|
1
|
Siegel RL, Miller KD and Jemal A: Cancer
statistics, 2015. CA Cancer J Clin. 65:5–29. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
2
|
Mao L, Hong WK and Papadimitrakopoulou VA:
Focus on head and neck cancer. Cancer Cell. 5:311–316. 2004.
View Article : Google Scholar : PubMed/NCBI
|
|
3
|
Tsuji T, Ibaragi S and Hu GF:
Epithelial-mesenchymal transition and cell cooperativity in
metastasis. Cancer Res. 69:7135–7139. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
4
|
Polyak K and Weinberg RA: Transitions
between epithelial and mesenchymal states: acquisition of malignant
and stem cell traits. Nat Rev Cancer. 9:265–273. 2009. View Article : Google Scholar : PubMed/NCBI
|
|
5
|
Zha L, Zhang J, Tang W, Zhang N, He M, Guo
Y and Wang Z: HMGA2 elicits EMT by activating the Wnt/β-catenin
pathway in gastric cancer. Dig Dis Sci. 58:724–733. 2013.
View Article : Google Scholar
|
|
6
|
Wu Y, Ginther C, Kim J, Mosher N, Chung S,
Slamon D and Vadgama JV: Expression of Wnt3 activates Wnt/β-catenin
pathway and promotes EMT-like phenotype in trastuzumab-resistant
HER2-overexpressing breast cancer cells. Mol Cancer Res.
10:1597–1606. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
7
|
Lin LC, Hsu SL, Wu CL and Hsueh CM: TGFβ
can stimulate the p(38)/β-catenin/PPARγ signaling pathway to
promote the EMT, invasion and migration of non-small cell lung
cancer (H460 cells). Clin Exp Metastasis. 31:881–895. 2014.
View Article : Google Scholar : PubMed/NCBI
|
|
8
|
Kamachi Y, Uchikawa M and Kondoh H:
Pairing SOX off: with partners in the regulation of embryonic
development. Trends Genet. 16:182–187. 2000. View Article : Google Scholar : PubMed/NCBI
|
|
9
|
Chen Y, Shi L, Zhang L, Li R, Liang J, Yu
W, Sun L, Yang X, Wang Y, Zhang Y, et al: The molecular mechanism
governing the oncogenic potential of SOX2 in breast cancer. J Biol
Chem. 283:17969–17978. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
10
|
Kregel S, Kiriluk KJ, Rosen AM, Cai Y,
Reyes EE, Otto KB, Tom W, Paner GP, Szmulewitz RZ and Vander Griend
DJ: Sox2 is an androgen receptor-repressed gene that promotes
castration-resistant prostate cancer. PLoS One. 8:e537012013.
View Article : Google Scholar : PubMed/NCBI
|
|
11
|
Gangemi RM, Griffero F, Marubbi D, Perera
M, Capra MC, Malatesta P, Ravetti GL, Zona GL, Daga A and Corte G:
SOX2 silencing in glioblastoma tumor-initiating cells causes stop
of proliferation and loss of tumorigenicity. Stem Cells. 27:40–48.
2009. View Article : Google Scholar
|
|
12
|
Li X, Xu Y, Chen Y, Chen S, Jia X, Sun T,
Liu Y, Li X, Xiang R and Li N: SOX2 promotes tumor metastasis by
stimulating epithelial-to-mesenchymal transition via regulation of
WNT/β-catenin signal network. Cancer Lett. 336:379–389. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
13
|
Kokalj Vokač N, Cizmarević B, Zagorac A,
Zagradišnik B and Lanišnik B: An evaluation of SOX2 and hTERC gene
amplifications as screening markers in oral and oropharyngeal
squamous cell carcinomas. Mol Cytogenet. 7:52014. View Article : Google Scholar
|
|
14
|
Michifuri Y, Hirohashi Y, Torigoe T,
Miyazaki A, Kobayashi J, Sasaki T, Fujino J, Asanuma H, Tamura Y,
Nakamori K, et al: High expression of ALDH1 and SOX2 diffuse
staining pattern of oral squamous cell carcinomas correlates to
lymph node metastasis. Pathol Int. 62:684–689. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
15
|
Sobin LH and Wittekind C: TNM
classification of malignant tumours. 6th edition. New York:
Wiley-Liss; 2002
|
|
16
|
Qiao B, Gopalan V, Chen Z, Smith RA, Tao Q
and Lam AK: Epithelial-mesenchymal transition and
mesenchymal-epithelial transition are essential for the acquisition
