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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
July-2018 Volume 42 Issue 1

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

Xianliang Dai, Li Hua, Yihong Chen, Jiamei Wang, Jingyi Li, Feng Wu, Yanda Zhang, Jiyuan Su, Zonggui Wu, Chun Liang
Pages: 3-12
Published online on: 30 March 2018

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Review

Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)

Mengwen Zhou, Jing Luo, Huiming Zhang
Pages: 13-20
Published online on: 16 April 2018

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Article Open Access

Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays

Hao Shen, Wei Wang, Bingbing Ni, Qiang Zou, Hua Lu, Zhanchao Wang
Pages: 21-30
Published online on: 27 March 2018

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Article Open Access

Liuwei Dihuang, a traditional Chinese medicinal formula, inhibits proliferation and migration of vascular smooth muscle cells via modulation of estrogen receptors

Yayun Zhang, Xing Qian, Xin Sun, Chao Lin, Yi Jing, Yuan Yao, Zhi Ma, Meiyu Kuai, Ying Lu, Xueyun Kong, Qi Chen, Xiang Wu, Xuan Zhao, Yu Li, Huimin Bian
Pages: 31-40
Published online on: 16 April 2018

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Article Open Access

Juglanin ameliorates UVB‑induced skin carcinogenesis via anti‑inflammatory and proapoptotic effects in vivo and in vitro

Gui‑Rong Hou, Kang Zeng, Hai‑Mei Lan, Qi Wang
Pages: 41-52
Published online on: 29 March 2018

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Article Open Access

Generation of haploid spermatids from chicken embryonal primordial germ cells

Meng Ji, Shuang Tang, Wenhua Pei, Mingming Ning, Yuehui Ma, Xiangchen Li, Weijun Guan
Pages: 53-60
Published online on: 30 March 2018

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Article Open Access

Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway

Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye
Pages: 61-70
Published online on: 22 March 2018

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Article Open Access

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway

Lixian He, Zhou Zhou, Yi Shao, Zhen Yang, Shuangshuang Zhou, Xuexiang Zou, Ying Zhou, Gang Tan
Pages: 71-80
Published online on: 22 March 2018

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Article Open Access

Abnormal expression of fibrosis markers, estrogen receptor α and stromal derived factor‑1/chemokine (C‑X‑C motif) receptor‑4 axis in intrauterine adhesions

Qin Zhou, Xixi Wu, Jianguo Hu, Rui Yuan
Pages: 81-90
Published online on: 22 March 2018

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Article Open Access

Gene microarray analysis of lncRNA and mRNA expression profiles in patients with high‑grade ovarian serous cancer

Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Xiangyu Wang, Lingzhi Wang, Yi Han
Pages: 91-104
Published online on: 23 March 2018

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Article Open Access

Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer Retraction in /10.3892/ijmm.2020.4484

Gui‑Feng Liu, Zong‑Qiang Wang, Shu‑Hua Zhang, Xue‑Feng Li, Lin Liu, Ying‑Ying Miao, Shao‑Nan Yu
Pages: 105-114
Published online on: 27 March 2018

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Article Open Access

Tripterygium glycoside protects against puromycin amino nucleoside‑induced podocyte injury by upregulating autophagy

Jianguang Gong, Juan Jin, Li Zhao, Yiqiao Li, Yiwen Li, Qiang He
Pages: 115-122
Published online on: 29 March 2018

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Article Open Access

Novel NADPH oxidase inhibitor VAS2870 suppresses TGF‑β‑dependent epithelial‑to‑mesenchymal transition in retinal pigment epithelial cells

Jing Yang, Jing Li, Qun Wang, Yao Xing, Zizhu Tan, Qianyan Kang
Pages: 123-130
Published online on: 03 April 2018

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Article Open Access

Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/‌Akt‑dependent Tbx‑3 activation pathway

