Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
September-2018 Volume 42 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
September-2018 Volume 42 Issue 3

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart

  • Authors:
    • Fei Liu
    • Yuan Wen
    • Jinyuan Kang
    • Chunying Wei
    • Menghong Wang
    • Zeqi Zheng
    • Jingtian Peng
  • View Affiliations / Copyright

    Affiliations: Department of Obstetrics and Gynecology, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Cardiovascular Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Cardiovascular Medicine, The Third Hospital of Nanchang, Nanchang, Jiangxi 330009, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1436-1444
    |
    Published online on: May 25, 2018
       https://doi.org/10.3892/ijmm.2018.3707
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

The mechanism underlying the anti‑inflammatory or antifibrotic activity of erythropoietin (EPO) in myocardial fibrosis (MF) remains elusive. In the current study, abdominal aortic constriction (AAC) was performed on rats and EPO and/or Toll‑like receptor (TLR)4 were overexpressed in rat hearts through intramyocardial administration of lentivirus expressing the EPO and TLR4 genes. Hematoxylin and eosin staining and Masson's trichrome staining were performed on tissue sections from rat hearts for histopathological examination. ELISA was used to determine the levels of inflammatory mediators in serum. Gene expression levels were determined by quantitative polymerase chain reaction analysis and protein expression levels were determined by western blot analysis and immunofluorescence staining. The results indicated that EPO overexpression improved MF in rat hearts, by inhibiting the release of transforming growth factor (TGF)‑β1, tumor necrosis factor (TNF)‑α, interleukin (IL)‑6, IL‑1β, IL‑17A, matrix metalloproteinase (MMP)‑9 and MMP‑2. Moreover, EPO overexpression suppressed the expression of TLR4, while promoting phosphoinositide 3‑kinase (PI3K) and phosphorylated AKT serine/threonine kinase 1 (Akt) expression levels. However, the beneficial effects of EPO were attenuated by overexpression of TLR4. In addition, inhibition of PI3K/Akt signaling activity by treatment with LY294002 markedly reversed the protective effect of EPO on the AAC‑induced MF. Taken together, the present study demonstrated that EPO may have a critical role against MF by activating PI3K/Akt signaling and by downregulating TLR4 expression, thereby inhibiting the release of TGF‑β1, TNF‑α, IL‑6, IL‑1β, IL‑17A, MMP‑9 and MMP‑2. These findings suggest that the PI3K/Akt/TLR4 signaling pathway is associated with the anti‑inflammatory effects of EPO and may play a role in attenuating AAC‑induced MF.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

View References

1 

Travers JG, Kamal FA, Robbins J, Yutzey KE and Blaxall BC: Cardiac fibrosis: The fibroblast awakens. Circ Res. 118:1021–1040. 2016. View Article : Google Scholar : PubMed/NCBI

2 

Moore-Morris T, Guimarães-Camboa N, Yutzey KE, Pucéat M and Evans SM: Cardiac fibroblasts: From development to heart failure. J Mol Med (Berl). 93:823–830. 2015. View Article : Google Scholar

3 

Lombardero M, Kovacs K and Scheithauer BW: Erythropoietin: A hormone with multiple functions. Pathobiology. 78:41–53. 2011. View Article : Google Scholar : PubMed/NCBI

4 

Ma BX, Li J, Li H and Wu SS: Recombinant human erythropoietin protects myocardial cells from apoptosis via the janus-activated kinase 2/signal transducer and activator of transcription 5 pathway in rats with epilepsy. Curr Ther Res Clin Exp. 77:90–98. 2015. View Article : Google Scholar : PubMed/NCBI

5 

Elshiekh M, Kadkhodaee M, Seifi B, Ranjbaran M and Ahghari P: Ameliorative effect of recombinant human erythropoietin and ischemic preconditioning on renal ischemia reperfusion injury in rats. Nephrourol Mon. 7:e311522015. View Article : Google Scholar

