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International Journal of Molecular Medicine
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Article

GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice

  • Authors:
    • Min Li
    • Kui Song
    • Xiaowen Huang
    • Simao Fu
    • Qiyi Zeng
  • View Affiliations / Copyright

    Affiliations: Department of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China, Department of Hematology, The First Affiliated Hospital of Jishou University, Jishou, Hunan 416000, P.R. China, Department of Pediatrics, Boai Hospital of Zhongshan City, Zhongshan, Guangdong 528400, P.R. China, Department of Pediatrics, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China
  • Pages: 1756-1764
    |
    Published online on: June 27, 2018
       https://doi.org/10.3892/ijmm.2018.3747
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Abstract

Growth differentiation factor‑15 (GDF‑15) is a transforming growth factor (TGF)‑β superfamily member with a poorly characterized biological activity, speculated to be implicated in several diseases. The present study aimed to determine whether GDF‑15 participates in sepsis‑induced acute liver injury in mice. Lipopolysaccharide (LPS) and D‑galactosamine (D‑GalN) were administered to mice to induce acute liver injury. Survival of mice, histological changes in liver tissue, and levels of inflammatory biomarkers in serum and liver tissue were evaluated following treatment with GDF‑15. The underlying mechanism was investigated by western blotting, ELISA, flow cytometry, and reverse transcription‑quantitative polymerase chain reaction using Kupffer cells. The results demonstrated that GDF‑15 prevented LPS/D‑GalN‑induced death, increase in inflammatory cell infiltration and serum alanine aminotransferase and aspartate aminotransferase activities. In addition, GDF‑15 treatment reduced the production of hepatic malondialdehyde and myeloperoxidase, and attenuated the increase of interleukin (IL)‑6, tumor necrosis factor (TNF)‑α, and IL‑1β expression in serum and liver tissue, accompanied by inducible nitric oxide synthase (iNOS) inactivation in the liver. Similar changes in the expression of inflammatory cytokines, IL‑6, TNF‑α and IL‑1β, and iNOS activation were observed in the Kupffer cells. Further mechanistic experiments revealed that GDF‑15 effectively protected against LPS‑induced nuclear factor (NF)‑κB pathway activation by regulating TGFβ‑activated kinase 1 (TAK1) phosphorylation in Kupffer cells. In conclusion, GDF‑15 reduced the activation of pro‑inflammatory factors, and prevented LPS‑induced liver injury, most likely by disrupting TAK1 phosphorylation, and consequently inhibiting the activation of the NF‑κB pathway in the liver.
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View References

1 

Angus DC and van der Poll T: Severe sepsis and septic shock. N Engl J Med. 369:840–851. 2013. View Article : Google Scholar : PubMed/NCBI

2 

Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, et al: The third international consensus definitions for sepsis and septic shock (Sepsis-3). JAMA. 315:801–810. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Cao Z and Robinson RA: The role of proteomics in understanding biological mechanisms of sepsis. Proteomics Clin Appl. 8:35–52. 2014. View Article : Google Scholar

4 

Hamers L, Kox M and Pickkers P: Sepsis-induced immunoparalysis: Mechanisms, markers, and treatment options. Minerva Anestesiol. 81:426–439. 2015.

5 

Chun K, Syndergaard C, Damas C, Trubey R, Mukindaraj A, Qian S, Jin X, Breslow S and Niemz A: Sepsis pathogen identification. J Lab Autom. 20:539–561. 2015. View Article : Google Scholar : PubMed/NCBI

6 

Tacke F and Zimmermann HW: Macrophage heterogeneity in liver injury and fibrosis. J Hepatol. 60:1090–1096. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ge X, Feng Z, Xu T, Wu B, Chen H, Xu F, Fu L, Shan X, Dai Y, Zhang Y and Liang G: A novel imidazopyridine derivative, X22, attenuates sepsis-induced lung and liver injury by inhibiting the inflammatory response in vitro and in vivo. Drug Des Devel Ther. 10:1947–1959. 2016. View Article : Google Scholar : PubMed/NCBI

8 

Huang C, Wang J, Chen Z, Wang Y and Zhang W: 2-Phenylethynesulfonamide prevents induction of pro-inflammatory factors and attenuates LPS-induced liver injury by targeting NHE1-Hsp70 complex in mice. PLoS One. 8:e675822013. View Article : Google Scholar : PubMed/NCBI

9 

Scott MJ, Liu S, Shapiro RA, Vodovotz Y and Billiar TR: Endotoxin uptake in mouse liver is blocked by endotoxin pretreatment through a suppressor of cytokine signaling-1-dependent mechanism. Hepatology. 49:1695–1708. 2009. View Article : Google Scholar : PubMed/NCBI

10 

Wang JB, Wang HT, Li LP, Yan YC, Wang W, Liu JY, Zhao YT, Gao WS and Zhang MX: Development of a rat model of D-galactosamine/lipopolysaccharide induced hepatorenal syndrome. World J Gastroenterol. 21:9927–9935. 2015. View Article : Google Scholar : PubMed/NCBI

