|
1
|
Ma J, Zhang Q, Chen S, Fang B, Yang Q,
Chen C, Miele L, Sarkar FH, Xia J and Wang Z: Mitochondrial
dysfunction promotes breast cancer cell migration and invasion
through HIF1α accumulation via increased production of reactive
oxygen species. PLoS One. 8:e694852013. View Article : Google Scholar
|
|
2
|
Thiery JP: Epithelial-mesenchymal
transitions in tumour progression. Nat Rev Cancer. 2:442–454. 2002.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Tsai JH and Yang J: Epithelial-mesenchymal
plasticity in carcinoma metastasis. Genes Dev. 27:2192–2206. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Thiery JP, Acloque H, Huang RY and Nieto
MA: Epithelial-mesenchymal transitions in development and disease.
Cell. 139:871–890. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Ji Q, Liu X, Han Z, Zhou L, Sui H, Yan L,
Jiang H, Ren J, Cai J and Li Q: Resveratrol suppresses
epithelial-to-mesenchymal transition in colorectal cancer through
TGF-β1/Smads signaling pathway mediated Snail/E-cadherin
expression. BMC Cancer. 15:972015. View Article : Google Scholar
|
|
6
|
Hou P, Zhao Y, Li Z, Yao R, Ma M, Gao Y,
Zhao L, Zhang Y, Huang B and Lu J: LincRNA-ROR induces
epithelial-to-mesenchymal transition and contributes to breast
cancer tumorigenesis and metastasis. Cell Death Dis. 5:e12872014.
View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Saxena M, Stephens MA, Pathak H and
Rangarajan A: Transcription factors that mediate
epithelial-mesenchymal transition lead to multidrug resistance by
upregulating ABC transporters. Cell Death Dis. 2:e1792011.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Dumitriu IE, Dunbar DR, Howie SE, Sethi T
and Gregory CD: Human dendritic cells produce TGF-beta 1 under the
influence of lung carcinoma cells and prime the differentiation of
CD4+CD25+Foxp3+ regulatory T
cells. J Immunol. 182:2795–2807. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Godlewski J, Nowicki MO, Bronisz A, Nuovo
G, Palatini J, De Lay M, Van Brocklyn J, Ostrowski MC, Chiocca EA
and Lawler SE: MicroRNA-451 regulates LKB1/AMPK signaling and
allows adaptation to metabolic stress in glioma cells. Mol Cell.
37:620–632. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Godlewski J, Newton HB, Chiocca EA and
Lawler SE: MicroRNAs and glioblastoma; the stem cell connection.
Cell Death Differ. 17:221–228. 2010. View Article : Google Scholar
|
|
11
|
Kowaltowski AJ, de Souza-Pinto NC,
Castilho RF and Vercesi AE: Mitochondria and reactive oxygen
species. Free Radic Biol Med. 47:333–343. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
12
|
Brandon M, Baldi P and Wallace DC:
Mitochondrial mutations in cancer. Oncogene. 25:4647–4662. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Zamzami N, Susin SA, Marchetti P, Hirsch
T, Gómez-Monterrey I, Castedo M and Kroemer G: Mitochondrial
control of nuclear apoptosis. J Exp Med. 183:1533–1544. 1996.
View Article : Google Scholar : PubMed/NCBI
|
|
14
|
Hung WY, Huang KH, Wu CW, Chi CW, Kao HL,
Li AF, Yin PH and Lee HC: Mitochondrial dysfunction promotes cell
migration via reactive oxygen species-enhanced β5-integrin
expression in human gastric cancer SC-M1 cells. Biochim Biophys
Acta. 1820:1102–1110. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Chang CJ, Yin PH, Yang DM, Wang CH, Hung
WY, Chi CW, Wei YH and Lee HC: Mitochondrial dysfunction-induced
amphiregulin upregulation mediates chemo-resistance and cell
migration in HepG2 cells. Cell Mol Life Sci. 66:1755–1765. 2009.
