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Article Open Access

Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway

Retraction in: /10.3892/ijmm.2025.5532
  • Authors:
    • Jun Fu
    • Luhua Yu
    • Jie Luo
    • Rui Huo
    • Bing Zhu
  • View Affiliations / Copyright

    Affiliations: Department of Gastrointestinal Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China, Department of Otolaryngology‑Head and Neck Surgery, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233004, P.R. China
    Copyright: © Fu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1473-1483
    |
    Published online on: May 23, 2018
       https://doi.org/10.3892/ijmm.2018.3704
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Abstract

The purpose of the present study was to analyze the association between paeonol and the known genes related to gastric cancer (GC) using bioinformatics methods, and to investigate the role of paeonol in the potential impact on the nuclear factor‑κB (NF‑κB) signaling pathway, in order to provide a theoretical basis for further elucidating the effect of paeonol on cancer cells. Cell viability, morphology and apoptosis were detected using an MTT assay, an inverted microscope, and flow cytometry, respectively. The correlation between drugs and genes was analyzed using the Search Tool for Interactions of Chemicals (STITCH) gene‑drug interaction network. The expression levels of related mRNA and proteins were determined using reverse transcription‑quantitative polymerase chain reaction analysis and enzyme‑linked immunosorbent assay. The changes in protein expression were examined using western blot analysis. The correlation network between target genes directly affected by paeonol and known GC genes was determined by analyzing the association between the compounds and genes recorded in the STITCH database. The GC‑related epidermal growth factor receptor 2 (ERBB2) gene was at the core position of the paeonol interaction network and may be an important potential target gene for the effect of paeonol on cancer cells. The effect of paeonol on the viability of the SGC‑7901 GC cell line was detected using an MTT assay, which showed that the inhibitory effect occurred in a time‑ and dose‑dependent manner. The observations of cell morphology demonstrated that the cells were floating, abnormal in shape, had unclear boundaries and were sparse in arrangement following paeonol treatment. Flow cytometry indicated that paeonol significantly accelerated the apoptotic rate of the SGC‑7901 GC cells. The examination of clinical samples suggested that ERBB2 was expressed at a high level in GC samples, and was significantly downregulated following the addition of paeonol. The western blot analysis revealed that downregulating ERBB2 affected the activation of the NF‑κB signaling pathway, thereby upregulating the pro‑apoptotic factor B‑cell lymphoma‑associated X protein. Taken together, paeonol significantly downregulated ERBB2 and inhibited the activation of the NF‑κB signaling pathway, thereby inhibiting the proliferation of SGC‑7901 cells and inducing apoptosis.
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View References

1 

Global Burden of Disease Cancer Collaboration; Fitzmaurice C, Dicker D, Pain A, Hamavid H, Moradi-Lakeh M, MacIntyre MF, Allen C, Hansen G, Woodbrook R, et al: The global burden of cancer 2013. JAMA Oncol. 1:505–527. 2015. View Article : Google Scholar : PubMed/NCBI

2 

Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T and Thun MJ: Cancer statistics, 2008. CA Cancer J Clin. 58:71–96. 2008. View Article : Google Scholar : PubMed/NCBI

3 

Khushalani N: Cancer of the esophagus and stomach. Mayo Clin Proc. 83:712–722. 2008. View Article : Google Scholar : PubMed/NCBI

4 

Zhang XY and Zhang PY: Gastric cancer: Somatic genetics as a guide to therapy. J Med Genet. 54:305–312. 2017. View Article : Google Scholar

5 

Toiyama Y, Tanaka K, Kitajima T, Shimura T, Imaoka H, Mori K, Okigami M, Yasuda H, Okugawa Y, Saigusa S, et al: Serum angiopoietin-like protein 2 as a potential biomarker for diagnosis, early recurrence and prognosis in gastric cancer patients. Carcinogenesis. 36:1474–1483. 2015.PubMed/NCBI

6 

Guo Y, Shi J, Zhang J, Li H, Liu B and Guo H: Polypeptide N-acetylgalactosaminyltransferase-6 expression in gastric cancer. Onco Targets Ther. 10:3337–3344. 2017. View Article : Google Scholar :

