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Article

Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion

  • Authors:
    • Hong‑Xu Jin
    • Yun‑Hu Zhang
    • Ruo‑Nan Guo
    • Su‑Nuan Zhao
  • View Affiliations / Copyright

    Affiliations: Department of Anesthesiology, Harrison International Peace Hospital, Hebei Medical University, Hengshui, Hebei 053000, P.R. China, Department of General Medicine, Harrison International Peace Hospital, Hebei Medical University, Hengshui, Hebei 053000, P.R. China, Department of Internal Medicine‑Pediatrics, The Fifth People's Hospital, Hengshui, Hebei 053000, P.R. China, Department of Pediatrics, Anping General Hospital, Anping, Hebei 053600, P.R. China
  • Pages: 1034-1043
    |
    Published online on: May 11, 2018
       https://doi.org/10.3892/ijmm.2018.3673
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Abstract

Studies have shown that oleuropein has antifungal, anti‑inflammatory, antiviral, antioxidant, anticancer and hypoglycemic functions. TTC solution staining was used to measure myocardial infarction size. A commercial kit was used to measure lactate dehydrogenase (LDH), creatinine kinase‑MB (CK‑MB), tumor necrosis factor‑α (TNF‑α), interleukin‑1β (IL‑1β), IL 6, superoxide dismutase (SOD), glutathione (GSH), malondialdehyde (MDA) and catalase levels. Western blot analysis was used to measure p53, p-MEK p-ERK and p‑IκBα protein expression. The present study reports that the protective effect of oleuropein also prevents against myocardial ischemia/reperfusion (myocardial I/R). The aim of this retrospective study was to evaluate this protective effect of oleuropein and the mechanisms by which myocardial I/R is prevented. Oleuropein inhibited myocardial infarction size, CK‑MB and LDH serum levels in a myocardial I/R rat model. Moreover, oleuropein also attenuated caspase‑3 activity, and p53, phosphorylated (p)‑mitogen‑activated protein kinase kinase (MEK), p‑extracellular signal‑regulated protein kinase (ERK) and p‑IκBα protein expression. TNF‑α, IL‑1β, IL‑6 and MDA were decreased; SOD, GSH and catalase levels inhibited TNF‑α, IL‑1β, IL-6 and MDA levels, and increased SOD, GSH and catalase levels in myocardial I/R rats treated with oleuropein. Rats orally administered the MEK inhibitor PD0325901, in addition to oleuropein, exhibited inhibited myocardial infarction size, CK‑MB and LDH serum levels compared with rats treated with oleuropein only. Rats treated with MEK inhibitor also exhibited suppressed caspase‑3 activity, p53, p‑MEK p‑ERK and p‑IκBα protein expression, TNF‑α, IL‑1β, IL‑6, SOD, GSH, MDA and catalase levels, and induced p‑signal transducer and activator of transcription 3 (STAT3) protein expression compared with rats treated with oleuropein only. Taken together, these results suggest that MEK/ERK/STAT3 signaling regulates the inhibition of myocardial I/R in rats treated with oleuropein.
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View References

1 

Nicholls SJ, Cavender MA, Kastelein JJ, Schwartz G, Waters DD, Rosenson RS, Bash D and Hislop C: Inhibition of secretory phospholipase A(2) in patients with acute coronary syndromes: Rationale and design of the vascular inflammation suppression to treat acute coronary syndrome for 16 weeks (VISTA-16) trial. Cardiovasc Drugs Ther. 26:71–75. 2012. View Article : Google Scholar

2 

Holme I, Szarek M, Cater NB, Faergeman O, Kastelein JJ, Olsson AG, Tikkanen MJ, Larsen ML, Lindahl C and Pedersen TR: Incremental Decrease in End Points Through Aggressive Lipid Lowering Study Group: Adherence-adjusted efficacy with intensive versus standard statin therapy in patients with acute myocardial infarction in the IDEAL study. Eur J Cardiovasc Prev Rehabil. 16:315–320. 2009. View Article : Google Scholar : PubMed/NCBI

3 

Vemulapalli S, Zhou Y, Gutberlet M, Kumar AS, Mills JS, Blaxill J, Smalling R, Ohman EM and Patel MR: Importance of total ischemic time and preprocedural infarct-related artery blood flow in predicting infarct size in patients with anterior wall myocardial infarction (from the CRISP-AMI Trial). Am J Cardiol. 112:911–917. 2013. View Article : Google Scholar : PubMed/NCBI