View Article : Google Scholar : PubMed/NCBI
|
|
16
|
Jeong JH, Kang SS, Park KK, Chang HW,
Magae J and Chang YC: p53-independent induction of G1 arrest and
p21WAF1/CIP1 expression by ascofuranone, an isoprenoid antibiotic,
through downregulation of c-Myc. Mol Cancer Ther. 9:2102–2113.
2010. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Lin CW, Hou WC, Shen SC, Juan SH, Ko CH,
Wang LM and Chen YC: Quercetin inhibition of tumor invasion via
suppressing PKC delta/ERK/AP-1-dependent matrix metalloproteinase-9
activation in breast carcinoma cells. Carcinogenesis. 29:1807–1815.
2008. View Article : Google Scholar : PubMed/NCBI
|
|
18
|
Yi BR, Kim TH, Kim YS and Choi KC:
Alteration of epithelial-mesenchymal transition markers in human
normal ovaries and neoplastic ovarian cancers. Int J Oncol.
46:272–280. 2015. View Article : Google Scholar
|
|
19
|
Cano A, Perez-Moreno MA, Rodrigo I,
Locascio A, Blanco MJ, del Barrio MG, Portillo F and Nieto MA: The
transcription factor snail controls epithelial-mesenchymal
transitions by repressing E-cadherin expression. Nat Cell Biol.
2:76–83. 2000. View
Article : Google Scholar : PubMed/NCBI
|
|
20
|
Blanco MJ, Barrallo-Gimeno A, Acloque H,
Reyes AE, Tada M, Allende ML, Mayor R and Nieto MA: Snail1a and
Snail1b cooperate in the anterior migration of the axial
mesendoderm in the zebrafish embryo. Development. 134:4073–4081.
2007. View Article : Google Scholar : PubMed/NCBI
|
|
21
|
Hu Y, He K, Wang D, Yuan X, Liu Y, Ji H
and Song J: TMEPAI regulates EMT in lung cancer cells by modulating
the ROS and IRS-1 signaling pathways. Carcinogenesis. 34:1764–1772.
2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Lu X and Kang Y: Hypoxia and
hypoxia-inducible factors: Master regulators of metastasis. Clin
Cancer Res. 16:5928–5935. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Giannoni E, Parri M and Chiarugi P: EMT
and oxidative stress: A bidirectional interplay affecting tumor
malignancy. Antioxid Redox Signal. 16:1248–1263. 2012. View Article : Google Scholar
|
|
24
|
Han B, Cui H, Kang L, Zhang X, Jin Z, Lu L
and Fan Z: Metformin inhibits thyroid cancer cell growth,
migration, and EMT through the mTOR pathway. Tumour Biol.
36:6295–6304. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Gilmore TD: Introduction to NF-kappaB:
Players, pathways, perspectives. Oncogene. 25:6680–6684. 2006.
View Article : Google Scholar : PubMed/NCBI
|
|
26
|
Liu XL, Zhang XT, Meng J, Zhang HF, Zhao
Y, Li C, Sun Y, Mei QB, Zhang F and Zhang T: ING5 knockdown
enhances migration and invasion of lung cancer cells by inducing
EMT via EGFR/PI3K/Akt and IL-6/STAT3 signaling pathways.
Oncotarget. 8:54265–54276. 2017.PubMed/NCBI
|
|
27
|
Upadhyay M, Samal J, Kandpal M, Singh OV
and Vivekanandan P: The Warburg effect: Insights from the past
decade. Pharmacol Ther. 137:318–330. 2013. View Article : Google Scholar
|
|
28
|
Guo Q: Changes in mitochondrial function
during EMT induced by TGFβ-1 in pancreatic cancer. Oncol Lett.
