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Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging

  • Authors:
    • Eren Ozcagli
    • Mehtap Kara
    • Tugba Kotil
    • Persefoni Fragkiadaki
    • Manolis N. Tzatzarakis
    • Christina Tsitsimpikou
    • Polychronis D. Stivaktakis
    • Dimitrios Tsoukalas
    • Demetrios A. Spandidos
    • Aristides M. Tsatsakis
    • Buket Alpertunga
  • View Affiliations / Copyright

    Affiliations: Department of Pharmaceutical Toxicology, Faculty of Pharmacy, Istanbul University, Istanbul 34116, Turkey, Department of Histology and Embryology, Faculty of Medicine, Istanbul University, Istanbul 34116, Turkey, Laboratory of Forensic Sciences and Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece, General Chemical State Laboratory of Greece, 11521 Athens, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece
    Copyright: © Ozcagli et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 405-413
    |
    Published online on: April 26, 2018
       https://doi.org/10.3892/ijmm.2018.3644
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Abstract

Anabolic agents are doping substances which are commonly used in sports. Stanozolol, a 17α‑alkylated derivative of testosterone, has a widespread use among athletes and bodybuilders. Several medical and behavioral adverse effects are associated with anabolic androgenic steroids (AAS) abuse, while the liver remains the most well recognized target organ. In the present study, the hepatic effects of stanozolol administration in rats at high doses resembling those used for doping purposes were investigated, in the presence or absence of exercise. Stanozolol and its metabolites, 16‑β‑hydroxystanozolol and 3'‑hydroxystanozolol, were detected in rat livers using liquid chromatography‑mass spectrometry (LC‑MS). Telomerase activity, which is involved in cellular aging and tumorigenesis, was detected by examining telomerase reverse transcriptase (TERT) and phosphatase and tensin homolog (PTEN) expression levels in the livers of stanozolol‑treated rats. Stanozolol induced telomerase activity at the molecular level in the liver tissue of rats and exercise reversed this induction, reflecting possible premature liver tissue aging. PTEN gene expression in the rat livers was practically unaffected either by exercise or by stanozolol administration.
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View References

1 

Balcells G, Matabosch X and Ventura R: Detection of stanozolol O- and N-sulfate metabolites and their evaluation as additional markers in doping control. Drug Test Anal. 9:1001–1010. 2017. View Article : Google Scholar

2 

Tsitsimpikou C, Vasilaki F, Tsarouhas K, Fragkiadaki P, Tzardi M, Goutzourelas N, Nepka C, Kalogeraki A, Heretis I, Epitropaki Z, et al: Nephrotoxicity in rabbits after long-term nandrolone decanoate administration. Toxicol Lett. 259:21–27. 2016. View Article : Google Scholar : PubMed/NCBI

3 

World Anti-doping Agency: The 2017 list of prohibited substances and methods. https://www.wada-ama.org/. Accessed Feb 14, 2018.

4 

Kioukia-Fougia N, Georgiadis N, Tsarouhas K, Vasilaki F, Fragiadaki P, Meimeti E and Tsitsimpikou C: Synthetic and natural nutritional supplements: Health 'allies' or risks to public health. Recent Pat Inflamm Allergy Drug Discov. 10:72–85. 2017. View Article : Google Scholar

5 

Tsitsimpikou C, Chrisostomou N, Papalexis P, Tsarouhas K, Tsatsakis A and Jamurtas A: The use of nutritional supplements among recreational athletes in Athens, Greece. Int J Sport Nutr Exerc Metab. 21:377–384. 2011. View Article : Google Scholar : PubMed/NCBI

6 

Sagoe D, Molde H, Andreassen CS, Torsheim T and Pallesen S: The global epidemiology of anabolic-androgenic steroid use: A meta-analysis and meta-regression analysis. Ann Epidemiol. 24:383–398. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ampuero J, García ES, Lorenzo MM, Calle R, Ferrero P and Gómez MR: Stanozolol-induced bland cholestasis. Gastroenterol Hepatol. 37:71–72. 2014. View Article : Google Scholar

8 

Bausserman LL, Saritelli AL and Herbert PN: Effects of short-term stanozolol administration on serum lipoproteins in hepatic lipase deficiency. Metabolism. 46:992–996. 1997. View Article : Google Scholar : PubMed/NCBI

