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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2018 Volume 42 Issue 5

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway

Ruixing Liu, Xiaoming Yan
Pages: 2315-2328
Published online on: 10 August 2018

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Article Open Access

Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A

Ruiyi Yang, Lu Wang, Jie Xie, Xiang Li, Shan Liu, Shengxiang Qiu, Yingjie Hu, Xiaoling Shen
Pages: 2329-2342
Published online on: 23 August 2018

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Article Open Access

ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple-negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Pages: 2343-2352
Published online on: 27 August 2018

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Article Open Access

Comprehensive literature data-mining analysis reveals a broad genetic network functionally associated with autism spectrum disorder

Cheng Xu, Hongbao Cao, Fuquan Zhang, Chris Cheadle
Pages: 2353-2362
Published online on: 28 August 2018

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Article Open Access

Microarray analysis of miRNAs during hindgut development in rat embryos with ethylenethiourea‑induced anorectal malformations

Cai‑Yun Long, Xiao‑Bing Tang, Wei‑Lin Wang, Zheng‑Wei Yuan, Yu‑Zuo Bai
Pages: 2363-2372
Published online on: 07 August 2018

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Article Open Access

Upregulated EFNB2 and EPHB4 promotes lung development in a nitrofen-induced congenital diaphragmatic hernia rat model

Hao Liu, Xue Li, Wen Qian Yu, Cai Xia Liu
Pages: 2373-2382
Published online on: 14 August 2018

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Article Open Access

miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR

Xiaofang Sui, Shuqian Yu, Lin Dou, Xiehui Chen, Xuejie Li, Jun Yang, Yanan Su, Shuyue Wang, Fengling Wang, Jian Li
Pages: 2383-2392
Published online on: 10 August 2018

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Article Open Access

An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome‑protamine-DNA-siRNA complex with cell permeable peptides

Xin Wang, Xueping Wang, Jin Sun, Shiou Fu
Pages: 2393-2402
Published online on: 08 August 2018

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Article Open Access

Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095

Chanchan Chen, Jianying Zhang, Junqi Ling, Yu Du, Yuluan Hou
Pages: 2403-2414
Published online on: 14 August 2018

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Article Open Access

Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease

Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Pages: 2415-2436
Published online on: 04 September 2018

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Article Open Access

miR‑760 mediates hypoxia-induced proliferation and apoptosis of human pulmonary artery smooth muscle cells via targeting TLR4 Retraction in /10.3892/ijmm.2025.5642

Yu‑Zhong Yang, Yun‑Feng Zhang, Lei Yang, Jing Xu, Xu‑Ming Mo, Wei Peng
Pages: 2437-2446
Published online on: 07 September 2018

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Article Open Access

Sulforaphane regulates apoptosis- and proliferation‑related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer Retraction in /10.3892/ijmm.2024.5367

Shi‑Feng Kan, Jian Wang, Guan‑Xing Sun
Pages: 2447-2458
Published online on: 06 September 2018

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Article Open Access

A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442

Yao Xu, Ying Luo, Chen Liang, Weibing Xing, Tongcun Zhang
Pages: 2459-2468
Published online on: 09 August 2018

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Article Open Access

Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin Retraction in /10.3892/ijmm.2024.5345

Hua Yan, Bing‑Mei Sun, Yu‑Ying Zhang, Yu‑Juan Li, Cheng‑Xiang Huang, Fu‑Zhong Feng, Cui Li
Pages: 2469-2480
Published online on: 04 September 2018

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Article Open Access

The effect of curcumin on the differentiation, apoptosis and cell cycle of neural stem cells is mediated through inhibiting autophagy by the modulation of Atg7 and p62

Jun‑Ling Wang, Jian‑Jun Wang, Zhen‑Nao Cai, Chao‑Jin Xu
Pages: 2481-2488
Published online on: 29 August 2018

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Article Open Access

Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches

Wen‑Hsien Lee, Ming‑Ju Tsai, Wei‑An Chang, Ling‑Yu Wu, Han‑Ying Wang, Kuo‑Feng Chang, Ho‑Ming Su, Po‑Lin Kuo
Pages: 2489-2502
Published online on: 31 August 2018

