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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2018 Volume 42 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Functions of EpCAM in physiological processes and diseases (Review)

Li Huang, Yanhong Yang, Fei Yang, Shaomin Liu, Ziqin Zhu, Zili Lei, Jiao Guo
Pages: 1771-1785
Published online on: 11 July 2018

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Review

Circular RNA, a novel marker for cancer determination (Review)

Yinjie Su, Guangzheng Zhong, Ning Jiang, Ming Huang, Tianxin Lin
Pages: 1786-1798
Published online on: 30 July 2018

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Article Open Access

TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma

Cuiyun Li, Jing Cai, Fugui Ge, Guilong Wang
Pages: 1799-1808
Published online on: 04 July 2018

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Article Open Access

Effects of FSS on the expression and localization of the core proteins in two Wnt signaling pathways, and their association with ciliogenesis

Xin Sheng, Yan Sheng, Yuehua Liu, Xiaoqiong Li, Bo Shu, Dayu Li
Pages: 1809-1818
Published online on: 05 July 2018

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Article Open Access

Targeted next‑generation sequencing identifies two novel COL2A1 gene mutations in Stickler syndrome with bilateral retinal detachment

Xinhua Huang, Ying Lin, Chuan Chen, Yi Zhu, Hongbin Gao, Tao Li, Bingqian Liu, Cancan Lyu, Ying Huang, Qingxiu Wu, Haichun Li, Chenjin Jin, Xiaoling Liang, Lin Lu
Pages: 1819-1826
Published online on: 04 July 2018

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Article Open Access

Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling

Penglai Wang, Shaoyue Zhu, Changyong Yuan, Lei Wang, Jianguang Xu, Zongxiang Liu
Pages: 1827-1836
Published online on: 06 July 2018

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Article Open Access

A comprehensive analysis of prognosis prediction models based on pathway‑level, gene‑level and clinical information for glioblastoma

Ruqing Liang, Meng Wang, Guizhi Zheng, Hua Zhu, Yaqin Zhi, Zongwen Sun
Pages: 1837-1846
Published online on: 11 July 2018

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Article Open Access

Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways

Jianli Liu, Meijia Liu, Shuai Wang, Yin He, Yapeng Huo, Zhijun Yang, Xiangyu Cao
Pages: 1847-1856
Published online on: 04 July 2018

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Article Open Access

Ulipristal acetate induces cell cycle delay and remodeling of extracellular matrix

So‑Jin Shin, Jinyoung Kim, Seungmee Lee, Jongwoo Baek, Jin Eui Lee, Chiheum Cho, Eunyoung Ha
Pages: 1857-1864
Published online on: 17 July 2018

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Article Open Access

Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus

Yuan Fang, Xiaoxia Wang, Wenqing Li, Jingli Han, Junhua Jin, Fei Su, Junhua Zhang, Wei Huang, Fei Xiao, Qi Pan, Lihui Zou
Pages: 1865-1874
Published online on: 18 July 2018

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Article Open Access

Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice

Jun Go, Tae‑Shin Park, Geun‑Hee Han, Hye‑Yeon Park, Young‑Kyoung Ryu, Yong‑Hoon Kim, Jung Hwan Hwang, Dong‑Hee Choi, Jung‑Ran Noh, Dae Youn Hwang, Sanghee Kim, Won Keun Oh, Chul‑Ho Lee, Kyoung‑Shim Kim
Pages: 1875-1884
Published online on: 18 July 2018

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Article Open Access

Oxidative stress in electrohypersensitivity self‑reporting patients: Results of a prospective in vivo investigation with comprehensive molecular analysis

Philippe Irigaray, Daniela Caccamo, Dominique Belpomme
Pages: 1885-1898
Published online on: 12 July 2018

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Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells by inhibiting the 5‑LO/BLT2 cascade

Ji‑Hyun Go, Jun‑Dong Wei, Jae‑In Park, Kyung‑Seop Ahn, Jae‑Hong Kim
Pages: 1899-1908
Published online on: 12 July 2018

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Article Open Access

Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF‑α pathway

Nan Wang, Zhiping Feng, Wei Zhao, Zhiqiang Zhang, Lixin Zhang
Pages: 1909-1916
Published online on: 19 July 2018

