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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
October-2018 Volume 42 Issue 4

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Functions of EpCAM in physiological processes and diseases (Review)

Li Huang, Yanhong Yang, Fei Yang, Shaomin Liu, Ziqin Zhu, Zili Lei, Jiao Guo
Pages: 1771-1785
Published online on: 11 July 2018

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Review

Circular RNA, a novel marker for cancer determination (Review)

Yinjie Su, Guangzheng Zhong, Ning Jiang, Ming Huang, Tianxin Lin
Pages: 1786-1798
Published online on: 30 July 2018

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Article Open Access

TGM2 knockdown reverses cisplatin chemoresistance in osteosarcoma

Cuiyun Li, Jing Cai, Fugui Ge, Guilong Wang
Pages: 1799-1808
Published online on: 04 July 2018

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Article Open Access

Effects of FSS on the expression and localization of the core proteins in two Wnt signaling pathways, and their association with ciliogenesis

Xin Sheng, Yan Sheng, Yuehua Liu, Xiaoqiong Li, Bo Shu, Dayu Li
Pages: 1809-1818
Published online on: 05 July 2018

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Article Open Access

Targeted next‑generation sequencing identifies two novel COL2A1 gene mutations in Stickler syndrome with bilateral retinal detachment

Xinhua Huang, Ying Lin, Chuan Chen, Yi Zhu, Hongbin Gao, Tao Li, Bingqian Liu, Cancan Lyu, Ying Huang, Qingxiu Wu, Haichun Li, Chenjin Jin, Xiaoling Liang, Lin Lu
Pages: 1819-1826
Published online on: 04 July 2018

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Article Open Access

Shear stress promotes differentiation of stem cells from human exfoliated deciduous teeth into endothelial cells via the downstream pathway of VEGF-Notch signaling

Penglai Wang, Shaoyue Zhu, Changyong Yuan, Lei Wang, Jianguang Xu, Zongxiang Liu
Pages: 1827-1836
Published online on: 06 July 2018

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Article Open Access

A comprehensive analysis of prognosis prediction models based on pathway‑level, gene‑level and clinical information for glioblastoma

Ruqing Liang, Meng Wang, Guizhi Zheng, Hua Zhu, Yaqin Zhi, Zongwen Sun
Pages: 1837-1846
Published online on: 11 July 2018

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Article Open Access

Alantolactone induces apoptosis and suppresses migration in MCF‑7 human breast cancer cells via the p38 MAPK, NF‑κB and Nrf2 signaling pathways

Jianli Liu, Meijia Liu, Shuai Wang, Yin He, Yapeng Huo, Zhijun Yang, Xiangyu Cao
Pages: 1847-1856
Published online on: 04 July 2018

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Article Open Access

Ulipristal acetate induces cell cycle delay and remodeling of extracellular matrix

So‑Jin Shin, Jinyoung Kim, Seungmee Lee, Jongwoo Baek, Jin Eui Lee, Chiheum Cho, Eunyoung Ha
Pages: 1857-1864
Published online on: 17 July 2018

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Article Open Access

Screening of circular RNAs and validation of circANKRD36 associated with inflammation in patients with type 2 diabetes mellitus

Yuan Fang, Xiaoxia Wang, Wenqing Li, Jingli Han, Junhua Jin, Fei Su, Junhua Zhang, Wei Huang, Fei Xiao, Qi Pan, Lihui Zou
Pages: 1865-1874
Published online on: 18 July 2018

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Article Open Access

Piperlongumine decreases cognitive impairment and improves hippocampal function in aged mice

Jun Go, Tae‑Shin Park, Geun‑Hee Han, Hye‑Yeon Park, Young‑Kyoung Ryu, Yong‑Hoon Kim, Jung Hwan Hwang, Dong‑Hee Choi, Jung‑Ran Noh, Dae Youn Hwang, Sanghee Kim, Won Keun Oh, Chul‑Ho Lee, Kyoung‑Shim Kim
Pages: 1875-1884
Published online on: 18 July 2018