Minxia Ke, Quan He, Danping Hong, Ouyang Li, Mengyi  Zhu, Wen‑Bin Ou, Yulong He, Yuehong Wu
Pages: 131-140
Published online on: 03 April 2018

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Article Open Access

miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3

Zhichun Liu, Jingwu Sun, Bin Liu, Mengjie Zhao, Entao Xing, Cunshu Dang
Pages: 141-148
Published online on: 20 April 2018

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Article Open Access

Prognostic significance of microsatellite instability‑associated pathways and genes in gastric cancer

Xiaosheng Hang, Dapeng Li, Jianping Wang, Ge Wang
Pages: 149-160
Published online on: 26 April 2018

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Article Open Access

Bromodomain‑containing protein 4 is critical for the antiproliferative and pro‑apoptotic effects of gambogic acid in anaplastic thyroid cancer

Yonghui Wang, Wei Wang, Hongqin Sun
Pages: 161-170
Published online on: 26 April 2018

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Article Open Access

Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor‑mediated angiogenesis

Qingfeng Ding, Peng Sun, Hao Zhou, Bowen Wan, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Jin Fan
Pages: 171-181
Published online on: 03 April 2018

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Article Open Access

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E Jian Lee
Pages: 182-192
Published online on: 30 March 2018

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Article Open Access

Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS

Hong-Mao Song, Xiang Li, Yuan-Yuan Liu, Wei-Ping Lu, Zhao-Hui Cui, Li Zhou, Di Yao, Hong-Man Zhang
Pages: 193-207
Published online on: 27 March 2018

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Article Open Access

Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway

Wei Huang, Ming-Li Li, Ming-Yue Xia, Jian-Ying Shao
Pages: 208-218
Published online on: 22 March 2018

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Article Open Access

Peroxisome proliferator-activated receptor-γ and its related pathway in bone marrow mesenchymal stem cell differentiation co-cultured with mechanically stretched ligament fibroblasts

Bing Zhao, Mengcai Hu, Huiyan Wu, Chenchen Ren, Juan Chen, Xiaodan Zhang, Shihong Cui
Pages: 219-227
Published online on: 20 March 2018

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Article Open Access

miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells

Fei Zhu, Qiong Wu, Zhen Ni, Chao Lei, Ting Li, Yongquan Shi
Pages: 228-236
Published online on: 22 March 2018

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Article Open Access

Fisetin administration improves LPS-induced acute otitis media in mouse in vivo

Peng Li, Dan Chen, Yang Huang
Pages: 237-247
Published online on: 22 March 2018

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Article Open Access

Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media

Yu-Kun Ma, Yu-Bin Chen, Peng Li
Pages: 248-258
Published online on: 20 March 2018

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Article Open Access

A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families

Shuo Yu, Cui Mao, Jinyi Yu, Xin Qi, Jing Wang, Hong Lu
Pages: 259-269
Published online on: 29 March 2018

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Article Open Access

Hypoxia induces endothelial‑mesenchymal transition in pulmonary vascular remodeling

Bo Zhang, Wen Niu, Hai‑Ying Dong, Man‑Ling Liu, Ying Luo, Zhi‑Chao Li
Pages: 270-278
Published online on: 22 March 2018

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Article Open Access

Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells

Hongjun Zhang, Baoling Ju, Ying Nie, Baohui Song, Yuanhong Xu, Ping Gao
Pages: 279-289
Published online on: 29 March 2018

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Article Open Access

Deregulation of microRNA‑31a‑5p is involved in the development of primary hypertension by suppressing apoptosis of pulmonary artery smooth muscle cells via targeting TP53

Qiang Feng, Tao Tian, Junfeng Liu, Li Zhang, Jiangang Qi, Xiaojuan Lin
Pages: 290-298
Published online on: 29 March 2018

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Article Open Access

Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice

Jia‑Li Zhang, Xue‑Min Qiu, Na Zhang, Wei Tang, Hans‑Jürgen Gober, Da‑Jin Li, Ling Wang
Pages: 299-308
Published online on: 26 April 2018