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Article Open Access

Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury

Xuefei Li, Xiaorong Hu, Jichun Wang, Weipan Xu, Chunfeng Yi, Ruisong Ma, Hong Jiang
Pages: 1917-1924
Published online on: 30 July 2018

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Article Open Access

Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells

Yunfei Ma, Tuo Tang, Lili Sheng, Ziqian Wang, Hong Tao, Qing Zhang, Yao Zhang, Zhilin Qi
Pages: 1925-1934
Published online on: 31 July 2018

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Article Open Access

Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain

Ge Li, Xiaofei He, Hang Li, Yu'e Wu, Yalun Guan, Shuhua Liu, Huanhuan Jia, Yunfeng Li, Lijing Wang, Ren Huang, Zhong Pei, Yue Lan, Yu Zhang
Pages: 1935-1944
Published online on: 02 August 2018

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Article Open Access

Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation

Xiaoyao Yang, Hui Liu, Xu Jiang, Chufeng Jin, Zhao Xu, Taosheng Li, Zhigang Wang, Jun Wang
Pages: 1945-1954
Published online on: 01 August 2018

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Article Open Access

Pro‑atherogenic activation of A7r5 cells induced by the oxLDL/β2GPI/anti‑β2GPI complex

Ting Wang, Hang Ouyang, Hong Zhou, Longfei Xia, Xiaoyan Wang
Pages: 1955-1966
Published online on: 02 August 2018

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Aspirin promotes osteogenic differentiation of human dental pulp stem cells

Mengtong Yuan, Yuanbo Zhan, Weiping Hu, Ying Li, Xiaohua Xie, Nan Miao, Han Jin, Bin Zhang
Pages: 1967-1976
Published online on: 02 August 2018

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Article Open Access

Reversibly immortalized hepatic progenitor cell line containing double suicide genes

Shu‑Yu Fang, Chao‑Qun Hu, Meng‑Nan Liu, Li Tao, Yi Wang, Meng‑Jia Gong, Yun He, Tong‑Chuan He, Yang Bi
Pages: 1977-1986
Published online on: 02 August 2018

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A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells

Ann‑Katrin Sommer, Adam Hermawan, Bojan Ljepoja, Thomas Fröhlich, Georg J. Arnold, Ernst Wagner, Andreas Roidl
Pages: 1987-1997
Published online on: 18 July 2018

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Article Open Access

BMS‑345541 inhibits airway inflammation and epithelial‑mesenchymal transition in airway remodeling of asthmatic mice

Xiaohua Zhu, Qiugen Li, Guozhu Hu, Jun Wang, Qinghua Hu, Zhiqiang Liu, Gang Wu, Ying Zhong
Pages: 1998-2008
Published online on: 06 July 2018

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Article Open Access

Effect of autophagy on allodynia, hyperalgesia and astrocyte activation in a rat model of neuropathic pain

Hongguang Chen, Yajiao Hu, Keliang Xie, Yajun Chen, Huixing Wang, Yingxue Bian, Yanyan Wang, Aili Dong, Yonghao Yu
Pages: 2009-2019
Published online on: 06 July 2018

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Article Open Access

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

Xueqing Zou, Yongmei Wang, Cheng Peng, Ben Wang, Zhengchuan Niu, Zequn Li, Jun Niu
Pages: 2020-2030
Published online on: 19 July 2018

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Article Open Access

Titanium particle‑mediated osteoclastogenesis may be attenuated via bidirectional ephrin‑B2/eph‑B4 signaling in vitro

Yu‑Wei Ge, Zhi‑Qing Liu, Zhen‑Yu Sun, De‑Gang Yu, Kai Feng, Zhen‑An Zhu, Yuan‑Qing Mao
Pages: 2031-2041
Published online on: 17 July 2018

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Article Open Access

miR‑330‑5p inhibits H2O2‑induced adipogenic differentiation of MSCs by regulating RXRγ

Weiping Huang, Ke Li, Aijun Liu, Zeyu Yang, Chenxia Hu, Dongfeng Chen, Hongqi Wang
Pages: 2042-2052
Published online on: 12 July 2018

