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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
November-2018 Volume 42 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Sulforaphane protects rabbit corneas against oxidative stress injury in keratoconus through activation of the Nrf-2/HO-1 antioxidant pathway

Ruixing Liu, Xiaoming Yan
Pages: 2315-2328
Published online on: 10 August 2018

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Article Open Access

Treatment of type 2 diabetes mellitus via reversing insulin resistance and regulating lipid homeostasis in vitro and in vivo using cajanonic acid A

Ruiyi Yang, Lu Wang, Jie Xie, Xiang Li, Shan Liu, Shengxiang Qiu, Yingjie Hu, Xiaoling Shen
Pages: 2329-2342
Published online on: 23 August 2018

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Article Open Access

ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple-negative breast cancer cells Expression of Concern in /10.3892/ijmm.2026.5846

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Pages: 2343-2352
Published online on: 27 August 2018

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Article Open Access

Comprehensive literature data-mining analysis reveals a broad genetic network functionally associated with autism spectrum disorder

Cheng Xu, Hongbao Cao, Fuquan Zhang, Chris Cheadle
Pages: 2353-2362
Published online on: 28 August 2018

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Article Open Access

Microarray analysis of miRNAs during hindgut development in rat embryos with ethylenethiourea‑induced anorectal malformations

Cai‑Yun Long, Xiao‑Bing Tang, Wei‑Lin Wang, Zheng‑Wei Yuan, Yu‑Zuo Bai
Pages: 2363-2372
Published online on: 07 August 2018

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Article Open Access

Upregulated EFNB2 and EPHB4 promotes lung development in a nitrofen-induced congenital diaphragmatic hernia rat model

Hao Liu, Xue Li, Wen Qian Yu, Cai Xia Liu
Pages: 2373-2382
Published online on: 14 August 2018

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Article Open Access

miR-291b-3p mediated ROS-induced endothelial cell dysfunction by targeting HUR

Xiaofang Sui, Shuqian Yu, Lin Dou, Xiehui Chen, Xuejie Li, Jun Yang, Yanan Su, Shuyue Wang, Fengling Wang, Jian Li
Pages: 2383-2392
Published online on: 10 August 2018

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Article Open Access

An enhanced RRM2 siRNA delivery to rheumatoid arthritis fibroblast-like synoviocytes through a liposome‑protamine-DNA-siRNA complex with cell permeable peptides

Xin Wang, Xueping Wang, Jin Sun, Shiou Fu
Pages: 2393-2402
Published online on: 08 August 2018

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Article Open Access

Nkd2 promotes the differentiation of dental follicle stem/progenitor cells into osteoblasts Corrigendum in /10.3892/ijmm.2019.4095

Chanchan Chen, Jianying Zhang, Junqi Ling, Yu Du, Yuluan Hou
Pages: 2403-2414
Published online on: 14 August 2018

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Article Open Access

Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease

Yoshiji Yamada, Kimihiko Kato, Mitsutoshi Oguri, Hideki Horibe, Tetsuo Fujimaki, Yoshiki Yasukochi, Ichiro Takeuchi, Jun Sakuma
Pages: 2415-2436
Published online on: 04 September 2018

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Article Open Access

miR‑760 mediates hypoxia-induced proliferation and apoptosis of human pulmonary artery smooth muscle cells via targeting TLR4 Retraction in /10.3892/ijmm.2025.5642

Yu‑Zhong Yang, Yun‑Feng Zhang, Lei Yang, Jing Xu, Xu‑Ming Mo, Wei Peng
Pages: 2437-2446
Published online on: 07 September 2018

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Article Open Access

Sulforaphane regulates apoptosis- and proliferation‑related signaling pathways and synergizes with cisplatin to suppress human ovarian cancer Retraction in /10.3892/ijmm.2024.5367

Shi‑Feng Kan, Jian Wang, Guan‑Xing Sun
Pages: 2447-2458
Published online on: 06 September 2018

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Article Open Access

A regulation loop between Nrf1α and MRTF-A controls migration and invasion in MDA-MB-231 breast cancer cells Corrigendum in /10.3892/ijmm.2024.5442

Yao Xu, Ying Luo, Chen Liang, Weibing Xing, Tongcun Zhang
Pages: 2459-2468
Published online on: 09 August 2018

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Article Open Access

Upregulation of miR-183-5p is responsible for the promotion of apoptosis and inhibition of the epithelial-mesenchymal transition, proliferation, invasion and migration of human endometrial cancer cells by downregulating Ezrin Retraction in /10.3892/ijmm.2024.5345

Hua Yan, Bing‑Mei Sun, Yu‑Ying Zhang, Yu‑Juan Li, Cheng‑Xiang Huang, Fu‑Zhong Feng, Cui Li
Pages: 2469-2480
Published online on: 04 September 2018