7 

Lee JC, Lee SY, Kim CY and Yang DH: Clinical utility of tumor marker cutoff ratio and a combination scoring system of preoperative carcinoembryonic antigen, carbohydrate antigen 19-9, carbohydrate antigen 72-4 levels in gastric cancer. J Korean Surg Soc. 85:283–289. 2013. View Article : Google Scholar : PubMed/NCBI

8 

Tocchi A, Costa G, Lepre L, Liotta G, Mazzoni G, Cianetti A and Vannini P: The role of serum and gastric juice levels of carcinoembryonic antigen, CA19.9 and CA72.4 in patients with gastric cancer. J Cancer Res Clin Oncol. 124:450–455. 1998. View Article : Google Scholar : PubMed/NCBI

9 

Zheng TH, Zhao JL and Guleng B: Advances in molecular biomarkers for gastric cancer. Crit Rev Eukaryot Gene Exp. 25:299–305. 2015. View Article : Google Scholar

10 

Weaver BA: How Taxol/paclitaxel kills cancer cells. Mol Biol Cell. 25:2677–2681. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Suzuki S, Sakurai K, Adachi K, Nagashima S, Hara Y, Amano S, Enomoto K and Makishima M: Examination of the response rate of paclitaxel and bevacizumab therapy for metastatic advanced breast cancer according to the lymphopenia grade. Gan To Kagaku Ryoho. 42:1249–1251. 2015.In Japanese. PubMed/NCBI

12 

Li H, Dai M and Jia W: Paeonol attenuates high-fat-diet-induced atherosclerosis in rabbits by anti-inflammatory activity. Planta Med. 75:7–11. 2009. View Article : Google Scholar

13 

Chunhu Z, Suiyu H, Meiqun C, Guilin X and Yunhui L: Antiproliferative and apoptotic effects of paeonol on human hepatocellular carcinoma cells. Anticancer Drugs. 19:401–409. 2008. View Article : Google Scholar : PubMed/NCBI

14 

Zhang LH, Xiao PG and Huang Y: Recent progresses in pharmacological and clinical studies of paeonol. Zhongguo Zhong XI Yi Jie He Za Zhi. 16:187–190. 1996.In Chinese. PubMed/NCBI

15 

Sun GP, Wan X, Xu SP, Wang H, Liu SH and Wang ZG: Antiproliferation and apoptosis induction of paeonol in human esophageal cancer cell lines. Dis Esophagus. 21:723–729. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Sun GP, Wang H, Xu SP, Shen YX, Wu Q, Chen ZD and Wei W: Anti-tumor effects of paeonol in a HepA-hepatoma bearing mouse model via induction of tumor cell apoptosis and stimulation of IL-2 and TNF-alpha production. Eur J Pharmacol. 584:246–252. 2008. View Article : Google Scholar : PubMed/NCBI

17 

Wan XA, Sun GP, Wang H, Xu SP, Wang ZG and Liu SH: Synergistic effect of paeonol and cisplatin on oesophageal cancer cell lines. Dig Liver Dis. 40:531–539. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Xu SP, Sun GP, Shen YX, Peng WR, Wang H and Wei W: Synergistic effect of combining paeonol and cisplatin on apoptotic induction of human hepatoma cell lines. Acta Pharmacol Sin. 28:869–878. 2007. View Article : Google Scholar : PubMed/NCBI

19 

Wang F, Sun JY, Zhu YH, Liu NT, Wu YF and Yu F: MicroRNA-181 inhibits glioma cell proliferation by targeting cyclin B1. Mol Med Rep. 10:2160–2164. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Li N, Fan LL, Sun GP, Wan XA, Wang ZG, Wu Q and Wang H: Paeonol inhibits tumor growth in gastric cancer in vitro and in vivo. World J Gastroenterol. 16:4483–4490. 2010. View Article : Google Scholar : PubMed/NCBI

