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Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury

  • Authors:
    • Xuefei Li
    • Xiaorong Hu
    • Jichun Wang
    • Weipan Xu
    • Chunfeng Yi
    • Ruisong Ma
    • Hong Jiang
  • View Affiliations / Copyright

    Affiliations: Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China, Department of Cardiology, Huangshi Center Hospital, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei 435000, P.R. China, Department of Cardiology, Wuhan No. 1 Hospital, Wuhan, Hubei 430060, P.R. China
    Copyright: © Li et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 1917-1924
    |
    Published online on: July 30, 2018
       https://doi.org/10.3892/ijmm.2018.3794
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Abstract

Hesperidin has been reported to attenuate myocardial ischemia/reperfusion (I/R) injury; however, its effect on autophagy during myocardial I/R and the underlying mechanism remains unknown. The present study aimed to investigate whether hesperidin inhibited I/R‑induced excessive myocardial autophagy through activating the phosphatidylinositol 3‑kinase (PI3K)/protein kinase B (Akt)/mammalian target of rapamycin (mTOR) pathway. Male adult rats were pretreated with hesperidin for a total of 3 days prior to ischemia in the absence or presence of LY294002, a PI3K inhibitor, and then subjected to ischemia for 30 min followed by reperfusion for 4 h. Myocardial infarct size was measured by Evans blue/triphenyltetrazolium chloride staining. Hematoxylin and eosin staining was used for observing the histological changes in the heart, and the serum levels of creatine kinase‑MB (CK‑MB) and cardiac troponin I (cTnI) were measured by enzyme‑linked immunosorbent assay. Additionally, the protein levels of light chain (LC) 3Ⅱ, Beclin1, phosphorylated (p)‑mTOR, p‑Akt and p‑PI3K were determined by western blot analysis. Hesperidin pretreatment significantly decreased the myocardial infarct size, myocardial damage and serum levels of CK‑MB and cTnI. Furthermore, the expression levels of LC3Ⅱ and Beclin1 were significantly downregulated and the expression levels of p‑mTOR, p‑Akt and p‑PI3K were markedly upregulated by hesperidin. However, the aforementioned effects as a result of hesperidin were significantly reversed by the presence of LY294002. These results demonstrated that hesperidin reduced myocardial I/R injury by suppressing excessive autophagy. Activation of the PI3K/Akt/mTOR pathway contributed to the inhibitory effect of hesperidin on excessive autophagy.
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View References

1 

Roger VL, Go AS, Lloyd-Jones DM, Benjamin EJ, Berry JD, Borden WB, Bravata DM, Dai S, Ford ES, Fox CS, et al: Executive Summary: Heart disease and stroke statistics-2012 update: A report from the american heart association. Circulation. 125:188–197. 2012. View Article : Google Scholar : PubMed/NCBI

2 

Yellon DM and Hausenloy DJ: Myocardial reperfusion injury. N Engl J Med. 357:1121–1135. 2007. View Article : Google Scholar : PubMed/NCBI

3 

Ogura Y, Ouchi N, Ohashi K, Shibata R, Kataoka Y, Kambara T, Kito T, Maruyama S, Yuasa D, Matsuo K, et al: Therapeutic impact of follistatin-like 1 on myocardial ischemic injury in preclinical models. Circulation. 126:1728–1738. 2012. View Article : Google Scholar : PubMed/NCBI

4 

Frangogiannis NG, Smith CW and Entman ML: The inflammatory response in myocardial infarction. Cardiovasc Res. 53:31–47. 2002. View Article : Google Scholar

5 

Gottlieb RA and Engler RL: Apoptosis in myocardial ischemia-reperfusion. Ann N Y Acad Sci. 874:412–426. 1999. View Article : Google Scholar : PubMed/NCBI

6 

Przyklenk K, Dong Y, Undyala VV and Whittaker P: Autophagy as a therapeutic target for ischaemia/reperfusion injury? Concepts, controversies, and challenges. Cardiovasc Res. 94:197–205. 2012. View Article : Google Scholar : PubMed/NCBI

