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October-2018 Volume 42 Issue 4

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Article

Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease

  • Authors:
    • Katherine J.P. Schwenger
    • Lina Chen
    • Adeline Chelliah
    • Hannah E. Da Silva
    • Anastasia Teterina
    • Elena M. Comelli
    • Amel Taibi
    • Bianca M. Arendt
    • Sandra Fischer
    • Johane P. Allard
  • View Affiliations / Copyright

    Affiliations: Department of Medicine, University of Toronto, Toronto, ON M5S 3E2, Canada, Department of Medicine, Toronto General Hospital, University Health Network, Toronto, ON M5G 2N2, Canada, Department of Pathology, University College Cork, Cork, Ireland, Department of Nutrition, Sunnybrook Health Sciences Center, Toronto, ON M4N 3M5, Canada, Department of Nutritional Sciences, University of Toronto, Toronto, ON M5S 3E2, Canada, Department of Pathology, Toronto General Hospital, University Health Network, Toronto, ON M5G 2N2, Canada
  • Pages: 2229-2237
    |
    Published online on: August 2, 2018
       https://doi.org/10.3892/ijmm.2018.3800
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Abstract

Several mechanisms contribute to the pathogenesis of non‑alcoholic fatty liver disease (NAFLD). The intestinal microbiota (IM) and liver immune cells (LIC) may serve a role, but there has been no previous study assessing potential associations between IM and LIC. The aim of the present study was to investigate whether there are differences in LIC markers between patients with NAFLD and healthy controls (HC), and to determine whether these markers are associated with specific IM. The present prospective, cross‑sectional study examined a cohort of adults with liver biopsy‑confirmed NAFLD and HC. Clinical and laboratory data were collected. Fecal IM was assessed by quantitative polymerase chain reaction and LIC, by immunohistochemistry. NAFLD activity score (NAS) was used for disease severity. Liver immune cell counts were increased in patients with NAFLD (n=34) vs. HC (n=8) and this was associated with disease severity. Hematopoietic cell marker cluster of differentiation (CD)45+ and Kupffer cell marker CD163+ were higher in NAFLD compared with HC, and those with an NAS ≥5 had higher levels of CD20+ cells, a marker of B cells, vs. a NAS of 0 or 1‑4. Additionally, from those patients (5 HC, 34 NAFLD), IM was measured. Specific immune cells in portal or lobular areas correlated with specific fecal IM, suggesting a potential association between IM and liver inflammation in patients with NAFLD. Specifically, Faecalibacterium prausnitzii was negatively correlated with CD45+ (r= ‑0.394; P=0.015) and CD163+ (r= ‑0.371; P=0.022) cells in the portal tract and Prevotella was negatively correlated with CD20+ (r= ‑0.353; P=0.028) cells in the liver lobule. Other taxa exhibited no correlation. In conclusion, the present study demonstrated a potential association between IM and liver inflammation in NAFLD.
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1 

Review Team; LaBrecque DR, Abbas Z, Anania F, Ferenci P, Khan AG, Goh KL, Hamid SS, Isakov V, Lizarzabal M, et al: World Gastroenterology Organisation global guidelines: Nonalcoholic fatty liver disease and nonalcoholic steatohepatitis. J Clin Gastroenterol. 48:467–473. 2014.PubMed/NCBI

2 

Zhu L, Baker SS, Gill C, Liu W, Alkhouri R, Baker RD and Gill SR: Characterization of gut microbiomes in nonalcoholic steatohepatitis (NASH) patients: A connection between endogenous alcohol and NASH. Hepatology. 57:601–609. 2013. View Article : Google Scholar

3 

Wong VW, Tse CH, Lam TT, Wong GL, Chim AM, Chu WC, Yeung DK, Law PT, Kwan HS, Yu J, et al: Molecular characterization of the fecal microbiota in patients with nonalcoholic steatohepatitis-a longitudinal study. PLoS One. 8:e628852013. View Article : Google Scholar