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Article Open Access

MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression

Ancheng Qin, Weifeng Qian
Pages: 2503-2514
Published online on: 07 September 2018

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Article Open Access

Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses

Han Yu, Yunzhou Li, Zongying Xu, Dingnan Wang, Shaohua Shi, Huifang Deng, Baihui Zeng, Zhili Zheng, Lili Sun, Xiulan Deng, Xianggen Zhong
Pages: 2515-2526
Published online on: 05 September 2018

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Article Open Access

MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression

Xukeng Guo, Minghua Cheng, Weiqi Ke, Yuting Wang, Xuan Ji
Pages: 2527-2537
Published online on: 08 August 2018

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Article Open Access

Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration Retraction in /10.3892/ijmm.2025.5672

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Pages: 2538-2550
Published online on: 07 August 2018

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Article Open Access

Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK

Seulki Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Jeong‑Hoon Lee, Jung‑Hwan Yoon, Yoon Jun Kim
Pages: 2551-2559
Published online on: 03 August 2018

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Article Open Access

miR‑204‑5p inhibits the occurrence and development of osteoarthritis by targeting Runx2

Jiaqing Cao, Xinyou Han, Xin Qi, Xiangyun Jin, Xiaolin Li
Pages: 2560-2568
Published online on: 07 August 2018

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Article Open Access

Anti‑apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro

Dong‑Ho Bak, Jungtae Na, Mi Ji Choi, Byung Chul Lee, Chang Taek Oh, Jeom‑Yong Kim, Hae Jung Han, Moo Joong Kim, Tae Ho Kim, Beom Joon Kim
Pages: 2569-2583
Published online on: 17 August 2018

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Article Open Access

TREK‑TRAAK two‑pore domain potassium channels protect human retinal pigment epithelium cells from oxidative stress

Hao Huang, Han Li, Kangpei Shi, Lei Wang, Xiaotong Zhang, Xiaobo Zhu
Pages: 2584-2594
Published online on: 08 August 2018

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Article Open Access

Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis

Toshiyuki Tsunoda, Keiko Doi, Shuhei Ishikura, Hao Luo, Kensuke Nishi, Hiroshi Matsuzaki, Midori Koyanagi, Yoko Tanaka, Tadashi Okamura, Senji Shirasawa
Pages: 2595-2603
Published online on: 03 August 2018

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Article Open Access

Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes

Jian Wang, Xiang Wang, Yun Cao, Tao Huang, Deng‑Xin Song, Hai‑Rong Tao
Pages: 2604-2614
Published online on: 09 August 2018

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Article Open Access

Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway

Aonan Li, Ke Gu, Qi Wang, Xiyan Chen, Xucheng Fu, Ying Wang, Yong Wen
Pages: 2615-2627
Published online on: 09 August 2018

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Article Open Access

Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model

Rui Lin, Jialin Duan, Fei Mu, Haixu Bian, Meina Zhao, Min Zhou, Yao Li, Aidong Wen, Yong Yang, Miaomiao Xi
Pages: 2628-2640
Published online on: 27 August 2018

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Article Open Access

Transcriptome and methylome profiling in a rat model of irritable bowel syndrome induced by stress

Shengtao Zhu, Li Min, Qingdong Guo, Hengcun Li, Yang Yu, Ye Zong, Liyong Wang, Peng Li, Junchao Gu, Shutian Zhang
Pages: 2641-2649
Published online on: 14 August 2018

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Article Open Access

Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches

Xia Yang, Yun Deng, Rong‑Quan He, Xiao‑Jiao Li, Jie Ma, Gang Chen, Xiao‑Hua Hu
Pages: 2650-2664
Published online on: 14 August 2018

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Article Open Access

Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd

Nuramina Mamat, Xue Ying Lu, Maidina Kabas, Haji Akber Aisa
Pages: 2665-2675
Published online on: 06 September 2018

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Article Open Access

Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells

Huiling Mei, Yu Xiang, Heng Mei, Bin Fang, Qiuguo Wang, Dedong Cao, Yu Hu, Tao Guo
Pages: 2676-2688
Published online on: 05 September 2018

