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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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July-2018 Volume 42 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms in hypertension and target organ damage: Is the role of the thymus key? (Review)

Xianliang Dai, Li Hua, Yihong Chen, Jiamei Wang, Jingyi Li, Feng Wu, Yanda Zhang, Jiyuan Su, Zonggui Wu, Chun Liang
Pages: 3-12
Published online on: 30 March 2018

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Review

Role of Sirtuin 1 in the pathogenesis of ocular disease (Review)

Mengwen Zhou, Jing Luo, Huiming Zhang
Pages: 13-20
Published online on: 16 April 2018

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Article Open Access

Exploring the molecular mechanisms of osteosarcoma by the integrated analysis of mRNAs and miRNA microarrays

Hao Shen, Wei Wang, Bingbing Ni, Qiang Zou, Hua Lu, Zhanchao Wang
Pages: 21-30
Published online on: 27 March 2018

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Article Open Access

Liuwei Dihuang, a traditional Chinese medicinal formula, inhibits proliferation and migration of vascular smooth muscle cells via modulation of estrogen receptors

Yayun Zhang, Xing Qian, Xin Sun, Chao Lin, Yi Jing, Yuan Yao, Zhi Ma, Meiyu Kuai, Ying Lu, Xueyun Kong, Qi Chen, Xiang Wu, Xuan Zhao, Yu Li, Huimin Bian
Pages: 31-40
Published online on: 16 April 2018

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Article Open Access

Juglanin ameliorates UVB‑induced skin carcinogenesis via anti‑inflammatory and proapoptotic effects in vivo and in vitro

Gui‑Rong Hou, Kang Zeng, Hai‑Mei Lan, Qi Wang
Pages: 41-52
Published online on: 29 March 2018

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Article Open Access

Generation of haploid spermatids from chicken embryonal primordial germ cells

Meng Ji, Shuang Tang, Wenhua Pei, Mingming Ning, Yuehui Ma, Xiangchen Li, Weijun Guan
Pages: 53-60
Published online on: 30 March 2018

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Article Open Access

Glucosamine promotes chondrocyte proliferation via the Wnt/β‑catenin signaling pathway

Yuhuan Ma, Wenwei Zheng, Houhuang Chen, Xiang Shao, Pingdong Lin, Xianxiang Liu, Xihai Li, Hongzhi Ye
Pages: 61-70
Published online on: 22 March 2018

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Article Open Access

Bradykinin potentially stimulates cell proliferation in rabbit corneal endothelial cells through the ZO‑1/ZONAB pathway

Lixian He, Zhou Zhou, Yi Shao, Zhen Yang, Shuangshuang Zhou, Xuexiang Zou, Ying Zhou, Gang Tan
Pages: 71-80
Published online on: 22 March 2018

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Article Open Access

Abnormal expression of fibrosis markers, estrogen receptor α and stromal derived factor‑1/chemokine (C‑X‑C motif) receptor‑4 axis in intrauterine adhesions

Qin Zhou, Xixi Wu, Jianguo Hu, Rui Yuan
Pages: 81-90
Published online on: 22 March 2018

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Article Open Access

Gene microarray analysis of lncRNA and mRNA expression profiles in patients with high‑grade ovarian serous cancer

Yanhui Lou, Huanhuan Jiang, Zhumei Cui, Xiangyu Wang, Lingzhi Wang, Yi Han
Pages: 91-104
Published online on: 23 March 2018

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Article Open Access

Diagnostic and prognostic values of contrast‑enhanced ultrasound combined with diffusion‑weighted magnetic resonance imaging in different subtypes of breast cancer Retraction in /10.3892/ijmm.2020.4484

Gui‑Feng Liu, Zong‑Qiang Wang, Shu‑Hua Zhang, Xue‑Feng Li, Lin Liu, Ying‑Ying Miao, Shao‑Nan Yu
Pages: 105-114
Published online on: 27 March 2018

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Article Open Access

Tripterygium glycoside protects against puromycin amino nucleoside‑induced podocyte injury by upregulating autophagy

Jianguang Gong, Juan Jin, Li Zhao, Yiqiao Li, Yiwen Li, Qiang He
Pages: 115-122
Published online on: 29 March 2018

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Article Open Access

Novel NADPH oxidase inhibitor VAS2870 suppresses TGF‑β‑dependent epithelial‑to‑mesenchymal transition in retinal pigment epithelial cells