4 

Winter JL, Lindefjeld DS, Veas N, Guarda E, Valdebenito M, Méndez M, Pérez O, Zuanic K, Mestas M and Martínez A: Angiographic and electrocardiographic parameters of myocardial reperfusion in angioplasty of patients with ST elevation acute myocardial infarction loaded with ticagrelor or clopidogrel (MICAMI-TICLO trial). Cardiovasc Revasc Med. 15:284–288. 2014. View Article : Google Scholar : PubMed/NCBI

5 

Wei C, Wang Y, Li M, Li H, Lu X, Shao H and Xu C: Spermine inhibits endoplasmic reticulum stress-induced apoptosis: A new strategy to prevent cardiomyocyte apoptosis. Cell Physiol Biochem. 38:531–544. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Zhang H, Wang Z, Feng SJ, Xu L, Shi HX, Chen LL, Yuan GD, Yan W, Zhuang W, Zhang YQ, et al: PEDF improves cardiac function in rats with acute myocardial infarction via inhibiting vascular permeability and cardiomyocyte apoptosis. Int J Mol Sci. 16:5618–5634. 2015. View Article : Google Scholar : PubMed/NCBI

7 

Ale A, Siebenhaar F, Kosanke K, Aichler M, Radrich K, Heydrich S, Schiemann M, Bielicki I, Noel PB, Braren R, et al: Cardioprotective C-kit+ bone marrow cells attenuate apoptosis after acute myocardial infarction in mice - in-vivo assessment with fluorescence molecular imaging. Theranostics. 3:903–913. 2013. View Article : Google Scholar :

8 

Li L, Guo Y, Zhai H, Yin Y, Zhang J, Chen H, Wang L, Li N, Liu R and Xia Y: Aging increases the susceptivity of MSCs to reactive oxygen species and impairs their therapeutic potency for myocardial infarction. PLoS One. 9:e1118502014. View Article : Google Scholar : PubMed/NCBI

9 

Becatti M, Fiorillo C, Gori AM, Marcucci R, Paniccia R, Giusti B, Violi F, Pignatelli P, Gensini GF and Abbate R: Platelet and leukocyte ROS production and lipoperoxidation are associated with high platelet reactivity in Non-ST elevation myocardial infarction (NSTEMI) patients on dual antiplatelet treatment. Atherosclerosis. 231:392–400. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Correa F, Martínez-Abundis E, Hernández-Reséndiz S, García N, Buelna-Chontal M, Arreguín F and Zazueta C: Pharmacological strategies to contend against myocardial reperfusion damage: Diverse chemicals for multiple targets. Curr Med Chem. 17:2261–2273. 2010. View Article : Google Scholar : PubMed/NCBI

11 

Sun SJ, Wu XP, Song HL and Li GQ: Baicalin ameliorates isoproterenol-induced acute myocardial infarction through iNOS, inflammation, oxidative stress and P38MAPK pathway in rat. Int J Clin Exp Med. 8:22063–22072. 2015.

12 

Protti A, Dong X, Andia ME, Yu B, Dokukina K, Chaubey S, Phinikaridou A, Vizcay-Barrena G, Taupitz M, Botnar RM, et al: Assessment of inflammation with a very small iron-oxide particle in a murine model of reperfused myocardial infarction. J Magn Reson Imaging. 39:598–608. 2014. View Article : Google Scholar

13 

Impellizzeri D, Esposito E, Mazzon E, Paterniti I, Di Paola R, Bramanti P, Morittu VM, Procopio A, Perri E, Britti D, et al: The effects of a polyphenol present in olive oil, oleuropein aglycone, in an experimental model of spinal cord injury in mice. Biochem Pharmacol. 83:1413–1426. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Lapi D, Di Maro M, Mastantuono T, Battiloro L, Sabatino L, Muscariello E and Colantuoni A: Effects of oleuropein and pinoresinol on microvascular damage induced by hypoperfusion and reperfusion in rat pial circulation. Microcirculation. 22:79–90. 2015. View Article : Google Scholar

