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International Journal of Molecular Medicine
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Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma

  • Authors:
    • Yuxi Chen
    • Qinghe Chen
    • Jilong Zou
    • Yan Zhang
    • Zhenggang Bi
  • View Affiliations / Copyright

    Affiliations: Department of Orthopedic Surgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang 150001, P.R. China, Department of Orthopedics, The PLA 211 Hospital, Harbin, Heilongjiang 150080, P.R. China
    Copyright: © Chen et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1237-1246
    |
    Published online on: May 29, 2018
       https://doi.org/10.3892/ijmm.2018.3709
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Abstract

Osteosarcoma is an aggressive cancer of the skeletal system, which is associated with a poor prognosis due to the high recurrence rate. Although previous studies have revealed that competitive endogenous RNAs (ceRNAs) are involved in various biological processes in the physiology and development of osteosarcoma, the roles of ceRNAs in osteosarcoma recurrence remain largely unexplored. The present study constructed a ceRNA‑ceRNA network for osteosarcoma by systematically integrating matched expression profiles for microRNAs (miRNAs/miRs) and mRNAs, and identified two ceRNA‑mediated modules that were associated with recurrence in patients with osteosarcoma. A multivariate Cox regression analysis demonstrated that the recurrence‑free prognosis associated with the expression of the two modules was independent of other clinical factors. In addition, hsa‑miR‑335‑3p was identified as an upstream regulating factor for both modules. In conclusion, the results of the present study suggested that ceRNAs may act as potential therapeutic biomarkers for predicting the recurrence of osteosarcoma, and may help to identify patients with osteosarcoma at a high risk of recurrence, who may benefit from adjuvant therapy.
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Copy and paste a formatted citation
Spandidos Publications style
Chen Y, Chen Q, Zou J, Zhang Y and Bi Z: Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma. Int J Mol Med 42: 1237-1246, 2018.
APA
Chen, Y., Chen, Q., Zou, J., Zhang, Y., & Bi, Z. (2018). Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma. International Journal of Molecular Medicine, 42, 1237-1246. https://doi.org/10.3892/ijmm.2018.3709
MLA
Chen, Y., Chen, Q., Zou, J., Zhang, Y., Bi, Z."Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma". International Journal of Molecular Medicine 42.3 (2018): 1237-1246.
Chicago
Chen, Y., Chen, Q., Zou, J., Zhang, Y., Bi, Z."Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma". International Journal of Molecular Medicine 42, no. 3 (2018): 1237-1246. https://doi.org/10.3892/ijmm.2018.3709
Copy and paste a formatted citation
x
Spandidos Publications style
Chen Y, Chen Q, Zou J, Zhang Y and Bi Z: Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma. Int J Mol Med 42: 1237-1246, 2018.
APA
Chen, Y., Chen, Q., Zou, J., Zhang, Y., & Bi, Z. (2018). Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma. International Journal of Molecular Medicine, 42, 1237-1246. https://doi.org/10.3892/ijmm.2018.3709
MLA
Chen, Y., Chen, Q., Zou, J., Zhang, Y., Bi, Z."Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma". International Journal of Molecular Medicine 42.3 (2018): 1237-1246.
Chicago
Chen, Y., Chen, Q., Zou, J., Zhang, Y., Bi, Z."Construction and analysis of a ceRNA‑ceRNA network reveals two potential prognostic modules regulated by hsa‑miR‑335‑5p in osteosarcoma". International Journal of Molecular Medicine 42, no. 3 (2018): 1237-1246. https://doi.org/10.3892/ijmm.2018.3709
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