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Article Open Access

Effect of celastrol on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells

Li‑Ping Han, Bei Sun, Chun‑Jun Li, Yun Xie, Li‑Ming Chen
Pages: 2053-2061
Published online on: 12 July 2018

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Article Open Access

Construction of a microRNA‑associated feed‑forward loop network that identifies regulators of cardiac hypertrophy and acute myocardial infarction

Wenbo Qu, Shuai Shi, Lixiu Sun, Fan Zhang, Shengming Zhang, Shuainan Mu, Yanru Zhao, Bingchen Liu, Xue Cao
Pages: 2062-2070
Published online on: 20 July 2018

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Article Open Access

Vγ9Vδ2 T cells inhibit immature dendritic cell transdifferentiation into osteoclasts through downregulation of RANK, c‑Fos and ATP6V0D2

Xiaolin Zhu, Zhiyong Zeng, Dongbiao Qiu, Junmin Chen
Pages: 2071-2079
Published online on: 23 July 2018

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Article Open Access

MicroRNAs as biomarkers for the progression and prognosis of colon carcinoma

Hui Zhang, Zhuo Wang, Rong Ma, Jianzhong Wu, Jifeng Feng
Pages: 2080-2088
Published online on: 25 July 2018

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Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells

Lili Sheng, Tuo Tang, Yinhua Liu, Yunfei Ma, Ziqian Wang, Hong Tao, Yao Zhang, Zhilin Qi
Pages: 2089-2097
Published online on: 19 July 2018

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Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice

Lei Wang, Zi Wang, Jiandang Shi, Qian Jiang, Hong Wang, Xu Li, Di Hao
Pages: 2098-2106
Published online on: 31 July 2018

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Article Open Access

High-fluence low-power laser irradiation promotes odontogenesis and inflammation resolution in periodontitis by enhancing stem cell proliferation and differentiation

Tiejun Hou, Shanyong Li, Guangwei Zhang, Yan Li
Pages: 2107-2119
Published online on: 02 August 2018

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Article

Evaluation of intestinal injury, inflammatory response and oxidative stress following intracerebral hemorrhage in mice

Yijun Cheng, Jieyu Zan, Yaying Song, Guoyuan Yang, Hanbing Shang, Weiguo Zhao
Pages: 2120-2128
Published online on: 04 July 2018

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Article

Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics

Valeria Righi, Caterina Constantinou, Meenu Kesarwani, Laurence G. Rahme, A. Aria Tzika
Pages: 2129-2136
Published online on: 06 July 2018

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Article

Downregulation of hepatic lipase is associated with decreased CD133 expression and clone formation in HepG2 cells

Xuehua Liu, Junhua Zuo, Yuan Fang, Jing Wen, Feihong Deng, Hui Zhong, Bo Jiang, Jide Wang, Biao Nie
Pages: 2137-2144
Published online on: 04 July 2018

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Article

MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction

Yajun Chang, Wei Huang, Qian Sun, Suli Li, Zhongkai Yan, Qiumin Wang, Xiumin Liu
Pages: 2145-2154
Published online on: 13 July 2018

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Article

Formononetin protects against balloon injury‑induced neointima formation in rats by regulating proliferation and migration of vascular smooth muscle cells via the TGF‑β1/Smad3 signaling pathway

Tao Song, Jingdong Zhao, Tongbai Jiang, Xing Jin, Yubin Li, Xinrong Liu
Pages: 2155-2162
Published online on: 18 July 2018

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Article

miR‑199a‑3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells

Shihua Zhou, Ziqian Min, Kang Sun, Sijie Qu, Jinrun Zhou, Hongyan Duan, Huawei Liu, Xiaowen Liu, Zhijun Gong, Dan Li
Pages: 2163-2174
Published online on: 12 July 2018

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Article

Role of lincRNA‑p21 in the protective effect of macrophage inhibition factor against hypoxia/serum deprivation‑induced apoptosis in mesenchymal stem cells

Wenzheng Xia, Lei Zhuang, Meng Hou
Pages: 2175-2184
Published online on: 12 July 2018