6 

Noguchi T, Ohta S, Kakinoki R, Ikeguchi R, Kaizawa Y, Oda H and Matsuda S: The neuroprotective effect of erythropoietin on spinal motor neurons after nerve root avulsion injury in rats. Restor Neurol Neurosci. 33:461–470. 2015.PubMed/NCBI

7 

Nakamura S, Sho M, Koyama F, Ueda T, Nishigori N, Inoue T, Nakamoto T, Fujii H, Yoshikawa S, Inatsugi N and Nakajima Y: Erythropoietin attenuates intestinal inflammation and promotes tissue regeneration. Scand J Gastroenterol. 50:1094–1102. 2015. View Article : Google Scholar : PubMed/NCBI

8 

Geng XC, Hu ZP and Lian GY: Erythropoietin ameliorates renal interstitial fibrosis via the inhibition of fibrocyte accumulation. Mol Med Rep. 11:3860–3865. 2015. View Article : Google Scholar : PubMed/NCBI

9 

Park SY, Lee JY, Tak WY, Kweon YO and Lee MS: Erythropoietin decreases carbon tetrachloride-induced hepatic fibrosis by inhibiting transforming growth factor-beta. Chin Med J (Engl). 125:3098–3103. 2012.

10 

Zhang XJ, Ma YX, Wen Y and Xu XJ: Erythropoietin suppresses the expressions of TGF-beta1 and collagen in rat cardiac fibroblasts induced by angiotensin II. Zhonghua Xin Xue Guan Bing Za Zhi. 36:636–640. 2008.In Chinese. PubMed/NCBI

11 

Wang LP, Yang XH, Wang XJ, Li SM, Sun N and Zhang T: Erythropoietin decreases the occurrence of myocardial fibrosis by inhibiting the NADPH-ERK-NF-x03BA;B pathway. Cardiology. 133:97–108. 2016. View Article : Google Scholar

12 

Tada H, Kagaya Y, Takeda M, Ohta J, Asaumi Y, Satoh K, Ito K, Karibe A, Shirato K, Minegishi N and Shimokawa H: Endogenous erythropoietin system in non-hematopoietic lineage cells plays a protective role in myocardial ischemia/reperfusion. Cardiovasc Res. 71:466–477. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Jun JH, Jun NH, Shim JK, Shin EJ and Kwak YL: Erythropoietin protects myocardium against ischemia-reperfusion injury under moderate hyperglycemia. Eur J Pharmacol. 745:1–9. 2014. View Article : Google Scholar : PubMed/NCBI

14 

Lu J, Yao YY, Dai QM, Ma GS, Zhang SF, Cao L, Ren LQ and Liu NF: Erythropoietin attenuates cardiac dysfunction by increasing myocardial angiogenesis and inhibiting interstitial fibrosis in diabetic rats. Cardiovasc Diabetol. 11:1052012. View Article : Google Scholar : PubMed/NCBI

15 

Liu S, Zhao C, Yang C, Li X, Huang H, Liu N, Li S, Wang X and Liu J: Gambogic acid suppresses pressure overload cardiac hypertrophy in rats. Am J Cardiovasc Dis. 3:227–238. 2013.PubMed/NCBI

16 

Merkulov S, Chen X, Chandler MP and Stelzer JE: In vivo cardiac myosin binding protein C gene transfer rescues myofilament contractile dysfunction in cardiac myosin binding protein C null mice. Circ Heart Fail. 5:635–644. 2012. View Article : Google Scholar : PubMed/NCBI

17 

Wei XL, Fang RT, Yang YH, Bi XY, Ren GX, Luo AL, Zhao M and Zang WJ: Protective effects of extracts from Pomegranate peels and seeds on liver fibrosisinduced by carbon tetrachloride in rats. BMC Complement Altern Med. 15:3892015. View Article : Google Scholar

18 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-delta delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

19 

Chen CJ, He H, Luo Y, Zhou M, Yin D and He M: Involvement of Bcl-2 Signal pathway in the protective effects of apigenin on anoxia/reoxygenation-induced myocardium injury. J Cardiovasc Pharmacol. 67:152–163. 2016. View Article : Google Scholar