Jing Yang, Jing Li, Qun Wang, Yao Xing, Zizhu Tan, Qianyan Kang
Pages: 123-130
Published online on: 03 April 2018

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Article Open Access

Leukemia inhibitory factor regulates marmoset induced pluripotent stem cell proliferation via a PI3K/‌Akt‑dependent Tbx‑3 activation pathway

Minxia Ke, Quan He, Danping Hong, Ouyang Li, Mengyi  Zhu, Wen‑Bin Ou, Yulong He, Yuehong Wu
Pages: 131-140
Published online on: 03 April 2018

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Article Open Access

miRNA‑222 promotes liver cancer cell proliferation, migration and invasion and inhibits apoptosis by targeting BBC3

Zhichun Liu, Jingwu Sun, Bin Liu, Mengjie Zhao, Entao Xing, Cunshu Dang
Pages: 141-148
Published online on: 20 April 2018

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Article Open Access

Prognostic significance of microsatellite instability‑associated pathways and genes in gastric cancer

Xiaosheng Hang, Dapeng Li, Jianping Wang, Ge Wang
Pages: 149-160
Published online on: 26 April 2018

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Article Open Access

Bromodomain‑containing protein 4 is critical for the antiproliferative and pro‑apoptotic effects of gambogic acid in anaplastic thyroid cancer

Yonghui Wang, Wei Wang, Hongqin Sun
Pages: 161-170
Published online on: 26 April 2018

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Article Open Access

Lack of endogenous parathyroid hormone delays fracture healing by inhibiting vascular endothelial growth factor‑mediated angiogenesis

Qingfeng Ding, Peng Sun, Hao Zhou, Bowen Wan, Jian Yin, Yao Huang, Qingqing Li, Guoyong Yin, Jin Fan
Pages: 171-181
Published online on: 03 April 2018

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Article Open Access

Melatonin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress

Yu Wen Lin, Tsung Ying Chen, Chia Yang Hung, Shih Huang Tai, Sheng Yang Huang, Che Chao Chang, Hsin Yi Hung, E Jian Lee
Pages: 182-192
Published online on: 30 March 2018

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Article Open Access

Carnosic acid protects mice from high-fat diet-induced NAFLD by regulating MARCKS

Hong-Mao Song, Xiang Li, Yuan-Yuan Liu, Wei-Ping Lu, Zhao-Hui Cui, Li Zhou, Di Yao, Hong-Man Zhang
Pages: 193-207
Published online on: 27 March 2018

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Article Open Access

Fisetin-treatment alleviates airway inflammation through inhbition of MyD88/NF-κB signaling pathway

Wei Huang, Ming-Li Li, Ming-Yue Xia, Jian-Ying Shao
Pages: 208-218
Published online on: 22 March 2018

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Article Open Access

Peroxisome proliferator-activated receptor-γ and its related pathway in bone marrow mesenchymal stem cell differentiation co-cultured with mechanically stretched ligament fibroblasts

Bing Zhao, Mengcai Hu, Huiyan Wu, Chenchen Ren, Juan Chen, Xiaodan Zhang, Shihong Cui
Pages: 219-227
Published online on: 20 March 2018

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Article Open Access

miR-19a/b and MeCP2 repress reciprocally to regulate multidrug resistance in gastric cancer cells

Fei Zhu, Qiong Wu, Zhen Ni, Chao Lei, Ting Li, Yongquan Shi
Pages: 228-236
Published online on: 22 March 2018

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Article Open Access

Fisetin administration improves LPS-induced acute otitis media in mouse in vivo

Peng Li, Dan Chen, Yang Huang
Pages: 237-247
Published online on: 22 March 2018

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Article Open Access

Quercetin inhibits NTHi-triggered CXCR4 activation through suppressing IKKα/NF-κB and MAPK signaling pathways in otitis media

Yu-Kun Ma, Yu-Bin Chen, Peng Li
Pages: 248-258
Published online on: 20 March 2018

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Article Open Access

A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families

Shuo Yu, Cui Mao, Jinyi Yu, Xin Qi, Jing Wang, Hong Lu
Pages: 259-269
Published online on: 29 March 2018

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Article Open Access

Hypoxia induces endothelial‑mesenchymal transition in pulmonary vascular remodeling

