Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
October-2018 Volume 42 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
October-2018 Volume 42 Issue 4

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways

  • Authors:
    • Jianli Liu
    • Meijia Liu
    • Shuai Wang
    • Yin He
    • Yapeng Huo
    • Zhijun Yang
    • Xiangyu Cao
  • View Affiliations / Copyright

    Affiliations: Department of Biological Sciences, School of Life Science, Liaoning University, Shenyang, Liaoning 110036, P.R. China
    Copyright: © Liu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1847-1856
    |
    Published online on: July 4, 2018
       https://doi.org/10.3892/ijmm.2018.3751
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Human breast cancer is a malignant type of cancer with high prevalence. In the present study, the anticancer effects of alantolactone, a sesquiterpene lactone, on the human breast cancer cell line MCF‑7 were investigated in vitro. The MCF‑7 cell morphology changed from diamond to round subsequent to treatment with alantolactone, and the cell viability reduced significantly compared with that of the control cells. Alantolactone induced apoptosis of MCF‑7 cells by regulating the protein expression levels of B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein, p53, caspase‑3 and caspase‑12, which are associated with the apoptotic pathway, and suppressed colony formation and migration by regulating the protein expression of matrix metalloproteinase (MMP)‑2, MMP‑7 and MMP‑9. Cell signaling pathway analysis confirmed that alantolactone increased the phosphorylation of p38, and decreased the nuclear expression levels of p65 and nuclear factor erythroid 2‑related factor 2 (Nrf2), suggesting that the apoptosis‑promoting and migration‑suppressing effect of alantolactone may partially depend on regulating the p38 MAPK, NF‑κB and Nrf2 pathways. These results also suggested that alantolactone may become a potential therapeutic strategy for treating breast cancer.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Chung TW, Choi H, Lee JM, Ha SH, Kwak CH, Abekura F, Park JY, Chang YC, Ha KT, Cho SH, et al: Oldenlandia diffusa suppresses metastatic potential through inhibiting matrix metalloproteinase-9 and intercellular adhesion molecule-1 expression via p38 and ERK1/2 MAPK pathways and induces apoptosis in human breast cancer mcf-7 cells. J Ethnopharmacol. 195:309–317. 2017. View Article : Google Scholar

2 

Jiang X, Li T and Liu RH: 2α-Hydroxyursolic acid inhibited cell proliferation and induced apoptosis in MDA-MB-231 human breast cancer cells through the p38/MAPK signal transduction pathway. J Agric Food Chem. 64:1806–1816. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Kreike B, Kouwenhove MV, Horlings H, Weigelt B, Peterse H, Bartelink H and van de Vijver MJ: Gene expression profiling and histopathological characterization of triple-negative/basal-like breast carcinomas. Breast Cancer Research. 9:R652007. View Article : Google Scholar : PubMed/NCBI

4 

Liao YF, Rao YK and Tzeng YM: Aqueous extract of Anisomeles indica and its purified compound exerts anti-metastatic activity through inhibition of NF-κB/AP-1-dependent MMP-9 activation in human breast cancer MCF-7 cells. Food Chem Toxicol. 50:2930–2936. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Elumalai P, Gunadharini DN, Senthilkumar K, Banudevi S, Arunkumar R, Benson CS, Sharmila G and Arunakaran J: Induction of apoptosis in human breast cancer cells by nimbolide through extrinsic and intrinsic pathway. Toxicol Lett. 215:131–142. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Tan PQ, Zhong YM, Hu ZY and Lou DM: Size distributions, PAHs and inorganic ions of exhaust particles from a heavy duty diesel engine using B20 biodiesel with different exhaust aftertreatments. Energy. 141:898–906. 2017. View Article : Google Scholar

7 

Patel DK, Kumar R, Laloo D and Hemalatha S: Natural medicines from plant source used for therapy of diabetes mellitus: An overview of its pharmacological aspects. Asian Pac J Trop D. 2:239–250. 2012. View Article : Google Scholar

