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Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin

  • Authors:
    • Jia‑Cheng Liao
    • Zhao‑Xia Wei
    • Chang Zhao
    • Zhong‑Ping Ma
    • Dao‑Zhang Cai
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedics, Southern Medical University Affiliated People's Hospital of Longhua District Shenzhen, Shenzhen, Guangdong 518109, P.R. China, Department of Neurology, Liwan Hospital of The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510000, P.R. China, Department of Orthopedics, The Third Affiliated Hospital of Southern Medical University, Guangzhou, Guangdong 510630, P.R. China, Department of Orthopedics, The Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia 510030, P.R. China
    Copyright: © Liao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1257-1264
    |
    Published online on: May 21, 2018
       https://doi.org/10.3892/ijmm.2018.3698
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Abstract

Periprosthetic osteolysis belongs to osteolytic diseases, which often occur due to an imbalance between osteoclast and osteoblast number or activity. Fraxetin, a natural plant extract, inhibits osteoblast apoptosis and has therapeutic potential for treating osteolytic diseases. However, data pertaining to the effects of fraxetin on osteoclasts are limited. In the present study, it was demonstrated that the inhibition of osteoclastogenesis by fraxetin had an important role on the therapy of titanium particle‑induced osteolysis in vivo. In addition, fraxetin was demonstrated to suppress receptor activator of nuclear factor‑κB ligand (RANKL)‑mediated osteoclast differentiation and bone resorption in vitro in a dose‑dependent manner. Fraxetin inhibited osteoclast differentiation and function through the suppression of p38 signaling and subsequently, the suppression of osteoclast‑specific gene expression, including tartrate‑resistant acid phosphatase, nuclear factor of activated T‑cells, cytoplasmic 1, and cathepsin K. In conclusion, fraxetin administration may have potential as a treatment method for periprosthetic osteolysis and other osteolytic diseases.
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Copy and paste a formatted citation
Spandidos Publications style
Liao JC, Wei ZX, Zhao C, Ma ZP and Cai DZ: Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin. Int J Mol Med 42: 1257-1264, 2018.
APA
Liao, J., Wei, Z., Zhao, C., Ma, Z., & Cai, D. (2018). Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin. International Journal of Molecular Medicine, 42, 1257-1264. https://doi.org/10.3892/ijmm.2018.3698
MLA
Liao, J., Wei, Z., Zhao, C., Ma, Z., Cai, D."Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin". International Journal of Molecular Medicine 42.3 (2018): 1257-1264.
Chicago
Liao, J., Wei, Z., Zhao, C., Ma, Z., Cai, D."Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin". International Journal of Molecular Medicine 42, no. 3 (2018): 1257-1264. https://doi.org/10.3892/ijmm.2018.3698
Copy and paste a formatted citation
x
Spandidos Publications style
Liao JC, Wei ZX, Zhao C, Ma ZP and Cai DZ: Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin. Int J Mol Med 42: 1257-1264, 2018.
APA
Liao, J., Wei, Z., Zhao, C., Ma, Z., & Cai, D. (2018). Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin. International Journal of Molecular Medicine, 42, 1257-1264. https://doi.org/10.3892/ijmm.2018.3698
MLA
Liao, J., Wei, Z., Zhao, C., Ma, Z., Cai, D."Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin". International Journal of Molecular Medicine 42.3 (2018): 1257-1264.
Chicago
Liao, J., Wei, Z., Zhao, C., Ma, Z., Cai, D."Inhibition of osteoclastogenesis for periprosthetic osteolysis therapy through the suppression of p38 signaling by fraxetin". International Journal of Molecular Medicine 42, no. 3 (2018): 1257-1264. https://doi.org/10.3892/ijmm.2018.3698
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