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Article Open Access

The effect of curcumin on the differentiation, apoptosis and cell cycle of neural stem cells is mediated through inhibiting autophagy by the modulation of Atg7 and p62

Jun‑Ling Wang, Jian‑Jun Wang, Zhen‑Nao Cai, Chao‑Jin Xu
Pages: 2481-2488
Published online on: 29 August 2018

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Article Open Access

Deduction of novel genes potentially involved in hypoxic AC16 human cardiomyocytes using next-generation sequencing and bioinformatics approaches

Wen‑Hsien Lee, Ming‑Ju Tsai, Wei‑An Chang, Ling‑Yu Wu, Han‑Ying Wang, Kuo‑Feng Chang, Ho‑Ming Su, Po‑Lin Kuo
Pages: 2489-2502
Published online on: 31 August 2018

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Article Open Access

MicroRNA-7 inhibits colorectal cancer cell proliferation, migration and invasion via TYRO3 and phosphoinositide 3-kinase/protein B kinase/mammalian target of rapamycin pathway suppression

Ancheng Qin, Weifeng Qian
Pages: 2503-2514
Published online on: 07 September 2018

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Article Open Access

Identification of potential biomarkers in cholestasis and the therapeutic effect of melatonin by metabolomics, multivariate data and pathway analyses

Han Yu, Yunzhou Li, Zongying Xu, Dingnan Wang, Shaohua Shi, Huifang Deng, Baihui Zeng, Zhili Zheng, Lili Sun, Xiulan Deng, Xianggen Zhong
Pages: 2515-2526
Published online on: 05 September 2018

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Article Open Access

MicroRNA‑214 suppresses propofol‑induced neuroapoptosis through activation of phosphoinositide 3‑kinase/protein kinase B signaling by targeting phosphatase and tensin homolog expression

Xukeng Guo, Minghua Cheng, Weiqi Ke, Yuting Wang, Xuan Ji
Pages: 2527-2537
Published online on: 08 August 2018

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Article Open Access

Hypoxic preconditioned bone mesenchymal stem cells ameliorate spinal cord injury in rats via improved survival and migration Retraction in /10.3892/ijmm.2025.5672

Weiheng Wang, Xiaodong Huang, Wenbo Lin, Yuanyuan Qiu, Yunfei He, Jiangming Yu, Yanhai Xi, Xiaojian Ye
Pages: 2538-2550
Published online on: 07 August 2018

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Article Open Access

Synergistic effect of ursodeoxycholic acid on the antitumor activity of sorafenib in hepatocellular carcinoma cells via modulation of STAT3 and ERK

Seulki Lee, Young Youn Cho, Eun Ju Cho, Su Jong Yu, Jeong‑Hoon Lee, Jung‑Hwan Yoon, Yoon Jun Kim
Pages: 2551-2559
Published online on: 03 August 2018

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Article Open Access

miR‑204‑5p inhibits the occurrence and development of osteoarthritis by targeting Runx2

Jiaqing Cao, Xinyou Han, Xin Qi, Xiangyun Jin, Xiaolin Li
Pages: 2560-2568
Published online on: 07 August 2018

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Article Open Access

Anti‑apoptotic effects of human placental hydrolysate against hepatocyte toxicity in vivo and in vitro

Dong‑Ho Bak, Jungtae Na, Mi Ji Choi, Byung Chul Lee, Chang Taek Oh, Jeom‑Yong Kim, Hae Jung Han, Moo Joong Kim, Tae Ho Kim, Beom Joon Kim
Pages: 2569-2583
Published online on: 17 August 2018

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Article Open Access

TREK‑TRAAK two‑pore domain potassium channels protect human retinal pigment epithelium cells from oxidative stress

Hao Huang, Han Li, Kangpei Shi, Lei Wang, Xiaotong Zhang, Xiaobo Zhu
Pages: 2584-2594
Published online on: 08 August 2018

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Article Open Access

Zfat expression in ZsGreen reporter gene knock‑in mice: Implications for a novel function of Zfat in definitive erythropoiesis

Toshiyuki Tsunoda, Keiko Doi, Shuhei Ishikura, Hao Luo, Kensuke Nishi, Hiroshi Matsuzaki, Midori Koyanagi, Yoko Tanaka, Tadashi Okamura, Senji Shirasawa
Pages: 2595-2603
Published online on: 03 August 2018

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Article Open Access

Therapeutic potential of hyaluronic acid/chitosan nanoparticles for the delivery of curcuminoid in knee osteoarthritis and an in vitro evaluation in chondrocytes

Jian Wang, Xiang Wang, Yun Cao, Tao Huang, Deng‑Xin Song, Hai‑Rong Tao
Pages: 2604-2614
Published online on: 09 August 2018

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Article Open Access

Epigallocatechin-3-gallate affects the proliferation, apoptosis, migration and invasion of tongue squamous cell carcinoma through the hippo-TAZ signaling pathway