8 

Wu T, Geng J, Guo W, Gao J and Zhu X: Asiatic acid inhibits lung cancer cell growth in vitro and in vivo by destroying mitochondria. Acta Pharm Sin B. 7:65–72. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Luo W, Liu Y, Zhang J, Luo X, Lin C and Guo J: Andrographolide inhibits the activation of NF-κB and MMP-9 activity in H3255 lung cancer cells. Exp Ther Med. 6:743–746. 2013. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Y, Bao YL, Wu Y, Yu CL, Huang YX, Sun Y, Zheng LH and Li YX: Alantolactone induces apoptosis in RKO cells through the generation of reactive oxygen species and the mitochondrial pathway. Mol Med Rep. 8:967–972. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Huo Y, Shi HM, Li WW, Wang MY and Li XB: HPLC determination and NMR structural elucidation of sesquiterpene lactones in. Inula Helenium J Pharm Biomed Anal. 51:942–946. 2010. View Article : Google Scholar

12 

Konishi T, Shimada Y, Nagao T, Okabe H and Konoshima T: Antiproliferative sesquiterpene lactones from the roots of. Inula Helenium Biol Pharm Bull. 25:1370–1372. 2002. View Article : Google Scholar

13 

Li Y, Ni ZY, Zhu MC, Dong M, Wang SM, Shi QW, Zhang ML, Wang YF, Huo CH, Kiyota H and Cong B: Antitumour activities of sesquiterpene lactones from Inula Helenium and Inula japonica. Z Naturforsch C. 67:375–380. 2012.PubMed/NCBI

14 

Chun J and Kim YS: Alantolactone, a sesquiterpene lactone isolated from Inula Helenium L. selectively suppresses STAT3 activation and exhibits anticancer activity in MDA-MB-231 cells. Planta Med. 81:2015. View Article : Google Scholar

15 

Khan M, Li T, Ahmad Khan MK, Rasul A, Nawaz F, Sun M, Zheng Y and Ma T: Alantolactone induces apoptosis in HepG2 cells through GSH depletion, inhibition of STAT3 activation, and Mitochondrial dysfunction. Biomed Res Int. 2013:7198582013. View Article : Google Scholar : PubMed/NCBI

16 

Zhao P, Pan Z, Luo Y, Zhang L, Li X, Zhang G, Zhang Y, Cui R, Sun M and Zhang X: Alantolactone induces apoptosis and cell cycle arrest on lung squamous cancer SK-MES-1 cells. J Biochem Mol Toxicol. 29:199–206. 2015. View Article : Google Scholar : PubMed/NCBI

17 

Khan M, Yi F, Rasul A, Li T, Wang N, Gao H, Gao R and Ma T: Alantolactone induces apoptosis in glioblastoma cells via GSH depletion, ROS generation, and mitochondrial dysfunction. IUBMB Life. 64:783–794. 2012. View Article : Google Scholar : PubMed/NCBI

18 

Li Y, Liu B, Yang F, Yu Y, Zeng A, Ye T, Yin W, Xie Y, Fu Z and Zhao C: Lobaplatin induces BGC-823 human gastric carcinoma cell apoptosis via ROS-mitochondrial apoptotic pathway and impairs cell migration and invasion. Biomed Pharmacother. 83:1239–1246. 2016. View Article : Google Scholar : PubMed/NCBI

19 

Lv J, Cao MQ and Yu JC: Alantolactone pyrazoline analogue inhibits cancer cell proliferation and induces apoptosis in non-small cell lung carcinoma cells. Bangl J Pharmacol. 10:409–415. 2015. View Article : Google Scholar

20 

Del Bino G, Darzynkiewicz Z, Degraef C, Mosselmans R, Fokan D and Galand P: Comparison of methods based on annexin-V binding, DNA content or TUNEL for evaluating cell death in HL-60 and adherent MCF-7 cells. Cell Prolif. 32:25–37. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Bielawski K, Bielawska A and Wołczyήski S: Synthesis, DNA-binding activity and cytotoxicity of carbamate derivatives of Hoechst 33258 in breast cancer MCF-7 cells. Biol Pharm Bull. 25:916–919. 2002. View Article : Google Scholar : PubMed/NCBI

22 

Ning L, Ma H, Jiang Z, Chen L, Li L, Chen Q and Qi H: Curcumol suppresses breast cancer cell metastasis by inhibiting MMP-9 via JNK1/2 and Akt-dependent NF-κB signaling pathways. Integr Cancer Ther. 15:216–225. 2016. View Article : Google Scholar : PubMed/NCBI

23 

Lutterbeck CA, Kern DI, Machado ÊL and Kümmerer K: Evaluation of the toxic effects of four anticancer drugs in plant bioassays and its potency for screening in the context of waste water reuse for irrigation. Chemosphere. 135:403–410. 2015. View Article : Google Scholar : PubMed/NCBI

24 

Min HY, Park HJ, Chung HJ, Lee JW, Kim MS, Park EJ and Lee SK: Inhibitory effects of alantolactone, a naturally occurring Sesquiterpenoid, on the growth of human colon cancer cells. Cancer Res. 64:13912004.