4 

Spencer MD, Hamp TJ, Reid RW, Fischer LM, Zeisel SH and Fodor AA: Association between composition of the human gastrointestinal microbiome and development of fatty liver with choline deficiency. Gastroenterology. 140:976–986. 2011. View Article : Google Scholar :

5 

Raman M, Ahmed I, Gillevet PM, Probert CS, Ratcliffe NM, Smith S, Greenwood R, Sikaroodi M, Lam V, Crotty P, et al: Fecal microbiome and volatile organic compound metabolome in obese humans with nonalcoholic fatty liver disease. Clin Gastroenterol Hepatol. 11:868–875. e1–e3. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Mouzaki M, Comelli EM, Arendt BM, Bonengel J, Fung SK, Fischer SE, McGilvray ID and Allard JP: Intestinal microbiota in patients with nonalcoholic fatty liver disease. Hepatology. 58:120–127. 2013. View Article : Google Scholar : PubMed/NCBI

7 

Nobili V, Cutrera R, Liccardo D, Pavone M, Devito R, Giorgio V, Verrillo E, Baviera G and Musso G: Obstructive sleep apnea syndrome affects liver histology and inflammatory cell activation in pediatric nonalcoholic fatty liver disease, regardless of obesity/insulin resistance. Am J Respir Crit Care Med. 189:66–76. 2014.

8 

Gadd VL, Skoien R, Powell EE, Fagan KJ, Winterford C, Horsfall L, Irvine K and Clouston AD: The portal inflammatory infiltrate and ductular reaction in human nonalcoholic fatty liver disease. Hepatology. 59:1393–1405. 2014. View Article : Google Scholar

9 

De Vito R, Alisi A, Masotti A, Ceccarelli S, Panera N, Citti A, Salata M, Valenti L, Feldstein AE and Nobili V: Markers of activated inflammatory cells correlate with severity of liver damage in children with nonalcoholic fatty liver disease. Int J Mol Med. 30:49–56. 2012.PubMed/NCBI

10 

Torlakovic EE, Naresh K, Kremer M, van der Walt J, Hyjek E and Porwit A: Call for a European programme in external quality assurance for bone marrow immunohistochemistry; report of a European Bone Marrow Working Group pilot study. J Clin Pathol. 62:547–551. 2009. View Article : Google Scholar : PubMed/NCBI

11 

Arrese M, Cabrera D, Kalergis AM and Feldstein AE: Innate immunity and inflammation in NAFLD/NASH. Dig Dis Sci. 61:1294–1303. 2016. View Article : Google Scholar : PubMed/NCBI

12 

Caldeira PC, Oliveira e Silva KR, Vidigal PV, Grossmann Sde M and do Carmo MA: Inflammatory cells in minor salivary glands of patients with chronic hepatitis C: Immunophenotype, pattern of distribution, and comparison with liver samples. Hum Immunol. 75:422–427. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Jiang W, Wu N, Wang X, Chi Y, Zhang Y, Qiu X, Hu Y, Li J and Liu Y: Dysbiosis gut microbiota associated with inflammation and impaired mucosal immune function in intestine of humans with non-alcoholic fatty liver disease. Sci Rep. 5:80962015. View Article : Google Scholar : PubMed/NCBI

14 

Kudo H, Takahara T, Yata Y, Kawai K, Zhang W and Sugiyama T: Lipopolysaccharide triggered TNF-alpha-induced hepatocyte apoptosis in a murine non-alcoholic steatohepatitis model. J Hepatol. 51:168–175. 2009. View Article : Google Scholar : PubMed/NCBI

15 

Thuy S, Ladurner R, Volynets V, Wagner S, Strahl S, Königsrainer A, Maier KP, Bischoff SC and Bergheim I: Nonalcoholic fatty liver disease in humans is associated with increased plasma endotoxin and plasminogen activator inhibitor 1 concentrations and with fructose intake. The J Nutr. 138:1452–1455. 2008. View Article : Google Scholar : PubMed/NCBI

16 

Alisi A, Manco M, Devito R, Piemonte F and Nobili V: Endotoxin and plasminogen activator inhibitor-1 serum levels associated with nonalcoholic steatohepatitis in children. J Pediatr Gastroenterol Nutr. 50:645–649. 2010. View Article : Google Scholar : PubMed/NCBI