21 

Sarada SK, Himadri P, Ruma D, Sharma SK, Pauline T and Mrinalini: Selenium protects the hypoxia induced apoptosis in neuroblastoma cells through upregulation of Bcl-2. Brain Res. 1209:29–39. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Laenen G, Thorrez L, Bornigen D and Moreau Y: Finding the targets of a drug by integration of gene expression data with a protein interaction network. Mol Biosyst. 9:1676–1685. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Ma W, Yang D, Gu Y, Guo X, Zhao W and Guo Z: Finding disease-specific coordinated functions by multi-function genes: Insight into the coordination mechanisms in diseases. Genomics. 94:94–100. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Ewald JA and Jarrard DF: Decreased Skp2 expression is necessary but not sufficient for therapy-induced senescence in prostate cancer. Transl Oncol. 5:278–287. 2012. View Article : Google Scholar : PubMed/NCBI

25 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

26 

Vadlamudi R, Mandal M, Adam L, Steinbach G, Mendelsohn J and Kumar R: Regulation of cyclooxygenase-2 pathway by HER2 receptor. Oncogene. 18:305–314. 1999. View Article : Google Scholar : PubMed/NCBI

27 

Elder DJ, Halton DE, Crew TE and Paraskeva C: Apoptosis induction and cyclooxygenase-2 regulation in human colorectal adenoma and carcinoma cell lines by the cyclooxygenase-2-selective non-steroidal anti-inflammatory drug NS-398. Int J Cancer. 86:553–560. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Li M, Tan SY and Wang XF: Paeonol exerts an anticancer effect on human colorectal cancer cells through inhibition of PGE2 synthesis and COX-2 expression. Oncol Rep. 32:2845–2853. 2014. View Article : Google Scholar : PubMed/NCBI

29 

Chen N, Liu D, Soromou LW, Sun J, Zhong W, Guo W, Huo M, Li H, Guan S, Chen Z and Feng H: Paeonol suppresses lipopoly-saccharide-induced inflammatory cytokines in macrophage cells and protects mice from lethal endotoxin shock. Fundam Clin Pharmacol. 28:268–276. 2014. View Article : Google Scholar

30 

Fu PK, Wu CL, Tsai TH and Hsieh CL: Anti-inflammatory and anticoagulative effects of paeonol on LPS-induced acute lung injury in rats. Evid Based Complement Alternat Med. 2012:8375132012. View Article : Google Scholar : PubMed/NCBI

31 

Li X, Zhou Y, Yu C, Yang H, Zhang C, Ye Y and Xiao S: Paeonol suppresses lipid accumulation in macrophages via upregulation of the ATP-binding cassette transporter A1 and downregulation of the cluster of differentiation 36. Int J Oncol. 46:764–774. 2015. View Article : Google Scholar

32 

Demaria S, Pikarsky E, Karin M, Coussens LM, Chen YC, El-Omar EM, Trinchieri G, Dubinett SM, Mao JT, Szabo E, et al: Cancer and inflammation: Promise for biological therapy. J Immunother. 33:335–351. 2010. View Article : Google Scholar : PubMed/NCBI

33 

Yang H, Bocchetta M, Kroczynska B, Elmishad AG, Chen Y, Liu Z, Bubici C, Mossman BT, Pass HI, Testa JR, et al: TNF-alpha inhibits asbestos-induced cytotoxicity via a NF-kappaB-dependent pathway, a possible mechanism for asbestos-induced oncogenesis. Proc Natl Acad Sci USA. 103:10397–10402. 2006. View Article : Google Scholar : PubMed/NCBI

34 

Kumar A and Yu FS: Toll-like receptors and corneal innate immunity. Curr Mol Med. 6:327–337. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Fan Y, Mao R and Yang J: NF-kappaB and STAT3 signaling pathways collaboratively link inflammation to cancer. Protein Cell. 4:176–185. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Gray GK, McFarland BC, Nozell SE and Benveniste EN: NF-κB and STAT3 in glioblastoma: Therapeutic targets coming of age. Expert Rev Neurother. 14:1293–1306. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Wang SW and Sun YM: The IL-6/JAK/STAT3 pathway: Potential therapeutic strategies in treating colorectal cancer (Review). Int J Oncol. 44:1032–1040. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Sethi G, Sung B and Aggarwal BB: Nuclear factor-kappaB activation: From bench to bedside. Exp Biol Med (Maywood). 233:21–31. 2008. View Article : Google Scholar

39 

Shishodia S and Aggarwal BB: Nuclear factor-kappaB activation: A question of life or death. J Biochem Mol Biol. 35:28–40. 2002.

