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Article Open Access

A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families

  • Authors:
    • Shuo Yu
    • Cui Mao
    • Jinyi Yu
    • Xin Qi
    • Jing Wang
    • Hong Lu
  • View Affiliations / Copyright

    Affiliations: Department of Ophthalmology, Peking University Third Hospital, Beijing 100083, P.R. China, Department of Ophthalmology, Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, P.R. China, Department of Ophthalmology, Yantai Yuhuangding Hospital, Affiliated Hospital of Medical College, Qingdao University, Yantai, Shandong 264000, P.R. China
    Copyright: © Yu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 259-269
    |
    Published online on: March 29, 2018
       https://doi.org/10.3892/ijmm.2018.3596
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Abstract

The present study was conducted to investigate the key genes and the inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis (AAU) families. Four families with HLA-B27‑positive aau patients and their HLA-B27-positive blood relatives were included in the study. peripheral blood monocytes were isolated from the subjects and stimulated by lipopolysaccharides (LPS). Gene expression microarrays were used to identify the differentially expressed genes (DEGs), and the DEGs were analyzed by a range of bioinformatics-based techniques, including Gene Ontology (GO), Pathway analysis, Signal-Net analysis and Gene Relation Network (Gene-Rel-Net). Finally, ELISA was used to quantify cytokines in the supernatant. The gene expression microarrays identified 801 DEGs, including 349 upregulated and 452 downregulated genes. The GO analysis revealed several important functions, including metabolic, immune and inflammatory responses. The pathway analysis highlighted the enhanced activity of Staphylococcus aureus infection, chemokine and metabolic signaling pathways, as well as cytokine-to‑cytokine receptor interactions. A total of 18 DEGs that were found to play critical roles by Signal-Net and Gene-Rel-Net and verified by quantitative polymerase chain reaction analysis were identified as key genes. In conclusion, monocytes from the AUU patients were more sensitive and exhibited a more prominent inflammatory response to stimulation by LPS compared with monocytes from healthy HLA-B27-positive blood relatives. These characterized DEGs may provide new evidence for the pathogenesis of AAU and help identify new therapeutic targets.
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1 

Muñoz-Fernández S and Martín-Mola E: Uveitis. Best Pract Res Clin Rheumatol. 20:487–505. 2006. View Article : Google Scholar : PubMed/NCBI

2 

Jabs DA, Nussenblatt RB and Rosenbaum JT; Standardization of Uveitis Nomenclature (SUN) Working Group: Standardization of uveitis nomenclature for reporting clinical data. Results of the First International Workshop. Am J Ophthalmol. 140:509–516. 2005. View Article : Google Scholar : PubMed/NCBI

3 

Wakefield D, Yates W, Amjadi S and McCluskey P: HLA-B27 anterior uveitis: Immunology and immunopathology. Ocul Immunol Inflamm. 24:450–459. 2016. View Article : Google Scholar : PubMed/NCBI

4 

McGonagle D and McDermott MF: A proposed classification of the immunological diseases. PLoS Med. 3:e2972006. View Article : Google Scholar : PubMed/NCBI

5 

Smith JA, Märker-Hermann E and Colbert RA: Pathogenesis of ankylosing spondylitis: Current concepts. Best Pract Res Clin Rheumatol. 20:571–591. 2006. View Article : Google Scholar : PubMed/NCBI

6 

Colbert RA: HLA-B27 misfolding: A solution to the spondyloarthropathy conundrum. Mol Med Today. 6:224–230. 2000. View Article : Google Scholar : PubMed/NCBI

7 

Schröder M and Kaufman RJ: ER stress and the unfolded protein response. Mutat Res. 569:29–63. 2005. View Article : Google Scholar

8 

Chang JH, McCluskey PJ and Wakefield D: Acute anterior uveitis and HLA-B27. Surv Ophthalmol. 50:364–388. 2005. View Article : Google Scholar : PubMed/NCBI

9 

Goldman M: Translational mini-review series on Toll-like receptors: Toll-like receptor ligands as novel pharmaceuticals for allergic disorders. Clin Exp Immunol. 147:208–216. 2007. View Article : Google Scholar : PubMed/NCBI

10 

Du L, Kijlstra A and Yang P: Immune response genes in uveitis. Ocul Immunol Inflamm. 17:249–256. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Bi HS, Liu ZF and Cui Y: Pathogenesis of innate immunity and adaptive immunity in the mouse model of experimental autoimmune uveitis. J Chin Med Assoc. 78:276–282. 2015. View Article : Google Scholar : PubMed/NCBI

12 

Hu XF, Lu H, Wang J, Zhang XS, Zhang XL, Liu XH, Xu ZZ, Hu JM and Lu QJ: Screening of key genes and inflammatory signalling pathway involved in the pathogenesis of HLA-B27-associated acute anterior uveitis by gene expression microarray. Zhonghua Yan Ke Za Zhi. 49:217–223. 2013.In Chinese. PubMed/NCBI