of stem cell properties in hTERT-immortalised oral epithelial
cells. Biol Cell. 104:476–489. 2012. View Article : Google Scholar : PubMed/NCBI
|
|
17
|
Vermeire J, Naessens E, Vanderstraeten H,
Landi A, Iannucci V, Van Nuffel A, Taghon T, Pizzato M and
Verhasselt B: Quantification of reverse transcriptase activity by
real-time PCR as a fast and accurate method for titration of HIV,
lentiand retroviral vectors. PLoS One. 7:e508592012. View Article : Google Scholar
|
|
18
|
Chi AC, Day TA and Neville BW: Oral cavity
and oropharyngeal squamous cell carcinoma an update. CA Cancer J
Clin. 65:401–421. 2015. View Article : Google Scholar : PubMed/NCBI
|
|
19
|
Heerboth S, Housman G, Leary M, Longacre
M, Byler S, Lapinska K, Willbanks A and Sarkar S: EMT and tumor
metastasis. Clin Transl Med. 4:62015. View Article : Google Scholar : PubMed/NCBI
|
|
20
|
Wang J, Zhu X, Hu J, He G, Li X, Wu P, Ren
X, Wang F, Liao W, Liang L, et al: The positive feedback between
Snail and DAB2IP regulates EMT, invasion and metastasis in
colorectal cancer. Oncotarget. 6:27427–27439. 2015.PubMed/NCBI
|
|
21
|
Demirkan B: The roles of
epithelial-to-mesenchymal transition (EMT) and
mesenchymal-to-epithelial transition (MET) in breast cancer bone
metastasis: potential targets for prevention and treatment. J Clin
Med. 2:264–282. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
22
|
Mulholland DJ, Kobayashi N, Ruscetti M,
Zhi A, Tran LM, Huang J, Gleave M and Wu H: Pte loss and RAS/MAPK
activation cooperate to promote EMT and metastasis initiated from
prostate cancer stem/progenitor cells. Cancer Res. 72:1878–1889.
2012. View Article : Google Scholar : PubMed/NCBI
|
|
23
|
Belotte J, Fletcher NM, Alexis M, Morris
RT, Munkarah AR, Diamond MP and Saed GM: Sox2 gene amplification
significantly impacts overall survival in serous epithelial ovarian
cancer. Reprod Sci. 22:38–46. 2015. View Article : Google Scholar :
|
|
24
|
Neumann J, Bahr F, Horst D, Kriegl L,
Engel J, Luque RM, Gerhard M, Kirchner T and Jung A: SOX2
expression correlates with lymph-node metastases and distant spread
in right-sided colon cancer. BMC Cancer. 11:5182011. View Article : Google Scholar : PubMed/NCBI
|
|
25
|
Yang F, Gao Y, Geng J, Qu D, Han Q, Qi J
and Chen G: Elevated expression of SOX2 and FGFR1 in correlation
with poor prognosis in patients with small cell lung cancer. Int J
Clin Exp Pathol. 6:2846–2854. 2013.PubMed/NCBI
|
|
26
|
Qiao B, He B, Cai J and Yang W: The
expression profile of Oct4 and Sox2 in the carcinogenesis of oral
mucosa. Int J Clin Exp Pathol. 7:28–37. 2013.
|
|
27
|
Nakayama S, Sasaki A, Mese H, Alcalde RE
and Matsumura T: Establishment of high and low metastasis cell
lines derived from a human tongue squamous cell carcinoma. Invasion
Metastasis. 18:219–228. 1999. View Article : Google Scholar
|
|
28
|
Kalluri R and Weinberg RA: The basics of
epithelial-mesenchymal transition. J Clin Invest. 119:1420–1428.
2009. View
Article : Google Scholar : PubMed/NCBI
|
|
29
|
Wang H, Zhang H, Tang L, Chen H, Wu C,
Zhao M, Yang Y, Chen X and Liu G: Resveratrol inhibits
TGF-β1-induced epithelial-to-mesenchymal transition and suppresses
lung cancer invasion and metastasis. Toxicology. 303:139–146. 2013.
View Article : Google Scholar
|
|
30
|
Micalizzi DS, Farabaugh SM and Ford HL:
Epithelial-mesenchymal transition in cancer: parallels between
normal development and tumor progression. J Mammary Gland Biol
Neoplasia. 15:117–134. 2010. View Article : Google Scholar : PubMed/NCBI
|
|
31
|
Han G, Lu SL, Li AG, He W, Corless CL,
Kulesz-Martin M and Wang XJ: Distinct mechanisms of
TGF-beta1-mediated epithelial-to-mesenchymal transition and
metastasis during skin carcinogenesis. J Clin Invest.
