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Article Open Access

A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells

Corrigendum in: /10.3892/ijmm.2024.5442
  • Authors:
    • Yao Xu
    • Ying Luo
    • Chen Liang
    • Weibing Xing
    • Tongcun Zhang
  • View Affiliations / Copyright

    Affiliations: Institute of Biology and Medicine, Wuhan University of Science and Technology, Wuhan, Hubei 430065, P.R. China
    Copyright: © Xu et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2459-2468
    |
    Published online on: August 9, 2018
       https://doi.org/10.3892/ijmm.2018.3816
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Abstract

As a strong transactivator of promoters containing CarG boxes, myocardin‑related transcription factor A (MRTF‑A) is critical for the process of metastasis in tumor cells. Nuclear factor erythroid 2‑like 1 (Nrf1) is well known as an important regulator of oxidative stress, which exists in multiple splicing forms with many unknown functions. The present study demonstrated a novel regulation loop between Nrf1α (the longest splicing form of Nrf1) and MRTF‑A that regulated the migration and invasion of breast cancer MDA‑MB‑231 cells. The underlying mechanism of this regulation look was further investigated. In particular, Nrf1α inhibited migration and invasion of breast cancer cells through inhibiting the expression of MRTF‑A via miR‑219. The current results revealed that miR‑219 could bind to the MRTF‑A 3'‑UTR to directly regulate its expression. However, MRTF‑A could reverse activate the Nrf1α expression through binding to the CarG box in the Nrf1α promoter. It can be speculated that this regulation loop may be a homeostasis mechanism in cells against tumorigenesis.
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Copy and paste a formatted citation
Spandidos Publications style
Xu Y, Luo Y, Liang C, Xing W and Zhang T: A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442. Int J Mol Med 42: 2459-2468, 2018.
APA
Xu, Y., Luo, Y., Liang, C., Xing, W., & Zhang, T. (2018). A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442. International Journal of Molecular Medicine, 42, 2459-2468. https://doi.org/10.3892/ijmm.2018.3816
MLA
Xu, Y., Luo, Y., Liang, C., Xing, W., Zhang, T."A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442". International Journal of Molecular Medicine 42.5 (2018): 2459-2468.
Chicago
Xu, Y., Luo, Y., Liang, C., Xing, W., Zhang, T."A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442". International Journal of Molecular Medicine 42, no. 5 (2018): 2459-2468. https://doi.org/10.3892/ijmm.2018.3816
Copy and paste a formatted citation
x
Spandidos Publications style
Xu Y, Luo Y, Liang C, Xing W and Zhang T: A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442. Int J Mol Med 42: 2459-2468, 2018.
APA
Xu, Y., Luo, Y., Liang, C., Xing, W., & Zhang, T. (2018). A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442. International Journal of Molecular Medicine, 42, 2459-2468. https://doi.org/10.3892/ijmm.2018.3816
MLA
Xu, Y., Luo, Y., Liang, C., Xing, W., Zhang, T."A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442". International Journal of Molecular Medicine 42.5 (2018): 2459-2468.
Chicago
Xu, Y., Luo, Y., Liang, C., Xing, W., Zhang, T."A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442". International Journal of Molecular Medicine 42, no. 5 (2018): 2459-2468. https://doi.org/10.3892/ijmm.2018.3816
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