Aonan Li, Ke Gu, Qi Wang, Xiyan Chen, Xucheng Fu, Ying Wang, Yong Wen
Pages: 2615-2627
Published online on: 09 August 2018

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Article Open Access

Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model

Rui Lin, Jialin Duan, Fei Mu, Haixu Bian, Meina Zhao, Min Zhou, Yao Li, Aidong Wen, Yong Yang, Miaomiao Xi
Pages: 2628-2640
Published online on: 27 August 2018

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Article Open Access

Transcriptome and methylome profiling in a rat model of irritable bowel syndrome induced by stress

Shengtao Zhu, Li Min, Qingdong Guo, Hengcun Li, Yang Yu, Ye Zong, Liyong Wang, Peng Li, Junchao Gu, Shutian Zhang
Pages: 2641-2649
Published online on: 14 August 2018

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Article Open Access

Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches

Xia Yang, Yun Deng, Rong‑Quan He, Xiao‑Jiao Li, Jie Ma, Gang Chen, Xiao‑Hua Hu
Pages: 2650-2664
Published online on: 14 August 2018

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Article Open Access

Potential anti-vitiligo properties of cynarine extracted from Vernonia anthelmintica (L.) Willd

Nuramina Mamat, Xue Ying Lu, Maidina Kabas, Haji Akber Aisa
Pages: 2665-2675
Published online on: 06 September 2018

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Article Open Access

Pterostilbene inhibits nutrient metabolism and induces apoptosis through AMPK activation in multiple myeloma cells

Huiling Mei, Yu Xiang, Heng Mei, Bin Fang, Qiuguo Wang, Dedong Cao, Yu Hu, Tao Guo
Pages: 2676-2688
Published online on: 05 September 2018

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Article Open Access

Sequence analysis of the Pre-S gene in chronic asymptomatic HBV carriers with low-level HBsAg Corrigendum in /10.3892/ijmm.2019.4055

Tong Wang, Yuzhu Dai, Meng Zhang, Dawei Cui, Xujian Xu, Changgui Sun, Jun Cheng
Pages: 2689-2699
Published online on: 17 August 2018

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Article Open Access

α-1,3-Fucosyltransferase-VII siRNA inhibits the expression of SLex and hepatocarcinoma cell proliferation

Dongsheng Li, Hongzhi Sun, Guang Bai, Wei Wang, Miaomiao Liu, Zhiye Bao, Jingjing Li, Hao Liu
Pages: 2700-2708
Published online on: 31 August 2018

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Article Open Access

Opening of mitoKATP improves cardiac function and inhibits apoptosis via the AKT-Foxo1 signaling pathway in diabetic cardiomyopathy

Peng Duan, Jinxin Wang, Yang Li, Shiqiang Wei, Feng Su, Sanlin Zhang, Yuhui Duan, Lin Wang, Qinglei Zhu
Pages: 2709-2719
Published online on: 21 August 2018

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Article Open Access

An impaired hepatic clock system effects lipid metabolism in rats with nephropathy

Peipei Chen, Ruiyu Zhang, Lijun Mou, Xuewang Li, Yan Qin, Xuemei Li
Pages: 2720-2736
Published online on: 22 August 2018

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Article Open Access

Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells

Yuanyi Xu, Xiaofei Wang, Yunning Huang, Yanmei Ma, Xiu Jin, Honghong Wang, Juan Wang
Pages: 2737-2749
Published online on: 04 September 2018

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Article Open Access

GPR17 mediates ischemia-like neuronal injury via microglial activation

Bing Zhao, Hao Wang, Cai‑Xia Li, Sheng‑Wen Song, San‑Hua Fang, Er‑Qing Wei, Qiao‑Juan Shi
Pages: 2750-2762
Published online on: 29 August 2018

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Article Open Access

3,5-Di-C-β-D-glucopyranosyl phloroacetophenone, a major component of Melicope ptelefolia, suppresses fibroblast activation and alleviates arthritis in a mouse model: Potential therapeutics for rheumatoid arthritis

Hyun Jong Kim, Ji Hyun Choi, Jung‑Hwan Hwang, Kyong‑Shim Kim, Jung‑Ran Noh, Dong‑Hee Choi, Sung Je Moon, Hyun‑Yong Kim, Sang‑Woo Kim, Sangho Choi, Sang Mi Eum, Tran The Bach, Jaerang Rho, Ju Yong Lee, Jung Geun Park, Sei‑Ryang Oh, Chul‑Ho Lee, Won Keun Oh, Yong‑Hoon Kim
Pages: 2763-2775
Published online on: 30 August 2018

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Article Open Access

Eleutheroside B1 mediates its anti-influenza activity through POLR2A and N-glycosylation

Wen Yan, Chunge Zheng, Jiayang He, Wenjie Zhang, Xin‑An Huang, Xiong Li, Yutao Wang, Xinhua Wang
Pages: 2776-2792
Published online on: 07 September 2018