9 

El-Serag HB, Kramer J, Duan Z and Kanwal F: Racial differences in the progression to cirrhosis and hepatocellular carcinoma in HCV-infected veterans. Am J Gastroenterol. 109:1427–1435. 2014. View Article : Google Scholar : PubMed/NCBI

10 

Hansma P, Diaz FJ and Njiwaji C: Fatal liver cyst rupture due to anabolic steroid use: A case presentation. Am J Forensic Med Pathol. 37:21–22. 2016. View Article : Google Scholar

11 

Harkin KR, Cowan LA, Andrews GA, Basaraba RJ, Fischer JR, DeBowes LJ, Roush JK, Guglielmino ML and Kirk CA: Hepatotoxicity of stanozolol in cats. J Am Vet Med Assoc. 217:681–684. 2000. View Article : Google Scholar : PubMed/NCBI

12 

Socas L, Zumbado M, Pérez-Luzardo O, Ramos A, Pérez C, Hernández JR and Boada LD: Hepatocellular adenomas associated with anabolic androgenic steroid abuse in bodybuilders: A report of two cases and a review of the literature. Br J Sports Med. 39:e272005. View Article : Google Scholar : PubMed/NCBI

13 

Stimac D, Milić S, Dintinjana RD, Kovac D and Ristić S: Androgenic/anabolic steroid-induced toxic hepatitis. J Clin Gastroenterol. 35:350–352. 2002. View Article : Google Scholar : PubMed/NCBI

14 

Deshmukh NI, Zachar G, Petróczi A, Székely AD, Barker J and Naughton DP: Determination of stanozolol and 3′-hydroxystanozolol in rat hair, urine and serum using liquid chromatography tandem mass spectrometry. Chem Cent J. 6:1622012. View Article : Google Scholar

15 

Mateus-Avois L, Mangin P and Saugy M: Use of ion trap gas chromatography-multiple mass spectrometry for the detection and confirmation of 3′hydroxystanozolol at trace levels in urine for doping control. J Chromatogr B Analyt Technol Biomed Life Sci. 816:193–201. 2005. View Article : Google Scholar : PubMed/NCBI

16 

Kicman AT: Pharmacology of anabolic steroids. Br J Pharmacol. 154:502–521. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Büttner A and Thieme D: Side effects of anabolic androgenic steroids: Pathological findings and structure-activity relationships. Handb Exp Pharmacol. 195:459–484. 2010. View Article : Google Scholar

18 

Rentoukas E, Tsarouhas K, Kaplanis I, Korou E, Nikolaou M, Marathonitis G, Kokkinou S, Haliassos A, Mamalaki A, Kouretas D, et al: Connection between telomerase activity in PBMC and markers of inflammation and endothelial dysfunction in patients with metabolic syndrome. PLoS One. 7:e357392012. View Article : Google Scholar : PubMed/NCBI

19 

Kumar M, Lechel A and Güneş Ç: Telomerase: The devil inside. Genes (Basel). 7:E432016. View Article : Google Scholar

20 

Xu Y and Goldkorn A: Telomere and telomerase therapeutics in cancer. Genes (Basel). 7:E222016. View Article : Google Scholar

21 

Zhou X, Zhu H and Lu J: PTEN and hTERT gene expression and the correlation with human hepatocellular carcinoma. Pathol Res Pract. 211:316–319. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Wojtyla A, Gladych M and Rubis B: Human telomerase activity regulation. Mol Biol Rep. 38:3339–3349. 2011. View Article : Google Scholar :

23 

Yang C, Li S, Wang M, Chang AK, Liu Y, Zhao F, Xiao L, Han L, Wang D, Li S and Wu H: PTEN suppresses the oncogenic function of AIB1 through decreasing its protein stability via mechanism involving Fbw7 alpha. Mol Cancer. 12:212013. View Article : Google Scholar : PubMed/NCBI

24 

Jung S, Li C, Jeong D, Lee S, Ohk J, Park M, Han S, Duan J, Kim C, Yang Y, et al: Oncogenic function of p34SEI-1 via NEDD4 1 mediated PTEN ubiquitination/degradation and activation of the PI3K/AKT pathway. Int J Oncol. 43:1587–1595. 2013. View Article : Google Scholar : PubMed/NCBI

