Open Access

Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches

  • Authors:
    • Xia Yang
    • Yun Deng
    • Rong‑Quan He
    • Xiao‑Jiao Li
    • Jie Ma
    • Gang Chen
    • Xiao‑Hua Hu
  • View Affiliations

  • Published online on: August 14, 2018     https://doi.org/10.3892/ijmm.2018.3826
  • Pages: 2650-2664
  • Copyright: © Yang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.

Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )


Abstract

The altered expression of homeobox (HOX)A11 has been observed in various malignant tumor types, but it has remained to be determined in human lung adenocarcinoma (LUAD). In the present study, the expression of HOXA11 in LUAD and the potential associated mechanisms were assessed. Data from The Cancer Genome Atlas and Oncomine microarrays were gathered and in‑house polymerase chain reaction data were produced to investigate the altered expression of HOXA11 in LUAD and its association with various clinicopathological characteristics. Genes co‑expressed with HOXA11 were also identified by searching the cBioPortal and Multi Experiment Matrix databases, and performing a bioinformatics analysis, through which the potential molecular mechanisms of HOXA11 in LUAD were explored. The data analyses indicated that HOXA11 was overexpressed in the LUAD samples, and together with its co‑expressed genes, it was indicated to participate in various key signaling pathways, including the focal adhesion, extracellular matrix‑receptor interaction, axon guidance and small cell lung cancer signaling pathways. Furthermore, collagen type III α 1 chain (COL3A1), ephrin B2 (EFNB2), integrin subunit α 8 (ITGA8) and syndecan 2 (SDC2) were confirmed to be differentially expressed in LUAD vs. normal controls at the mRNA and protein level. Of note, LUAD patients with low expression of HOXA11 and ITGB1 had better overall survival rates. The present study indicated that HOXA11 may function as an oncogene in LUAD, and HOXA11 protein probably combines with ITGB1, COL3A1, EFNB2, ITGA8 and SDC2 to have a role in the focal adhesion pathway.
View Figures
View References

Related Articles

Journal Cover

November-2018
Volume 42 Issue 5

Print ISSN: 1107-3756
Online ISSN:1791-244X

Sign up for eToc alerts

Recommend to Library

Copy and paste a formatted citation
x
Spandidos Publications style
Yang X, Deng Y, He RQ, Li XJ, Ma J, Chen G and Hu XH: Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches. Int J Mol Med 42: 2650-2664, 2018
APA
Yang, X., Deng, Y., He, R., Li, X., Ma, J., Chen, G., & Hu, X. (2018). Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches. International Journal of Molecular Medicine, 42, 2650-2664. https://doi.org/10.3892/ijmm.2018.3826
MLA
Yang, X., Deng, Y., He, R., Li, X., Ma, J., Chen, G., Hu, X."Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches". International Journal of Molecular Medicine 42.5 (2018): 2650-2664.
Chicago
Yang, X., Deng, Y., He, R., Li, X., Ma, J., Chen, G., Hu, X."Upregulation of HOXA11 during the progression of lung adenocarcinoma detected via multiple approaches". International Journal of Molecular Medicine 42, no. 5 (2018): 2650-2664. https://doi.org/10.3892/ijmm.2018.3826