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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
August-2018 Volume 42 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Personalized regulation of glioblastoma cancer stem cells based on biomedical technologies: From theory to experiment (Review)

Igor Bryukhovetskiy, Arina Ponomarenko, Irina Lyakhova, Sergey Zaitsev, Yulia Zayats, Maria Korneyko, Marina Eliseikina, Polina Mischenko, Valerie Shevchenko, Hari Shanker Sharma, Aruna Sharma, Yuri Khotimchenko
Pages: 691-702
Published online on: 10 May 2018

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Article Open Access

CTLA‑4 interferes with the HBV‑specific T cell immune response (Review)

Hui Cao, Ruiwen Zhang, Wei Zhang
Pages: 703-712
Published online on: 17 May 2018

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Review Open Access

Multi‑layered prevention and treatment of chronic inflammation, organ fibrosis and cancer associated with canonical WNT/β‑catenin signaling activation (Review)

Masaru Katoh
Pages: 713-725
Published online on: 17 May 2018

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Article Open Access

Antibacterial and antioxidant activity of different types of honey derived from Mount Olympus in Greece

Dimitrios Stagos, Nikolaos Soulitsiotis, Christina Tsadila, Stamatina Papaeconomou, Charalampos Arvanitis, Alexandros Ntontos, Fani Karkanta, Soultana Adamou‑Androulaki, Konstantinos Petrotos, Demetrios A. Spandidos, Demetrios Kouretas, Dimitris Mossialos
Pages: 726-734
Published online on: 04 May 2018

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Article Open Access

Comparative whole genome transcriptome analysis and fenugreek leaf extract modulation on cadmium‑induced toxicity in liver cells

Caroline Odewumi, Lekan M. Latinwo, Roy Leonard Lyles, Veera L.D. Badisa, Cobb‑Abdullah Ahkinyala, Marijo Kent‑First
Pages: 735-744
Published online on: 10 May 2018

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Article Open Access

Physcion 8‑O‑β‑glucopyranoside extracted from Polygonum cuspidatum exhibits anti‑proliferative and anti‑inflammatory effects on MH7A rheumatoid arthritis‑derived fibroblast‑like synoviocytes through the TGF‑β/MAPK pathway

Qin Geng, Qiaofeng Wei, Shujun Wang, Huili Qi, Qin Zhu, Xia Liu, Xiaojun Shi, Shuyun Wen
Pages: 745-754
Published online on: 30 April 2018

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Article Open Access

Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation

Yu Liu, Pei‑Hao Wen, Xin‑Xue Zhang, Yang Dai, Qiang He
Pages: 755-768
Published online on: 02 May 2018

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Article Open Access

Xanthatin inhibits corneal neovascularization by inhibiting the VEGFR2‑mediated STAT3/PI3K/Akt signaling pathway

Mei Shen, Xue‑Zhi Zhou, Lei Ye, Qing Yuan, Ce Shi, Pei‑Wen Zhu, Nan Jiang, Ming‑Yang Ma, Qi‑Chen Yang, Yi Shao
Pages: 769-778
Published online on: 30 April 2018

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Article Open Access

MicroRNA‑195 inhibits cell proliferation, migration and invasion by targeting defective in cullin neddylation 1 domain containing 1 in cervical cancer Retraction in /10.3892/ijmm.2021.4973

Jinyan Zhong, Hui Yuan, Xiangqian Xu, Shoufang Kong
Pages: 779-788
Published online on: 08 May 2018

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Article Open Access

Identification and antioxidant activity of synthetic peptides from phycobiliproteins of Pyropia yezoensis

Eun‑Young Kim, Youn Hee Choi, Taek‑Jeong Nam
Pages: 789-798
Published online on: 30 April 2018

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Article Open Access

High glucose suppresses the viability and proliferation of HTR‑8/SVneo cells through regulation of the miR‑137/PRKAA1/IL‑6 axis

Hai‑Yan Peng, Ming‑Qing Li, Hua‑Ping Li
Pages: 799-810
Published online on: 17 May 2018

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Article Open Access

Anti‑cancer effects of fisetin on mammary carcinoma cells via regulation of the PI3K/Akt/mTOR pathway: In vitro and in vivo studies

Xu Sun, Xueman Ma, Qiwei Li, Yong Yang, Xiaolong Xu, Jiaqi Sun, Mingwei Yu, Kexin Cao, Lin Yang, Guowang Yang, Ganlin Zhang, Xiaomin Wang
Pages: 811-820
Published online on: 02 May 2018

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Article Open Access

Expression of annexin II and stromal tenascin C promotes epithelial to mesenchymal transition and correlates with distant metastasis in pancreatic cancer