17 

Ganz M and Szabo G: Immune and inflammatory pathways in NASH. Hepatol Int. 7(Suppl 2): S771–S781. 2013. View Article : Google Scholar

18 

Aron-Wisnewsky J, Gaborit B, Dutour A and Clement K: Gut microbiota and non-alcoholic fatty liver disease: New insights. Clin Microbiol Infect. 19:338–348. 2013. View Article : Google Scholar : PubMed/NCBI

19 

Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF and Turner RC: Homeostasis model assessment: Insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 28:412–419. 1985. View Article : Google Scholar : PubMed/NCBI

20 

Brunt EM, Janney CG, Di Bisceglie AM, Neuschwander-Tetri BA and Bacon BR: Nonalcoholic steatohepatitis: A proposal for grading and staging the histological lesions. Am J Gastroenterol. 94:2467–2474. 1999. View Article : Google Scholar : PubMed/NCBI

21 

Brunt EM, Kleiner DE, Wilson LA and Belt P: Nonalcoholic fatty liver disease (NAFLD) activity score and the histopathologic diagnosis in NAFLD: Distinct clinico-pathologic meanings. Hepatology. 53:810–820. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Qin J, Li R, Raes J, Arumugam M, Burgdorf KS, Manichanh C, Nielsen T, Pons N, Levenez F, Yamada T, et al: A human gut microbial gene catalogue established by metagenomic sequencing. Nature. 464:59–65. 2010. View Article : Google Scholar : PubMed/NCBI

23 

Furet JP, Firmesse O, Gourmelon M, Bridonneau C, Tap J, Mondot S, Doré J and Corthier G: Comparative assessment of human and farm animal faecal microbiota using real-time quantitative PCR. FEMS Microbiol Ecol. 68:351–362. 2009. View Article : Google Scholar : PubMed/NCBI

24 

Mariat D, Firmesse O, Levenez F, Guimarăes V, Sokol H, Doré J, Corthier G and Furet JP: The Firmicutes/Bacteroidetes ratio of the human microbiota changes with age. BMC Microbiol. 9:1232009. View Article : Google Scholar : PubMed/NCBI

25 

Da Silva HE, Teterina A, Comelli EM, Taibi A, Arendt BM, Fischer SE, Lou W and Allard JP: Nonalcoholic fatty liver disease is associated with dysbiosis independent of body mass index and insulin resistance. Sci Rep. 8:14662018. View Article : Google Scholar : PubMed/NCBI

26 

Boursier J, Mueller O, Barret M, Machado M, Fizanne L, Araujo-Perez F, Guy CD, Seed PC, Rawls JF, David LA, et al: The severity of nonalcoholic fatty liver disease is associated with gut dysbiosis and shift in the metabolic function of the gut microbiota. Hepatology. 63:764–775. 2016. View Article : Google Scholar :

27 

Adler M, Taylor S, Okebugwu K, Yee H, Fielding C, Fielding G and Poles M: Intrahepatic natural killer T cell populations are increased in human hepatic steatosis. World J Gastroenterol. 17:1725–1731. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Tajiri K, Shimizu Y, Tsuneyama K and Sugiyama T: Role of liver-infiltrating CD3+CD56+ natural killer T cells in the pathogenesis of nonalcoholic fatty liver disease. Eur J Gastroenterol Hepatol. 21:673–680. 2009. View Article : Google Scholar : PubMed/NCBI

29 

Lotowska JM, Sobaniec-Lotowska ME and Lebensztejn DM: The role of Kupffer cells in the morphogenesis of nonalcoholic steatohepatitis-ultrastructural findings. The first report in pediatric patients. Scand J Gastroenterol. 48:352–357. 2013. View Article : Google Scholar

30 

Kazankov K, Tordjman J, Møller HJ, Vilstrup H, Poitou C, Bedossa P, Bouillot JL, Clement K and Grønbaek H: Macrophage activation marker soluble CD163 and non-alcoholic fatty liver disease in morbidly obese patients undergoing bariatric surgery. J Gastroenterol Hepatol. 30:1293–1300. 2015. View Article : Google Scholar : PubMed/NCBI