13 

Deschenes J, Murray PI, Rao NA and Nussenblatt RB; International Uveitis Study Group: International Uveitis Study Group (IUSG): clinical classification of uveitis. Ocul Immunol Inflamm. 16:1–2. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Wright GW and Simon RM: A random variance model for detection of differential gene expression in small microarray experiments. Bioinformatics. 19:2448–2455. 2003. View Article : Google Scholar : PubMed/NCBI

15 

Yang H, Crawford N, Lukes L, Finney R, Lancaster M and Hunter KW: Metastasis predictive signature profiles pre-exist in normal tissues. Clin Exp Metastasis. 22:593–603. 2005. View Article : Google Scholar

16 

Clarke R, Ressom HW, Wang A, Xuan J, Liu MC, Gehan EA and Wang Y: The properties of high-dimensional data spaces: Implications for exploring gene and protein expression data. Nat Rev Cancer. 8:37–49. 2008. View Article : Google Scholar :

17 

Dupuy D, Bertin N, Hidalgo CA, venkatesan K, Tu D, Lee D, Rosenberg J, Svrzikapa N, Blanc A, Carnec A, et al: Genome-scale analysis of in vivo spatiotemporal promoter activity in Caenorhabditis elegans. Nat Biotechnol. 25:663–668. 2007. View Article : Google Scholar : PubMed/NCBI

18 

Gene Ontology Consortium: The Gene Ontology (GO) project in 2006. Nucleic Acids Res. 34:D322–D326. 2006. View Article : Google Scholar :

19 

Ashburner M, Ball CA, Blake JA, Botstein D, Butler H, Cherry JM, Davis AP, Dolinski K, Dwight SS, Eppig JT, et al The Gene Ontology Consortium: Gene ontology: Tool for the unification of biology. Nat Genet. 25:25–29. 2000. View Article : Google Scholar : PubMed/NCBI

20 

Wei Z and Li H: A Markov random field model for network-based analysis of genomic data. Bioinformatics. 23:1537–1544. 2007. View Article : Google Scholar : PubMed/NCBI

21 

Li C and Li H: Network-constrained regularization and variable selection for analysis of genomic data. Bioinformatics. 24:1175–1182. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Zhang JD and Wiemann S: KEGGgraph: A graph approach to KEGG PATHWAY in R and bioconductor. Bioinformatics. 25:1470–1471. 2009. View Article : Google Scholar : PubMed/NCBI

23 

Pujana MA, Han JD, Starita LM, Stevens KN, Tewari M, Ahn JS, Rennert G, Moreno V, Kirchhoff T, Gold B, et al: Network modeling links breast cancer susceptibility and centrosome dysfunction. Nat Genet. 39:1338–1349. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Prieto C, Risueño A, Fontanillo C and De las Rivas J: Human gene coexpression landscape: Confident network derived from tissue transcriptomic profiles. PLoS One. 3:e39112008. View Article : Google Scholar : PubMed/NCBI

25 

Chang JH and Wakefield D: Uveitis: A global perspective. Ocul Immunol Inflamm. 10:263–279. 2002. View Article : Google Scholar

26 

Bhattacherjee P, Williams RN and Eakins KE: An evaluation of ocular inflammation following the injection of bacterial endotoxin into the rat foot pad. Invest Ophthalmol vis Sci. 24:196–202. 1983.PubMed/NCBI

27 

McMenamin PG and Crewe J: Endotoxin-induced uveitis. Kinetics and phenotype of the inflammatory cell infiltrate and the response of the resident tissue macrophages and dendritic cells in the iris and ciliary body. Invest Ophthalmol vis Sci. 36:1949–1959. 1995.PubMed/NCBI

28 

de vos AF, van Haren MA, Verhagen C, Hoekzema R and Kijlstra A: Kinetics of intraocular tumor necrosis factor and interleukin-6 in endotoxin-induced uveitis in the rat. Invest Ophthalmol vis Sci. 35:1100–1106. 1994.PubMed/NCBI

29 

Zheng C, Lei C, Chen Z, Zheng S, Yang H, Qiu Y and Lei B: Topical administration of diminazene aceturate decreases inflammation in endotoxin-induced uveitis. Mol vis. 21:403–411. 2015.PubMed/NCBI

30 

Chen W, Hu X, Zhao L, Li S and Lu H: Expression of toll-like receptor 4 in uvea-resident tissue macrophages during endotoxin-induced uveitis. Mol vis. 15:619–628. 2009.PubMed/NCBI

31 

Li S, Lu H, Hu X, Chen W, Xu Y and Wang J: Expression of TLR4-MyD88 and NF-κB in the iris during endotoxin-induced uveitis. Mediators Inflamm. 2010:748218. 2010. View Article : Google Scholar

32 

Wakefield D, Chang JH, Amjadi S, Maconochie Z, Abu El-Asrar A and McCluskey P: What is new HLA-B27 acute anterior uveitis. Ocul Immunol Inflamm. 19:139–144. 2011. View Article : Google Scholar : PubMed/NCBI

33 

Ito TK, Yokoyama M, Yoshida Y, Nojima A, Kassai H, Oishi K, Okada S, Kinoshita D, Kobayashi Y, Fruttiger M, et al: A crucial role for CDC42 in senescence-associated inflammation and atherosclerosis. PLoS One. 9:e1021862014. View Article : Google Scholar : PubMed/NCBI

