Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2018 Volume 42 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 42 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article

Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling

  • Authors:
    • Novi Kusumaningrum
    • Dong Hun Lee
    • Hyun‑Sun Yoon
    • Chi‑Hyun Park
    • Jin Ho Chung
  • View Affiliations / Copyright

    Affiliations: Department of Biomedical Sciences, Seoul National University Graduate School, Seoul 110‑744, Republic of Korea, Department of Dermatology, Seoul National University College of Medicine, Seoul 110‑744, Republic of Korea
  • Pages: 2859-2866
    |
    Published online on: August 24, 2018
       https://doi.org/10.3892/ijmm.2018.3839
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Gasdermin (GSDM)‑C is a member of the GSDM gene family and is expressed in the epithelial cells of various tissue types, including skin. GSDMC expression is induced by ultraviolet (UV) irradiation and contributes to UV‑induced matrix metalloproteinase 1 expression in human skin keratinocytes. However, how UV irradiation induces GSDMC expression remains unclear. The present study aimed to investigate the role of transient receptor potential cation channel subfamily V member 1 (TRPV1) and a calcium/calcineurin‑signaling pathway in UV‑induced GSDMC expression in human skin keratinocytes. Suppression of TRPV1 activity by treatment with the TRPV1 antagonists capsazepine and ruthenium red significantly reduced UV‑induced GSDMC expression, whereas direct activation of TRPV1 by capsaicin, a TRPV1 agonist, increased GSDMC expression. The results demonstrated that extracellular calcium and calcineurin activity may be necessary for UV‑induced GSDMC expression in HaCaT cells. In addition, UV‑induced GSDMC expression was either decreased or increased following knockdown or overexpression of nuclear factor of activated T‑cells, cytoplasmic 1 (NFATc1), respectively. These data suggested that TRPV1 may serve an important role in the induction of GSDMC expression by UV and that UV‑induced GSDMC expression may be mediated via a calcium/calcineurin/NFATc1 pathway.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

View References

1 

Rittie L and Fisher GJ: UV-light-induced signal cascades and skin aging. Ageing Res Rev. 1:705–720. 2002. View Article : Google Scholar : PubMed/NCBI

2 

Xu YR and Fisher GJ: Ultraviolet (UV) light irradiation induced signal transduction in skin photoaging. J Dermatol Sci. S12005.

3 

Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S and Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. N Engl J Med. 337:1419–1428. 1997. View Article : Google Scholar : PubMed/NCBI

4 

Kahari VM and Saarialho-Kere U: Matrix metalloproteinases in skin. Exp Dermatol. 6:199–213. 1997. View Article : Google Scholar

5 

Saeki N, Kuwahara Y, Sasaki H, Satoh H and Shiroishi T: Gasdermin (Gsdm) localizing to mouse Chromosome 11 is predominantly expressed in upper gastrointestinal tract but significantly suppressed in human gastric cancer cells. Mamm Genome. 11:718–724. 2000. View Article : Google Scholar : PubMed/NCBI

6 

Kusumaningrum N, Lee DH, Yoon HS, Kim YK, Park CH and Chung JH: Gasdermin C is induced by ultraviolet light and contributes to MMP-1 expression via activation of ERK and JNK pathways. J Dermatol Sci. 90:180–189. 2018. View Article : Google Scholar : PubMed/NCBI

7 

Saeki N and Sasaki H: Gasdermin superfamily: A novel gene family functioning in epithelial cells. Endothelium and Epithelium: Composition, Functions and Pathology. Nova Science Publishers, Inc.; New York: pp. 193–211. 2012

8 

Tamura M, Tanaka S, Fujii T, Aoki A, Komiyama H, Ezawa K, Sumiyama K, Sagai T and Shiroishi T: Members of a novel gene family, Gsdm, are expressed exclusively in the epithelium of the skin and gastrointestinal tract in a highly tissue-specific manner. Genomics. 89:618–629. 2007. View Article : Google Scholar : PubMed/NCBI

9 

Watabe K, Ito A, Asada H, Endo Y, Kobayashi T, Nakamoto K, Itami S, Takao S, Shinomura Y, Aikou T, et al: Structure, expression and chromosome mapping of MLZE, a novel gene which is preferentially expressed in metastatic melanoma cells. Jpn J Cancer Res. 92:140–151. 2001. View Article : Google Scholar : PubMed/NCBI

10 

Saeki N, Usui T, Aoyagi K, Kim DH, Sato M, Mabuchi T, Yanagihara K, Ogawa K, Sakamoto H, Yoshida T and Sasaki H: Distinctive expression and function of four GSDM family genes (GSDMA-D) in normal and malignant upper gastrointestinal epithelium. Genes Chromosomes Cancer. 48:261–271. 2009. View Article : Google Scholar