15 

Nekooeian AA, Khalili A and Khosravi MB: Oleuropein offers cardioprotection in rats with simultaneous type 2 diabetes and renal hypertension. Indian J Pharmacol. 46:398–403. 2014. View Article : Google Scholar : PubMed/NCBI

16 

Giner E, Recio MC, Ríos JL, Cerdá-Nicolás JM and Giner RM: Chemopreventive effect of oleuropein in colitis-associated colorectal cancer in c57bl/6 mice. Mol Nutr Food Res. 60:242–255. 2016. View Article : Google Scholar

17 

Elbarouni B, Cantor WJ, Ducas J, Borgundvaag B, Džavík V, Heffernan M, Buller CE, Langer A, Goodman SG and Yan AT; TRANSFER-AMI Trial Investigators: Efficacy of an early invasive strategy after fibrinolysis in ST-elevation myocardial infarction relative to the extent of coronary artery disease. Can J Cardiol. 30:1555–1561. 2014. View Article : Google Scholar : PubMed/NCBI

18 

Boghdady A and Elbadry MI: Comparison of successful myocardial reperfusion and adverse events in patients with ST-elevation myocardial infarction who underwent rescue percutaneous coronary intervention after failed fibrinolytic therapy with versus without manual coronary thrombus aspiration. Am J Cardiol. 116:1185–1192. 2015. View Article : Google Scholar : PubMed/NCBI

19 

She T, Wang X, Gan Y, Kuang D, Yue J, Ni J, Zhao X and Wang G: Hyperglycemia suppresses cardiac stem cell homing to peri-infarcted myocardium via regulation of ERK1/2 and p38 MAPK activities. Int J Mol Med. 30:1313–1320. 2012. View Article : Google Scholar : PubMed/NCBI

20 

Przybyt E, Krenning G, Brinker MG and Harmsen MC: Adipose stromal cells primed with hypoxia and inflammation enhance cardiomyocyte proliferation rate in vitro through STAT3 and Erk1/2. J Transl Med. 11:392013. View Article : Google Scholar : PubMed/NCBI

21 

Potočnjak I, Škoda M, Pernjak-Pugel E, Peršić MP and Domitrović R: Oral administration of oleuropein attenuates cisplatin-induced acute renal injury in mice through inhibition of ERK signaling. Mol Nutr Food Res. 60:530–541. 2016. View Article : Google Scholar

22 

Yang X, Qin Y, Shao S, Yu Y, Zhang C, Dong H, Lv G and Dong S: MicroRNA-214 Inhibits Left Ventricular Remodeling in an Acute Myocardial Infarction Rat Model by Suppressing Cellular Apoptosis via the Phosphatase and Tensin Homolog (PTEN). Int Heart J. 57:247–250. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Zhang RL, Guo Z, Wang LL and Wu J: Degeneration of capsaicin sensitive sensory nerves enhances myocardial injury in acute myocardial infarction in rats. Int J Cardiol. 160:41–47. 2012. View Article : Google Scholar

24 

Sygitowicz G, Maciejak A, Piniewska-Juraszek J, Pawlak M, Góra M, Burzyńska B, Dłużniewski M, Opolski G and Sitkiewicz D: Interindividual variability of atorvastatin treatment influence on the MPO gene expression in patients after acute myocardial infarction. Acta Biochim Pol. 63:10142016. View Article : Google Scholar

25 

Mladenka P, Filipský T, Ríha M, Vávrová J, Holecková M, Palicka V and Hrdina R: The relationship of oxidative stress markers and parameters of myocardial function in a rat model of cardiotoxicity. Free Radic Biol Med. 75(Suppl 1): S422014. View Article : Google Scholar

26 

Carvalheiro T, Velada I, Valado A, Mendes F, Martinho A, António N, Gonçalves L, Providência L, Pais ML and Paiva A: Phenotypic and functional alterations on inflammatory peripheral blood cells after acute myocardial infarction. J Cardiovasc Transl Res. 5:309–320. 2012. View Article : Google Scholar : PubMed/NCBI

27 

Shrivastava AK, Singh HV, Raizada A and Singh SK: Serial measurement of lipid profile and inflammatory markers in patients with acute myocardial infarction. EXCLI J. 14:517–526. 2015.PubMed/NCBI

28 

Prato FS, Butler J, Sykes J, Keenliside L, Blackwood KJ, Thompson RT, White JA, Mikami Y, Thiessen JD and Wisenberg G: Can the inflammatory response be evaluated using 18F-FDG within zones of microvascular obstruction after myocardial infarction? J Nucl Med. 56:299–304. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Xia KP, Ca HM and Shao CZ: Protective effect of notoginsenoside R1 in a rat model of myocardial ischemia reperfusion injury by regulation of vitamin D3 upregulated protein 1/NF-κB pathway. Pharmazie. 70:740–744. 2015.