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Article

Systematic analysis of hsa-miR-363 gene overexpression pattern in endometrial stromal cells

Wenqu Li, Xuemei Fan, Mi Zhang, Lei Huang, Shanshan Lv, Luyu Wang, Ying Wu, Chencheng Dai, Juan Xu, Pengfei Xu, Ziyi Fu, Xuemei Jia, Xiaoyan Shi
Pages: 2793-2800
Published online on: 24 August 2018

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Article

Long noncoding RNA cancer susceptibility candidate 9 promotes doxorubicin‑resistant breast cancer by binding to enhancer of zeste homolog 2

Baohong Jiang, Yuehua Li, Xiaofei Qu, Hongbo Zhu, Yeru Tan, Qun Fan, Yiling Jiang, Mingchu Liao, Xiaoping Wu
Pages: 2801-2810
Published online on: 07 August 2018

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Article

Inhibition of Cx43 attenuates ERK1/2 activation, enhances the expression of Cav‑1 and suppresses cell proliferation

Muhammad Arshad, Charlotte Conzelmann, Muhammad Assad Riaz, Thomas Noll, Dursun Gündüz
Pages: 2811-2818
Published online on: 16 August 2018

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Article

Stra8 may inhibit apoptosis during mouse spermatogenesis via the AKT signaling pathway

Xueyi Shen, Changmin Niu, Jiaqian Guo, Mengmeng Xia, Jing Xia, Yanqiu Hu, Ying Zheng
Pages: 2819-2830
Published online on: 14 August 2018

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Article

The differentiation of human MSCs derived from adipose and amniotic tissues into insulin-producing cells, induced by PEI@Fe3O4 nanoparticles-mediated NRSF and SHH silencing

Rui Wang, Dianbao Zhang, Tao Zhang, Feng Zhao, Hongxin Lang, Xuewen Lin, Xining Pang
Pages: 2831-2838
Published online on: 14 August 2018

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Article

Long non-coding RNA SNHG20 promotes bladder cancer via activating the Wnt/β-catenin signalling pathway Expression of Concern in /10.3892/ijmm.2026.5737

Qingsong Zhao, Saiyue Gao, Qingyan Du, Ye Liu
Pages: 2839-2848
Published online on: 10 August 2018

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Article

Macrophage migration inhibitory factor serves a pivotal role in the regulation of radiation-induced cardiac senescencethrough rebalancing the microRNA-34a/sirtuin 1 signaling pathway

Yiwang Hu, Wenzheng Xia, Meng Hou
Pages: 2849-2858
Published online on: 23 August 2018

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Article

Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling

Novi Kusumaningrum, Dong Hun Lee, Hyun‑Sun Yoon, Chi‑Hyun Park, Jin Ho Chung
Pages: 2859-2866
Published online on: 24 August 2018

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Article

Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats

Bi‑Lei Wang, Hong Jin, Xi‑Qiong Han, Yang Xia, Nai‑Feng Liu
Pages: 2867-2880
Published online on: 24 August 2018

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Article

Thymosin β4 is associated with bone sialoprotein expression via ERK and Smad3 signaling pathways in MDPC-23 odontoblastic cells

Baik‑Dong Choi, Hee‑Jung Lim, Seung‑Yeon Lee, Myoung‑Hwa Lee, Ki‑Sung Kil, Do‑Seon Lim, Soon‑Jeong Jeong, Moon‑Jin Jeong
Pages: 2881-2890
Published online on: 07 September 2018

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Article

Bax inhibitor-1 suppresses early brain injury following experimental subarachnoid hemorrhage in rats Corrigendum in /10.3892/ijmm.2024.5362

Jiaxin Liu, Shuai Zhou, Yueting Zhang, Xiuying Li, Xiying Qian, Weihua Tao, Lide Jin, Jianhua Zhao
Pages: 2891-2902
Published online on: 05 September 2018

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Article

Inhibition of lncRNA NEAT1 suppresses the inflammatory response in IBD by modulating the intestinal epithelial barrier and by exosome-mediated polarization of macrophages

Rui Liu, Anliu Tang, Xiaoyan Wang, Xiong Chen, Lian Zhao, Zhiming Xiao, Shourong Shen
Pages: 2903-2913
Published online on: 17 August 2018

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Article

Cannabinoid receptor 2 agonist attenuates blood‑brain barrier damage in a rat model of intracerebral hemorrhage by activating the Rac1 pathway

Zhe Wang, Yongfu Li, Shuangyong Cai, Rui Li, Guanbo Cao
Pages: 2914-2922
Published online on: 22 August 2018

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Article

Jam3 promotes migration and suppresses apoptosis of renal carcinoma cell lines

Xudong Li, Aiping Yin, Wenjing Zhang, Fei Zhao, Jia Lv, Jing Lv, Jiping Sun
Pages: 2923-2929
Published online on: 04 September 2018