7 

Marino G, Madeo F and Kroemer G: Autophagy for tissue homeostasis and neuroprotection. Curr Opin Cell Biol. 23:198–206. 2011. View Article : Google Scholar

8 

Loos B, Engelbrecht AM, Lockshin RA, Klionsky DJ and Zakeri Z: The variability of autophagy and cell death susceptibility: Unanswered questions. Autophagy. 9:1270–1285. 2013. View Article : Google Scholar : PubMed/NCBI

9 

Ke J, Yao B, Li T, Cui S and Ding H: A2 Adenosine receptor-mediated cardioprotection against reperfusion injury in rat hearts is associated with autophagy downregulation. J Cardiovasc Pharmacol. 66:25–34. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Cao X, Chen A, Yang P, Song X, Liu Y, Li Z, Wang X, Wang L and Li Y: Alpha-lipoic acid protects cardiomyocytes against hypoxia/reoxygenation injury by inhibiting autophagy. Biochem Biophys Res Commun. 441:935–940. 2013. View Article : Google Scholar : PubMed/NCBI

11 

Cheng BC, Huang HS, Chao CM, Hsu CC, Chen CY and Chang CP: Hypothermia may attenuate ischemia/reperfusion-induced cardiomyocyte death by reducing autophagy. Int J Cardiol. 168:2064–2069. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Garg A, Garg S, Zaneveld LJ and Singla AK: Chemistry and pharmacology of the Citrus bioflavonoid hesperidin. Phytother Res. 15:655–669. 2001. View Article : Google Scholar : PubMed/NCBI

13 

Kuntic V, Brboric J, Holclajtner-Antunovic I and Uskokovic-Markovic S: Evaluating the bioactive effects of flavonoid hesperidin-a new literature data survey. Vojnosanit Pregl. 71:60–65. 2014. View Article : Google Scholar

14 

Wei D, Ci X, Chu X, Wei M, Hua S and Deng X: Hesperidin suppresses ovalbumin-induced airway inflammation in a mouse allergic asthma model. Inflammation. 35:114–121. 2012. View Article : Google Scholar

15 

Yumnam S, Hong GE, Raha S, Saralamma VV, Lee HJ, Lee WS, Kim EH and Kim GS: Mitochondrial dysfunction and Ca(2+) overload contributes to hesperidin induced paraptosis in hepatoblastoma cells, HepG2. J Cell Physiol. 231:1261–1268. 2016. View Article : Google Scholar

16 

Petrova A, Davids LM, Rautenbach F and Marnewick JL: Photoprotection by honeybush extracts, hesperidin and mangiferin against UVB-induced skin damage in SKH-1 mice. J Photochem Photobiol B. 103:126–139. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Kim SH, Kim BK and Lee YC: Antiasthmatic effects of hesperidin, a potential Th2 cytokine antagonist, in a mouse model of allergic asthma. Mediators Inflamm. 2011:4854022011. View Article : Google Scholar : PubMed/NCBI

18 

Selvaraj P and Pugalendi KV: Hesperidin, a flavanone glycoside, on lipid peroxidation and antioxidant status in experimental myocardial ischemic rats. Redox Rep. 15:217–223. 2010. View Article : Google Scholar : PubMed/NCBI

19 

Gandhi C, Upaganalawar A and Balaraman R: Protection against in vivo focal myocardial ischemia/reperfusion injury-induced arrhythmias and apoptosis by hesperidin. Free Radic Res. 43:817–827. 2009. View Article : Google Scholar : PubMed/NCBI

20 

Li X, Hu X, Wang J, Xu W, Yi C, Ma R and Jiang H: Short-term hesperidin pretreatment attenuates rat myocardial ischemia/reperfusion injury by inhibiting high mobility group box 1 protein expression via the PI3K/Akt pathway. Cell Physiol Biochem. 39:1850–1862. 2016. View Article : Google Scholar : PubMed/NCBI

21 

Wymann MP, Zvelebil M and Laffargue M: Phosphoinositide 3-kinase signalling-which way to target? Trends Pharmacol Sci. 24:366–376. 2003. View Article : Google Scholar : PubMed/NCBI