115:1714–1723. 2005. View
Article : Google Scholar : PubMed/NCBI
|
|
32
|
Graham TR, Zhau HE, Odero-Marah VA,
Osunkoya AO, Kimbro KS, Tighiouart M, Liu T, Simons JW and O'Regan
RM: Insulin-like growth factor-I-dependent up-regulation of ZEB1
drives epithelial-to-mesenchymal transition in human prostate
cancer cells. Cancer Res. 68:2479–2488. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
33
|
Lee MY, Chou CY, Tang MJ and Shen MR:
Epithelial-mesenchymal transition in cervical cancer: correlation
with tumor progression, epidermal growth factor receptor
overexpression, and snail up-regulation. Clin Cancer Res.
14:4743–4750. 2008. View Article : Google Scholar : PubMed/NCBI
|
|
34
|
Vesuna F, van Diest P, Chen JH and Raman
V: Twist is a transcriptional repressor of E-cadherin gene
expression in breast cancer. Biochem Biophys Res Commun.
367:235–241. 2008. View Article : Google Scholar
|
|
35
|
Aigner K, Dampier B, Descovich L, Mikula
M, Sultan A, Schreiber M, Mikulits W, Brabletz T, Strand D, Obrist
P, et al: The transcription factor ZEB1 (deltaEF1) promotes tumour
cell dedifferentiation by repressing master regulators of
epithelial polarity. Oncogene. 26:6979–6988. 2007. View Article : Google Scholar : PubMed/NCBI
|
|
36
|
Spaderna S, Schmalhofer O, Wahlbuhl M,
Dimmler A, Bauer K, Sultan A, Hlubek F, Jung A, Strand D, Eger A,
et al: The transcriptional repressor ZEB1 promotes metastasis and
loss of cell polarity in cancer. Cancer Res. 68:537–544. 2008.
View Article : Google Scholar : PubMed/NCBI
|
|
37
|
Ye X, Wu F, Wu C, Wang P, Jung K, Gopal K,
Ma Y, Li L and Lai R: β-catenin, a Sox2 binding partner, regulates
the DNA binding and transcriptional activity of Sox2 in breast
cancer cells. Cell Signal. 26:492–501. 2014. View Article : Google Scholar
|
|
38
|
Gen Y, Yasui K, Nishikawa T and Yoshikawa
T: SOX2 promotes tumor growth of esophageal squamous cell carcinoma
through the AKT/mammalian target of rapamycin complex 1 signaling
pathway. Cancer Sci. 104:810–816. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
39
|
Bora-Singhal N, Perumal D, Nguyen J and
Chellappan S: Gli1-mediated regulation of Sox2 facilitates
self-renewal of stem-like cells and confers resistance to EGFR
inhibitors in non-small cell lung cancer. Neoplasia. 17:538–551.
2015. View Article : Google Scholar : PubMed/NCBI
|
|
40
|
Singh S, Trevino J, Bora-Singhal N,
Coppola D, Haura E, Altiok S and Chellappan SP: EGFR/Src/Akt
signaling modulates Sox2 expression and self-renewal of stem-like
side-population cells in non-small cell lung cancer. Mol Cancer.
11:732012. View Article : Google Scholar : PubMed/NCBI
|
|
41
|
Corominas-Faja B, Cufí S,
Oliveras-Ferraros C, Cuyàs E, López-Bonet E, Lupu R, Alarcón T,
Vellon L, Iglesias JM, Leis O, et al: Nuclear reprogramming of
luminal-like breast cancer cells generates Sox2-overexpressing
cancer stem-like cellular states harboring transcriptional
activation of the mTOR pathway. Cell Cycle. 12:3109–3124. 2013.
View Article : Google Scholar : PubMed/NCBI
|
|
42
|
Bass AJ and Wang TC: An inflammatory
situation: SOX2 and STAT3 cooperate in squamous cell carcinoma
initiation. Cell Stem Cell. 12:266–268. 2013. View Article : Google Scholar : PubMed/NCBI
|
|
43
|
Yang N, Hui L, Wang Y, Yang H and Jiang X:
Overexpression of SOX2 promotes migration, invasion, and
epithelial-mesenchymal transition through the Wnt/β-catenin pathway
in laryngeal cancer Hep-2 cells. Tumour Biol. 35:7965–7973. 2014.
View Article : Google Scholar : PubMed/NCBI
|