20 

Steward R, McNally FJ and Schedl P: Isolation of the dorsal locus of Drosophila. Nature. 311:262–265. 1984. View Article : Google Scholar : PubMed/NCBI

21 

Medzhitov R, Preston-Hurlburt P and Janeway CA Jr: A human homologue of the Drosophila Toll protein signals activation of adaptive immunity. Nature. 388:394–397. 1997. View Article : Google Scholar : PubMed/NCBI

22 

Yang Y, Lv J, Jiang S, Ma Z, Wang D, Hu W, Deng C, Fan C, Di S, Sun Y and Yi W: The emerging role of Toll-like receptor 4 in myocardial inflammation. Cell Death Dis. 7:e22342016. View Article : Google Scholar : PubMed/NCBI

23 

Zhao HW, Zhang ZF, Chai X, Li GQ, Cui HR, Wang HB, Meng YK, Liu HM, Wang JB, Li RS, et al: Oxymatrine attenuates CCl4-induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. Int Immunopharmacol. 36:249–255. 2016. View Article : Google Scholar : PubMed/NCBI

24 

Zhang Y, Peng W, Ao X, Dai H, Yuan L, Huang X and Zhou Q: TAK-242, a Toll-like receptor 4 antagonist, protects against aldosterone-induced cardiac and renal injury. PLoS One. 10:e01424562015. View Article : Google Scholar : PubMed/NCBI

25 

Ma ZJ, Zhang XN, Li L, Yang W, Wang SS, Guo X, Sun P and Chen LM: Tripterygium glycosides tablet ameliorates renal tubulointerstitial fibrosis via the Toll-like receptor 4/nuclear factor kappa B signaling pathway in high-fat diet fed and streptozotocin-induced diabetic rats. J Diabetes Res. 2015:3904282015. View Article : Google Scholar : PubMed/NCBI

26 

Yang HZ, Wang JP, Mi S, Liu HZ, Cui B, Yan HM, Yan J, Li Z, Liu H, Hua F, et al: TLR4 activity is required in the resolution of pulmonary inflammation and fibrosis after acute and chronic lung injury. Am J Pathol. 180:275–292. 2012. View Article : Google Scholar

27 

Qi W, Shen Q, Zhang L, Han LP and Wang S: Study on the inflammatory intervention of erythropoietin on NEC. Exp Ther Med. 11:2221–2224. 2016. View Article : Google Scholar : PubMed/NCBI

28 

Glezeva N and Baugh JA: Role of inflammation in the pathogenesis of heart failure with preserved ejection fraction and its potential as a therapeutic target. Heart Fail Rev. 19:681–694. 2014. View Article : Google Scholar

29 

Zhang W, Lavine KJ, Epelman S, Evans SA, Weinheimer CJ, Barger PM and Mann DL: Necrotic myocardial cells release damage-associated molecular patterns that provoke fibroblast activation in vitro and trigger myocardial inflammation and fibrosis in vivo. J Am Heart Assoc. 4:e0019932015. View Article : Google Scholar : PubMed/NCBI

30 

Stifano G, Affandi AJ, Mathes AL, Rice LM, Nakerakanti S, Nazari B, Lee J, Christmann RB and Lafyatis R: Chronic Toll-like receptor 4 stimulation in skin induces inflammation, macrophage activation, transforming growth factor beta signature gene expression, and fibrosis. Arthritis Res Ther. 16:R1362014. View Article : Google Scholar : PubMed/NCBI

31 

Zhang Y, Wang JH, Zhang YY, Wang YZ, Wang J, Zhao Y, Jin XX, Xue GL, Li PH, Sun YL, et al: Deletion of interleukin-6 alleviated interstitial fibrosis in streptozotocin-induced diabetic cardiomyopathy of mice through affecting TGFβ1 and miR-29 pathways. Sci Rep. 6:230102016. View Article : Google Scholar