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Article

Decreased human antigen R expression confers resistance to tyrosine kinase inhibitors in epidermal growth factor receptor-mutant lung cancer by inhibiting Bim expression

Yunfeng Yao, Huili Chu, Jun Wang, Baocheng Wang
Pages: 2930-2942
Published online on: 22 August 2018

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Article

Downregulation of glucose-regulated protein 78 enhances the cytotoxic effects of curcumin on human nasopharyngeal carcinoma cells

Xiaoming Yu, Long Shi, Li Yan, Hui Wang, Yan Wen, Xiuping Zhang
Pages: 2943-2951
Published online on: 23 August 2018

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Article

The active participation of p22phox-214T/C in the formation of intracranial aneurysm and the suppressive potential of edaravone

Juntao Hu, Jie Luo, Hui Wang, Chaojia Wang, Rongpei Long, Anrong Li, Yi Zhou, Zhicheng Fang, Qianxue Chen
Pages: 2952-2960
Published online on: 28 August 2018

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Oral administration of Cervus nippon mantchuricus extract suppresses 2,4-dinitrochlorobenzene-induced atopic dermatitis in BALB/c mice and inflammatory effects in mast cells

Se Hyang Hong, Jin Mo Ku, Hyo In Kim, Sol Ji Lee, Ye Seul Lim, Hye Sook Seo, Yong Cheol Shin, Seong‑Gyu Ko
Pages: 2961-2971
Published online on: 05 September 2018

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[Corrigendum] Correlation between the expression of IL‑18 and deep venous thrombosis

Guangdi Li, Rudan Zhou, Xueling Zhao, Riguang Liu, Chuan Ye
Pages: 2972-2972
Published online on: 27 August 2018

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November-2026 Volume 58 Issue 5

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

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Spatial multi‑omics identifies an SPP1+ macrophage‑driven anti‑apoptotic niche in osteoarthritis synovium via the SPP1‑CD44 axis

Han Gong, Hao Shen, Feng Zhang, Wei Wang, Sheng Zhou, Lei Wang, Yu Sun
Article Number: 334
Published online on: 29 September 2026

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Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review)

Jialiang Wang, Zhangcheng Liao, Minghui Liu, Yizhou Wang, Yu Cui, Hequn Chen, Feng Zeng, Zewu Zhu
Article Number: 333
Published online on: 29 September 2026

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[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model

Jingfei Chen, Zhimin Long, Yanzhen Li, Min  Luo, Shifang  Luo, Guiqiong He
Article Number: 332
Published online on: 28 September 2026

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miR‑222‑3p inhibits diabetic skin wound healing by targeting APLN

Ruyan Jie, Ying Tang, Tingting Wu, Chenfan Zhang, Man Song, Xiaotong Zhao, Mingwei Chen
Article Number: 331
Published online on: 25 September 2026

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[Corrigendum] Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Article Number: 330
Published online on: 23 September 2026

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Salidroside attenuates myocardial ischemia‑reperfusion‑induced oxidative stress and ferroptosis by promoting USP11‑mediated  deubiquitination of PRDX2

Zhi-Cong Qiu, Jian-Nan Li, Yi-Zhou Li, Zi-Ming Wu, Xu-Dong Luo, Rui-Yuan Zeng, Song-Qing Lai, Shi-Tao Zhao, Li Wan
Article Number: 329
Published online on: 23 September 2026

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Reprogramming of cell death in gastric cancer: From molecular mechanisms to therapeutic potential (Review)

Mengru Liu, Zhujun Wu, Qiao Chen, Weiguo Ni, Ying Chen, Yixin Zhu, Yu Chen, Haifeng Ma, Yan Lin
Article Number: 328
Published online on: 23 September 2026

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Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis

Xiyuan Chen, Jianghong Zhao, Xingtong He, Yuqi Zhang, Jiao Wu, Chao Jiang, Yi Yang, Ji Xiao
Article Number: 327
Published online on: 22 September 2026

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Tumor‑immune spatiotemporal co‑evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration‑resistant prostate cancer (Review)

Li Yan, Xiaoke Sun, Pengxiao Su
Article Number: 326
Published online on: 21 September 2026

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Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review)

Hongjing Wang, Renukha Arjune, Weiyu Gan, Na Guo, Nan Yu, Ting Xiong
Article Number: 325
Published online on: 21 September 2026

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Expression of Concern Open Access

[Expression of Concern] PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids

Elena Grasselli, Adriana Voci, Carlo Pesce, Laura Canesi, Emilia Fugassa, Gabriella Gallo, Laura Vergani
Article Number: 324
Published online on: 21 September 2026

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Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review)

Zhao Wang, Mingde Chang, Wenyu Shang, Yunfeng Jia, Xiaoyu Shan, Xinnong Chen, Yingxi Yang, Junping Zhang
Article Number: 323
Published online on: 18 September 2026