30 

Xu H, Wang D, Peng C, Huang X, Ou M, Wang N, Wang P, Zhou L and Ye X: Rabbit sera containing compound danshen dripping pill attenuate leukocytes adhesion to TNF-alpha-activated human umbilical vein endothelial cells by suppressing endothelial ICAM-1 and VCAM-1 expression through NF-kappaB signaling pathway. J Cardiovasc Pharmacol. 63:323–332. 2014. View Article : Google Scholar : PubMed/NCBI

31 

Arslan S, Korkmaz Ö, Özbilüm N and Berkan Ö: Association between NF-κBI and NF-κBIA polymorphisms and coronary artery disease. Biomed Rep. 3:736–740. 2015. View Article : Google Scholar : PubMed/NCBI

32 

Campolo M, Di Paola R, Impellizzeri D, Crupi R, Morittu VM, Procopio A, Perri E, Britti D, Peli A, Esposito E, et al: Effects of a polyphenol present in olive oil, oleuropein aglycone, in a murine model of intestinal ischemia/reperfusion injury. J Leukoc Biol. 93:277–287. 2013. View Article : Google Scholar

33 

Grossi V, Lucarelli G, Forte G, Peserico A, Matrone A, Germani A, Rutigliano M, Stella A, Bagnulo R, Loconte D, et al: Loss of STK11 expression is an early event in prostate carcinogenesis and predicts therapeutic response to targeted therapy against MAPK/p38. Autophagy. 11:2102–2113. 2015. View Article : Google Scholar : PubMed/NCBI

34 

Armstrong SC: Protein kinase activation and myocardial ischemia/reperfusion injury. Cardiovasc Res. 61:427–436. 2004. View Article : Google Scholar : PubMed/NCBI

35 

Ruisong M, Xiaorong H, Gangying H, Chunfeng Y, Changjiang Z, Xuefei L, Yuanhong L and Hong J: The protective role of interleukin-33 in myocardial ischemia and reperfusion is associated with decreased HMGB1 expression and upregulation of the p38 MAPK signaling pathway. PLoS One. 10:e01430642015. View Article : Google Scholar

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Copy and paste a formatted citation
Spandidos Publications style
Jin HX, Zhang YH, Guo RN and Zhao SN: Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion. Int J Mol Med 42: 1034-1043, 2018.
APA
Jin, H., Zhang, Y., Guo, R., & Zhao, S. (2018). Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion. International Journal of Molecular Medicine, 42, 1034-1043. https://doi.org/10.3892/ijmm.2018.3673
MLA
Jin, H., Zhang, Y., Guo, R., Zhao, S."Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion". International Journal of Molecular Medicine 42.2 (2018): 1034-1043.
Chicago
Jin, H., Zhang, Y., Guo, R., Zhao, S."Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion". International Journal of Molecular Medicine 42, no. 2 (2018): 1034-1043. https://doi.org/10.3892/ijmm.2018.3673
Copy and paste a formatted citation
x
Spandidos Publications style
Jin HX, Zhang YH, Guo RN and Zhao SN: Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion. Int J Mol Med 42: 1034-1043, 2018.
APA
Jin, H., Zhang, Y., Guo, R., & Zhao, S. (2018). Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion. International Journal of Molecular Medicine, 42, 1034-1043. https://doi.org/10.3892/ijmm.2018.3673
MLA
Jin, H., Zhang, Y., Guo, R., Zhao, S."Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion". International Journal of Molecular Medicine 42.2 (2018): 1034-1043.
Chicago
Jin, H., Zhang, Y., Guo, R., Zhao, S."Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion". International Journal of Molecular Medicine 42, no. 2 (2018): 1034-1043. https://doi.org/10.3892/ijmm.2018.3673
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