13:1575–1580. 2017. View Article : Google Scholar : PubMed/NCBI
|
|
29
|
Favre C, Zhdanov A, Leahy M, Papkovsky D
and O'Connor R: Mitochondrial pyrimidine nucleotide carrier (PNC1)
regulates mitochondrial biogenesis and the invasive phenotype of
cancer cells. Oncogene. 29:3964–3976. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
30
|
Sequeira A, Martin MV, Rollins B, Moon EA,
Bunney WE, Macciardi F, Lupoli S, Smith EN, Kelsoe J, Magnan CN, et
al: Mitochondrial mutations and polymorphisms in psychiatric
disorders. Front Genet. 3:1032012. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Kwong JQ, Henning MS, Starkov AA and
Manfredi G: The mitochondrial respiratory chain is a modulator of
apoptosis. J Cell Biol. 179:1163–1177. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
32
|
Nunes JB, Peixoto J, Soares P, Maximo V,
Carvalho S, Pinho SS, Vieira AF, Paredes J, Rego AC, Ferreira IL,
et al: OXPHOS dysfunction regulates integrin-β1 modifications and
enhances cell motility and migration. Hum Mol Genet. 24:1977–1990.
2015. View Article : Google Scholar
|
|
33
|
Yi EY, Park SY, Jung SY, Jang WJ and Kim
YJ: Mitochondrial dysfunction induces EMT through the
TGF-β/Smad/Snail signaling pathway in Hep3B hepatocellular
carcinoma cells. Int J Oncol. 47:1845–1853. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Pirozzi G, Tirino V, Camerlingo R, Franco
R, La Rocca A, Liguori E, Martucci N, Paino F, Normanno N and Rocco
G: Epithelial to mesenchymal transition by TGFβ-1 induction
increases stemness characteristics in primary non small cell lung
cancer cell line. PLoS One. 6:e215482011. View Article : Google Scholar
|
|
35
|
Bao B, Wang Z, Ali S, Ahmad A, Azmi AS,
Sarkar SH, Banerjee S, Kong D, Li Y, Thakur S and Sarkar FH:
Metformin inhibits cell proliferation, migration and invasion by
attenuating CSC function mediated by deregulating miRNAs in
pancreatic cancer cells. Cancer Prev Res (Phila). 5:355–364. 2012.
View Article : Google Scholar
|
|
36
|
He X, Zhou A, Lu H, Chen Y, Huang G, Yue
X, Zhao P and Wu Y: Suppression of mitochondrial complex I
influences cell metastatic properties. PLoS One. 8:e616772013.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Imanishi H, Hattori K, Wada R, Ishikawa K,
Fukuda S, Takenaga K, Nakada K and Hayashi J: Mitochondrial DNA
mutations regulate metastasis of human breast cancer cells. PLoS
One. 6:e234012011. View Article : Google Scholar : PubMed/NCBI
|
|
38
|
Perez-Moreno M, Jamora C and Fuchs E:
Sticky business: Orchestrating cellular signals at adherens
junctions. Cell. 112:535–548. 2003. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Son H and Moon A: Epithelial-mesenchymal
transition and cell invasion. Toxicol Res. 26:245–252. 2010.
View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Xu M, Li J, Wang X, Meng S, Shen J, Wang
S, Xu X, Xie B, Liu B and Xie L: MiR-22 suppresses
epithelial-mesenchymal transition in bladder cancer by inhibiting
Snail and MAPK1/Slug/vimentin feedback loop. Cell Death Dis.
9:2092018. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Marshall S: Role of insulin, adipocyte
hormones, and nutrient-sensing pathways in regulating fuel
metabolism and energy homeostasis: A nutritional perspective of
diabetes, obesity, and cancer. Sci STKE. 2006:re72006. View Article : Google Scholar : PubMed/NCBI
|
|
42
|
He K, Guo X, Liu Y, Li J, Hu Y, Wang D and
Song J: TUFM downregulation induces epithelial-mesenchymal
transition and invasion in lung cancer cells via a mechanism
involving AMPK-GSK3β signaling. Cell Mol Life Sci. 73:2105–2121.
2016. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Manning BD and Cantley LC: AKT/PKB
signaling: Navigating downstream. Cell. 129:1261–1274. 2007.
View Article : Google Scholar : PubMed/NCBI
|
|
44
|
Li CH, Cheng YW, Liao PL, Yang YT and Kang
JJ: Chloramphenicol causes mitochondrial stress, decreases ATP
biosynthesis, induces matrix metalloproteinase-13 expression, and
solid-tumor cell invasion. Toxicol Sci. 116:140–150. 2010.
View Article : Google Scholar : PubMed/NCBI
|