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Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis

Fei Yan, Lei Shi, Yuechan Wang, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Yunheng Liang, Ning Wang, Hongwang Cui, Minni Zhang
Article Number: 322
Published online on: 18 September 2026

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Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation‑mediated FOXO signalling

Sisi Tan, Xiaochen Wang, Yunfan Zheng, Zhenni Mou, Lihong Zeng, Jingchang Yuan, Xiao Fan, Miao Wei, Yujia Huo, Ruotong Ouyang, Yanyu Pu, Junqin Lei, Xi Gao, Dangdang Wang, Yang Peng, Hong Li
Article Number: 321
Published online on: 17 September 2026

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ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review)

Jingwen Zhang, Lili Bao, Jiaxi Li, Xia Li, Lu Qiao, Jiaxian Cui, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Yaoqing Feng, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 320
Published online on: 17 September 2026

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Small extracellular vesicles in osteoarthritis: A double‑edged sword regulating inflammation and cartilage homeostasis (Review)

Yifan Yang, Jiachen Liang, Xiangyu Shi, Anqi Niu, Ruifang Gao, Xiuping Wu, Xiaojuan Guo, Xiaotong Shi, Kejie Cao, Bing Li, Ran Li
Article Number: 319
Published online on: 17 September 2026

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Exosomal circular RNAs in the tumor immune microenvironment: From regulatory mechanisms to therapeutic opportunities and translational hurdles (Review)

Wenlong Zhang, Nuo Chen, Liya Gong, Yu Dong, Hui Shen, Xin Liu, Jie Sun, Luxuan Liu, Zhe Jin, Liaoyuan Wang, Xue Han, Bin Zhang, Shuixing Zhang
Article Number: 318
Published online on: 17 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro

Tan-Zhen Xu, Xiao-Yan Shen, Ling-Ling Sun, Ya-Li Chen, Bi-Qiong Zhang, Da-Ke Huang, Wei-Zu Li
Article Number: 317
Published online on: 16 September 2026

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tRNA‑derived RNAs in hepatic diseases: From biological functions to clinical translation (Review)

Yaotian Cai, Yifei Chen, Fuji Yang, Yongmin Yan, Ting Jiang
Article Number: 316
Published online on: 15 September 2026

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Monocytes in pneumonia: Functional plasticity and innate memory (Review) 

Run-Ze Li, Zhi-Han Xie, Li Chen, Yun-Xiao Shang, Fei Wang, Wan-Jie Huang, Qi Cheng
Article Number: 315
Published online on: 15 September 2026

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Correction Open Access

[Corrigendum] Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 314
Published online on: 14 September 2026

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Ferroptosis in heatstroke: Mechanisms and therapeutic perspectives (Review)

Hongguang Gao, Yang Chen, Tianshan Zhang, Yujun Shi, Rong Yao
Article Number: 313
Published online on: 10 September 2026

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[Corrigendum] Inactivation of von Hippel‑Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR‑210/VMP1 signaling pathway

Ting Liu, Le Zhao, Wei Chen, Zhen Li, Huilian Hou, Lu Ding, Xu Li
Article Number: 312
Published online on: 10 September 2026

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Review Open Access

Interferon regulatory factors orchestrate CD8+ T cell function (Review)

Fa-Xi Wang, Chun-Liang Yang, Shan-Jie Rong, Qi-Jie Chen, Xiong-Tao Yue, Fei Sun
Article Number: 311
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1

Pan Tan, Haiqin Wang, Junkun Zhan, Xinyu Ma, Xingjun Cui, Yanjiao Wang, Yi Wang, Jiayu Zhong, Youshuo Liu
Article Number: 310
Published online on: 07 September 2026

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Deciphering the function and mechanism of extracorporeal shock wave therapy in knee osteoarthritis (Review)

Yixuan Chen, Siqi Song, Yuchen Zhu, Shiqi Wang, Jieyuan Hu, Chenxu Liu, Yuchen Cai, Yushi Hu
Article Number: 309
Published online on: 04 September 2026

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Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)

Ying Yang, Ruichen Zheng, Yun Zhang, Dongmei Ye, Jiale Xie, Changliang Zhu
Article Number: 308
Published online on: 03 September 2026

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Autophagy determines the fate of immune cells by regulating metabolic remodeling and PANoptosis (Review)

Yanan Guo, Xinyue Zhou, Yixiao Tian, Dan Chen, Xiaofeng Xie, Bin Zhou, Yingxia Tian, Yaqing Zhang
Article Number: 307
Published online on: 03 September 2026

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Programmed cell death in metabolic syndrome: From molecular mechanisms to therapeutic strategies (Review)

Jialin Zhong, Maofu Zhang, Yafang Zheng, Cuicui Gong, Yasheng Deng, Lisha Sun, Dongqi Zhou, Qian Zhou, Qiu Chen
Article Number: 306
Published online on: 03 September 2026