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Article

HSP90 limits thrombin‑stimulated IL‑6 synthesis in osteoblast‑like MC3T3‑E1 cells: Regulation of p38 MAPK

Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Shingo Kainuma, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 2185-2192
Published online on: 18 July 2018

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Article

Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration

Hao Wu, Yupan Shang, Jiayue Yu, Xiaoli Zeng, Jinhua Lin, Mei Tu, Lek Hang Cheang, Jiaqing Zhang
Pages: 2193-2202
Published online on: 12 July 2018

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Article

Loss of conserved ubiquitylation sites in conserved proteins during human evolution

Dongbin Park, Chul Jun Goh, Hyein Kim, Ji Seok Lee, Yoonsoo Hahn
Pages: 2203-2212
Published online on: 12 July 2018

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Article

Effect of phlorotannins on myofibroblast differentiation and ECM protein expression in transforming growth factor β1‑induced nasal polyp‑derived fibroblasts

Jungik Park, Grace Choi, Mi‑Jin Yim, Jeong Min Lee, Jong Su Yoo, Won Sun Park, Seong Kook Park, Saegwang Park, Su‑Kil Seo, Tae‑Geum Kim, Dae‑Sung Lee, Il‑Whan Choi
Pages: 2213-2220
Published online on: 12 July 2018

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Article

Melatonin inhibits epithelial‑to‑mesenchymal transition in gastric cancer cells via attenuation of IL‑1β/NF‑κB/MMP2/MMP9 signaling

Xiaoting Wang, Bin Wang, Jieqiong Xie, Diyu Hou, Hui Zhang, Huifang Huang
Pages: 2221-2228
Published online on: 19 July 2018

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Article

Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease

Katherine J.P. Schwenger, Lina Chen, Adeline Chelliah, Hannah E. Da Silva, Anastasia Teterina, Elena M. Comelli, Amel Taibi, Bianca M. Arendt, Sandra Fischer, Johane P. Allard
Pages: 2229-2237
Published online on: 02 August 2018

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Article

Identification of genes and signaling pathways associated with arthrogryposis‑renal dysfunction‑cholestasis syndrome using weighted correlation network analysis

Miao Chai, Liju Su, Xiaolei Hao, Meng Zhang, Lihui Zheng, Jiabing Bi, Xiao Han, Bohai Yu
Pages: 2238-2246
Published online on: 12 July 2018

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Article

Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer

Li Fan, Chunxian Huang, Jing Li, Tian Gao, Zhongqiu Lin, Tingting Yao
Pages: 2247-2259
Published online on: 13 July 2018

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Article

Potential repositioning of GV1001 as a therapeutic agent for testosterone‑induced benign prostatic hyperplasia

Kyeong Seok Kim, Hun Yong Yang, Seung‑Cheol Chang, Young‑Mi Kim, Kwang Youl Lee, Byung Mu Lee, Hyung Sik Kim
Pages: 2260-2268
Published online on: 05 July 2018

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Article

Efficient increase of the novel recombinant human plasminogen activator expression level and stability through the use of homozygote transgenic rabbits

Zhengyi He, Lei Jiang, Ting Zhang, Minya Zhou, Daijin Wu, Tingting Yuan, Yuguo Yuan, Yong Cheng
Pages: 2269-2275
Published online on: 04 July 2018

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Article

Notch signalling induces epithelial‑mesenchymal transition to promote metastasis in oral squamous cell carcinoma

Jianping Zhang, Genjian Zheng, Lan Zhou, Pengcheng Li, Man Yun, Qi Shi, Tingli Wang, Xiaotong Wu
Pages: 2276-2284
Published online on: 12 July 2018

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Article

Scopoletin downregulates MMP‑1 expression in human fibroblasts via inhibition of p38 phosphorylation

Hae‑Lim Kim, Sung Min Woo, Woo Rin Choi, Hong‑Suk Kim, Chunsik Yi, Kyung‑Hyeon Kim, Jinhua Cheng, Seung Hwan Yang, Joo‑Won Suh
Pages: 2285-2293
Published online on: 04 July 2018