Naoko Yoneura, Shigetsugu Takano, Hideyuki Yoshitomi, Yasuyuki Nakata, Reiri Shimazaki, Shingo Kagawa, Katsunori Furukawa, Tsukasa Takayashiki, Satoshi Kuboki, Masaru Miyazaki, Masayuki Ohtsuka
Pages: 821-830
Published online on: 02 May 2018

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Article Open Access

Icariin promotes wound healing by enhancing the migration and proliferation of keratinocytes via the AKT and ERK signaling pathway

Bobin Mi, Jing Liu, Guohui Liu, Wu Zhou, Yi Liu, Liangcong Hu, Liming Xiong, Shunan Ye, Yongchao Wu
Pages: 831-838
Published online on: 14 May 2018

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Article Open Access

miR‑133b regulates proliferation and apoptosis in high‑glucose‑induced human retinal endothelial cells by targeting ras homolog family member A

Jun Yao, Jihong Wang, Yong Yao, Kelei Wang, Qianqian Zhou, Ying Tang
Pages: 839-850
Published online on: 18 May 2018

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Article Open Access

Role of Smad3 signaling in the epithelial‑mesenchymal transition of the lens epithelium following injury

Fanlan Meng, Jun Li, Xiao Yang, Xiaoyong Yuan, Xin Tang
Pages: 851-860
Published online on: 09 May 2018

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Article Open Access

Upregulation of allograft inflammatory factor‑1 expression and secretion by macrophages stimulated with aldosterone promotes renal fibroblasts to a profibrotic phenotype

Yushu Li, Xingzhi Wang, Lei Zhang, Xueying Yuan, Jianbing Hao, Jie Ni, Lirong Hao
Pages: 861-872
Published online on: 10 May 2018

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Article Open Access

Overexpression of C‑sis inhibits H2O2‑induced Buffalo rat liver cell apoptosis in vitro and alleviates liver injury in a rat model of fulminant hepatic failure

Hao Ding, Zhili Wen
Pages: 873-882
Published online on: 17 May 2018

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Article Open Access

Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in /10.3892/ijmm.2018.3843

Guangdi Li, Rudan Zhou, Xueling Zhao, Riguang Liu, Chuan Ye
Pages: 883-896
Published online on: 16 May 2018

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Article Open Access

Role of TGF‑β1 expressed in bone marrow‑derived mesenchymal stem cells in promoting bone formation in a rabbit femoral defect model

Bing‑Yin Sun, Bao‑Xiang Zhao, Jie‑Ying Zhu, Zheng‑Ping Sun, Yong‑An Shi, Feng Huang
Pages: 897-904
Published online on: 17 May 2018

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Article Open Access

GSK3β‑mediated Ser156 phosphorylation modulates a BH3‑like domain in BCL2L12 during TMZ‑induced apoptosis and autophagy in glioma cells

Cheng‑Wei Chu, Ming‑Chang Yang, Chia‑Hua Chou, Wen‑Sheng Huang, Bo‑Xiu Hsiao, Yeng‑Tseng Wang, Shean‑Jaw Chiou, Joon‑Khim Loh, Yi‑Ren Hong
Pages: 905-918
Published online on: 11 May 2018

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Article Open Access

Cannabinoid WIN-55,212-2 mesylate inhibits tumor necrosis factor-α-induced expression of nitric oxide synthase in dorsal root ganglion neurons

Rong Tan, Lijun Cao
Pages: 919-925
Published online on: 17 May 2018

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Article Open Access

Knockdown of TNF‑α alleviates acute lung injury in rats with intestinal ischemia and reperfusion injury by upregulating IL‑10 expression

Zhen Yang, Xue‑Rong Zhang, Qiong Zhao, Sheng‑Lan Wang, Liu‑Lin Xiong, Piao Zhang, Bing Yuan, Zi‑Bing Zhang, Shu‑Yuan Fan, Ting‑Hua Wang, Yun‑Hui Zhang
Pages: 926-934
Published online on: 14 May 2018

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Article Open Access

Role of TXNDC5 in tumorigenesis of colorectal cancer cells: In vivo and in vitro evidence

Fengbo Tan, Hong Zhu, Xiao He, Nanhui Yu, Xingwen Zhang, Haifan Xu, Haiping Pei
Pages: 935-945
Published online on: 09 May 2018

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Article Open Access

Enhanced proliferation and differentiation of HO-1 gene-modified bone marrow-derived mesenchymal stem cells in the acute injured kidney

Nanmei Liu, Huiling Wang, Guofeng Han, Jin Cheng, Weifeng Hu, Jinyuan Zhang
Pages: 946-956
Published online on: 11 May 2018

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Article Open Access

Regulation of interferon signaling and HCV‑RNA replication by extracellular matrix