25 

OECD: Guidance document on the recognition, assessment, and use of clinical signs as humane endpoints for experimental animals used in safety evaluation. OECD; Paris: 2000

26 

Cherici Camargo IC, Barreiros de Souza R, de Fátima Paccola Mesquita S, Chuffa LG and Frei F: Ovarian histology and follicular score in female rats treated with nandrolone decanoate and submitted to physical effort. Acta Biol Hung. 60:253–261. 2009. View Article : Google Scholar : PubMed/NCBI

27 

de Almeida Chuffa LG, de Souza RB, Frei F, de Fátima Paccola Mesquita S and Camargo IC: Nandrolone decanoate and physical effort: Histological and morphometrical assessment in adult rat uterus. Anat Rec (Hoboken). 294:335–341. 2011. View Article : Google Scholar

28 

Gopinathan S, O'Neill E, Rodriguez LA, Champ R, Phillips M, Nouraldeen A, Wendt M, Wilson AGE and Kramer JA: In vivo toxicology of excipients commonly employed in drug discovery in rats. J Pharmacol Toxicol Methods. 68:284–295. 2013. View Article : Google Scholar : PubMed/NCBI

29 

Healing G, Sulemann T, Cotton P, Harris J, Hargreaves A, Finney R, Kirk S, Schramm C, Garner C, Pivette P and Burdett L: Safety data on 19 vehicles for use in 1 month oral rodent pre-clinical studies: Administration of hydroxypropyl-β-cyclodextrin causes renal toxicity. J Appl Toxicol. 36:140–150. 2016. View Article : Google Scholar

30 

Aye M, Di Giorgio C, De Mo M, Botta A, Perrin J and Courbiere B: Assessment of the genotoxicity of three cryoprotectants used for human oocyte vitrification: Dimethyl sulfoxide, ethylene glycol and propylene glycol. Food Chem Toxicol. 48:1905–1912. 2010. View Article : Google Scholar : PubMed/NCBI

31 

Berthelot-Ricou A, Perrin J, di Giorgio C, de Meo M, Botta A and Courbiere B: Assessment of 1,2-propanediol (PrOH) genotoxicity on mouse oocytes by comet assay. Fertil Steril. 96:1002–1007. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Cunningham RL and McGinnis MY: Physical provocation of pubertal anabolic androgenic steroid exposed male rats elicits aggression towards females. Horm Behav. 50:410–416. 2006. View Article : Google Scholar : PubMed/NCBI

33 

Matrisciano F, Modafferi AM, Togna GI, Barone Y, Pinna G, Nicoletti F and Scaccianoce S: Repeated anabolic androgenic steroid treatment causes antidepressant-reversible alterations of the hypothalamic-pituitary-adrenal axis, BDNF levels and behavior. Neuropharmacology. 58:1078–1084. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Tucci P, Morgese MG, Colaianna M, Zotti M, Schiavone S, Cuomo V and Trabace L: Neurochemical consequence of steroid abuse: Stanozolol-induced monoaminergic changes. Steroids. 77:269–275. 2012. View Article : Google Scholar

35 

Kara M, Ozcagli E, Fragkiadaki P, Kotil T, Stivaktakis PD, Spandidos DA, Tsatsakis AM and Alpertunga B: Determination of DNA damage and telomerase activity in stanozolol-treated rats. Exp Ther Med. 13:614–618. 2017. View Article : Google Scholar : PubMed/NCBI

36 

Tsitsimpikou C, Tzatzarakis M, Fragkiadaki P, Kovatsi L, Stivaktakis P, Kalogeraki A, Kouretas D and Tsatsakis AM: Histopathological lesions, oxidative stress and genotoxic effects in liver and kidneys following long term exposure of rabbits to diazinon and propoxur. Toxicology. 307:109–114. 2013. View Article : Google Scholar

37 

Solbach P, Potthoff A, Raatschen HJ, Soudah B, Lehmann U, Schneider A, Gebel MJ, Manns MP and Vogel A: Testosterone-receptor positive hepatocellular carcinoma in a 29-year old bodybuilder with a history of anabolic androgenic steroid abuse: A case report. BMC Gastroenterol. 15:602015. View Article : Google Scholar : PubMed/NCBI