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Article Open Access

Sequence analysis of the Pre-S gene in chronic asymptomatic HBV carriers with low-level HBsAg Corrigendum in /10.3892/ijmm.2019.4055

Tong Wang, Yuzhu Dai, Meng Zhang, Dawei Cui, Xujian Xu, Changgui Sun, Jun Cheng
Pages: 2689-2699
Published online on: 17 August 2018

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Article Open Access

α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation

Dongsheng Li, Hongzhi Sun, Guang Bai, Wei Wang, Miaomiao Liu, Zhiye Bao, Jingjing Li, Hao Liu
Pages: 2700-2708
Published online on: 31 August 2018

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Article Open Access

Opening of mitoKATP improves cardiac function and inhibits apoptosis via the AKT-Foxo1 signaling pathway in diabetic cardiomyopathy

Peng Duan, Jinxin Wang, Yang Li, Shiqiang Wei, Feng Su, Sanlin Zhang, Yuhui Duan, Lin Wang, Qinglei Zhu
Pages: 2709-2719
Published online on: 21 August 2018

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Article Open Access

An impaired hepatic clock system effects lipid metabolism in rats with nephropathy

Peipei Chen, Ruiyu Zhang, Lijun Mou, Xuewang Li, Yan Qin, Xuemei Li
Pages: 2720-2736
Published online on: 22 August 2018

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Article Open Access

Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells

Yuanyi Xu, Xiaofei Wang, Yunning Huang, Yanmei Ma, Xiu Jin, Honghong Wang, Juan Wang
Pages: 2737-2749
Published online on: 04 September 2018

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Article Open Access

GPR17 mediates ischemia-like neuronal injury via microglial activation

Bing Zhao, Hao Wang, Cai‑Xia Li, Sheng‑Wen Song, San‑Hua Fang, Er‑Qing Wei, Qiao‑Juan Shi
Pages: 2750-2762
Published online on: 29 August 2018

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Article Open Access

3,5-Di-C-β-D-glucopyranosyl phloroacetophenone, a major component of Melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse model: Potential therapeutics for rheumatoid arthritis

Hyun Jong Kim, Ji Hyun Choi, Jung‑Hwan Hwang, Kyong‑Shim Kim, Jung‑Ran Noh, Dong‑Hee Choi, Sung Je Moon, Hyun‑Yong Kim, Sang‑Woo Kim, Sangho Choi, Sang Mi Eum, Tran The Bach, Jaerang Rho, Ju Yong Lee, Jung Geun Park, Sei‑Ryang Oh, Chul‑Ho Lee, Won Keun Oh, Yong‑Hoon Kim
Pages: 2763-2775
Published online on: 30 August 2018

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Article Open Access

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation

Wen Yan, Chunge Zheng, Jiayang He, Wenjie Zhang, Xin‑An Huang, Xiong Li, Yutao Wang, Xinhua Wang
Pages: 2776-2792
Published online on: 07 September 2018

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Article

Systematic analysis of hsa-miR-363 gene overexpression pattern in endometrial stromal cells

Wenqu Li, Xuemei Fan, Mi Zhang, Lei Huang, Shanshan Lv, Luyu Wang, Ying Wu, Chencheng Dai, Juan Xu, Pengfei Xu, Ziyi Fu, Xuemei Jia, Xiaoyan Shi
Pages: 2793-2800
Published online on: 24 August 2018

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Article

Long noncoding RNA cancer susceptibility candidate 9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2

Baohong Jiang, Yuehua Li, Xiaofei Qu, Hongbo Zhu, Yeru Tan, Qun Fan, Yiling Jiang, Mingchu Liao, Xiaoping Wu
Pages: 2801-2810
Published online on: 07 August 2018

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Article

Inhibition of Cx43 attenuates ERK1/2 activation, enhances the expression of Cav‑1 and suppresses cell proliferation

Muhammad Arshad, Charlotte Conzelmann, Muhammad Assad Riaz, Thomas Noll, Dursun Gündüz
Pages: 2811-2818
Published online on: 16 August 2018