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Review Open Access

Research progress on lysine acetylation (Review)

Minghui Zhang, Yuqi Zhang, Haoxin Yin, Junyuan Yan, Yingling Dong, Xin Zhao, Tianyi Cui, Bin Lv, Xiumei Gao
Article Number: 305
Published online on: 02 September 2026

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Expression of Concern Open Access

[Expression of Concern] Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway

Shuting Ma, Yun Zhao, Miaomiao Cao, Chaofeng Sun
Article Number: 304
Published online on: 02 September 2026

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Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review)

Lin Song, Aifeng He, Wei Jiang, Keran Shi, Jing Wang, Lu Xu, Jiangquan Yu, Ruiqiang Zheng
Article Number: 303
Published online on: 31 August 2026

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Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease

Yuanlong Li, Hua Fan, Xiong Han, Ming Ni, Xiaodan Hou, Hailan Xia, Yinzhu Shi, Lin Zhang, Jun Sun
Article Number: 302
Published online on: 31 August 2026

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Salvianolic acid monomers against metastasis: Decoding the multilayered interception of EMT, angiogenesis and immune evasion (Review)

Shiting Jiang, Dan Liu, Tingting Wei, Qiwei Shi, Haowen Wang, Yidan Gao, Pingsu Mao, Wenli Yang
Article Number: 301
Published online on: 31 August 2026

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Retraction Open Access

[Retracted] Silencing of decoy receptor 3 (DcR3) expression by siRNA in pancreatic carcinoma cells induces Fas ligand‑mediated apoptosis in vitro and in vivo

Jian Zhou, Shiduo Song, Songbin He, Zhenxin Wang, Bing Zhang, Dechun Li, Dongming Zhu
Article Number: 300
Published online on: 31 August 2026

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Research progress on BTG2 in non‑tumor diseases (Review)

Shuling Li, Xiaomei Liu, Zheng Zhang, Ling Yang, Yuxuan Li, Qiongdan Hu
Article Number: 299
Published online on: 28 August 2026

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Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Xincheng Feng, Jue Zhang, Qinghong Ma, Chao Sun
Article Number: 298
Published online on: 27 August 2026

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Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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Journal Cover
December-2026 Volume 58 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Targeting ferroptosis in metabolic dysfunction‑associated steatotic liver disease: From mechanisms to cell type‑specific therapeutic strategies (Review)

Xiang Tao, Mei Liu
Article Number: 357
Published online on: 26 October 2026

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Hormonal remodeling and molecular mechanisms in postmenopausal osteoporosis: Pathogenesis and therapeutic implications (Review)

Wenjun Liu, Zhengzheng Li, Penglin Wang, Jiahao Zeng, Haimin Zeng, Yining Xie, Ruhui Yang, Liu Yang, Sijian Lin, Chenyu Zhang
Article Number: 356
Published online on: 26 October 2026

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[Corrigendum] Apelin‑13 attenuates ER stress‑associated apoptosis induced by MPP+ in SH‑SY5Y cells 

Yunlu Jiang, Haiqing Liu, Bingyuan Ji, Zhengwen Wang, Chunmei Wang, Chunqing Yang, Yanyou Pan, Jing Chen, Baohua Cheng, Bo Bai
Article Number: 355
Published online on: 26 October 2026

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Mechanisms and therapeutic implications of ferritinophagy in fibrotic diseases (Review)

Siying Sun, Jie Yu, Xuemei Li, Hongfei Liao
Article Number: 354
Published online on: 23 October 2026

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Immune remodeling in inflammatory bowel disease-associated colorectal cancer: Mechanisms and immunotherapeutic implications (Review)

Tao Zhang, Zhetan Ren, Ling Wang, Ru Man, Lin Wang, Jing Wang, Xiaozhen Cheng, Jirun Peng, Yongduo Yu
Article Number: 353
Published online on: 22 October 2026

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Inflammatory regulatory mechanisms and targeted therapy of antineutrophil cytoplasmic antibodies in atherosclerosis (Review)

Jingjing Cui, Qi Cui, Jinying Dou, Xiaoyan Li, Wenlong Chang, Lanchun Shi, Liyun An
Article Number: 352
Published online on: 22 October 2026

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HMGN5 promotes renal tubular inflammation and pyroptosis‑associated signaling in chronic kidney disease via the IFNAR2 axis

Xue Rong, Jing Xu, Jienan Zhang, Qi Zhang, Jiangli Wang, Guoxin Zhang, Limin Nie
Article Number: 351
Published online on: 22 October 2026

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[Corrigendum] Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro

Yuyang Wang, Linshan Xu, Jianping Wang, Jiangtao Bai, Jianglong Zhai, Guoying Zhu
Article Number: 350
Published online on: 21 October 2026

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Transcription factors in liver fibrosis: Mechanistic insights and nanotechnology‑driven therapeutic strategies (Review)