Bo Zhang, Wen Niu, Hai‑Ying Dong, Man‑Ling Liu, Ying Luo, Zhi‑Chao Li
Pages: 270-278
Published online on: 22 March 2018

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Article Open Access

Adenovirus‑mediated knockdown of activin A receptor type 2A attenuates immune‑induced hepatic fibrosis in mice and inhibits interleukin‑17‑induced activation of primary hepatic stellate cells

Hongjun Zhang, Baoling Ju, Ying Nie, Baohui Song, Yuanhong Xu, Ping Gao
Pages: 279-289
Published online on: 29 March 2018

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Article Open Access

Deregulation of microRNA‑31a‑5p is involved in the development of primary hypertension by suppressing apoptosis of pulmonary artery smooth muscle cells via targeting TP53

Qiang Feng, Tao Tian, Junfeng Liu, Li Zhang, Jiangang Qi, Xiaojuan Lin
Pages: 290-298
Published online on: 29 March 2018

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Article Open Access

Bu‑Shen‑Ning‑Xin decoction suppresses osteoclastogenesis by modulating RANKL/OPG imbalance in the CD4+ T lymphocytes of ovariectomized mice

Jia‑Li Zhang, Xue‑Min Qiu, Na Zhang, Wei Tang, Hans‑Jürgen Gober, Da‑Jin Li, Ling Wang
Pages: 299-308
Published online on: 26 April 2018

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Article Open Access

Imaging of immunogold labeling in cells and tissues by helium ion microscopy

Chikara Sato, Mari Sato, Shinichi Ogawa
Pages: 309-321
Published online on: 30 March 2018

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Article Open Access

Low‑intensity pulsed ultrasound promotes periodontal ligament stem cell migration through TWIST1‑mediated SDF‑1 expression Corrigendum in /10.3892/ijmm.2022.5093

Yunji Wang, Jie Li, Ye Qiu, Bo Hu, Jin Chen, Tiwei Fu, Pengfei Zhou, Jinlin Song
Pages: 322-330
Published online on: 27 March 2018

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Article Open Access

Poligoni Multiflori Radix enhances osteoblast formation and reduces osteoclast differentiation

Sang‑Yong Han, Kyung‑Hee Lee, Yun‑Kyung Kim
Pages: 331-345
Published online on: 30 March 2018

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Article Open Access

TIM‑4 blockade of KCs combined with exogenous TGF‑β injection helps to reverse acute rejection and prolong the survival rate of mice receiving liver allografts

Hao Wu, Xuesong Xu, Jinzheng Li, Jianping Gong, Min Li
Pages: 346-358
Published online on: 30 March 2018

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Article Open Access

PFK15, a PFKFB3 antagonist, inhibits autophagy and proliferation in rhabdomyosarcoma cells

Chunhui Wang, Jianghong Qu, Siyuan Yan, Quan Gao, Sibin Hao, Dongsheng Zhou
Pages: 359-367
Published online on: 29 March 2018

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Article Open Access

Inflammatory genes are novel prognostic biomarkers for colorectal cancer

Hao Jiang, Li Dong, Fangyan Gong, Yuping Gu, Henghun Zhang, Dong Fan, Zhiguo Sun
Pages: 368-380
Published online on: 18 April 2018

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Article Open Access

miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640

Naixin Ding, Xiujin Sun, Tingting Wang, Lei Huang, Jing Wen, Yiqin Zhou
Pages: 381-391
Published online on: 24 April 2018

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Article Open Access

FOXP3 expression is modulated by TGF‑β1/NOTCH1 pathway in human melanoma

Eva Skarmoutsou, Valentina Bevelacqua, Fabio D' Amico, Angela Russo, Demetrios   A. Spandidos, Aurora Scalisi, Grazia Malaponte, Claudio Guarneri
Pages: 392-404
Published online on: 04 April 2018

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Article Open Access

Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging

Eren Ozcagli, Mehtap Kara, Tugba Kotil, Persefoni Fragkiadaki, Manolis N. Tzatzarakis, Christina Tsitsimpikou, Polychronis D. Stivaktakis, Dimitrios Tsoukalas, Demetrios A. Spandidos, Aristides M. Tsatsakis, Buket Alpertunga
Pages: 405-413
Published online on: 26 April 2018