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Article Open Access

Oxidative stress in electrohypersensitivity self‑reporting patients: Results of a prospective in vivo investigation with comprehensive molecular analysis

Philippe Irigaray, Daniela Caccamo, Dominique Belpomme
Pages: 1885-1898
Published online on: 12 July 2018

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Article Open Access

Wogonin suppresses the LPS‑enhanced invasiveness of MDA‑MB‑231 breast cancer cells by inhibiting the 5‑LO/BLT2 cascade

Ji‑Hyun Go, Jun‑Dong Wei, Jae‑In Park, Kyung‑Seop Ahn, Jae‑Hong Kim
Pages: 1899-1908
Published online on: 12 July 2018

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Article Open Access

Ultrashortwave radiation promotes the recovery of spinal cord injury by inhibiting inflammation via suppression of the MK2/TNF‑α pathway

Nan Wang, Zhiping Feng, Wei Zhao, Zhiqiang Zhang, Lixin Zhang
Pages: 1909-1916
Published online on: 19 July 2018

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Article Open Access

Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury

Xuefei Li, Xiaorong Hu, Jichun Wang, Weipan Xu, Chunfeng Yi, Ruisong Ma, Hong Jiang
Pages: 1917-1924
Published online on: 30 July 2018

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Article Open Access

Aloin suppresses lipopolysaccharide‑induced inflammation by inhibiting JAK1‑STAT1/3 activation and ROS production in RAW264.7 cells

Yunfei Ma, Tuo Tang, Lili Sheng, Ziqian Wang, Hong Tao, Qing Zhang, Yao Zhang, Zhilin Qi
Pages: 1925-1934
Published online on: 31 July 2018

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Article Open Access

Overexpression of Slit2 improves function of the paravascular pathway in the aging mouse brain

Ge Li, Xiaofei He, Hang Li, Yu'e Wu, Yalun Guan, Shuhua Liu, Huanhuan Jia, Yunfeng Li, Lijing Wang, Ren Huang, Zhong Pei, Yue Lan, Yu Zhang
Pages: 1935-1944
Published online on: 02 August 2018

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Article Open Access

Cyclooxygenase‑2‑mediated upregulation of heme oxygenase 1 mitigates the toxicity of deuterium‑tritium fusion radiation

Xiaoyao Yang, Hui Liu, Xu Jiang, Chufeng Jin, Zhao Xu, Taosheng Li, Zhigang Wang, Jun Wang
Pages: 1945-1954
Published online on: 01 August 2018

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Article Open Access

Pro‑atherogenic activation of A7r5 cells induced by the oxLDL/β2GPI/anti‑β2GPI complex

Ting Wang, Hang Ouyang, Hong Zhou, Longfei Xia, Xiaoyan Wang
Pages: 1955-1966
Published online on: 02 August 2018

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Article Open Access

Aspirin promotes osteogenic differentiation of human dental pulp stem cells

Mengtong Yuan, Yuanbo Zhan, Weiping Hu, Ying Li, Xiaohua Xie, Nan Miao, Han Jin, Bin Zhang
Pages: 1967-1976
Published online on: 02 August 2018

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Article Open Access

Reversibly immortalized hepatic progenitor cell line containing double suicide genes

Shu‑Yu Fang, Chao‑Qun Hu, Meng‑Nan Liu, Li Tao, Yi Wang, Meng‑Jia Gong, Yun He, Tong‑Chuan He, Yang Bi
Pages: 1977-1986
Published online on: 02 August 2018

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Article Open Access

A proteomic analysis of chemoresistance development via sequential treatment with doxorubicin reveals novel players in MCF‑7 breast cancer cells

Ann‑Katrin Sommer, Adam Hermawan, Bojan Ljepoja, Thomas Fröhlich, Georg J. Arnold, Ernst Wagner, Andreas Roidl
Pages: 1987-1997
Published online on: 18 July 2018