38 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−4Delta Delta C(T)) Method. Methods. 25:402–408. 2001. View Article : Google Scholar

39 

Kesler T, Sandhu RS and Krishnamoorthy S: Hepatology: Hepatocellular carcinoma in a young man secondary to androgenic anabolic steroid abuse. J Gastroenterol Hepatol. 29:18522014. View Article : Google Scholar : PubMed/NCBI

40 

Boada LD, Zumbado M, Torres S, López A, Díaz-Chico BN, Cabrera JJ and Luzardo OP: Evaluation of acute and chronic hepatotoxic effects exerted by anabolic-androgenic steroid stanozolol in adult male rats. Arch Toxicol. 73:465–472. 1999. View Article : Google Scholar

41 

Kanayama G, Hudson JI and Pope HG Jr: Long-term psychiatric and medical consequences of anabolic-androgenic steroid abuse: A looming public health concern? Drug Alcohol Depend. 98:1–12. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Ornish D, Lin J, Chan JM, Epel E, Kemp C, Weidner G, Marlin R, Frenda SJ, Magbanua MJM, Daubenmier J, et al: Effect of comprehensive lifestyle changes on telomerase activity and telomere length in men with biopsy-proven low-risk prostate cancer: 5-year follow-up of a descriptive pilot study. Lancet Oncol. 14:1112–1120. 2013. View Article : Google Scholar : PubMed/NCBI

43 

Mishra S, Kumar R, Malhotra N, Singh N and Dada R: Mild oxidative stress is beneficial for sperm telomere length maintenance. World J Methodol. 6:163–170. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Zar T, Graeber C and Perazella MA: Recognition, treatment, and prevention of propylene glycol toxicity. Semin Dial. 20:217–219. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Djojosubroto MW, Chin AC, Go N, Schaetzlein S, Manns MP, Gryaznov S, Harley CB and Rudolph KL: Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology. 42:1127–1136. 2005. View Article : Google Scholar : PubMed/NCBI

46 

Vasilaki F, Tsitsimpikou C, Tsarouhas K, Germanakis I, Tzardi M, Kavvalakis M, Ozcagli E, Kouretas D and Tsatsakis AM: Cardiotoxicity in rabbits after long-term nandrolone decanoate administration. Toxicol Lett. 241:143–151. 2016. View Article : Google Scholar

47 

Pilati C, Letouzé E, Nault JC, Imbeaud S, Boulai A, Calderaro J, Poussin K, Franconi A, Couchy G, Morcrette G, et al: Genomic profiling of hepatocellular adenomas reveals recurrent FRK-activating mutations and the mechanisms of malignant transformation. Cancer Cell. 25:428–441. 2014. View Article : Google Scholar

48 

Akincilar SC, Unal B and Tergaonkar V: Reactivation of telomerase in cancer. Cell Mol Life Sci. 73:1659–1670. 2016. View Article : Google Scholar : PubMed/NCBI

49 

Jungermann K and Kietzmann T: Zonation of parenchymal and nonparenchymal metabolism in liver. Annu Rev Nutr. 16:179–203. 1996. View Article : Google Scholar : PubMed/NCBI

50 

Jungermann K: Metabolic zonation of liver parenchyma. Semin Liver Dis. 8:329–341. 1988. View Article : Google Scholar : PubMed/NCBI

51 

Salvador JP, Sánchez-Baeza F and Marco MP: Simultaneous immunochemical detection of stanozolol and the main human metabolite, 3′-hydroxy-stanozolol, in urine and serum samples. Anal Biochem. 376:221–228. 2008. View Article : Google Scholar : PubMed/NCBI

52 

Chilton WL, Marques FZ, West J, Kannourakis G, Berzins SP, O'Brien BJ and Charchar FJ: Acute exercise leads to regulation of telomere-associated genes and microRNA expression in immune cells. PLoS One. 9:e920882014. View Article : Google Scholar : PubMed/NCBI

53 

Ludlow AT, Gratidão L, Ludlow LW, Spangenburg EE and Roth SM: Acute exercise activates p38 MAPK and increases the expression of telomere-protective genes in cardiac muscle. Exp Physiol. 102:397–410. 2017. View Article : Google Scholar : PubMed/NCBI