25 

Kumari S, Badana AK, Mohan GM, Shailender Naik G and Malla R: Synergistic effects of coralyne and paclitaxel on cell migration and proliferation of breast cancer cells lines. Biomed Pharmacother. 91:436–445. 2017. View Article : Google Scholar : PubMed/NCBI

26 

Nikhil K, Sharan S, Chakraborty A, Bodipati N, Krishna Peddinti R and Roy P: Role of isothiocyanate conjugate of Pterostilbene on the inhibition of MCF-7 cell proliferation and tumor growth in Ehrlich ascitic cell induced tumor bearing mice. Exp Cell Res. 320:311–328. 2014. View Article : Google Scholar

27 

Surichan S, Arroo RR, Tsatsakis AM and Androutsopoulos VP: Tangeretin inhibits the proliferation of human breast cancer cells via cyp1a1/cyp1B1 enzyme induction and cyp1a1/cyp1B1-mediated metabolism to the product 4′ hydroxy tangeretin. Toxicol In Vitro. 50:274–284. 2018. View Article : Google Scholar : PubMed/NCBI

28 

Hamaratoglu F, Willecke M, Kango-Singh M, Nolo R, Hyun E, Tao C, Jafar-Nejad H and Halder G: The tumour-suppressor genes NF2/Merlin and Expanded act through Hippo signalling to regulate cell proliferation and apoptosis. Nat Cell Biol. 8:27–36. 2006. View Article : Google Scholar

29 

Dolka I, Król M and Sapierzynski R: Evaluation of apoptosis-associated protein (Bcl-2, Bax, cleaved caspase-3 and p53) expression in canine mammary tumors: An immunohistochemical and prognostic study. Res Vet Sci. 105:124–133. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Zhou N, Zhang Y, Zhang X, Lei Z, Hu R, Li H, Mao Y, Wang X, Irwin DM, Niu G and Tan H: Exposure of tumor-associated macrophages to apoptotic MCF-7 cells promotes breast cancer growth and metastasis. Int J Mol Sci. 16:11966–11982. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Yan W, Zhu F, Zhao Z, Chai Y, Yue W, Shao C, Lu F, Li Q and Wang C: Improved PCR-based subtractive hybridization, a new trategy on cloning differential expression genes in apoptotic MCF-7 cells. Cell Mol Immunol. 17:35–37. 2001.In Chinese.

32 

Kalid M, Jahanshiri F, Rahman A and Yusoff K: Gene expression profiling in apoptotic MCF-7 cells infected with newcastle disease virus. Global Vet. 5:334–340. 2010.

33 

Rasul A, Di J, Millimouno FM, Malhi M, Tsuji I, Ali M, Li J and Li X: Reactive oxygen species mediate isoalantolactone-induced apoptosis in human prostate cancer cells. Molecules. 18:9382–9396. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Lei JC, Yu JQ, Yin Y, Liu YW and Zou GL: Alantolactone induces activation of apoptosis in human hepatoma cells. Food Chem Toxicol. 50:3313–3319. 2012. View Article : Google Scholar : PubMed/NCBI

35 

Huang Y, Ray S, Reed JC, Ibrado AM, Tang C, Nawabi A and Bhalla K: Estrogen increases intracellular p26Bcl-2 to p21Bax ratios and inhibits taxol-induced apoptosis of human breast cancer MCF-7 cells. Breast Cancer Res Treat. 42:73–81. 1997. View Article : Google Scholar : PubMed/NCBI

36 

Yoshimoto K, Iwahana H, Fukuda A, Sano T, Saito S and Itakura M: Role of p53 mutations in endocrine tumorigenesis: Mutation detection by polymerase chain reaction-single strand conformation polymorphism. Cancer Res. 52:5061–5064. 1992.PubMed/NCBI