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Article

Antiproliferative effects of imatinib mesylate on ZR‑75‑1 and MDA‑MB‑231 cell lines via PDGFR‑β, PDGF‑BB, c‑Kit and SCF expression Corrigendum in /10.3892/ijmm.2019.4119

Ali Kadivar, Mohamed Ibrahim Noordin, Arya Aditya, Behnam Kamalidehghan, Ehsan Taghizadeh Davoudi, Reihaneh Sedghi, Hamid Akbari Javar
Pages: 414-424
Published online on: 27 March 2018

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Article

Ashwagandha root extract exerts anti‑inflammatory effects in HaCaT cells by inhibiting the MAPK/NF‑κB pathways and by regulating cytokines

Abudubari Sikandan, Takahisa Shinomiya, Yukitoshi Nagahara
Pages: 425-434
Published online on: 02 April 2018

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Article

Histone deacetylase inhibitors alter the expression of molecular markers in breast cancer cells via microRNAs

Yehui Shi, Yongsheng Jia, Weipeng Zhao, Liyan Zhou, Xiaojuan Xie, Zhongsheng Tong
Pages: 435-442
Published online on: 03 April 2018

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Article

Genome-wide analysis of DNA methylation in human peripheral leukocytes identifies potential biomarkers of nonalcoholic fatty liver disease

Rui-Nan Zhang, Qin Pan, Rui-Dan Zheng, Yu-Qiang Mi, Feng Shen, Da Zhou, Guang-Yu Chen, Chan-Yan Zhu, Jian-Gao Fan
Pages: 443-452
Published online on: 22 March 2018

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Article

miR-29b regulates Ang II-induced EMT of rat renal tubular epithelial cells via targeting PI3K/AKT signaling pathway

Hongtao Hu, Shuang Hu, Shen Xu, Yue Gao, Fang Zeng, Hua Shui
Pages: 453-460
Published online on: 22 March 2018

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Article

TWIST1 upregulates miR-214 to promote epithelial-to-mesenchymal transition and metastasis in lung adenocarcinoma

Chao Liu, Jing Luo, Yue-Tao Zhao, Zhong-Yu Wang, Jie Zhou, Shuo Huang, Jia-Ni Huang, Hai-Xia Long, Bo Zhu
Pages: 461-470
Published online on: 17 April 2018

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Article

Plasma cholesterol lowering in an AngII‑infused atherosclerotic mouse model with moderate hypercholesterolemia

Aránzazu Rossignoli, Emina Vorkapic, Anders Wanhainen, Toste Länne, Josefin Skogberg, Erika Folestad, Dick Wågsäter
Pages: 471-478
Published online on: 05 April 2018

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Article

Thromboxane A2 receptor antagonist SQ29548 attenuates SH‑SY5Y neuroblastoma cell impairments induced by oxidative stress

Gaoyu Cai, Aijuan Yan, Ningzhen Fu, Yi Fu
Pages: 479-488
Published online on: 27 March 2018

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Article

lncRNA PVT1 promotes the angiogenesis of vascular endothelial cell by targeting miR‑26b to activate CTGF/ANGPT2

Jifu Zheng, Lili Hu, Jing Cheng, Jing Xu, Zhiqiang Zhong, Yuan Yang, Zheng Yuan
Pages: 489-496
Published online on: 29 March 2018

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Article

Curcumin suppresses MUC5AC production via interfering with the EGFR signaling pathway

Lingling Tang, Qingge Chen, Li Sun, Linyun Zhu, Jinjin Liu, Ziyu Meng, Zhenhua Ni, Xiongbiao Wang
Pages: 497-504
Published online on: 02 April 2018

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Article

RP105 ameliorates hypoxia̸reoxygenation injury in cardiac microvascular endothelial cells by suppressing TLR4̸MAPKs̸NF-κB signaling

Xin Guo, Hong Jiang, Jing Chen, Bo-Fang Zhang, Qi Hu, Shuo Yang, Jian Yang, Jing Zhang
Pages: 505-513
Published online on: 16 April 2018

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Article

Bioinformatics analysis and verification of key genes associated with recurrent respiratory tract infections

Xiang Jin, Zhiyong Ji, Xiaodan Li, Rui Liu, Yinghui Guan
Pages: 514-524
Published online on: 24 April 2018

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Article

Isolation and biological characteristic evaluation of a novel type of cartilage stem/progenitor cell derived from Small‑tailed Han sheep embryos