32 

Zhou SF, Yuan J, Liao MY, Xia N, Tang TT, Li JJ, Jiao J, Dong WY, Nie SF, Zhu ZF, et al: IL-17A promotes ventricular remodeling after myocardial infarction. J Mol Med (Berl). 92:1105–1116. 2014. View Article : Google Scholar

33 

Pulskens WP, Rampanelli E, Teske GJ, Butter LM, Claessen N, Luirink IK, van der Poll T, Florquin S and Leemans JC: TLR4 promotes fibrosis but attenuates tubular damage in progressive renal injury. J Am Soc Nephrol. 21:1299–1308. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Turhan AH, Atici A, Muşlu N, Polat A and Sungur MA: Erythropoietin may attenuate lung inflammation in a rat model of meconium aspiration syndrome. Exp Lung Res. 42:199–204. 2016. View Article : Google Scholar : PubMed/NCBI

35 

Sifringer M, Genz K, Brait D, Brehmer F, Löber R, Weichelt U, Kaindl AM, Gerstner B and Felderhoff-Mueser U: Erythropoietin attenuates hyperoxia-induced cell death by modulation of inflammatory mediators and matrix metalloproteinases. Dev Neurosci. 31:394–402. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Pang L, Zhang N, Dong N, Wang DW, Xu DH, Zhang P and Meng XW: Erythropoietin protects rat brain injury from carbon monoxide poisoning by inhibiting Toll-like receptor 4/NF-kappa B-dependent inflammatory responses. Inflammation. 39:561–568. 2016. View Article : Google Scholar

37 

Santhanam AV, d'Uscio LV and Katusic ZS: Cardiovascular effects of erythropoietin an update. Adv Pharmacol. 60:257–285. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Rong R and Xijun X: Erythropoietin pretreatment suppresses inflammation by activating the PI3K/Akt signaling pathway in myocardial ischemia-reperfusion injury. Exp Ther Med. 10:413–418. 2015. View Article : Google Scholar : PubMed/NCBI

39 

Dong H, Zhang X, Dai X, Lu S, Gui B, Jin W, Zhang S, Zhang S and Qian Y: Lithium ameliorates lipopolysaccharide-induced microglial activation via inhibition of Toll-like receptor 4 expression by activating the PI3K/Akt/FoxO1 pathway. J Neuroinflammation. 14:140–144. 2014. View Article : Google Scholar

40 

Wang J, Bai X, Song Q, Fan F, Hu Z, Cheng G and Zhang Y: mir-223 inhibits lipid deposition and inflammation by suppressing Toll-like receptor 4 signaling in macrophages. Int J Mol Sci. 16:24965–24982. 2015. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z and Peng J: Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart. Int J Mol Med 42: 1436-1444, 2018.
APA
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., & Peng, J. (2018). Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart. International Journal of Molecular Medicine, 42, 1436-1444. https://doi.org/10.3892/ijmm.2018.3707
MLA
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., Peng, J."Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart". International Journal of Molecular Medicine 42.3 (2018): 1436-1444.
Chicago
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., Peng, J."Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart". International Journal of Molecular Medicine 42, no. 3 (2018): 1436-1444. https://doi.org/10.3892/ijmm.2018.3707
Copy and paste a formatted citation
x
Spandidos Publications style
Liu F, Wen Y, Kang J, Wei C, Wang M, Zheng Z and Peng J: Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart. Int J Mol Med 42: 1436-1444, 2018.
APA
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., & Peng, J. (2018). Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart. International Journal of Molecular Medicine, 42, 1436-1444. https://doi.org/10.3892/ijmm.2018.3707
MLA
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., Peng, J."Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart". International Journal of Molecular Medicine 42.3 (2018): 1436-1444.
Chicago
Liu, F., Wen, Y., Kang, J., Wei, C., Wang, M., Zheng, Z., Peng, J."Regulation of TLR4 expression mediates the attenuating effect of erythropoietin on inflammation and myocardial fibrosis in rat heart". International Journal of Molecular Medicine 42, no. 3 (2018): 1436-1444. https://doi.org/10.3892/ijmm.2018.3707
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team