Takuya Kuwashiro, Shinji Iwane, Xia Jinghe, Sachiko Matsuhashi, Yuichiro Eguchi, Keizo Anzai, Kazuma Fujimoto, Toshihiko Mizuta, Naoya Sakamoto, Masanori Ikeda, Nobuyuki Kato, Iwata Ozaki
Pages: 957-965
Published online on: 18 May 2018

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Article Open Access

Overexpression of PRDM13 inhibits glioma cells via Rho and GTP enzyme activation protein

Linna Zhang, Huimei Cao, Tao He, Jijuan Yang, Hong Tao, Yin Wang, Qikuan Hu
Pages: 966-974
Published online on: 14 May 2018

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Article Open Access

MicroRNA‑20b‑5p promotes ventricular remodeling by targeting the TGF‑β/Smad signaling pathway in a rat model of ischemia‑reperfusion injury

Zhao‑Guang Liang, Hong Yao, Rong‑Sheng Xie, Chun‑Lin Gong, Ye Tian
Pages: 975-987
Published online on: 18 May 2018

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Article

Engulfment of platelets delays endothelial cell aging via girdin and its phosphorylation

Yong Lan, Yongjun Li, Dajun Li, Peng Li, Jiyang Wang, Yongpeng Diao, Guodong Ye, Yangfang Li
Pages: 988-997
Published online on: 17 May 2018

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Article

miR‑494 inhibits cancer‑initiating cell phenotypes and reverses resistance to lapatinib by downregulating FGFR2 in HER2‑positive gastric cancer

Yanxia Yu, Xuejuan Yu, Hong Liu, Qingxun Song, Yongmei Yang
Pages: 998-1007
Published online on: 16 May 2018

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Article

MicroRNA‑381/Hes1 is a potential therapeutic target for spinal cord injury

Wendong Ruan, Guangzhi Ning, Shiqing Feng, Shijie Gao, Yan Hao
Pages: 1008-1017
Published online on: 08 May 2018

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Article

Cucurbitacin B inhibits tumor angiogenesis by triggering the mitochondrial signaling pathway in endothelial cells

Xian-Mei Piao, Feng Gao, Jiu-Xin Zhu, Li-Juan Wang, Xin Zhao, Xin Li, Miao-Miao Sheng, Yan Zhang
Pages: 1018-1025
Published online on: 30 April 2018

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Article

MicroRNA-137 dysregulation predisposes to osteoporotic fracture by impeding ALP activity and expression via suppression of leucine-rich repeat-containing G-protein-coupled receptor 4 expression

Xiangjun Liu, Xiaohui Xu
Pages: 1026-1033
Published online on: 17 May 2018

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Article

Inhibition of MEK/ERK/STAT3 signaling in oleuropein treatment inhibits myocardial ischemia/reperfusion

Hong‑Xu Jin, Yun‑Hu Zhang, Ruo‑Nan Guo, Su‑Nuan Zhao
Pages: 1034-1043
Published online on: 11 May 2018

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Article

Ectromelia virus upregulates the expression of heat shock protein 70 to promote viral replication

Wenyu Cheng, Huaijie Jia, Xiaoxia Wang, Xiaobing He, Qiwang Jin, Jingxin Cao, Zhizhong Jing
Pages: 1044-1053
Published online on: 04 May 2018

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Article

CTRP9 ameliorates cellular senescence via PGC‑1α/AMPK signaling in mesenchymal stem cells

Qun Li, Zhangzhang Zhu, Chengde Wang, Lin Cai, Jianglong Lu, Yongchun Wang, Jiadong Xu, Zhipeng Su, Weiming Zheng, Xianbin Chen
Pages: 1054-1063
Published online on: 09 May 2018

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Article

DNAJC3 mutation in Thai familial type 2 diabetes mellitus

Sirikul Kulanuwat, Watip Tangjittipokin, Prapaporn Jungtrakoon, Chutima Chanprasert, Jatuporn Sujjitjoon, Ninareeman Binnima, Pa‑Thai Yenchitsomanus, Nattachet Plengvidhya
Pages: 1064-1073
Published online on: 14 May 2018

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Article

Upregulated 14‑3‑3β aggravates restenosis by promoting cell migration following vascular injury in diabetic rats with elevated levels of free fatty acids

Lishuai Feng, Chaoran Dou, Jianbo Wang, Chunyu Jiang, Xu Ma, Jingjing Liu
Pages: 1074-1085
Published online on: 11 May 2018

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Article

Silencing of miR‑155 suppresses inflammatory responses in psoriasis through inflammasome NLRP3 regulation

Quan Luo, Jingxin Zeng, Wei Li, Ling Lin, Xin Zhou, Xin Tian, Weiyu Liu, Lidan Zhang, Xibao Zhang
Pages: 1086-1095
Published online on: 14 May 2018