Caiyun Ma, Tengfei Lu, Hebao Wen, Yanjie Zheng, Xiao Han, Xongda Ji, Weijun Guan
Pages: 525-533
Published online on: 17 April 2018

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Article

Novel zinc‑ and silicon‑phthalocyanines as photosensitizers for photodynamic therapy of cholangiocarcinoma

Jacob Schmidt, Weronika Kuzyniak, Janine Berkholz, Gustav Steinemann, Racheal Ogbodu, Björn Hoffmann, Geraldine Nouailles, Ayşe Gül Gürek, Bianca Nitzsche, Michael Höpfner
Pages: 534-546
Published online on: 16 April 2018

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Article

MicroRNA‑497 attenuates cerebral infarction in patients via the TLR4 and CREB signaling pathways

Si Chen, Wenwei Yin, Kun Bi, Bin Lu
Pages: 547-556
Published online on: 03 April 2018

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Article

IDO decreases glycolysis and glutaminolysis by activating GCN2K, while it increases fatty acid oxidation by activating AhR, thus preserving CD4+ T‑cell survival and proliferation

Theodoros Eleftheriadis, Georgios Pissas, Vassilios Liakopoulos, Ioannis Stefanidis
Pages: 557-568
Published online on: 16 April 2018

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Article

Desoxyrhapontigenin inhibits RANKL‑induced osteoclast formation and prevents inflammation‑mediated bone loss

Phuong Thao Tran, Dong‑Hwa Park, Okhwa Kim, Seung‑Hae Kwon, Byung‑Sun Min, Jeong‑Hyung Lee
Pages: 569-578
Published online on: 17 April 2018

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Article

Emodin inhibits epithelial‑mesenchymal transition and metastasis of triple negative breast cancer via antagonism of CC‑chemokine ligand 5 secreted from adipocytes

Xiaoyun Song, Xiqiu Zhou, Yuenong Qin, Jianfeng Yang, Yu Wang, Zhenping Sun, Kui Yu, Shuai Zhang, Sheng Liu
Pages: 579-588
Published online on: 23 April 2018

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Article

MicroRNA‑221‑3p contributes to cardiomyocyte injury in H2O2‑treated H9c2 cells and a rat model of myocardial ischemia‑reperfusion by targeting p57

Qingfeng Meng, Yang Liu, Xiuyue Huo, Hui Sun, Yingcui Wang, Fangfang Bu
Pages: 589-596
Published online on: 17 April 2018

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Article

Human circular RNA‑0054633 regulates high glucose‑induced vascular endothelial cell dysfunction through the microRNA‑218/roundabout 1 and microRNA‑218/heme oxygenase‑1 axes

Long Pan, Weishuai Lian, Xiaojun Zhang, Shilong Han, Chuanwu Cao, Xue Li, Maoquan Li
Pages: 597-606
Published online on: 16 April 2018

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Article

Adenosine A(2A) receptor activation reverses hypoxia‑induced rat pulmonary artery smooth muscle cell proliferation via cyclic AMP‑mediated inhibition of the SDF1‑CXC4 signaling pathway

Yang Wang, Lei Ying, Ke‑Ke Jin, Yan Nan, Suhua Hu, Xueqin Wu, Ruyi Qi, Xin Luo, Liangxing Wang
Pages: 607-614
Published online on: 16 April 2018

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Article

Inhibitory effects of luteolin‑4'‑O‑β‑D‑glucopyranoside on P2Y12 and thromboxane A2 receptor‑mediated amplification of platelet activation in vitro

Huanjun Xu, Hong Lu, Xiaocui Zhu, Wei Wang, Zhoumiao Zhang, Huizheng Fu, Shuangcheng Ma, Yuehua Luo, Jianjiang Fu
Pages: 615-624
Published online on: 19 April 2018

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Downregulation of Lgr6 inhibits proliferation and invasion and increases apoptosis in human colorectal cancer

Fei Wang, Chun‑Qian Dai, Li‑Rong Zhang, Cao Bing, Jun Qin, Yi‑Fei Liu
Pages: 625-632
Published online on: 18 April 2018

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Article

JMJD6 exerts function in neuropathic pain by regulating NF‑κB following peripheral nerve injury in rats