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Article Open Access

BMS‑345541 inhibits airway inflammation and epithelial‑mesenchymal transition in airway remodeling of asthmatic mice

Xiaohua Zhu, Qiugen Li, Guozhu Hu, Jun Wang, Qinghua Hu, Zhiqiang Liu, Gang Wu, Ying Zhong
Pages: 1998-2008
Published online on: 06 July 2018

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Article Open Access

Effect of autophagy on allodynia, hyperalgesia and astrocyte activation in a rat model of neuropathic pain

Hongguang Chen, Yajiao Hu, Keliang Xie, Yajun Chen, Huixing Wang, Yingxue Bian, Yanyan Wang, Aili Dong, Yonghao Yu
Pages: 2009-2019
Published online on: 06 July 2018

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Article Open Access

Magnesium isoglycyrrhizinate has hepatoprotective effects in an oxaliplatin‑induced model of liver injury

Xueqing Zou, Yongmei Wang, Cheng Peng, Ben Wang, Zhengchuan Niu, Zequn Li, Jun Niu
Pages: 2020-2030
Published online on: 19 July 2018

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Article Open Access

Titanium particle‑mediated osteoclastogenesis may be attenuated via bidirectional ephrin‑B2/eph‑B4 signaling in vitro

Yu‑Wei Ge, Zhi‑Qing Liu, Zhen‑Yu Sun, De‑Gang Yu, Kai Feng, Zhen‑An Zhu, Yuan‑Qing Mao
Pages: 2031-2041
Published online on: 17 July 2018

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Article Open Access

miR‑330‑5p inhibits H2O2‑induced adipogenic differentiation of MSCs by regulating RXRγ

Weiping Huang, Ke Li, Aijun Liu, Zeyu Yang, Chenxia Hu, Dongfeng Chen, Hongqi Wang
Pages: 2042-2052
Published online on: 12 July 2018

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Article Open Access

Effect of celastrol on toll‑like receptor 4‑mediated inflammatory response in free fatty acid‑induced HepG2 cells

Li‑Ping Han, Bei Sun, Chun‑Jun Li, Yun Xie, Li‑Ming Chen
Pages: 2053-2061
Published online on: 12 July 2018

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Article Open Access

Construction of a microRNA‑associated feed‑forward loop network that identifies regulators of cardiac hypertrophy and acute myocardial infarction

Wenbo Qu, Shuai Shi, Lixiu Sun, Fan Zhang, Shengming Zhang, Shuainan Mu, Yanru Zhao, Bingchen Liu, Xue Cao
Pages: 2062-2070
Published online on: 20 July 2018

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Article Open Access

Vγ9Vδ2 T cells inhibit immature dendritic cell transdifferentiation into osteoclasts through downregulation of RANK, c‑Fos and ATP6V0D2

Xiaolin Zhu, Zhiyong Zeng, Dongbiao Qiu, Junmin Chen
Pages: 2071-2079
Published online on: 23 July 2018

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Article Open Access

MicroRNAs as biomarkers for the progression and prognosis of colon carcinoma

Hui Zhang, Zhuo Wang, Rong Ma, Jianzhong Wu, Jifeng Feng
Pages: 2080-2088
Published online on: 25 July 2018

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Article Open Access

Inducible HSP70 antagonizes cisplatin‑induced cell apoptosis through inhibition of the MAPK signaling pathway in HGC‑27 cells

Lili Sheng, Tuo Tang, Yinhua Liu, Yunfei Ma, Ziqian Wang, Hong Tao, Yao Zhang, Zhilin Qi
Pages: 2089-2097
Published online on: 19 July 2018

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Article Open Access

Inhibition of proprotein convertase subtilisin/kexin type 9 attenuates neuronal apoptosis following focal cerebral ischemia via apolipoprotein E receptor 2 downregulation in hyperlipidemic mice

Lei Wang, Zi Wang, Jiandang Shi, Qian Jiang, Hong Wang, Xu Li, Di Hao
Pages: 2098-2106
Published online on: 31 July 2018