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Article

Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway

Xueyi Shen, Changmin Niu, Jiaqian Guo, Mengmeng Xia, Jing Xia, Yanqiu Hu, Ying Zheng
Pages: 2819-2830
Published online on: 14 August 2018

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Article

The differentiation of human MSCs derived from adipose and amniotic tissues into insulin-producing cells, induced by PEI@Fe3O4 nanoparticles-mediated NRSF and SHH silencing

Rui Wang, Dianbao Zhang, Tao Zhang, Feng Zhao, Hongxin Lang, Xuewen Lin, Xining Pang
Pages: 2831-2838
Published online on: 14 August 2018

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Article

Long non-coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β-catenin signalling pathway

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Pages: 2839-2848
Published online on: 10 August 2018

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Article

Macrophage migration inhibitory factor serves a pivotal role in the regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway

Yiwang Hu, Wenzheng Xia, Meng Hou
Pages: 2849-2858
Published online on: 23 August 2018

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Article

Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling

Novi Kusumaningrum, Dong Hun Lee, Hyun‑Sun Yoon, Chi‑Hyun Park, Jin Ho Chung
Pages: 2859-2866
Published online on: 24 August 2018

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Article

Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats

Bi‑Lei Wang, Hong Jin, Xi‑Qiong Han, Yang Xia, Nai‑Feng Liu
Pages: 2867-2880
Published online on: 24 August 2018

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Article

Thymosin β4 is associated with bone sialoprotein expression via ERK and Smad3 signaling pathways in MDPC-23 odontoblastic cells

Baik‑Dong Choi, Hee‑Jung Lim, Seung‑Yeon Lee, Myoung‑Hwa Lee, Ki‑Sung Kil, Do‑Seon Lim, Soon‑Jeong Jeong, Moon‑Jin Jeong
Pages: 2881-2890
Published online on: 07 September 2018

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Article

Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats Corrigendum in /10.3892/ijmm.2024.5362

Jiaxin Liu, Shuai Zhou, Yueting Zhang, Xiuying Li, Xiying Qian, Weihua Tao, Lide Jin, Jianhua Zhao
Pages: 2891-2902
Published online on: 05 September 2018

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Article

Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages

Rui Liu, Anliu Tang, Xiaoyan Wang, Xiong Chen, Lian Zhao, Zhiming Xiao, Shourong Shen
Pages: 2903-2913
Published online on: 17 August 2018

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Article

Cannabinoid receptor 2 agonist attenuates blood‑brain barrier damage in a rat model of intracerebral hemorrhage by activating the Rac1 pathway

Zhe Wang, Yongfu Li, Shuangyong Cai, Rui Li, Guanbo Cao
Pages: 2914-2922
Published online on: 22 August 2018

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Article

Jam3 promotes migration and suppresses apoptosis of renal carcinoma cell lines

Xudong Li, Aiping Yin, Wenjing Zhang, Fei Zhao, Jia Lv, Jing Lv, Jiping Sun
Pages: 2923-2929
Published online on: 04 September 2018

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Article

Decreased human antigen R expression confers resistance to tyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression

Yunfeng Yao, Huili Chu, Jun Wang, Baocheng Wang
Pages: 2930-2942
Published online on: 22 August 2018

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Article

Downregulation of glucose-regulated protein 78 enhances the cytotoxic effects of curcumin on human nasopharyngeal carcinoma cells

Xiaoming Yu, Long Shi, Li Yan, Hui Wang, Yan Wen, Xiuping Zhang
Pages: 2943-2951
Published online on: 23 August 2018

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Article

The active participation of p22phox-214T/C in the formation of intracranial aneurysm and the suppressive potential of edaravone

Juntao Hu, Jie Luo, Hui Wang, Chaojia Wang, Rongpei Long, Anrong Li, Yi Zhou, Zhicheng Fang, Qianxue Chen
Pages: 2952-2960
Published online on: 28 August 2018

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Oral administration of Cervus nippon mantchuricus extract suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice and inflammatory effects in mast cells

Se Hyang Hong, Jin Mo Ku, Hyo In Kim, Sol Ji Lee, Ye Seul Lim, Hye Sook Seo, Yong Cheol Shin, Seong‑Gyu Ko
Pages: 2961-2971
Published online on: 05 September 2018