Cen Wen, Mengyuan Xu, Cheng Mo, Zhigang Cheng, Qulian Guo, Xiaoyan Zhu
Pages: 633-642
Published online on: 03 April 2018

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Article

miR‑152 inhibits rheumatoid arthritis synovial fibroblast proliferation and induces apoptosis by targeting ADAM10 Retraction in /10.3892/ijmm.2021.5007

Jialong Guo, Juan Du, Dan Fei, Jie Xing, Jinxiang Liu, Honghua Lu
Pages: 643-650
Published online on: 20 April 2018

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Article

Bisphosfonate matrix metalloproteinase inhibitors for the treatment of periodontitis: An in vitro study

Marianna De Colli, Paolo Tortorella, Mariangela Agamennone, Cristina Campestre, Fulvio Loiodice, Amelia Cataldi, Susi Zara
Pages: 651-657
Published online on: 25 April 2018

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Article

Effect of hydroxyl group position in flavonoids on inducing single‑stranded DNA damage mediated by cupric ions

Suad Elmegerhi, Cathy Su, Dylan John Buglewicz, Yasushi Aizawa, Takamitsu A Kato
Pages: 658-664
Published online on: 03 April 2018

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Article

MicroRNA‑125 inhibits RKO colorectal cancer cell growth by targeting VEGF

Qi‑Bing Wu, Jing Chen, Jia‑Wei Zhu, Xin Yin, He‑Yang You, Yi‑Rong Lin, Hua‑Qing Zhu
Pages: 665-673
Published online on: 18 April 2018

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Article

Mesenchymal stem cells attenuate doxorubicin‑induced cellular senescence through the VEGF/Notch/TGF‑β signaling pathway in H9c2 cardiomyocytes

Lingli Chen, Wenzheng Xia, Meng Hou
Pages: 674-684
Published online on: 19 April 2018

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Correction Open Access

[Corrigendum] Inhibition of RANKL‑induced osteoclastogenesis through the suppression of the ERK signaling pathway by astragaloside IV and attenuation of titanium‑particle‑induced osteolysis

Mingjun Li, Wengang Wang, Li Geng, Yanru Qin, Wenjie Dong, Xudong Zhang, An Qin, Mingzhi Zhang
Pages: 685-685
Published online on: 03 April 2018

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June-2026 Volume 57 Issue 6

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article

Gilteritinib overcomes second‑generation TKIs resistance in ALK‑rearranged non‑small‑cell lung cancer by inhibiting PD‑L1 and CD8 co‑expression

Hang Guo, Yaoji Li, Chengyan Jin, Xiao Qi, Jincheng Wang, Baofeng Li, Chunguang Wang
Article Number: 168
Published online on: 28 April 2026

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Retraction Open Access

[Retracted] Metformin‑induced activation of AMPK inhibits the proliferation and migration of human aortic smooth muscle cells through upregulation of p53 and IFI16

Biao Hao, Yan Xiao, Fang Song, Xiangshu Long, Jing Huang, Maobo Tian, Shiyan Deng, Qiang Wu
Article Number: 167
Published online on: 22 April 2026

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Dysregulation of the DNA repair‑immune axis: Targeted therapeutic strategies for autoimmune diseases (Review)

Ke Wan, Miao Wang, Qingqing Xia, Hui Fang, Ying Chen, Tongsheng Zhou, Xue Yang, Lu Wang, Jianwen Ye, Han Shu, Xiao-Feng Li, Jun Li
Article Number: 166
Published online on: 22 April 2026

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[Retracted] Puerarin attenuates glucocorticoid‑induced apoptosis of hFOB1.19 cells through the JNK‑ and Akt‑mediated mitochondrial apoptotic pathways

Dongdong Yu, Shuai Mu, Danyang Zhao, Guangbin Wang, Zhiguang Chen, Hongfei Ren, Qin Fu
Article Number: 165
Published online on: 20 April 2026

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High‑altitude polycythemia: Unveiling the molecular landscape beyond erythropoietin (Review)

Haiyan Li, Hongjuan Zhang, Hujun Zhang, Yujie Li, Yigang He, Jia Luan
Article Number: 164
Published online on: 17 April 2026

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Mechanistic roles of interleukin‑18 in colonic immunity across infection, inflammatory bowel disease, and colorectal cancer (Review)

