Open Access

Correlation between the expression of IL‑18 and deep venous thrombosis

Corrigendum in: /10.3892/ijmm.2018.3843

  • Authors:
    • Guangdi Li
    • Rudan Zhou
    • Xueling Zhao
    • Riguang Liu
    • Chuan Ye
  • View Affiliations

  • Published online on: May 16, 2018     https://doi.org/10.3892/ijmm.2018.3682
  • Pages: 883-896
  • Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The present study aimed to investigate the effect of the expression of interleukin (IL)‑18 and related markers on deep venous thrombosis (DVT) to examine their correlation. Sprague‑Dawley rats of different models were established and were randomly assigned into three groups. The expression of IL‑18, nuclear factor (NF)‑κB and von Willebrand factor (vWF) were detected in blood samples. The inferior vena cava (IVC) was ligated to establish the DVT model. Rat IL‑18 overexpression and inhibition vectors were constructed. The expression levels of IL‑18 and related markers in the venous wall were compared between the model group and the control group using reverse transcription‑quantitative polymerase chain reaction and western blot analyses. Following the culture of human umbilical vein endothelial cells (HUVECs), IL‑18 was added to the cells, following which the growth of the HUVECs, and changes in vWF and other endothelial functional markers were analyzed. The IVC model demonstrated complete thrombosis at 8 h and stable thrombosis at 24 h. At 24 h following model establishment, the expression levels of IL‑18, NF‑κB and vWF were high in the blood samples with the occurrence and development of thrombosis (P<0.05). The weight, length and weight/length ratio of thrombi in each model group showed significant differences from those in the control group (P<0.05) with the overexpression of IL‑18, and the expression levels of NF‑κB and vWF in venous tissues were altered with abnormal expression levels of IL‑18. IL‑18 damaged HUVECs and significantly increased viability in early‑stage apoptosis, promoted the upregulation of vWF and P‑selectin, and reduced tissue plasminogen activator. IL‑18 and the related markers were closely associated with the occurrence and development of DVT.
View Figures
View References

Related Articles

Journal Cover

August-2018
Volume 42 Issue 2

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

The Cancer Story
Copy and paste a formatted citation
x
Spandidos Publications style
Li G, Zhou R, Zhao X, Liu R and Ye C: Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in /10.3892/ijmm.2018.3843. Int J Mol Med 42: 883-896, 2018
APA
Li, G., Zhou, R., Zhao, X., Liu, R., & Ye, C. (2018). Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in /10.3892/ijmm.2018.3843. International Journal of Molecular Medicine, 42, 883-896. https://doi.org/10.3892/ijmm.2018.3682
MLA
Li, G., Zhou, R., Zhao, X., Liu, R., Ye, C."Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in /10.3892/ijmm.2018.3843". International Journal of Molecular Medicine 42.2 (2018): 883-896.
Chicago
Li, G., Zhou, R., Zhao, X., Liu, R., Ye, C."Correlation between the expression of IL‑18 and deep venous thrombosis Corrigendum in /10.3892/ijmm.2018.3843". International Journal of Molecular Medicine 42, no. 2 (2018): 883-896. https://doi.org/10.3892/ijmm.2018.3682