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Article Open Access

Imaging of immunogold labeling in cells and tissues by helium ion microscopy

Chikara Sato, Mari Sato, Shinichi Ogawa
Pages: 309-321
Published online on: 30 March 2018

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Article Open Access

Low‑intensity pulsed ultrasound promotes periodontal ligament stem cell migration through TWIST1‑mediated SDF‑1 expression Corrigendum in /10.3892/ijmm.2022.5093

Yunji Wang, Jie Li, Ye Qiu, Bo Hu, Jin Chen, Tiwei Fu, Pengfei Zhou, Jinlin Song
Pages: 322-330
Published online on: 27 March 2018

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Article Open Access

Poligoni Multiflori Radix enhances osteoblast formation and reduces osteoclast differentiation

Sang‑Yong Han, Kyung‑Hee Lee, Yun‑Kyung Kim
Pages: 331-345
Published online on: 30 March 2018

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Article Open Access

TIM‑4 blockade of KCs combined with exogenous TGF‑β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts

Hao Wu, Xuesong Xu, Jinzheng Li, Jianping Gong, Min Li
Pages: 346-358
Published online on: 30 March 2018

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Article Open Access

PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells

Chunhui Wang, Jianghong Qu, Siyuan Yan, Quan Gao, Sibin Hao, Dongsheng Zhou
Pages: 359-367
Published online on: 29 March 2018

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Article Open Access

Inflammatory genes are novel prognostic biomarkers for colorectal cancer

Hao Jiang, Li Dong, Fangyan Gong, Yuping Gu, Henghun Zhang, Dong Fan, Zhiguo Sun
Pages: 368-380
Published online on: 18 April 2018

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Article Open Access

miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640

Naixin Ding, Xiujin Sun, Tingting Wang, Lei Huang, Jing Wen, Yiqin Zhou
Pages: 381-391
Published online on: 24 April 2018

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Article Open Access

FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma

Eva Skarmoutsou, Valentina Bevelacqua, Fabio D' Amico, Angela Russo, Demetrios   A. Spandidos, Aurora Scalisi, Grazia Malaponte, Claudio Guarneri
Pages: 392-404
Published online on: 04 April 2018

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Article Open Access

Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging

Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N. Tzatzarakis, Christina Tsitsimpikou, Polychronis D. Stivaktakis, Dimitrios Tsoukalas, Demetrios A. Spandidos, Aristides M. Tsatsakis, Buket Alpertunga
Pages: 405-413
Published online on: 26 April 2018

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Article

Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression Corrigendum in /10.3892/ijmm.2019.4119

Ali Kadivar, Mohamed Ibrahim Noordin, Arya Aditya, Behnam Kamalidehghan, Ehsan Taghizadeh Davoudi, Reihaneh Sedghi, Hamid Akbari Javar
Pages: 414-424
Published online on: 27 March 2018

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Article

Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines

Abudubari Sikandan, Takahisa Shinomiya, Yukitoshi Nagahara
Pages: 425-434
Published online on: 02 April 2018

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Article

Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs

Yehui Shi, Yongsheng Jia, Weipeng Zhao, Liyan Zhou, Xiaojuan Xie, Zhongsheng Tong
Pages: 435-442
Published online on: 03 April 2018

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Article

Genome-wide analysis of DNA methylation in human peripheral leukocytes identifies potential biomarkers of nonalcoholic fatty liver disease

Rui-Nan Zhang, Qin Pan, Rui-Dan Zheng, Yu-Qiang Mi, Feng Shen, Da Zhou, Guang-Yu Chen, Chan-Yan Zhu, Jian-Gao Fan
Pages: 443-452
Published online on: 22 March 2018

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Article

miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway

Hongtao Hu, Shuang Hu, Shen Xu, Yue Gao, Fang Zeng, Hua Shui
Pages: 453-460
Published online on: 22 March 2018