11 

Miguchi M, Hinoi T, Shimomura M, Adachi T, Saito Y, Niitsu H, Kochi M, Sada H, Sotomaru Y, Ikenoue T, et al: Gasdermin C Is upregulated by inactivation of transforming growth factor β receptor type II in the presence of mutated Apc, promoting colorectal cancer proliferation. PLoS One. 11:e01664222016. View Article : Google Scholar

12 

Lee YM, Kim YK, Kim KH, Park SJ, Kim SJ and Chung JH: A novel role for the TRPV1 channel in UV-induced matrix metalloproteinase (MMP)-1 expression in HaCaT cells. J Cell Physiol. 219:766–775. 2009. View Article : Google Scholar : PubMed/NCBI

13 

Li WH, Lee YM, Kim JY, Kang S, Kim S, Kim KH, Park CH and Chung JH: Transient receptor potential vanilloid-1 mediates heat-shock-induced matrix metalloproteinase-1 expression in human epidermal keratinocytes. J Invest Dermatol. 127:2328–2335. 2007. View Article : Google Scholar : PubMed/NCBI

14 

Ahern GP, Brooks IM, Miyares RL and Wang XB: Extracellular cations sensitize and gate capsaicin receptor TRPV1 modulating pain signaling. J Neurosci. 25:5109–5116. 2005. View Article : Google Scholar : PubMed/NCBI

15 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2 (-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

16 

Rami HK, Thompson M, Stemp G, Fell S, Jerman JC, Stevens AJ, Smart D, Sargent B, Sanderson D, Randall AD, et al: Discovery of SB-705498: A potent, selective and orally bioavailable TRPV1 antagonist suitable for clinical development. Bioorg Med Chem Lett. 16:3287–3291. 2006. View Article : Google Scholar : PubMed/NCBI

17 

Knotkova H, Pappagallo M and Szallasi A: Capsaicin (TRPV1 Agonist) therapy for pain relief: farewell or revival? Clin J Pain. 24:142–154. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Li H, Wang S, Chuang AY, Cohen BE and Chuang HH: Activity-dependent targeting of TRPV1 with a pore-permeating capsaicin analog. Proc Natl Acad Sci USA. 108:8497–8502. 2011. View Article : Google Scholar : PubMed/NCBI

19 

Wilkins BJ and Molkentin JD: Calcium-calcineurin signaling in the regulation of cardiac hypertrophy. Biochem Biophys Res Commun. 322:1178–1191. 2004. View Article : Google Scholar : PubMed/NCBI

20 

Schulz RA and Yutzey KE: Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol. 266:1–16. 2004. View Article : Google Scholar : PubMed/NCBI

21 

Crabtree GR: Calcium, calcineurin, and the control of transcription. J Biol Chem. 276:2313–2316. 2001. View Article : Google Scholar

22 

Crabtree GR: Generic signals and specific outcomes: Signaling through Ca2+, calcineurin, and NF-AT. Cell. 96:611–614. 1999. View Article : Google Scholar : PubMed/NCBI

23 

Al-Daraji WI, Grant KR, Ryan K, Saxton A and Reynolds NJ: Localization of calcineurin/NFAT in human skin and psoriasis and inhibition of calcineurin/NFAT activation in human keratinocytes by cyclosporin A. J Invest Dermatol. 118:779–788. 2002. View Article : Google Scholar : PubMed/NCBI

24 

Smit NP, Van Rossum HH, Romijn FP, Sellar KJ, Breetveld M, Gibbs S and Van Pelt J: Calcineurin activity and inhibition in skin and (epi)dermal cell cultures. J Invest Dermatol. 128:1686–1690. 2008. View Article : Google Scholar : PubMed/NCBI

25 

Hwang E, Ngo HTT, Seo SA, Park B, Zhang M, Gao W and Yi TH: Urtica thunbergiana prevents UVB-induced premature skin aging by regulating the transcription factor NFATc1: An in vitro and in vivo study. J Funct Foods. 36:162–177. 2017. View Article : Google Scholar

26 

Brenneisen P, Sies H and Scharffetter-Kochanek K: Ultraviolet-B irradiation and matrix metalloproteinases: From induction via signaling to initial events. Ann NY Acad Sci. 973:31–43. 2002. View Article : Google Scholar : PubMed/NCBI

27 

Nelson AR, Fingleton B, Rothenberg ML and Matrisian LM: Matrix metalloproteinases: Biologic activity and clinical implications. J Clin Oncol. 18:1135–1149. 2000. View Article : Google Scholar : PubMed/NCBI