Jingwen Zhang, Lili Bao, Xia Li, Jiaxi Li, Jiaxian Cui, Lu Qiao, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Tuya Bai, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 163
Published online on: 17 April 2026

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IDH2 lactylation regulates mitochondrial dysfunction injury induced by myocardial ischemia‑reperfusion via the AMPK signaling pathway

Changsen Wang, Siman Shen, Suyun Chen, Jinda Lin, Simeng Li, Jianning Chen, Shuyun Cai, Xiaodong Yuan, Ziqiang Yang, Kun Ding, Li Xu, Liangqing Zhang
Article Number: 162
Published online on: 17 April 2026

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Context‑dependent duality of the apelin/elabela‑APJ system in diabetes and its complications (Review)

Zhenyuan Han, Jiale Zhang, Min Shi, Juan Chen, Anni Li, Yuxuan Ye, Hong Zhang
Article Number: 161
Published online on: 17 April 2026

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Glycolytic lactylation modulates cell death decisions in diabetic kidney disease: Metabolic‑epigenetic interplay between ferroptosis and autophagy in fibrotic remodeling (Review)

Taimin Zhang, Xizhe Zhang, Yaru Xie, Yue Liu, Siyu Xia, Xiaodie Yin, Tian Li, Libin Liao
Article Number: 160
Published online on: 16 April 2026

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Retraction Open Access

[Retracted] Quercetin promotes the apoptosis of fibroblast‑like synoviocytes in rheumatoid arthritis by upregulating lncRNA MALAT1

Fang Pan, Lihua Zhu, Haozhe Lv, Chunpeng Pei
Article Number: 159
Published online on: 15 April 2026

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Article Open Access

Triptolide exerts antiviral effects and alleviates influenza A‑induced pneumonia by inhibiting the overactivation of absent in melanoma 2 signaling in immune cells

Yeyang Chen, Hua Wu, Xiangjian Wu, Likun Che, Xiaoyan Fu, Ruihan Qi, Dan Jia, Minfang Li, Wei Xie, Wenxiang Zhu
Article Number: 158
Published online on: 15 April 2026

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ETS‑1/ETS‑2 transcription factors in CVD (Review)

Shasha Yang, Jing Zhang, Ying Yang, Yunbo Lv, Jian Yang, Huibo Wang
Article Number: 157
Published online on: 15 April 2026

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RNA‑binding proteins as epithelial transcriptome orchestrators in gastric cancer: Immune‑metabolic crosstalk and therapeutic vulnerability (Review)

Shuhui Liu, Zhiyuan Ma, Bei Ji, Jiaxing Zhu, Shun Yao, Shuji Terai, Biguang Tuo, Taolang Li, Xuemei Liu
Article Number: 156
Published online on: 14 April 2026

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[Retracted] Role of miR‑146a in human chondrocyte apoptosis in response to mechanical pressure injury in vitro  

Lei Jin, Jian Zhao, Wensen Jing, Shiju Yan, Xin Wang, Chun Xiao, Baoan Ma
Article Number: 155
Published online on: 07 April 2026

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A tale of dual role: HECT‑type E3 ubiquitin ligase mechanisms in liver diseases (Review)

Tongxi Li, Hao Chen, Peng Zhao, Chuanzheng Yin, Zifang Song
Article Number: 154
Published online on: 07 April 2026

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Correction Open Access

[Corrigendum] Macrophage‑derived foam cells impair endothelial barrier function by inducing endothelial‑mesenchymal transition via CCL‑4 

Ying Yang, Nian-Sang Luo, Ru Ying, Yong Xie, Jia-Yuan Chen, Xiao-Qiao Wang, Zhen-Jie Gu, Jing-Ting Mai, Wen-Hao Liu, Mao-Xiong Wu, Zhi-Teng Chen, Yong-Biao Fang, Hai-Feng Zhang, Zhi-Yi Zuo, Jing-Feng Wang, Yang-Xin Chen
Article Number: 153
Published online on: 03 April 2026

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Review Open Access

Macrophage metabolism reprogramming in sepsis: Pathogenesis and therapeutic implications (Review)

Tong Zhao, Wenzhe Zhang, Zixuan Ren, Xiujing Feng
Article Number: 152
Published online on: 03 April 2026

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Article Open Access

Astragaloside IV targets TUBB4B to inhibit proliferation and promote apoptosis of pituitary tumor cells via the STMN1/ERK pathway