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Article

TWIST1 upregulates miR-214 to promote epithelial-to-mesenchymal transition and metastasis in lung adenocarcinoma

Chao Liu, Jing Luo, Yue-Tao Zhao, Zhong-Yu Wang, Jie Zhou, Shuo Huang, Jia-Ni Huang, Hai-Xia Long, Bo Zhu
Pages: 461-470
Published online on: 17 April 2018

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Article

Plasma cholesterol lowering in an AngII‑infused atherosclerotic mouse model with moderate hypercholesterolemia

Aránzazu Rossignoli, Emina Vorkapic, Anders Wanhainen, Toste Länne, Josefin Skogberg, Erika Folestad, Dick Wågsäter
Pages: 471-478
Published online on: 05 April 2018

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Article

Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress

Gaoyu Cai, Aijuan Yan, Ningzhen Fu, Yi Fu
Pages: 479-488
Published online on: 27 March 2018

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Article

lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR‑26b to activate CTGF/ANGPT2

Jifu Zheng, Lili Hu, Jing Cheng, Jing Xu, Zhiqiang Zhong, Yuan Yang, Zheng Yuan
Pages: 489-496
Published online on: 29 March 2018

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Article

Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway

Lingling Tang, Qingge Chen, Li Sun, Linyun Zhu, Jinjin Liu, Ziyu Meng, Zhenhua Ni, Xiongbiao Wang
Pages: 497-504
Published online on: 02 April 2018

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Article

RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling

Xin Guo, Hong Jiang, Jing Chen, Bo-Fang Zhang, Qi Hu, Shuo Yang, Jian Yang, Jing Zhang
Pages: 505-513
Published online on: 16 April 2018

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Article

Bioinformatics analysis and verification of key genes associated with recurrent respiratory tract infections

Xiang Jin, Zhiyong Ji, Xiaodan Li, Rui Liu, Yinghui Guan
Pages: 514-524
Published online on: 24 April 2018

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Article

Isolation and biological characteristic evaluation of a novel type of cartilage stem/progenitor cell derived from Small‑tailed Han sheep embryos

Caiyun Ma, Tengfei Lu, Hebao Wen, Yanjie Zheng, Xiao Han, Xongda Ji, Weijun Guan
Pages: 525-533
Published online on: 17 April 2018

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Article

Novel zinc‑ and silicon‑phthalocyanines as photosensitizers for photodynamic therapy of cholangiocarcinoma

Jacob Schmidt, Weronika Kuzyniak, Janine Berkholz, Gustav Steinemann, Racheal Ogbodu, Björn Hoffmann, Geraldine Nouailles, Ayşe Gül Gürek, Bianca Nitzsche, Michael Höpfner
Pages: 534-546
Published online on: 16 April 2018

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Article

MicroRNA‑497 attenuates cerebral infarction in patients via the TLR4 and CREB signaling pathways

Si Chen, Wenwei Yin, Kun Bi, Bin Lu
Pages: 547-556
Published online on: 03 April 2018

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Article

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation

Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 557-568
Published online on: 16 April 2018

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Article

Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss

Phuong Thao Tran, Dong‑Hwa Park, Okhwa Kim, Seung‑Hae Kwon, Byung‑Sun Min, Jeong‑Hyung Lee
Pages: 569-578
Published online on: 17 April 2018

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Article

Emodin inhibits epithelial‑mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC‑chemokine ligand 5 secreted from adipocytes

Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang, Yu Wang, Zhenping Sun, Kui Yu, Shuai Zhang, Sheng Liu
Pages: 579-588
Published online on: 23 April 2018

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Article

MicroRNA‑221‑3p contributes to cardiomyocyte injury in H2O2‑treated H9c2 cells and a rat model of myocardial ischemia‑reperfusion by targeting p57

Qingfeng Meng, Yang Liu, Xiuyue Huo, Hui Sun, Yingcui Wang, Fangfang Bu
Pages: 589-596
Published online on: 17 April 2018