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[Corrigendum] Correlation between the expression of IL‑18 and deep venous thrombosis

Guangdi Li, Rudan Zhou, Xueling Zhao, Riguang Liu, Chuan Ye
Pages: 2972-2972
Published online on: 27 August 2018

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January-2026 Volume 57 Issue 1

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Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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FK506‑binding proteins as emerging bridges linking proteostasis to multi‑system pathogenesis and therapeutic strategies (Review)

Zhi Li, Xiaolei Liu, Hesong Zeng
Article Number: 30
Published online on: 24 November 2025

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[Retracted] Suppression of SIK1 by miR‑141 in human ovarian cancer cell lines and tissues

Jin-Long Chen, Fang Chen, Ting-Ting Zhang, Nai-Fu Liu
Article Number: 29
Published online on: 24 November 2025

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METTL3 inhibits LINC00312 to suppress osteoporosis progression in a YTHDF2‑dependent manner

Yang Wang, Yihao Tian, Gang Yao
Article Number: 28
Published online on: 20 November 2025

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Decoding structural birth defects through genomic landscapes: Innovative frameworks for diagnosis (Review)

Ruihao Xu, Haoming Ren, Zhengwei Yuan, Wanqi Huang, Hui Gu
Article Number: 27
Published online on: 20 November 2025

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MOTS‑c protects against placental injury via Nrf2 activation in hypoxia‑induced intrauterine growth restriction mice

Dan Chen, Hui-Min Zhao, Xiao-Lin Sun, Zhi-Xuan Xing, Sheng-Peng Li, Shuai-Chao Li, Ya-Xian Wu, Qing-Feng Pang, Jian-Feng Huang
Article Number: 26
Published online on: 18 November 2025

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Synergistic effects of Akebia saponin D and Semaglutide on diabetic nephropathy and osteoporosis via the Klotho‑p53 signaling axis

Qian Zhang, Dan Wang, Hongxia Jia, Zongji Zheng, Liyan Lin, Linna Li, Ling Wang, Yaoming Xue
Article Number: 25
Published online on: 18 November 2025

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[Retracted] MicroRNA‑103 modulates tumor progression by targeting KLF7 in non‑small cell lung cancer

Ke Li, Conghu Yuan
Article Number: 24
Published online on: 17 November 2025

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Comparative analysis of pan MHC‑I epitopes immunoreactivity on Hantaan virus nucleocapsid protein

Zhikui Li, Weijie Ding, Yubo Sun, Chenfeng Tian, Shuaishuai Fu, Fei Shi, Zhenchi Fang, Yuanzhe Li, Jianchang Li, Sirui Cai, Haobo Kang, Baozeng Sun, Junqi Zhang, Yuanjie Sun, Shuya Yang, Yusi Zhang, Chunmei Zhang, Yun Zhang, Xiyang Zhang, Kun Yang, Dongbo Jiang
Article Number: 23
Published online on: 14 November 2025

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Human papillomavirus E7 inhibits immune responses in keratinocytes by activating HTRA1‑mediated mitophagy

Boya Zhang, Defeng Kong, Siji Chen, Xuewu Sun, Hao Cheng
Article Number: 22
Published online on: 14 November 2025

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Targeting p38 MAPK signaling pathway: 
Quercetin as a novel therapy for TMJ synovitis

Mosha Cheng, Yuhe Guan, Xiaotao Xin, Xin Yi, Yi Liu
Article Number: 21
Published online on: 13 November 2025

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Lipid droplets in astrocytes: Key organelles for CNS homeostasis and disease (Review)

Yuchen Wang, Boxuan Wang, Jinchao Hou, Xiaodong Huo, Chenlin Liu, Ruili Guan, Honggang Chen, Yang Zhou, Jianbin Zhang, Congcong Zhuang, Yuankang Zou
Article Number: 20
Published online on: 13 November 2025

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Copper dyshomeostasis and cardiovascular disease: Molecular mechanisms and new strategies for targeted intervention with cuproptosis (Review)

Peiyu Li, Yinghui Li, Qian Meng, Jie Wang, Kun Wang, Sumin Yang
Article Number: 19
Published online on: 13 November 2025