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Article

BMP‑6 protects retinal pigment epithelial cells from oxidative stress‑induced injury by inhibiting the MAPK signaling pathways

Li Chen, Ming Liu, Yan Luan, Yingfei Liu, Zhichao Zhang, Bo Ma, Xuan Liu, Yong Liu
Pages: 1096-1105
Published online on: 14 May 2018

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Article

Luteolin induces myelodysplastic syndrome‑derived cell apoptosis via the p53‑dependent mitochondrial signaling pathway mediated by reactive oxygen species

Weimin Dong, Yan Lin, Yang Cao, Yue Liu, Xiaobao Xie, Weiying Gu
Pages: 1106-1115
Published online on: 18 May 2018

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Article

Accumulation of CD69+ tissue‑resident memory T cells in the nasal polyps of patients with chronic rhinosinusitis

Pascal Ickrath, Norbert Kleinsasser, Xin Ding, Christian Ginzkey, Niklas Beyersdorf, Rudolf Hagen, Thomas Kerkau, Stephan Hackenberg
Pages: 1116-1124
Published online on: 02 May 2018

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Article

Connexin 43 reduces susceptibility to sympathetic atrial fibrillation Corrigendum in /10.3892/ijmm.2020.4773

Beibei Luo, Yifei Yan, Zhiyu Zeng, Zhengnan Zhang, Haide Liu, Hao Liu, Jinyi Li, Weiqiang Huang, Jiangtao Wu, Yan He
Pages: 1125-1133
Published online on: 30 April 2018

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Article

Downregulation of microRNA‑34a inhibits oxidized low‑density lipoprotein‑induced apoptosis and oxidative stress in human umbilical vein endothelial cells

Xiaoming Zhong, Peng Li, Juan Li, Ruili He, Guanchang Cheng, Yanming Li
Pages: 1134-1144
Published online on: 09 May 2018

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Article

E3 ubiquitin ligase Hakai regulates cell growth and invasion, and increases the chemosensitivity to cisplatin in non‑small‑cell lung cancer cells

Zi Liu, Yuqing Wu, Zijian Tao, Liang Ma
Pages: 1145-1151
Published online on: 17 May 2018

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Article

LncRNA uc.48+ is involved in the diabetic immune and inflammatory responses mediated by P2X7 receptor in RAW264.7 macrophages

Hong Wu, Fang Wen, Mei Jiang, Qiang Liu, Yijun Nie
Pages: 1152-1160
Published online on: 09 May 2018

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Article

Apelin protects against sepsis‑induced cardiomyopathy by inhibiting the TLR4 and NLRP3 signaling pathways

Qiancheng Luo, Guorong Liu, Guo Chen, Dongfeng Guo, Lei Xu, Min Hang, Mingming Jin
Pages: 1161-1167
Published online on: 09 May 2018

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Article

Collagen peptides from soft‑shelled turtle induce calpain‑1 expression and regulate inflammatory cytokine expression in HaCaT human skin keratinocytes

Tetsushi Yamamoto, Saori Nakanishi, Kuniko Mitamura, Atsushi Taga
Pages: 1168-1180
Published online on: 08 May 2018

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Article

Efficient delivery of HBV NLS siRNAs into HepG2.2.15 cells for HBV inhibition through novel recombinant preS1‑tP proteins

Yanli Zeng, Zixi Li, Jia Shang, Yi Kang
Pages: 1181-1189
Published online on: 16 May 2018

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Article

Protective effects of dehydrocostuslactone on rat hippocampal slice injury induced by oxygen‑glucose deprivation/reoxygenation

Qipeng Zhao, Ailing Chen, Xiaobo Wang, Zhuanzhuan Zhang, Yunsheng Zhao, Yu Huang, Shuanglai Ren, Yafei Zhu
Pages: 1190-1198
Published online on: 17 May 2018

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Correction Open Access

[Corrigendum] Protective effect of angiotensin‑(1‑7) against hyperglycaemia‑induced injury in H9c2 cardiomyoblast cells via the PI3K̸Akt signaling pathway

Yi-Ying Yang, Xiu-Ting Sun, Zheng-Xun Li, Wei-Yan Chen, Xiang Wang, Mei-Ling Liang, Hui Shi, Zhi-Sheng Yang, Wu-Tao Zeng
Pages: 1199-1199
Published online on: 07 May 2018

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Review Open Access

Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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Article Open Access

MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Article Open Access

Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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Retraction Open Access

[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Review Open Access

Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Article Open Access

Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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Correction Open Access

[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Review Open Access

Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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Article Open Access

ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Review Open Access

Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Review

Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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Article Open Access

TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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Retraction Open Access

[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Article Open Access

Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Article Open Access

Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Review

Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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Retraction Open Access

[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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Journal Cover
February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Review Open Access

Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Review

Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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Retraction Open Access

[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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