22 

Shao X, Lai D, Zhang L and Xu H: Induction of autophagy and apoptosis via PI3K/AKT/TOR pathways by azadirachtin a in spodoptera litura cells. Sci Rep. 6:354822016. View Article : Google Scholar : PubMed/NCBI

23 

Rong Z, Pan R, Xu Y, Zhang C, Cao Y and Liu D: Hesperidin pretreatment protects hypoxia-ischemic brain injury in neonatal rat. Neuroscience. 255:292–299. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Wang J, Yang H, Hu X, Fu W, Xie J, Zhou X, Xu W and Jiang H: Dobutamine-mediated heme oxygenase-1 induction via PI3K and p38 MAPK inhibits high mobility group box 1 protein release and attenuates rat myocardial ischemia/reperfusion injury in vivo. J Surg Res. 183:509–516. 2013. View Article : Google Scholar : PubMed/NCBI

25 

Ruisong M, Xiaorong H, Gangying H, Chunfeng Y, Changjiang Z, Xuefei L, Yuanhong L and Hong J: The protective role of interleukin-33 in myocardial ischemia and reperfusion is associated with decreased HMGB1 expression and up-regulation of the P38 MAPK signaling pathway. PloS One. 10:e01430642015. View Article : Google Scholar : PubMed/NCBI

26 

Yang J, Jiang H, Yang J, Ding JW, Chen LH, Li S and Zhang XD: Valsartan preconditioning protects against myocardial ischemia-reperfusion injury through TLR4/NF-kappaB signaling pathway. Mol Cell Biochem. 330:39–46. 2009. View Article : Google Scholar : PubMed/NCBI

27 

Wang ZG, Wang Y, Huang Y, Lu Q, Zheng L, Hu D, Feng WK, Liu YL, Ji KT, Zhang HY, et al: bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway. Sci Rep. 5:92872015. View Article : Google Scholar : PubMed/NCBI

28 

Xu Q, Li X, Lu Y, Shen L, Zhang J, Cao S, Huang X, Bin J and Liao Y: Pharmacological modulation of autophagy to protect cardiomyocytes according to the time windows of ischaemia/reperfusion. Br J Pharmacol. 172:3072–3085. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Luo T, Liu G, Ma H, Lu B, Xu H, Wang Y, Wu J, Ge P and Liang J: Inhibition of autophagy via activation of PI3K/Akt pathway contributes to the protection of ginsenoside Rb1 against neuronal death caused by ischemic insults. Int J Mol Sci. 15:15426–15442. 2014. View Article : Google Scholar : PubMed/NCBI

30 

Kabeya Y, Mizushima N, Ueno T, Yamamoto A, Kirisako T, Noda T, Kominami E, Ohsumi Y and Yoshimori T: LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing. EMBO J. 19:5720–5728. 2000. View Article : Google Scholar : PubMed/NCBI

31 

Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H and Levine B: Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature. 402:672–676. 1999. View Article : Google Scholar : PubMed/NCBI

32 

Godar RJ, Ma X, Liu H, Murphy JT, Weinheimer CJ, Kovacs A, Crosby SD, Saftig P and Diwan A: Repetitive stimulation of autophagy-lysosome machinery by intermittent fasting preconditions the myocardium to ischemia-reperfusion injury. Autophagy. 11:1537–1560. 2015. View Article : Google Scholar : PubMed/NCBI

33 

Kuma A, Hatano M, Matsui M, Yamamoto A, Nakaya H, Yoshimori T, Ohsumi Y, Tokuhisa T and Mizushima N: The role of autophagy during the early neonatal starvation period. Nature. 432:1032–1036. 2004. View Article : Google Scholar : PubMed/NCBI

34 

Hamacher-Brady A, Brady NR, Logue SE, Sayen MR, Jinno M, Kirshenbaum LA, Gottlieb RA and Gustafsson AB: Response to myocardial ischemia/reperfusion injury involves Bnip3 and autophagy. Cell Death Differ. 14:146–157. 2007. View Article : Google Scholar