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Elevated FTO alleviates sepsis‑induced acute kidney injury by regulating macrophage inflammatory phenotypes

Xiaona Chen, Ziqi Sun, Jiabo Chen, Jinquan Zhang, Zeyu Liu, Zhengzheng Yan, Quan Li, Zhixia Chen
Article Number: 18
Published online on: 12 November 2025

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[Corrigendum]  Suppression of PAX6 promotes cell proliferation and inhibits apoptosis in human retinoblastoma cells

Bo Meng, Yisong Wang, Bin Li
Article Number: 17
Published online on: 10 November 2025

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Microbial short chain fatty acids: Effective histone deacetylase inhibitors in immune regulation (Review)

Jing Wang, Qin Zhao, Shuwan Zhang, Jia Liu, Xingyue Fan, Bin Han, Yaqin Hou, Xiaopeng Ai
Article Number: 16
Published online on: 05 November 2025

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High‑fat diet and cognitive dysfunction: Mechanistic insights into diet‑induced neurodegeneration (Review)

Min You, Fan Wu, Feng Xiong, Xue-Fei Hu, Huan Wu, Li Zhou, Hong-Xing Zhang
Article Number: 15
Published online on: 05 November 2025

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ROCK inhibition promotes axon and myelin regeneration via PI3K/Akt/GSK3β in a mouse sciatic nerve injury model

Shuang Dou, Zhijun Li, Boyao Zheng, Zhenyu Ren, Hai Wang, Qing Zuo, Fang Fang, Yuehong Zhuang
Article Number: 14
Published online on: 05 November 2025

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Mechanisms of mTORC1 and GCN2 amino acid sensing pathways in tumorigenesis and metastatic progression (Review)

Chaowei Zhang, Yuxuan Han, Weiyi Yao, Qing Hong, Na Chen
Article Number: 13
Published online on: 04 November 2025

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β‑hydroxybutyric acid as a potential therapeutic metabolite for type 2 diabetes mellitus (Review)

Xianyi Ding, Jiabin Wu, Lian Wang, Ke Li, Haoyang Gao, Mingyu Wu, Qiuyu Zhang, Ruonan Han, Wenhong Wang, Weihua Xiao
Article Number: 12
Published online on: 03 November 2025

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Histone lactylation: Unveiling a novel pathway for the impact of lactate on physiological and pathological processes (Review)

Xunjie Jian, Chang Cheng, Wenjie Lu, Hui Peng, Diqi Yang
Article Number: 11
Published online on: 03 November 2025

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Interpretation of the molecular mechanism and therapeutic potential of microRNA‑155 in cardiovascular and cerebrovascular diseases (Review)

Xitong Zhao, Pengqin Wang
Article Number: 10
Published online on: 03 November 2025

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Expression of Concern Open Access

[Expression of Concern]  CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas

Yiyuan Chen, Zhenye Li, Qiuyue Fang, Hongyun Wang, Chuzhong Li, Hua Gao, Yazhuo Zhang
Article Number: 9
Published online on: 29 October 2025

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TWEAK modulates the characteristics of periodontal ligament stem cells via the Fn14/NF‑κB pathway

Linlin Xiao, Man Qu, Lulu Chen, Mingli Xiang, Qian Long, Jianguo Liu, Xiaoyan Guan, Chengcheng Liao
Article Number: 8
Published online on: 27 October 2025

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Harnessing copper: Innovative approaches to combat neurodegenerative diseases and cancer (Review)

Tao Duan, Hanhai Mao, Xingyue Jiang, Ying Tian, Jidong Zhang, Jun Tan
Article Number: 7
Published online on: 27 October 2025

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[Retracted] Effects of miR‑106b‑3p on cell proliferation and epithelial‑mesenchymal transition, and targeting of ZNRF3 in esophageal squamous cell carcinoma

Guanen Qiao, Chenguang Dai, Yang He, Junjie Shi, Chunfang Xu
Article Number: 6
Published online on: 27 October 2025

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Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review)

Yiming Shao, Ke Song, Ruixin Yu, He Xiao, Chengjun Li, Yuling Deng, Yuan Zhang, Yixing Ren
Article Number: 5
Published online on: 24 October 2025