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Article

Effects of Ca2+/calmodulin‑dependent protein kinase pathway inhibitor KN93 on osteoclastogenesis

Yingxiao Fu, Dequn Niu, Wenfang Su, Qingling Yang, Wenrui Wang, Baoding Tang, Zhongwen Li, Ding Zhang, Yingji Mao, Chuang Li, Xue Li, Shihao Ye, Xu Su, Fanyuan Xu, Xuemin Sun, Changjie Chen
Pages: 2294-2302
Published online on: 25 July 2018

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Article

Gene expression profiles for predicting antibody‑mediated kidney allograft rejection: Analysis of GEO datasets

In‑Wha Kim, Jae Hyun Kim, Nayoung Han, Sangsoo Kim, Yon Su Kim, Jung Mi Oh
Pages: 2303-2311
Published online on: 31 July 2018

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Myokines in exercise‑mediated bone homeostasis: Molecular signaling mechanisms and therapeutic implications for bone disorders (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 231
Published online on: 24 June 2026

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Neutrophil extracellular traps in thrombosis of hematologic malignancies: Underlying mechanisms and therapeutic opportunities (Review)

Kebing Lv, Zijie Ma, Qiuni Chen, Yang Su, Jingjing Ma, Chunling Wang, Liang Yu
Article Number: 230
Published online on: 23 June 2026

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Recombinant myonectin ameliorates sepsis‑induced cardiomyopathy by alleviating mitochondrial dysfunction via the AdipoR1/AMPK pathway

Peipei Li, Rui Chen, Hanmo Zhang, Lihong Li, Huiling Luo, Beibei Du, Ping Yang
Article Number: 229
Published online on: 23 June 2026

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MTA2: Decoding pathogenic mechanisms, clinical implications and therapeutic frontiers across disease landscapes (Review)

Hao Xie, Ling Chen, Jing Gou, Xuehong Long, Ya Yang, Hai Hu, Ping Wu, Qibing Yan, Yongkang Wu
Article Number: 228
Published online on: 22 June 2026

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Mitochondria‑endoplasmic reticulum contact site nexus: Molecular integration, disease pathogenesis and therapeutic opportunities (Review)

Yi Liu, Xianda Che, Wei Wei, Chong Teng, Huimin Li
Article Number: 227
Published online on: 22 June 2026

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Metabolic messengers from the gut to the joint: Toward precision management of osteoarthritis (Review)

Ruipu Zhang, Liang Zhang, Yiqun Wang, Xin Kang, Jiang Zheng
Article Number: 226
Published online on: 22 June 2026

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Retraction Open Access

[Retracted] Protection of telomeres 1 protein levels are associated with telomere length in gastric cancer

Kiyomu Fujii, Tomonori Sasahira, Yukiko Moriwaka, Naohide Oue, Wataru Yasui, Hiroki Kuniyasu
Article Number: 225
Published online on: 22 June 2026

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Molecular mechanism of hydromorphone preconditioning in cerebral ischemia/reperfusion‑induced inflammatory injury

Jing Yao, Zeqing Huang, Songze Li, Minghui Lun, Jianing Fan
Article Number: 224
Published online on: 18 June 2026

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Oridonin ameliorates ulcerative colitis by regulating the PI3K/AKT/mTOR signaling pathway to activate autophagy

Zhongxing Miao, Baohong Liu, Xingzhi Zhou, Mengru Lu, Ni Jia, Huamin Zhang, Ying Qi, Xiaoyu Tan, Qinggao Zhang
Article Number: 223
Published online on: 18 June 2026

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Article

Arsenic exposure and skin cancer: Mechanisms, clinical evidence and public health implications (Review)

Dimitrios A. Andreikos, Michael Aschner, Dimitrios C. Ziogas, Aristidis Tsatsakis, Demetrios A. Spandidos
Article Number: 222
Published online on: 18 June 2026

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Targeting glutathione metabolism for tumor radiosensitization (Review)

Haonan Xu, Meng Du, Xiaowen Liang, Xilin Xiao, Zhiyi Chen
Article Number: 221
Published online on: 16 June 2026

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Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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Correction Open Access

[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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September-2026 Volume 58 Issue 3

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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