54 

Vardavas AI, Stivaktakis PD, Tzatzarakis MN, Fragkiadaki P, Vasilaki F, Tzardi M, Datseri G, Tsiaoussis J, Alegakis AK, Tsitsimpikou C, et al: Long-term exposure to cypermethrin and piperonyl butoxide cause liver and kidney inflammation and induce genotoxicity in New Zealand white male rabbits. Food Chem Toxicol. 94:250–259. 2016. View Article : Google Scholar : PubMed/NCBI

55 

Huang CC, Chiang WD, Huang WC, Huang CY, Hsu MC and Lin WT: Hepatoprotective effects of swimming exercise against D-galactose-induced senescence rat model. Evid Based Complement Alternat Med. 2013:2754312013. View Article : Google Scholar : PubMed/NCBI

56 

Yi X, Cao S, Chang B, Zhao D, Gao H, Wan Y, Shi J, Wei W and Guan Y: Effects of acute exercise and chronic exercise on the liver leptin-AMPK-ACC signaling pathway in rats with type 2 diabetes. J Diabetes Res. 2013:9464322013. View Article : Google Scholar

57 

Pettersson J, Hindorf U, Persson P, Bengtsson T, Malmqvist U, Werkström V and Ekelund M: Muscular exercise can cause highly pathological liver function tests in healthy men. Br J Clin Pharmacol. 65:253–259. 2008. View Article : Google Scholar

58 

Brustia R, Savier E and Scatton O: Physical exercise in cirrhotic patients: Towards prehabilitation on waiting list for liver transplantation. A systematic review and meta-analysis. Clin Res Hepatol Gastroenterol. Nov 18–2017.Epub ahead of print. PubMed/NCBI

59 

Tapis F: Telomeres are protective caps on the end of chromosomes. Cell, chromosome and DNA vector illustration. Digital image ID: 710795275, Shutterstock. https://www.shutterstock.com/image-illustration/telomeres-protective-caps-on-end-chromosomes-735264379.

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Spandidos Publications style
Ozcagli E, Kara M, Kotil T, Fragkiadaki P, Tzatzarakis MN, Tsitsimpikou C, Stivaktakis PD, Tsoukalas D, Spandidos DA, Tsatsakis AM, Tsatsakis AM, et al: Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging. Int J Mol Med 42: 405-413, 2018.
APA
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M.N., Tsitsimpikou, C. ... Alpertunga, B. (2018). Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging. International Journal of Molecular Medicine, 42, 405-413. https://doi.org/10.3892/ijmm.2018.3644
MLA
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M. N., Tsitsimpikou, C., Stivaktakis, P. D., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A. M., Alpertunga, B."Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging". International Journal of Molecular Medicine 42.1 (2018): 405-413.
Chicago
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M. N., Tsitsimpikou, C., Stivaktakis, P. D., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A. M., Alpertunga, B."Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging". International Journal of Molecular Medicine 42, no. 1 (2018): 405-413. https://doi.org/10.3892/ijmm.2018.3644
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Spandidos Publications style
Ozcagli E, Kara M, Kotil T, Fragkiadaki P, Tzatzarakis MN, Tsitsimpikou C, Stivaktakis PD, Tsoukalas D, Spandidos DA, Tsatsakis AM, Tsatsakis AM, et al: Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging. Int J Mol Med 42: 405-413, 2018.
APA
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M.N., Tsitsimpikou, C. ... Alpertunga, B. (2018). Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging. International Journal of Molecular Medicine, 42, 405-413. https://doi.org/10.3892/ijmm.2018.3644
MLA
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M. N., Tsitsimpikou, C., Stivaktakis, P. D., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A. M., Alpertunga, B."Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging". International Journal of Molecular Medicine 42.1 (2018): 405-413.
Chicago
Ozcagli, E., Kara, M., Kotil, T., Fragkiadaki, P., Tzatzarakis, M. N., Tsitsimpikou, C., Stivaktakis, P. D., Tsoukalas, D., Spandidos, D. A., Tsatsakis, A. M., Alpertunga, B."Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging". International Journal of Molecular Medicine 42, no. 1 (2018): 405-413. https://doi.org/10.3892/ijmm.2018.3644
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