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Article Open Access

High-fluence low-power laser irradiation promotes odontogenesis and inflammation resolution in periodontitis by enhancing stem cell proliferation and differentiation

Tiejun Hou, Shanyong Li, Guangwei Zhang, Yan Li
Pages: 2107-2119
Published online on: 02 August 2018

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Article

Evaluation of intestinal injury, inflammatory response and oxidative stress following intracerebral hemorrhage in mice

Yijun Cheng, Jieyu Zan, Yaying Song, Guoyuan Yang, Hanbing Shang, Weiguo Zhao
Pages: 2120-2128
Published online on: 04 July 2018

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Article

Effects of a small, volatile bacterial molecule on Pseudomonas aeruginosa bacteria using whole cell high-resolution magic angle spinning nuclear magnetic resonance spectroscopy and genomics

Valeria Righi, Caterina Constantinou, Meenu Kesarwani, Laurence G. Rahme, A. Aria Tzika
Pages: 2129-2136
Published online on: 06 July 2018

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Article

Downregulation of hepatic lipase is associated with decreased CD133 expression and clone formation in HepG2 cells

Xuehua Liu, Junhua Zuo, Yuan Fang, Jing Wen, Feihong Deng, Hui Zhong, Bo Jiang, Jide Wang, Biao Nie
Pages: 2137-2144
Published online on: 04 July 2018

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Article

MicroRNA‑634 alters nerve apoptosis via the PI3K/Akt pathway in cerebral infarction

Yajun Chang, Wei Huang, Qian Sun, Suli Li, Zhongkai Yan, Qiumin Wang, Xiumin Liu
Pages: 2145-2154
Published online on: 13 July 2018

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Article

Formononetin protects against balloon injury‑induced neointima formation in rats by regulating proliferation and migration of vascular smooth muscle cells via the TGF‑β1/Smad3 signaling pathway

Tao Song, Jingdong Zhao, Tongbai Jiang, Xing Jin, Yubin Li, Xinrong Liu
Pages: 2155-2162
Published online on: 18 July 2018

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Article

miR‑199a‑3p/Sp1/LDHA axis controls aerobic glycolysis in testicular tumor cells

Shihua Zhou, Ziqian Min, Kang Sun, Sijie Qu, Jinrun Zhou, Hongyan Duan, Huawei Liu, Xiaowen Liu, Zhijun Gong, Dan Li
Pages: 2163-2174
Published online on: 12 July 2018

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Article

Role of lincRNA‑p21 in the protective effect of macrophage inhibition factor against hypoxia/serum deprivation‑induced apoptosis in mesenchymal stem cells

Wenzheng Xia, Lei Zhuang, Meng Hou
Pages: 2175-2184
Published online on: 12 July 2018

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Article

HSP90 limits thrombin‑stimulated IL‑6 synthesis in osteoblast‑like MC3T3‑E1 cells: Regulation of p38 MAPK

Kazuhiko Fujita, Takanobu Otsuka, Tetsu Kawabata, Shingo Kainuma, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 2185-2192
Published online on: 18 July 2018

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Article

Regenerative potential of human nucleus pulposus resident stem/progenitor cells declines with ageing and intervertebral disc degeneration

Hao Wu, Yupan Shang, Jiayue Yu, Xiaoli Zeng, Jinhua Lin, Mei Tu, Lek Hang Cheang, Jiaqing Zhang
Pages: 2193-2202
Published online on: 12 July 2018

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Article

Loss of conserved ubiquitylation sites in conserved proteins during human evolution

Dongbin Park, Chul Jun Goh, Hyein Kim, Ji Seok Lee, Yoonsoo Hahn
Pages: 2203-2212
Published online on: 12 July 2018

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Article

Effect of phlorotannins on myofibroblast differentiation and ECM protein expression in transforming growth factor β1‑induced nasal polyp‑derived fibroblasts