35 

Mink PJ, Scrafford CG, Barraj LM, Harnack L, Hong CP, Nettleton JA and Jacobs DR Jr: Flavonoid intake and cardiovascular disease mortality: A prospective study in postmenopausal women. Am J Clin Nutr. 85:895–909. 2007. View Article : Google Scholar : PubMed/NCBI

36 

Banerjee SK and Maulik SK: Effect of garlic on cardiovascular disorders: A review. Nutr J. 1:42002. View Article : Google Scholar

37 

Morand C, Dubray C, Milenkovic D, Lioger D, Martin JF, Scalbert A and Mazur A: Hesperidin contributes to the vascular protective effects of orange juice: A randomized crossover study in healthy volunteers. Am J Clin Nutr. 93:73–80. 2011. View Article : Google Scholar

38 

Rizza S, Muniyappa R, Iantorno M, Kim JA, Chen H, Pullikotil P, Senese N, Tesauro M, Lauro D, Cardillo C and Quon MJ: Citrus polyphenol hesperidin stimulates production of nitric oxide in endothelial cells while improving endothelial function and reducing inflammatory markers in patients with metabolic syndrome. J Clin Endocrinol Metab. 96:E782–E792. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Reagan-Shaw S, Nihal M and Ahmad N: Dose translation from animal to human studies revisited. FASEB J. 22:659–661. 2008. View Article : Google Scholar

40 

Huang SM, Tsai SY, Lin JA, Wu CH and Yen GC: Cytoprotective effects of hesperetin and hesperidin against amyloid β-induced impairment of glucose transport through downregulation of neuronal autophagy. Mol Nutr Food Res. 56:601–609. 2012. View Article : Google Scholar : PubMed/NCBI

41 

Sciarretta S, Volpe M and Sadoshima J: Mammalian target of rapamycin signaling in cardiac physiology and disease. Circ Res. 114:549–564. 2014. View Article : Google Scholar : PubMed/NCBI

42 

Justin-Thenmozhi A, Dhivya Bharathi M, Kiruthika R, Manivasagam T, Borah A and Essa MM: Attenuation of aluminum chloride-induced neuroinflammation and caspase activation through the AKT/GSK-3β pathway by hesperidin in wistar rats. Neurotox Res. 2018. View Article : Google Scholar

43 

Saiprasad G, Chitra P, Manikandan R and Sudhandiran G: Hesperidin induces apoptosis and triggers autophagic markers through inhibition of aurora-A mediated phosphoinositide-3-kinase/Akt/mammalian target of rapamycin and glycogen synthase kinase-3 beta signalling cascades in experimental colon carcinogenesis. Eur J Cancer. 50:2489–2507. 2014. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Li X, Hu X, Wang J, Xu W, Yi C, Ma R and Jiang H: Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. Int J Mol Med 42: 1917-1924, 2018.
APA
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., & Jiang, H. (2018). Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. International Journal of Molecular Medicine, 42, 1917-1924. https://doi.org/10.3892/ijmm.2018.3794
MLA
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., Jiang, H."Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury". International Journal of Molecular Medicine 42.4 (2018): 1917-1924.
Chicago
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., Jiang, H."Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury". International Journal of Molecular Medicine 42, no. 4 (2018): 1917-1924. https://doi.org/10.3892/ijmm.2018.3794
Copy and paste a formatted citation
x
Spandidos Publications style
Li X, Hu X, Wang J, Xu W, Yi C, Ma R and Jiang H: Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. Int J Mol Med 42: 1917-1924, 2018.
APA
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., & Jiang, H. (2018). Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury. International Journal of Molecular Medicine, 42, 1917-1924. https://doi.org/10.3892/ijmm.2018.3794
MLA
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., Jiang, H."Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury". International Journal of Molecular Medicine 42.4 (2018): 1917-1924.
Chicago
Li, X., Hu, X., Wang, J., Xu, W., Yi, C., Ma, R., Jiang, H."Inhibition of autophagy via activation of PI3K/Akt/mTOR pathway contributes to the protection of hesperidin against myocardial ischemia/reperfusion injury". International Journal of Molecular Medicine 42, no. 4 (2018): 1917-1924. https://doi.org/10.3892/ijmm.2018.3794
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