11 

Unsicker K, Spittau B and Krieglstein K: The multiple facets of the TGF-β family cytokine growth/differentiation factor-15/macrophage inhibitory cytokine-1. Cytokine Growth Factor Rev. 24:373–384. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Hijazi Z, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW, Ezekowitz MD, Reilly PA, Yusuf S, Siegbahn A and Wallentin L: Growth-differentiation factor 15 and risk of major bleeding in atrial fibrillation: Insights from the randomized evaluation of long-term anticoagulation therapy (RE-LY) trial. Am Heart J. 190:94–103. 2017. View Article : Google Scholar : PubMed/NCBI

13 

Cotter G, Voors AA, Prescott MF, Felker GM, Filippatos G, Greenberg BH, Pang PS, Ponikowski P, Milo O, Hua TA, et al: Growth differentiation factor 15 (GDF-15) in patients admitted for acute heart failure: Results from the RELAX-AHF study. Eur J Heart Fail. 17:1133–1143. 2015. View Article : Google Scholar : PubMed/NCBI

14 

Abulizi P, Loganathan N, Zhao D, Mele T, Zhang Y, Zwiep T, Liu K and Zheng X: Growth differentiation factor-15 deficiency augments inflammatory response and exacerbates septic heart and renal injury induced by lipopolysaccharide. Sci Rep. 7:10372017. View Article : Google Scholar : PubMed/NCBI

15 

Yan D, Liu HL, Yu ZJ, Huang YH, Gao D, Hao H, Liao SS, Xu FY and Zhou XY: BML-111 protected LPS/D-GalN-induced acute liver injury in rats. Int J Mol Sci. 17:pii: E1114. 2016. View Article : Google Scholar

16 

Dai L, Cui X, Zhang X, Cheng L, Liu Y, Yang Y, Fan P, Wang Q, Lin Y, Zhang J, et al: SARI inhibits angiogenesis and tumour growth of human colon cancer through directly targeting cerulo-plasmin. Nat Commun. 7:119962016. View Article : Google Scholar

17 

t'Hart BA, Vervoordeldonk M, Heeney JL and Tak PP: Gene therapy in nonhuman primate models of human autoimmune disease. Gene Ther. 10:890–901. 2003. View Article : Google Scholar : PubMed/NCBI

18 

Mikic AN, Brkic S, Maric D, Sekulic B, Cetkovic A and Mitic G: Thiobarbituric acid reactive substances as marker of oxidative stress in pregnancies with pre-eclampsia. Med Pregl. 64:377–380. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Liu MW, Liu R, Wu HY, Zhang W, Xia J, Dong MN, Yu W, Wang Q, Xie FM, Wang R, et al: Protective effect of Xuebijing injection on D-galactosamine- and lipopolysaccharide-induced acute liver injury in rats through the regulation of p38 MAPK, MMP-9 and HO-1 expression by increasing TIPE2 expression. Int J Mol Med. 38:1419–1432. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Kim JM, Kosak JP, Kim JK, Kissling G, Germolec DR, Zeldin DC, Bradbury JA, Baek SJ and Eling TE: NAG-1/GDF15 transgenic mouse has less white adipose tissue and a reduced inflammatory response. Mediators Inflamm. 2013:6418512013. View Article : Google Scholar : PubMed/NCBI

21 

Schneider CA, Rasband WS and Eliceiri KW: NIH Image to ImageJ: 25 years of image analysis. Nat Methods. 9:671–675. 2012. View Article : Google Scholar : PubMed/NCBI

22 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2−ΔΔCT method. Methods. 25:402–408. 2001. View Article : Google Scholar

23 

Ratnam NM, Peterson JM, Talbert EE, Ladner KJ, Rajasekera PV, Schmidt CR, Dillhoff ME, Swanson BJ, Haverick E, Kladney RD, et al: NF-kappaB regulates GDF-15 to suppress macrophage surveillance during early tumor development. J Clin Invest. 127:3796–3809. 2017. View Article : Google Scholar : PubMed/NCBI

24 

Bootcov MR, Bauskin AR, Valenzuela SM, Moore AG, Bansal M, He XY, Zhang HP, Donnellan M, Mahler S, Pryor K, et al: MIC-1, a novel macrophage inhibitory cytokine, is a divergent member of the TGF-beta superfamily. Proc Natl Acad Sci USA. 94:11514–11519. 1997. View Article : Google Scholar : PubMed/NCBI

25 

Liu DD and Mei YA: Effects of growth differentiation factor-15 (GDF-15) on neurological systems, cardiovascular diseases, and cancer progression. Sheng Li Xue Bao. 69:109–121. 2017.In Chinese. PubMed/NCBI

26 

Sandor N, Schilling-Toth B, Kis E, Benedek A, Lumniczky K, Safrany G and Hegyesi H: Growth differentiation factor-15 (GDF-15) is a potential marker of radiation response and radiation sensitivity. Mutat Res Genet Toxicol Environ Mutagen. 793:142–149. 2015. View Article : Google Scholar : PubMed/NCBI

27 

Unal B, Alan S, Bassorgun CI, Karakas AA, Elpek GO and Ciftcioglu MA: The divergent roles of growth differentiation factor-15 (GDF-15) in benign and malignant skin pathologies. Arch Dermatol Res. 307:551–557. 2015. View Article : Google Scholar : PubMed/NCBI

28 

Zhou YM, Li MJ, Zhou YL, Ma LL and Yi X: Growth differentiation factor-15 (GDF-15), novel biomarker for assessing atrial fibrosis in patients with atrial fibrillation and rheumatic heart disease. Int J Clin Exp Med. 8:21201–21207. 2015.

