Open Access

A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes

  • Authors:
    • Xiaoyan Zhao
    • Yuan Li
    • Haibing Wu
  • View Affiliations

  • Published online on: June 21, 2018     https://doi.org/10.3892/ijmm.2018.3739
  • Pages: 1495-1507
  • Copyright: © Zhao et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

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Abstract

Acute myeloid leukemia (AML) is the most common type of acute leukemia and is a heterogeneous clonal disorder. At present, the pathogenesis of AML and potential methods to effectively prevent AML have become areas of interest in research. In the present study, two messenger ribonucleic acid sequencing datasets of patients with AML were downloaded from the Cancer Genome Atlas and Gene Expression Omnibus databases. The differentially expressed genes (DEGs) of the poor and good prognosis groups were screened using the Linear Models for Microarray Data package, and the prognosis‑related genes were screened using univariate Cox regression analysis. A total of 206 significant DEGs were identified. Following univariate and multivariate Cox regression analysis, 14 genes significantly associated with prognosis were screened and six of these genes, including triggering receptor expressed on myeloid cells 2 (TREML2), cysteine‑glutamate transporter (SLC7A11), NACHT, LRR, and PYD domains‑containing protein 2 (NLRP2), DNA damage‑inducible transcript 4 protein (DDIT4), lymphocyte‑specific protein 1 (LSP1) and C‑type lectin domain family 11 member A (CLEC11A), were used to construct model equations for risk assessment. The prognostic scoring system was used to evaluate risk for each patient, and the results showed that patients in the low‑risk group had a longer survival time, compared with those in the high‑risk group (P=9.59e‑06 for the training dataset and P=0.00543 for the validation dataset). A total of eight main Kyoto Encyclopedia of Genes and Genomes pathways were identified, the top three of which were hematopoietic cell lineage, focal adhesion, and regulation of actin cytoskeleton. Taken together, the results showed that the scoring system established in the present study was credible and that the six genes were identified, which were significantly associated with the risk assessment of AML, offer potential as prognostic biomarkers. These findings may provide clues for further clarifying the pathogenesis of AML.
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September-2018
Volume 42 Issue 3

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Spandidos Publications style
Zhao X, Li Y and Wu H: A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes. Int J Mol Med 42: 1495-1507, 2018
APA
Zhao, X., Li, Y., & Wu, H. (2018). A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes. International Journal of Molecular Medicine, 42, 1495-1507. https://doi.org/10.3892/ijmm.2018.3739
MLA
Zhao, X., Li, Y., Wu, H."A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes". International Journal of Molecular Medicine 42.3 (2018): 1495-1507.
Chicago
Zhao, X., Li, Y., Wu, H."A novel scoring system for acute myeloid leukemia risk assessment based on the expression levels of six genes". International Journal of Molecular Medicine 42, no. 3 (2018): 1495-1507. https://doi.org/10.3892/ijmm.2018.3739