37 

Tang D, Lahti JM and Kidd VJ: Caspase-8 activation and bid cleavage contribute to MCF7 cellular execution in a caspase-3-dependent manner during staurosporine-mediated apoptosis. J Biol Chem. 275:9303–9307. 2000. View Article : Google Scholar : PubMed/NCBI

38 

Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, et al: Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases. Pharmacol Res. 132:47–68. 2018. View Article : Google Scholar : PubMed/NCBI

39 

Aglund K, Rauvala M, Puistola U, Angström T, Turpeenniemi-Hujanen T, Zackrisson B and Stendahl U: Gelatinases A and B (MMP-2 and MMP-9) in endometrial cancer-MMP-9 correlates to the grade and the stage. Gynecol Oncol. 94:699–704. 2004. View Article : Google Scholar : PubMed/NCBI

40 

Chun J and Kim YS: Platycodin D inhibits migration, invasion, and growth of MDA-MB-231 human breast cancer cells via suppression of EGFR-mediated Akt and MAPK pathways. Chem Biol Interact. 205:212–221. 2013. View Article : Google Scholar : PubMed/NCBI

41 

Chun J, Choi RJ, Khan S, Lee DS, Kim YC, Nam YJ, Lee DU and Kim YS: Alantolactone suppresses inducible nitric oxide synthase and cyclooxygenase-2 expression by down-regulating nf-kb, MAPK and AP-1 via the MyD88 signaling pathway in LPS-activated RAW 264.7 cells. Int Immunopharmacol. 14:375–383. 2012. View Article : Google Scholar : PubMed/NCBI

42 

Jiang Y, Tang X, Zhou B, Sun T, Chen H, Zhao X and Wang Y: The ROS-mediated pathway coupled with the MAPK-p38 signalling pathway and antioxidant system plays roles in the responses of Mytilus edulis haemocytes induced by BDE-47. Aquat Toxicol. 187:55–63. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Liu Y, Wen PH, Zhang XX, Dai Y and He Q: Breviscapine ameliorates CCl4-induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. Int J Mol Med. 42:755–768. 2018.PubMed/NCBI

44 

Yoon H and Liu RH: Effect of selected phytochemicals and apple extracts on NF-κB activation in human breast cancer MCF-7 cells. J Agric Food Chem. 55:3167–3173. 2007. View Article : Google Scholar : PubMed/NCBI

45 

Park EJ, Kim YM, Park SW, Kim HJ, Lee JH, Lee DU and Chang KC: Induction of HO-1 through p38 MAPK/Nrf2 signaling pathway by ethanol extract of Inula Helenium L. reduces inflammation in LPS-activated RAW 264.7 cells and CLP-induced septic mice. Food Chem Toxicol. 55:386–395. 2013. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Liu J, Liu M, Wang S, He Y, Huo Y, Yang Z and Cao X: Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. Int J Mol Med 42: 1847-1856, 2018.
APA
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., & Cao, X. (2018). Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. International Journal of Molecular Medicine, 42, 1847-1856. https://doi.org/10.3892/ijmm.2018.3751
MLA
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., Cao, X."Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways". International Journal of Molecular Medicine 42.4 (2018): 1847-1856.
Chicago
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., Cao, X."Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways". International Journal of Molecular Medicine 42, no. 4 (2018): 1847-1856. https://doi.org/10.3892/ijmm.2018.3751
Copy and paste a formatted citation
x
Spandidos Publications style
Liu J, Liu M, Wang S, He Y, Huo Y, Yang Z and Cao X: Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. Int J Mol Med 42: 1847-1856, 2018.
APA
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., & Cao, X. (2018). Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways. International Journal of Molecular Medicine, 42, 1847-1856. https://doi.org/10.3892/ijmm.2018.3751
MLA
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., Cao, X."Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways". International Journal of Molecular Medicine 42.4 (2018): 1847-1856.
Chicago
Liu, J., Liu, M., Wang, S., He, Y., Huo, Y., Yang, Z., Cao, X."Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways". International Journal of Molecular Medicine 42, no. 4 (2018): 1847-1856. https://doi.org/10.3892/ijmm.2018.3751
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team