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Exportin 1 inhibitor KPT‑330 reverses oxaliplatin resistance via p53 nuclear retention in colorectal cancer

Chuanxi Lai, Xiya Jia, Yiyi Chen, Kangke Chen, Fei Wang, Qiqi Zhang, Xiaonan Xiang, Zhe-Sheng Chen, Lingna Xu, Sheng Dai
Article Number: 4
Published online on: 23 October 2025

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Targeting of CIRP attenuates osteoarthritis progression via suppressing TLR4/NF‑κB/NLRP3 signaling axis

Weichao Sun, Yi Liao, Jianguo Feng, Jianhui Liang, Qifei He, Yinxing Cui, Dixi Huang, Houyin Shi, Wei You, Wei Sun, Qian Yi
Article Number: 3
Published online on: 23 October 2025

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Importance of B cells (Review)

Zhiyuan Liu, Haoran Dai, Xiaoyu Cui, Yeping Liu, Zhaocheng Dong
Article Number: 2
Published online on: 22 October 2025

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[Retracted] Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Article Number: 1
Published online on: 22 October 2025

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February-2026 Volume 57 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 13.2

CiteScore Rank: Q1: #23/348 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

FGF4 alleviates the lung cell damage caused by high glucose via AMPK‑PGC‑1 signaling axis in vitro and in vivo

Qiujuan Fu, Yongfang Ou, Qin Wu, Jue Gong, Feixia Li, Tuxing Wang, Zhitai Lin, Kejie Huang, Jianlong Xie
Article Number: 39
Published online on: 05 December 2025

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STOML2 interacts with PHB to activate the MEK/ERK signaling pathway and mediates autophagy‑related proteins in the progression of hepatocellular carcinoma

Haoyang Hu, Haozhe Zhang, Shuai Han, Jianli Chen, Ying Xie
Article Number: 38
Published online on: 04 December 2025

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HMGB1 mediates low-dose ionizing radiation-induced Wnt/β-catenin activation in SRA01/04 cells: Mechanistic clues to early cataractogenesis

Ping Wang, Chunnan Piao, Dong Yan, Yingxue He, Yaru Li, Li Fan, Mei Tian
Article Number: 37
Published online on: 04 December 2025

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FBXO22 promotes hepatocellular carcinoma progression via paracrine myo‑inositol‑induced M2‑type polarization of macrophages

Liangliang Bai, Jing Xiong, Sihai Chen, Jiahao Hu, Meixia Zhang, Bimin Li, Jing Hu, Mingyan He
Article Number: 36
Published online on: 02 December 2025

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Branched‑chain amino acid metabolism and bone metabolism: Implications for osteoporosis pathogenesis and therapeutic strategies (Review)

Qi Xiao, Haimin Zeng, Ruhui Yang, Yuxin Zhan, Fangzhen Lin, Bofan Chen, Xiang Chen
Article Number: 35
Published online on: 02 December 2025

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Mitochondria-associated endoplasmic reticulum membranes: Emerging regulators of cardiac microvascular ischemia/reperfusion injury (Review)

Yan Wang, Baowei Feng, Yanting Wu, Zongle Sun, Hao Yuan, Wei Chen, Chang Zhao, Zhi Liu
Article Number: 34
Published online on: 02 December 2025

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Role of matrix metalloproteinases in the invasion of glioblastoma and drug interventions (Review)

Bohao Zheng, Ying Han, Haiying Zhang
Article Number: 33
Published online on: 01 December 2025

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Bridging bench to bedside: Exosome‑based strategies for endometriosis diagnosis and treatment (Review)

Wanmeng Chen, Yujiu Ma, Xudong Zhang, Siwen Zhang, Shanshan Wu, Yimeng Lu, Jichun Tan
Article Number: 32
Published online on: 01 December 2025

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[Retracted] miR‑381 functions as a tumor suppressor by targeting ETS1 in pancreatic cancer

Guanen Qiao, Jing Li, Jun Wang, Zhaoyang Wang, Wei Bian
Article Number: 31
Published online on: 01 December 2025

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