34 

Perona R, Montaner S, Saniger L, Sánchez-Pérez I, Bravo R and Lacal JC: Activation of the nuclear factor-kappaB by Rho, CDC42, and Rac-1 proteins. Genes Dev. 11:463–475. 1997. View Article : Google Scholar : PubMed/NCBI

35 

Puls A, Eliopoulos AG, Nobes CD, Bridges T, Young LS and Hall A: Activation of the small GTPase Cdc42 by the inflammatory cytokines TNF(alpha) and IL-1, and by the Epstein-Barr virus transforming protein LMP1. J Cell Sci. 112:2983–2992. 1999.PubMed/NCBI

36 

Kobayashi K, Hernandez LD, Galán JE, Janeway CA Jr, Medzhitov R and Flavell RA: IRAK-M is a negative regulator of Toll-like receptor signaling. Cell. 110:191–202. 2002. View Article : Google Scholar : PubMed/NCBI

37 

Nakayama K, Okugawa S, Yanagimoto S, Kitazawa T, Tsukada K, Kawada M, Kimura S, Hirai K, Takagaki Y and Ota Y: Involvement of IRAK-M in peptidoglycan-induced tolerance in macrophages. J Biol Chem. 279:6629–6634. 2004. View Article : Google Scholar

38 

Gottipati S, Rao NL and Fung-Leung WP: IRAK1: A critical signaling mediator of innate immunity. Cell Signal. 20:269–276. 2008. View Article : Google Scholar

39 

Maldifassi MC, Atienza G, Arnalich F, López-Collazo E, Cedillo JL, Martín-Sánchez C, Bordas A, Renart J and Montiel C: A new IRAK-M-mediated mechanism implicated in the anti-inflammatory effect of nicotine via α7 nicotinic receptors in human macrophages. PLoS One. 9:e1083972014. View Article : Google Scholar

40 

Xu Y, Chen W, Lu H, Hu X, Li S, Wang J and Zhao L: The expression of cytokines in the aqueous humor and serum during endotoxin-induced uveitis in C3H̸HeN mice. Mol vis. 16:1689–1695. 2010.PubMed/NCBI

41 

Liu X, Hu X, Zhang X, Li Z and Lu H: Role of rheum polysaccharide in the cytokines produced by peripheral blood monocytes in TLR4 mediated HLA-B27 associated AAU. Biomed Res Int. 2013:4312322013. View Article : Google Scholar : PubMed/NCBI

42 

Santos Lacomba M, Marcos Martín C, Gallardo Galera JM, Gómez vidal MA, Collantes Estévez E, Ramírez Chamond R and Omar M: Aqueous humor and serum tumor necrosis factor-alpha in clinical uveitis. Ophthalmic Res. 33:251–255. 2001. View Article : Google Scholar : PubMed/NCBI

43 

Pérez-Guijo V, Santos-Lacomba M, Sánchez-Hernández M, Castro-villegas MC, Gallardo-Galera JM and Collantes-Estévez E: Tumour necrosis factor-alpha levels in aqueous humour and serum from patients with uveitis: The involvement of HLA-B27. Curr Med Res Opin. 20:155–157. 2004. View Article : Google Scholar : PubMed/NCBI

44 

Mosmann TR: Properties and functions of interleukin-10. Adv Immunol. 56:1–26. 1994. View Article : Google Scholar : PubMed/NCBI

45 

Groux H, Bigler M, de vries JE and Roncarolo MG: Inhibitory and stimulatory effects of IL-10 on human CD8+ T cells. J Immunol. 160:3188–3193. 1998.PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yu S, Mao C, Yu J, Qi X, Wang J and Lu H: A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. Int J Mol Med 42: 259-269, 2018.
APA
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., & Lu, H. (2018). A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. International Journal of Molecular Medicine, 42, 259-269. https://doi.org/10.3892/ijmm.2018.3596
MLA
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., Lu, H."A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families". International Journal of Molecular Medicine 42.1 (2018): 259-269.
Chicago
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., Lu, H."A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families". International Journal of Molecular Medicine 42, no. 1 (2018): 259-269. https://doi.org/10.3892/ijmm.2018.3596
Copy and paste a formatted citation
x
Spandidos Publications style
Yu S, Mao C, Yu J, Qi X, Wang J and Lu H: A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. Int J Mol Med 42: 259-269, 2018.
APA
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., & Lu, H. (2018). A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families. International Journal of Molecular Medicine, 42, 259-269. https://doi.org/10.3892/ijmm.2018.3596
MLA
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., Lu, H."A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families". International Journal of Molecular Medicine 42.1 (2018): 259-269.
Chicago
Yu, S., Mao, C., Yu, J., Qi, X., Wang, J., Lu, H."A study of the key genes and inflammatory signaling pathways involved in HLA-B27-associated acute anterior uveitis families". International Journal of Molecular Medicine 42, no. 1 (2018): 259-269. https://doi.org/10.3892/ijmm.2018.3596
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