40 

Galang CK, García-Ramírez J, Solski PA, Westwick JK, Der CJ, Neznanov NN, Oshima RG and Hauser CA: Oncogenic Neu/ErbB-2 increases ets, AP-1, and NF-kappaB-dependent gene expression, and inhibiting ets activation blocks Neu-mediated cellular transformation. J Biol Chem. 271:7992–7998. 1996. View Article : Google Scholar : PubMed/NCBI

41 

Cao N, Li S, Wang Z, Ahmed KM, Degnan ME, Fan M, Dynlacht JR and Li JJ: NF-kappaB-mediated HER2 overexpression in radiation-adaptive resistance. Radiat Res. 171:9–21. 2009. View Article : Google Scholar : PubMed/NCBI

42 

Guo G, Wang T, Gao Q, Tamae D, Wong P, Chen T, Chen WC, Shively JE, Wong JY and Li JJ: Expression of ErbB2 enhances radiation-induced NF-kappaB activation. Oncogene. 23:535–545. 2004. View Article : Google Scholar : PubMed/NCBI

43 

Pianetti S, Arsura M, Romieu-Mourez R, Coffey RJ and Sonenshein GE: Her-2/neu overexpression induces NF-kappaB via a PI3-kinase/Akt pathway involving calpain-mediated degradation of IkappaB-alpha that can be inhibited by the tumor suppressor. PTEN Oncogene. 20:1287–1299. 2001. View Article : Google Scholar

44 

Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY and Hung MC: HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem. 275:8027–8031. 2000. View Article : Google Scholar : PubMed/NCBI

45 

Diehl N and Schaal H: Make yourself at home: Viral hijacking of the PI3K/Akt signaling pathway. Viruses. 5:3192–3212. 2013. View Article : Google Scholar : PubMed/NCBI

46 

Tian J, Zhang X, Wu H, Liu C, Li Z, Hu X, Su S, Wang LF and Qu L: Blocking the PI3K/AKT pathway enhances mammalian reovirus replication by repressing IFN-stimulated genes. Front Microbiol. 6:8862015. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Fu J, Yu L, Luo J, Huo R and Zhu B: Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532. Int J Mol Med 42: 1473-1483, 2018.
APA
Fu, J., Yu, L., Luo, J., Huo, R., & Zhu, B. (2018). Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532. International Journal of Molecular Medicine, 42, 1473-1483. https://doi.org/10.3892/ijmm.2018.3704
MLA
Fu, J., Yu, L., Luo, J., Huo, R., Zhu, B."Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532". International Journal of Molecular Medicine 42.3 (2018): 1473-1483.
Chicago
Fu, J., Yu, L., Luo, J., Huo, R., Zhu, B."Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532". International Journal of Molecular Medicine 42, no. 3 (2018): 1473-1483. https://doi.org/10.3892/ijmm.2018.3704
Copy and paste a formatted citation
x
Spandidos Publications style
Fu J, Yu L, Luo J, Huo R and Zhu B: Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532. Int J Mol Med 42: 1473-1483, 2018.
APA
Fu, J., Yu, L., Luo, J., Huo, R., & Zhu, B. (2018). Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532. International Journal of Molecular Medicine, 42, 1473-1483. https://doi.org/10.3892/ijmm.2018.3704
MLA
Fu, J., Yu, L., Luo, J., Huo, R., Zhu, B."Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532". International Journal of Molecular Medicine 42.3 (2018): 1473-1483.
Chicago
Fu, J., Yu, L., Luo, J., Huo, R., Zhu, B."Paeonol induces the apoptosis of the SGC‑7901 gastric cancer cell line by downregulating ERBB2 and inhibiting the NF‑κB signaling pathway Retraction in /10.3892/ijmm.2025.5532". International Journal of Molecular Medicine 42, no. 3 (2018): 1473-1483. https://doi.org/10.3892/ijmm.2018.3704
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