Jiale Li, Yufei Qu, Wenge Zhang, Zexu Yang, Yangdong Zeng, Jisheng Xu, Kuncen Xie, Qi Liu
Article Number: 151
Published online on: 01 April 2026

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Expression of Concern Open Access

[Expression of Concern] Increased expression of heat shock protein 90 under chemical hypoxic conditions protects cardiomyocytes against injury induced by serum and glucose deprivation

Keng Wu, Wenming Xu, Qiong You, Runmin Guo, Jianqiang Feng, Changran Zhang, Wen Wu
Article Number: 150
Published online on: 01 April 2026

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Review Open Access

Animal models accurately representing acute liver failure (Review)

Sang Luo, Fang Wu, Yiran Jin, Xiaofen Huang, Dan Liu, Bingren Tian
Article Number: 149
Published online on: 01 April 2026

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Correction Open Access

[Corrigendum] Influence of aspirin on the CX3CL1/CX3CR1 signaling pathway in acute pulmonary embolism 

Zhirong Zhang, Weiji Yang, Rongbiao Ying, Ying Shi, Huifang Jiang, Danli Cai, Jing Kuang, Ruhui Yang, Lingcong Wang
Article Number: 148
Published online on: 31 March 2026

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Review Open Access

Targeting pyroptosis to treat aortic aneurysms: From mechanism to drug discovery (Review)

Jing Mao, Mandi Luo, Lei Ruan, Cuntai Zhang
Article Number: 147
Published online on: 31 March 2026

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Review Open Access

Role of aging‑related cytokines in neurodegenerative disease (Review)

Xinke Dai, Xinran Rao, Yuandi Wang, Weijiang Zhao
Article Number: 146
Published online on: 31 March 2026

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Expression of Concern Open Access

[Expression of Concern] DTX3L is upregulated in glioma and is associated with glioma progression

Peng Xu, Xuelei Tao, Chengjin Zhao, Qingfeng Huang, Hao Chang, Na Ban, Yuanqi Bei, Xiaojie Xia, Chaoyan Shen, Kun Wang, Li Xu, Peizhang Wu, Jianbing Ren, Donglin Wang
Article Number: 145
Published online on: 30 March 2026

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Review Open Access

Role of itaconate in intestinal disease (Review)

Xin Li, Qian Liu, Jiajia Li, Li Zhang, Shun Yao, Lulu Tang, Bingqi Yang, Yongfeng Wang, Guorong Wen, Jiaxing An, Hai Jin, Biguang Tuo
Article Number: 144
Published online on: 27 March 2026

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Review Open Access

Unveiling lactylation: A novel frontier in the pathogenesis of diabetic nephropathy (Review)

Yuanyuan Xiao, Niansong Wang, Dingkun Gui, Youhua Xu
Article Number: 143
Published online on: 27 March 2026

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Review Open Access

Crosstalk between autophagy and ferroptosis in liver diseases (Review)

Yanming Wei, Kun Zhou, Yuerui Su, Zhihua Luan, Pengcheng Li, Yinxia Chang, Bo Han, Huifang Li, Yuanbiao Qiao, Jinhong Ren
Article Number: 142
Published online on: 26 March 2026

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Article Open Access

circOMA1 delivered by exosomes regulates DRD2‑mediated prolactinoma resistance

Qing Rao, Dimin Zhu, Zongming Wang, Shaolin Zhang, Xueli Li, Shashikiran Tagilapalli, Nan Wang, Weiyu Hu, Wenli Chen, Yonghong Zhu
Article Number: 141
Published online on: 26 March 2026

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Expression of Concern Open Access

[Expression of Concern] Involvement of Cyr61 in the growth, invasiveness and adhesion of esophageal squamous cell carcinoma cells

Jian-Jun Xie, Li-Yan Xu, Yang-Min Xie, Ze-Peng Du, Cai-Hua Feng, Hui Dong, En-Min Li
Article Number: 140
Published online on: 24 March 2026

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Article Open Access

Novel Hsp90 inhibitor JD‑02 inhibits HSV‑1 infection via the Raf/MEK/ERK signaling pathway

Yexuan Zhu, Xiaohui Wang, Jiaying Lin, Xiao Wang, Kai Zheng, Zhe Ren, Ji Xiao, Yifei Wang
Article Number: 139
Published online on: 24 March 2026

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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