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Article

Human circular RNA‑0054633 regulates high glucose‑induced vascular endothelial cell dysfunction through the microRNA‑218/roundabout 1 and microRNA‑218/heme oxygenase‑1 axes

Long Pan, Weishuai Lian, Xiaojun Zhang, Shilong Han, Chuanwu Cao, Xue Li, Maoquan Li
Pages: 597-606
Published online on: 16 April 2018

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Article

Adenosine A(2A) receptor activation reverses hypoxia‑induced rat pulmonary artery smooth muscle cell proliferation via cyclic AMP‑mediated inhibition of the SDF1‑CXC4 signaling pathway

Yang Wang, Lei Ying, Ke‑Ke Jin, Yan Nan, Suhua Hu, Xueqin Wu, Ruyi Qi, Xin Luo, Liangxing Wang
Pages: 607-614
Published online on: 16 April 2018

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Article

Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro

Huanjun Xu, Hong Lu, Xiaocui Zhu, Wei Wang, Zhoumiao Zhang, Huizheng Fu, Shuangcheng Ma, Yuehua Luo, Jianjiang Fu
Pages: 615-624
Published online on: 19 April 2018

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Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer

Fei Wang, Chun‑Qian Dai, Li‑Rong Zhang, Cao Bing, Jun Qin, Yi‑Fei Liu
Pages: 625-632
Published online on: 18 April 2018

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Article

JMJD6 exerts function in neuropathic pain by regulating NF‑κB following peripheral nerve injury in rats

Cen Wen, Mengyuan Xu, Cheng Mo, Zhigang Cheng, Qulian Guo, Xiaoyan Zhu
Pages: 633-642
Published online on: 03 April 2018

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miR‑152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10 Retraction in /10.3892/ijmm.2021.5007

Jialong Guo, Juan Du, Dan Fei, Jie Xing, Jinxiang Liu, Honghua Lu
Pages: 643-650
Published online on: 20 April 2018

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Article

Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study

Marianna De Colli, Paolo Tortorella, Mariangela Agamennone, Cristina Campestre, Fulvio Loiodice, Amelia Cataldi, Susi Zara
Pages: 651-657
Published online on: 25 April 2018

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Article

Effect of hydroxyl group position in flavonoids on inducing single‑stranded DNA damage mediated by cupric ions

Suad Elmegerhi, Cathy Su, Dylan John Buglewicz, Yasushi Aizawa, Takamitsu A Kato
Pages: 658-664
Published online on: 03 April 2018

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Article

MicroRNA‑125 inhibits RKO colorectal cancer cell growth by targeting VEGF

Qi‑Bing Wu, Jing Chen, Jia‑Wei Zhu, Xin Yin, He‑Yang You, Yi‑Rong Lin, Hua‑Qing Zhu
Pages: 665-673
Published online on: 18 April 2018

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Article

Mesenchymal stem cells attenuate doxorubicin‑induced cellular senescence through the VEGF/Notch/TGF‑β signaling pathway in H9c2 cardiomyocytes

Lingli Chen, Wenzheng Xia, Meng Hou
Pages: 674-684
Published online on: 19 April 2018

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Correction Open Access

[Corrigendum] Inhibition of RANKL‑induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium‑particle‑induced osteolysis

Mingjun Li, Wengang Wang, Li Geng, Yanru Qin, Wenjie Dong, Xudong Zhang, An Qin, Mingzhi Zhang
Pages: 685-685
Published online on: 03 April 2018

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Journal Cover
August-2026 Volume 58 Issue 2

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Article Open Access

Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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Journal Cover
September-2026 Volume 58 Issue 3

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Review Open Access

Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Article Open Access

Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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Retraction Open Access

[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Article Open Access

Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Review Open Access

Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Article Open Access

Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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Review Open Access

FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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Review Open Access

TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Review Open Access

Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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Article Open Access

FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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