31 

Cani PD and Delzenne NM: The role of the gut microbiota in energy metabolism and metabolic disease. Curr Pharm Des. 15:1546–1558. 2009. View Article : Google Scholar : PubMed/NCBI

32 

Miquel S, Martín R, Rossi O, Bermúdez-Humarán LG, Chatel JM, Sokol H, Thomas M, Wells JM and Langella P: Faecalibacterium prausnitzii and human intestinal health. Curr Opin Microbiol. 16:255–261. 2013. View Article : Google Scholar : PubMed/NCBI

33 

Zhang M, Qiu X, Zhang H, Yang X, Hong N, Yang Y, Chen H and Yu C: Faecalibacterium prausnitzii inhibits interleukin-17 to ameliorate colorectal colitis in rats. PLoS One. 9:e1091462014. View Article : Google Scholar : PubMed/NCBI

34 

Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermúdez-Humarán LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, et al: Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA. 105:16731–16736. 2008. View Article : Google Scholar : PubMed/NCBI

35 

Mattace Raso G, Simeoli R, Russo R, Iacono A, Santoro A, Paciello O, Ferrante MC, Canani RB, Calignano A and Meli R: Effects of sodium butyrate and its synthetic amide derivative on liver inflammation and glucose tolerance in an animal model of steatosis induced by high fat diet. PLoS One. 8:e686262013. View Article : Google Scholar : PubMed/NCBI

36 

Kles KA and Chang EB: Short-chain fatty acids impact on intestinal adaptation, inflammation, carcinoma, and failure. Gastroenterology. 130(Suppl 1): S100–S105. 2006. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Schwenger KJ, Chen L, Chelliah A, Da Silva HE, Teterina A, Comelli EM, Taibi A, Arendt BM, Fischer S, Allard JP, Allard JP, et al: Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease. Int J Mol Med 42: 2229-2237, 2018.
APA
Schwenger, K.J., Chen, L., Chelliah, A., Da Silva, H.E., Teterina, A., Comelli, E.M. ... Allard, J.P. (2018). Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease. International Journal of Molecular Medicine, 42, 2229-2237. https://doi.org/10.3892/ijmm.2018.3800
MLA
Schwenger, K. J., Chen, L., Chelliah, A., Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S., Allard, J. P."Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease". International Journal of Molecular Medicine 42.4 (2018): 2229-2237.
Chicago
Schwenger, K. J., Chen, L., Chelliah, A., Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S., Allard, J. P."Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease". International Journal of Molecular Medicine 42, no. 4 (2018): 2229-2237. https://doi.org/10.3892/ijmm.2018.3800
Copy and paste a formatted citation
x
Spandidos Publications style
Schwenger KJ, Chen L, Chelliah A, Da Silva HE, Teterina A, Comelli EM, Taibi A, Arendt BM, Fischer S, Allard JP, Allard JP, et al: Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease. Int J Mol Med 42: 2229-2237, 2018.
APA
Schwenger, K.J., Chen, L., Chelliah, A., Da Silva, H.E., Teterina, A., Comelli, E.M. ... Allard, J.P. (2018). Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease. International Journal of Molecular Medicine, 42, 2229-2237. https://doi.org/10.3892/ijmm.2018.3800
MLA
Schwenger, K. J., Chen, L., Chelliah, A., Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S., Allard, J. P."Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease". International Journal of Molecular Medicine 42.4 (2018): 2229-2237.
Chicago
Schwenger, K. J., Chen, L., Chelliah, A., Da Silva, H. E., Teterina, A., Comelli, E. M., Taibi, A., Arendt, B. M., Fischer, S., Allard, J. P."Markers of activated inflammatory cells are associated with disease severity and intestinal microbiota in adults with non‑alcoholic fatty liver disease". International Journal of Molecular Medicine 42, no. 4 (2018): 2229-2237. https://doi.org/10.3892/ijmm.2018.3800
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