28 

Sternlicht MD and Werb Z: How matrix metalloproteinases regulate cell behavior. Annu Rev Cell Dev Biol. 17:463–516. 2001. View Article : Google Scholar : PubMed/NCBI

29 

Bootman MD, Collins TJ, Peppiatt CM, Prothero LS, MacKenzie L, De Smet P, Travers M, Tovey SC, Seo JT, Berridge MJ, et al: Calcium signalling-an overview. Semin Cell Dev Biol. 12:3–10. 2001. View Article : Google Scholar : PubMed/NCBI

30 

Bootman MD: Calcium signaling. Cold Spring Harb Perspect Biol. 4:a0111712012. View Article : Google Scholar : PubMed/NCBI

31 

Huang C, Mattjus P, Ma WY, Rincon M, Chen NY, Brown RE and Dong Z: Involvement of nuclear factor of activated T cells activation in UV response. Evidence from cell culture and transgenic mice. J Biol Chem. 275:9143–9149. 2000. View Article : Google Scholar : PubMed/NCBI

32 

Flockhart RJ, Diffey BL, Farr PM, Lloyd J and Reynolds NJ: NFAT regulates induction of COX-2 and apoptosis of keratinocytes in response to ultraviolet radiation exposure. FASEB J. 22:4218–4227. 2008. View Article : Google Scholar : PubMed/NCBI

33 

Maziere C, Morliere P, Louandre C, Conte MA, Gomilla C, Santus R, Antonicelli F, Hornebeck W and Mazière JC: Low UVA doses activate the transcription factor NFAT in human fibroblasts by a calcium-calcineurin pathway. Free Radic Biol Med. 39:1629–1637. 2005. View Article : Google Scholar : PubMed/NCBI

34 

Xu Y, Voorhees JJ and Fisher GJ: Epidermal growth factor receptor is a critical mediator of ultraviolet B irradiation-induced signal transduction in immortalized human keratinocyte HaCaT cells. Am J Pathol. 169:823–830. 2006. View Article : Google Scholar : PubMed/NCBI

35 

Xu Y, Shao Y, Voorhees JJ and Fisher GJ: Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irradiation activates epidermal growth factor receptor in human keratinocytes. J Biol Chem. 281:27389–27397. 2006. View Article : Google Scholar : PubMed/NCBI

36 

Han S, Kang SM, Oh JH, Lee DH and Chung JH: Src kinase mediates UV-induced TRPV1 trafficking into cell membrane in HaCaT keratinocytes. Photodermatol Photoimmunol Photomed. 34:214–216. 2018. View Article : Google Scholar

37 

Di Girolamo N, Coroneo M and Wakefield D: Epidermal growth factor receptor signaling is partially responsible for the increased matrix metalloproteinase-1 expression in ocular epithelial cells after UVB radiation. Am J Pathol. 167:489–503. 2005. View Article : Google Scholar : PubMed/NCBI

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Kusumaningrum N, Lee DH, Yoon HS, Park CH and Chung JH: Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling. Int J Mol Med 42: 2859-2866, 2018.
APA
Kusumaningrum, N., Lee, D.H., Yoon, H., Park, C., & Chung, J.H. (2018). Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling. International Journal of Molecular Medicine, 42, 2859-2866. https://doi.org/10.3892/ijmm.2018.3839
MLA
Kusumaningrum, N., Lee, D. H., Yoon, H., Park, C., Chung, J. H."Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling". International Journal of Molecular Medicine 42.5 (2018): 2859-2866.
Chicago
Kusumaningrum, N., Lee, D. H., Yoon, H., Park, C., Chung, J. H."Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling". International Journal of Molecular Medicine 42, no. 5 (2018): 2859-2866. https://doi.org/10.3892/ijmm.2018.3839
Copy and paste a formatted citation
x
Spandidos Publications style
Kusumaningrum N, Lee DH, Yoon HS, Park CH and Chung JH: Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling. Int J Mol Med 42: 2859-2866, 2018.
APA
Kusumaningrum, N., Lee, D.H., Yoon, H., Park, C., & Chung, J.H. (2018). Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling. International Journal of Molecular Medicine, 42, 2859-2866. https://doi.org/10.3892/ijmm.2018.3839
MLA
Kusumaningrum, N., Lee, D. H., Yoon, H., Park, C., Chung, J. H."Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling". International Journal of Molecular Medicine 42.5 (2018): 2859-2866.
Chicago
Kusumaningrum, N., Lee, D. H., Yoon, H., Park, C., Chung, J. H."Ultraviolet light-induced gasdermin C expression is mediated via TRPV1/calcium/calcineurin/NFATc1 signaling". International Journal of Molecular Medicine 42, no. 5 (2018): 2859-2866. https://doi.org/10.3892/ijmm.2018.3839
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team