Jungik Park, Grace Choi, Mi‑Jin Yim, Jeong Min Lee, Jong Su Yoo, Won Sun Park, Seong Kook Park, Saegwang Park, Su‑Kil Seo, Tae‑Geum Kim, Dae‑Sung Lee, Il‑Whan Choi
Pages: 2213-2220
Published online on: 12 July 2018

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Article

Melatonin inhibits epithelial‑to‑mesenchymal transition in gastric cancer cells via attenuation of IL‑1β/NF‑κB/MMP2/MMP9 signaling

Xiaoting Wang, Bin Wang, Jieqiong Xie, Diyu Hou, Hui Zhang, Huifang Huang
Pages: 2221-2228
Published online on: 19 July 2018

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Article

Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease

Katherine J.P. Schwenger, Lina Chen, Adeline Chelliah, Hannah E. Da Silva, Anastasia Teterina, Elena M. Comelli, Amel Taibi, Bianca M. Arendt, Sandra Fischer, Johane P. Allard
Pages: 2229-2237
Published online on: 02 August 2018

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Article

Identification of genes and signaling pathways associated with arthrogryposis‑renal dysfunction‑cholestasis syndrome using weighted correlation network analysis

Miao Chai, Liju Su, Xiaolei Hao, Meng Zhang, Lihui Zheng, Jiabing Bi, Xiao Han, Bohai Yu
Pages: 2238-2246
Published online on: 12 July 2018

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Article

Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer

Li Fan, Chunxian Huang, Jing Li, Tian Gao, Zhongqiu Lin, Tingting Yao
Pages: 2247-2259
Published online on: 13 July 2018

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Article

Potential repositioning of GV1001 as a therapeutic agent for testosterone‑induced benign prostatic hyperplasia

Kyeong Seok Kim, Hun Yong Yang, Seung‑Cheol Chang, Young‑Mi Kim, Kwang Youl Lee, Byung Mu Lee, Hyung Sik Kim
Pages: 2260-2268
Published online on: 05 July 2018

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Article

Efficient increase of the novel recombinant human plasminogen activator expression level and stability through the use of homozygote transgenic rabbits

Zhengyi He, Lei Jiang, Ting Zhang, Minya Zhou, Daijin Wu, Tingting Yuan, Yuguo Yuan, Yong Cheng
Pages: 2269-2275
Published online on: 04 July 2018

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Article

Notch signalling induces epithelial‑mesenchymal transition to promote metastasis in oral squamous cell carcinoma

Jianping Zhang, Genjian Zheng, Lan Zhou, Pengcheng Li, Man Yun, Qi Shi, Tingli Wang, Xiaotong Wu
Pages: 2276-2284
Published online on: 12 July 2018

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Article

Scopoletin downregulates MMP‑1 expression in human fibroblasts via inhibition of p38 phosphorylation

Hae‑Lim Kim, Sung Min Woo, Woo Rin Choi, Hong‑Suk Kim, Chunsik Yi, Kyung‑Hyeon Kim, Jinhua Cheng, Seung Hwan Yang, Joo‑Won Suh
Pages: 2285-2293
Published online on: 04 July 2018

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Article

Effects of Ca2+/calmodulin‑dependent protein kinase pathway inhibitor KN93 on osteoclastogenesis

Yingxiao Fu, Dequn Niu, Wenfang Su, Qingling Yang, Wenrui Wang, Baoding Tang, Zhongwen Li, Ding Zhang, Yingji Mao, Chuang Li, Xue Li, Shihao Ye, Xu Su, Fanyuan Xu, Xuemin Sun, Changjie Chen
Pages: 2294-2302
Published online on: 25 July 2018

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Article

Gene expression profiles for predicting antibody‑mediated kidney allograft rejection: Analysis of GEO datasets

In‑Wha Kim, Jae Hyun Kim, Nayoung Han, Sangsoo Kim, Yon Su Kim, Jung Mi Oh
Pages: 2303-2311
Published online on: 31 July 2018

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Journal Cover
January-2026 Volume 57 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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Retraction Open Access

[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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Article Open Access

METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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