse model with moderate hypercholesterolemia

Aránzazu Rossignoli, Emina Vorkapic, Anders Wanhainen, Toste Länne, Josefin Skogberg, Erika Folestad, Dick Wågsäter

Pages: 471-478 Published online on: 05 April 2018

Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress

Gaoyu Cai, Aijuan Yan, Ningzhen Fu, Yi Fu

Pages: 479-488 Published online on: 27 March 2018

lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR‑26b to activate CTGF/ANGPT2

Jifu Zheng, Lili Hu, Jing Cheng, Jing Xu, Zhiqiang Zhong, Yuan Yang, Zheng Yuan

Pages: 489-496 Published online on: 29 March 2018

Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway

Lingling Tang, Qingge Chen, Li Sun, Linyun Zhu, Jinjin Liu, Ziyu Meng, Zhenhua Ni, Xiongbiao Wang

Pages: 497-504 Published online on: 02 April 2018

RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling

Xin Guo, Hong Jiang, Jing Chen, Bo-Fang Zhang, Qi Hu, Shuo Yang, Jian Yang, Jing Zhang

Pages: 505-513 Published online on: 16 April 2018

Bioinformatics analysis and verification of key genes associated with recurrent respiratory tract infections

Xiang Jin, Zhiyong Ji, Xiaodan Li, Rui Liu, Yinghui Guan

Pages: 514-524 Published online on: 24 April 2018

Isolation and biological characteristic evaluation of a novel type of cartilage stem/progenitor cell derived from Small‑tailed Han sheep embryos

Caiyun Ma, Tengfei Lu, Hebao Wen, Yanjie Zheng, Xiao Han, Xongda Ji, Weijun Guan

Pages: 525-533 Published online on: 17 April 2018

Novel zinc‑ and silicon‑phthalocyanines as photosensitizers for photodynamic therapy of cholangiocarcinoma

Jacob Schmidt, Weronika Kuzyniak, Janine Berkholz, Gustav Steinemann, Racheal Ogbodu, Björn Hoffmann, Geraldine Nouailles, Ayşe Gül Gürek, Bianca Nitzsche, Michael Höpfner

Pages: 534-546 Published online on: 16 April 2018

MicroRNA‑497 attenuates cerebral infarction in patients via the TLR4 and CREB signaling pathways

Si Chen, Wenwei Yin, Kun Bi, Bin Lu

Pages: 547-556 Published online on: 03 April 2018

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation

Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis

Pages: 557-568 Published online on: 16 April 2018

Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss

Phuong Thao Tran, Dong‑Hwa Park, Okhwa Kim, Seung‑Hae Kwon, Byung‑Sun Min, Jeong‑Hyung Lee

Pages: 569-578 Published online on: 17 April 2018

Emodin inhibits epithelial‑mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC‑chemokine ligand 5 secreted from adipocytes

Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang, Yu Wang, Zhenping Sun, Kui Yu, Shuai Zhang, Sheng Liu

Pages: 579-588 Published online on: 23 April 2018

MicroRNA‑221‑3p contributes to cardiomyocyte injury in H2O2‑treated H9c2 cells and a rat model of myocardial ischemia‑reperfusion by targeting p57

Qingfeng Meng, Yang Liu, Xiuyue Huo, Hui Sun, Yingcui Wang, Fangfang Bu

Pages: 589-596 Published online on: 17 April 2018

Human circular RNA‑0054633 regulates high glucose‑induced vascular endothelial cell dysfunction through the microRNA‑218/roundabout 1 and microRNA‑218/heme oxygenase‑1 axes

Long Pan, Weishuai Lian, Xiaojun Zhang, Shilong Han, Chuanwu Cao, Xue Li, Maoquan Li

Pages: 597-606 Published online on: 16 April 2018

Adenosine A(2A) receptor activation reverses hypoxia‑induced rat pulmonary artery smooth muscle cell proliferation via cyclic AMP‑mediated inhibition of the SDF1‑CXC4 signaling pathway

Yang Wang, Lei Ying, Ke‑Ke Jin, Yan Nan, Suhua Hu, Xueqin Wu, Ruyi Qi, Xin Luo, Liangxing Wang

Pages: 607-614 Published online on: 16 April 2018

Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro

Huanjun Xu, Hong Lu, Xiaocui Zhu, Wei Wang, Zhoumiao Zhang, Huizheng Fu, Shuangcheng Ma, Yuehua Luo, Jianjiang Fu

Pages: 615-624 Published online on: 19 April 2018

Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer

Fei Wang, Chun‑Qian Dai, Li‑Rong Zhang, Cao Bing, Jun Qin, Yi‑Fei Liu

Pages: 625-632 Published online on: 18 April 2018

JMJD6 exerts function in neuropathic pain by regulating NF‑κB following peripheral nerve injury in rats

Cen Wen, Mengyuan Xu, Cheng Mo, Zhigang Cheng, Qulian Guo, Xiaoyan Zhu

Pages: 633-642 Published online on: 03 April 2018

miR‑152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10

Jialong Guo, Juan Du, Dan Fei, Jie Xing, Jinxiang Liu, Honghua Lu

Pages: 643-650 Published online on: 20 April 2018

Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study

Marianna De Colli, Paolo Tortorella, Mariangela Agamennone, Cristina Campestre, Fulvio Loiodice, Amelia Cataldi, Susi Zara

Pages: 651-657 Published online on: 25 April 2018

Effect of hydroxyl group position in flavonoids on inducing single‑stranded DNA damage mediated by cupric ions

Suad Elmegerhi, Cathy Su, Dylan John Buglewicz, Yasushi Aizawa, Takamitsu A Kato

Pages: 658-664 Published online on: 03 April 2018

MicroRNA‑125 inhibits RKO colorectal cancer cell growth by targeting VEGF

Qi‑Bing Wu, Jing Chen, Jia‑Wei Zhu, Xin Yin, He‑Yang You, Yi‑Rong Lin, Hua‑Qing Zhu

Pages: 665-673 Published online on: 18 April 2018
Open Access

[Corrigendum] Inhibition of RANKL‑induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium‑particle‑induced osteolysis

Mingjun Li, Wengang Wang, Li Geng, Yanru Qin, Wenjie Dong, Xudong Zhang, An Qin, Mingzhi Zhang

Pages: 685-685 Published online on: 03 April 2018
Journal Cover

July 2018
Volume 42 Issue 1

Print ISSN: 1107-3756
Online ISSN: 1791-244X

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