Xianfei Zhou, Chongjun Yang, Zhiyong Weng, Lihua Li
Article Number: 349
Published online on: 21 October 2026

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From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)

Yuanli Zhou, Bolv Zhu, Xingzhou Tang, Shuishui Yin
Article Number: 348
Published online on: 20 October 2026

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[Corrigendum] Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis 

Dong Ding, Jiangbo Yan, Gangning Feng, Yong Zhou, Long Ma, Qunhua Jin
Article Number: 347
Published online on: 19 October 2026

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Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)

Sanmei Nong, Qiudong Huang, Kuibo Huang, Xiao Luo, Yin Huang, Wenlian Zheng, Weiyi Huang, Zhaoyun Liu
Article Number: 346
Published online on: 16 October 2026

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Multiple strategies to improve the therapeutic efficacy of mesenchymal stem cell‑derived exosome transplantation in ischemic stroke (Review)

Yan Xu, Xiaolei Zhou, Wenhui Zeng, Jiabing Wang, Lin Zhou, Lincai Li, Zhengwei Zou, Cixiang Chen, Yichi Zhang, Zhengyi He, Junsong Ye
Article Number: 345
Published online on: 14 October 2026

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Resveratrol alleviates osteoarthritis progression by inhibiting NLRP3 inflammasome response via the AMPK/PPARγ signaling pathway

Shanshan Cui, Zifan Luo, Wen Qin, Bo Chen, Qiaoxia Zhang, Jianbing Ma, Jie Ma, Rui Zhang
Article Number: 344
Published online on: 14 October 2026

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Expression of Concern Open Access

[Expression of Concern] Anti‑metastatic and differential effects on protein expression of epigallocatechin‑3‑gallate in HCCLM6 hepatocellular carcinoma cells

Yunjuan Zhang, Lawrence Owusu, Wei Duan, Tao Jiang, Shizhu Zang, Ayaz Ahmed, Yi Xin
Article Number: 343
Published online on: 14 October 2026

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Article Open Access

Six3 promoting the migration and neural differentiation of BMSCs via Btg2‑mediated Akt signaling pathway activation: A therapeutic strategy for stroke

Zhenqiang Fu, Zhixin Li, Limin Zhang, Wentao Hu, Hecheng Yang, Jingtao Wang
Article Number: 342
Published online on: 12 October 2026

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Expression of Concern Open Access

[Expression of Concern] EETs and CYP2J2 inhibit TNF‑α‑induced apoptosis in pulmonary artery endothelial cells and TGF‑β1‑induced migration in pulmonary artery smooth muscle cells

Wenjing Feng, Xizhen Xu, Gang Zhao, Geng Li, Tiantian Liu, Junjie Zhao, Ruolan Dong, Dao Wen Wang, Ling Tu
Article Number: 341
Published online on: 12 October 2026

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Gomisin A as a multi‑target therapeutic agent: Pharmacological mechanisms, pharmacokinetics and network pharmacology (Review)

Jiaqi Xu, Sha Shi, Chengkai Zhu, Qi Sui, Shanhao Zhu, Jingnan Zhang, Yi Zhang, Peng Chen
Article Number: 340
Published online on: 09 October 2026

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Multi‑target mechanisms of paeoniflorin in inflammatory regulation: A network pharmacology (Review)

Jin Zhang, Junjie Ye, Kun Jin, Xuan Sun, Xinyu Yu, Yuan Zhao, Ni Zhu
Article Number: 339
Published online on: 09 October 2026

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Mechanisms of neuroimmune crosstalk in vestibular disorders: Linking inflammation with neural circuit dysfunction (Review)

Xianfang Pan, Jin Fan, Zhiyi Yang, Zegang Yin, Zhen Li, Zhifeng Rui, Hujun Zhang, Yujie Li, Hongjuan Zhang
Article Number: 338
Published online on: 08 October 2026

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Expression of Concern Open Access

[Expression of Concern] Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP‑1

Zeng-Feng Xin, Cheng-Chun Shen, Li-Jiang Tao, Shi-Gui Yan, Hao-Bo Wu
Article Number: 337
Published online on: 08 October 2026

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Anesthetics and cancer biology: Translational evidence from perioperative modulation to drug repurposing (Review)

Ting Yang, Jiao Tang, Muhammad Saqib Mudabbar, Huan Hu, Qiang Fu, Chunlan Pu
Article Number: 336
Published online on: 05 October 2026

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Expression of Concern Open Access

[Expression of Concern] Multiple roles of SOCS proteins: Differential expression of SOCS1 and SOCS3 in atherosclerosis

Xiao Liang, Ming He, Tao Chen, Yan Liu, Yu-Ling Tian, Yu-Liang Wu, Yan Zhao, Yan Shen, Zu-Yi Yuan
Article Number: 335
Published online on: 30 September 2026

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