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Article Open Access

miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10

Retraction in: /10.3892/ijmm.2025.5640
  • Authors:
    • Naixin Ding
    • Xiujin Sun
    • Tingting Wang
    • Lei Huang
    • Jing Wen
    • Yiqin Zhou
  • View Affiliations / Copyright

    Affiliations: Department of Radiotherapy, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research, The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, Jiangsu 210009, P.R. China
    Copyright: © Ding et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 381-391
    |
    Published online on: April 24, 2018
       https://doi.org/10.3892/ijmm.2018.3639
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Abstract

Esophageal squamous cell carcinoma (ESCC) is a life‑threatening cancer with increasing incidence worldwide. MicroRNAs (miRs) have been reported to be involved in the progression of various types of cancer. In previous studies, the expression of miR‑378a‑3p was shown to be reduced in ESCC tissues. However, the mechanism underlying the effect of miR‑378a‑3p in ESCC remains to be elucidated. By employing a reverse transcription‑quantitative polymerase chain reaction, miR‑378a‑3p expression was tested in ESCC tissues and cell lines. In addition, the effects of miR‑378a‑3p on cell viability, proliferation, apoptosis, migration and invasion were studied using an MTT assay, an EdU assay, flow cytometry analysis, wound healing analysis and a Transwell assay. In the present study, the level of miR‑378a‑3p was significantly downregulated in ESCC clinical tissues and cell lines (EC109 and KYSE150). In addition, the overexpression of miR‑378a‑3p suppressed the viability, proliferation, migration and invasion of the ESCC cells. The upregulated expression of miR‑378a‑3p also increased the expression levels of B‑cell lymphoma 2‑associated X protein and caspase‑3, and decreased the expression levels of matrix metalloproteinase (MMP)‑2 and MMP‑9, which attenuated ESCC tumorigenesis. Furthermore, Rab10 was confirmed to be a direct target gene of miR‑378a‑3p, and was negatively affected by miR‑378a‑3p. The silencing of Rab10 revealed antitumor effects in ESCC cell lines, and the expression of miR‑378a‑3p was negatively correlated with that of Rab10 in ESCC. Collectively, miR‑378a‑3p may act as a tumor‑suppressor in ESCC cells through negatively regulating Rab10.
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Copy and paste a formatted citation
Spandidos Publications style
Ding N, Sun X, Wang T, Huang L, Wen J and Zhou Y: miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640. Int J Mol Med 42: 381-391, 2018.
APA
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., & Zhou, Y. (2018). miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640. International Journal of Molecular Medicine, 42, 381-391. https://doi.org/10.3892/ijmm.2018.3639
MLA
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., Zhou, Y."miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640". International Journal of Molecular Medicine 42.1 (2018): 381-391.
Chicago
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., Zhou, Y."miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640". International Journal of Molecular Medicine 42, no. 1 (2018): 381-391. https://doi.org/10.3892/ijmm.2018.3639
Copy and paste a formatted citation
x
Spandidos Publications style
Ding N, Sun X, Wang T, Huang L, Wen J and Zhou Y: miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640. Int J Mol Med 42: 381-391, 2018.
APA
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., & Zhou, Y. (2018). miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640. International Journal of Molecular Medicine, 42, 381-391. https://doi.org/10.3892/ijmm.2018.3639
MLA
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., Zhou, Y."miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640". International Journal of Molecular Medicine 42.1 (2018): 381-391.
Chicago
Ding, N., Sun, X., Wang, T., Huang, L., Wen, J., Zhou, Y."miR‑378a‑3p exerts tumor suppressive function on the tumorigenesis of esophageal squamous cell carcinoma by targeting Rab10 Retraction in /10.3892/ijmm.2025.5640". International Journal of Molecular Medicine 42, no. 1 (2018): 381-391. https://doi.org/10.3892/ijmm.2018.3639
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