29 

Kahli A, Guenancia C, Zeller M, Grosjean S, Stamboul K, Rochette L, Girard C and Vergely C: Growth differentiation factor-15 (GDF-15) levels are associated with cardiac and renal injury in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass. PLoS One. 9:e1057592014. View Article : Google Scholar : PubMed/NCBI

30 

Lee ES, Kim SH, Kim HJ, Kim KH, Lee BS and Ku BJ: Growth differentiation factor 15 predicts chronic liver disease severity. Gut Liver. 11:276–282. 2017. View Article : Google Scholar :

31 

Buendgens L, Yagmur E, Bruensing J, Herbers U, Baeck C, Trautwein C, Koch A and Tacke F: Growth differentiation factor-15 is a predictor of mortality in critically Ill patients with sepsis. Dis Markers. 5271203:20172017.

32 

Hoque R, Farooq A and Mehal WZ: Sterile inflammation in the liver and pancreas. J Gastroenterol Hepatol. 28(Suppl 1): S61–S67. 2013. View Article : Google Scholar

33 

Mehal WZ: The inflammasome in liver injury and non-alcoholic fatty liver disease. Dig Dis. 32:507–515. 2014. View Article : Google Scholar : PubMed/NCBI

34 

Ambade A, Catalano D, Lim A and Mandrekar P: Inhibition of heat shock protein (molecular weight 90 kDa) attenuates proinflammatory cytokines and prevents lipopolysaccharide-induced liver injury in mice. Hepatology. 55:1585–1595. 2012. View Article : Google Scholar :

35 

Baranova IN, Souza AC, Bocharov AV, Vishnyakova TG, Hu X, Vaisman BL, Amar MJ, Chen Z, Kost Y, Remaley AT, et al: Human SR-BI and SR-BII potentiate lipopolysaccharide-induced inflammation and acute liver and kidney injury in mice. 196:3135–3147. 2016.

36 

Liao WQ, Qi YL, Wang L, Dong XM, Xu T, Ding CD, Liu R, Liang WC, Lu LT, Li H, et al: Recql5 protects against lipopolysaccharide/D-galactosamine-induced liver injury in mice. J Immunol. 21:10375–10384. 2015.

37 

Zhang J, Xu L, Zhang L, Ying Z, Su W and Wang T: Curcumin attenuates D-galactosamine/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice. J Nutr. 144:1211–1218. 2014. View Article : Google Scholar : PubMed/NCBI

38 

Yan J and Li S and Li S: The role of the liver in sepsis. Int Rev Immunol. 33:498–510. 2014. View Article : Google Scholar : PubMed/NCBI

39 

Dixon LJ, Barnes M, Tang H, Pritchard MT and Nagy LE: Kupffer cells in the liver. Compr Physiol. 3:785–797. 2013.PubMed/NCBI

40 

Tsutsui H and Nishiguchi S: Importance of Kupffer cells in the development of acute liver injuries in mice. Int J Mol Sci. 15:7711–7730. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li M, Song K, Huang X, Fu S and Zeng Q: GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice. Int J Mol Med 42: 1756-1764, 2018.
APA
Li, M., Song, K., Huang, X., Fu, S., & Zeng, Q. (2018). GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice. International Journal of Molecular Medicine, 42, 1756-1764. https://doi.org/10.3892/ijmm.2018.3747
MLA
Li, M., Song, K., Huang, X., Fu, S., Zeng, Q."GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice". International Journal of Molecular Medicine 42.3 (2018): 1756-1764.
Chicago
Li, M., Song, K., Huang, X., Fu, S., Zeng, Q."GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice". International Journal of Molecular Medicine 42, no. 3 (2018): 1756-1764. https://doi.org/10.3892/ijmm.2018.3747
Copy and paste a formatted citation
x
Spandidos Publications style
Li M, Song K, Huang X, Fu S and Zeng Q: GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice. Int J Mol Med 42: 1756-1764, 2018.
APA
Li, M., Song, K., Huang, X., Fu, S., & Zeng, Q. (2018). GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice. International Journal of Molecular Medicine, 42, 1756-1764. https://doi.org/10.3892/ijmm.2018.3747
MLA
Li, M., Song, K., Huang, X., Fu, S., Zeng, Q."GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice". International Journal of Molecular Medicine 42.3 (2018): 1756-1764.
Chicago
Li, M., Song, K., Huang, X., Fu, S., Zeng, Q."GDF‑15 prevents LPS and D‑galactosamine‑induced inflammation and acute liver injury in mice". International Journal of Molecular Medicine 42, no. 3 (2018): 1756-1764. https://doi.org/10.3892/ijmm.2018.3747
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