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Article

Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats

  • Authors:
    • Bi‑Lei Wang
    • Hong Jin
    • Xi‑Qiong Han
    • Yang Xia
    • Nai‑Feng Liu
  • View Affiliations / Copyright

    Affiliations: Department of Rehabilitation, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China, Department and Institute of Cardiology, Zhongda Hospital, Medical School of Southeast University, Nanjing, Jiangsu 210009, P.R. China
  • Pages: 2867-2880
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    Published online on: August 24, 2018
       https://doi.org/10.3892/ijmm.2018.3841
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Abstract

Exercise induces a number of benefits, including angiogenesis in post‑myocardial infarction (MI); however, the underlying mechanisms have not been fully clarified. Neurotrophic brain‑derived neurotrophic factor (BDNF) serves a protective role in certain adult cardiac diseases through its specific receptor, BDNF/NT‑3 growth factors receptor (TrkB). The present study explored the mechanisms by which exercise improves cardiac function, with a focus on the involvement of the BDNF/TrkB axis. MI rats were assigned to Sham, sedentary, exercise, exercise with K252a (a TrkB inhibitor), and exercise with NG‑nitro‑L‑arginine methyl ester (L‑NAME) groups. The exercise group was subjected to 8 weeks of treadmill running. The results demonstrated that the rats in the exercise group exhibited increased myocardial angiogenesis and improved cardiac function, which was attenuated by K252a. Exercise induced activation of the BDNF/TrkB axis in the ischaemic myocardium and increased serum BDNF levels were abated by exposure to L‑NAME. Improvements in angiogenesis and left ventricular function exhibited a positive association, with changes in serum BDNF. In the in vitro experiments, human umbilical vein endothelial cells were exposed to shear stress (SS) of 12 dyn/cm2 to mimic the effects of exercise training on vascular tissue. An increased tube‑forming capacity, and a nitric oxide (NO)‑dependent prolonged activation of the BDNF/TrkB‑full‑length axis over 12 h, but not the TrkB‑truncated axis, was observed. The SS‑related angiogenic response was attenuated by TrkB inhibition. Overall, these results demonstrate that exercise confers certain aspects of its cardioprotective effects through the activation of the BDNF/TrkB axis in an NO‑dependent manner, a process in which fluid‑induced SS may serve a crucial role.
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View References

1 

Barbacid M: Neurotrophic factors and their receptors. Curr Opin Cell Biol. 7:148–155. 1995. View Article : Google Scholar : PubMed/NCBI

2 

Chao MV: Neurotrophins and their receptors: A convergence point for many signalling pathways. Nat Rev Neurosci. 4:299–309. 2003. View Article : Google Scholar : PubMed/NCBI

3 

Monteggia LM, Barrot M, Powell CM, Berton O, Galanis V, Gemelli T, Meuth S, Nagy A, Greene RW and Nestler EJ: Essential role of brain-derived neurotrophic factor in adult hippocampal function. Proc Natl Acad Sci USA. 101:10827–10832. 2004. View Article : Google Scholar : PubMed/NCBI

4 

Okada S, Yokoyama M, Toko H, Tateno K, Moriya J, Shimizu I, Nojima A, Ito T, Yoshida Y, Kobayashi Y, et al: Brain-derived neurotrophic factor protects against cardiac dysfunction after myocardial infarction via a central nervous system-mediated pathway. Arterioscler Thromb Vasc Biol. 32:1902–1909. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Kermani P, Rafii D, Jin DK, Whitlock P, Schaffer W, Chiang A, Vincent L, Friedrich M, Shido K, Hackett NR, et al: Neurotrophins promote revascularization by local recruitment of TrkB+ endothelial cells and systemic mobilization of hematopoietic progenitors. J Clin Invest. 115:653–663. 2005. View Article : Google Scholar : PubMed/NCBI

6 

Donovan MJ, Lin MI, Wiegn P, Ringstedt T, Kraemer R, Hahn R, Wang S, Ibañez CF, Rafii S and Hempstead BL: Brain derived neurotrophic factor is an endothelial cell survival factor required for intramyocardial vessel stabilization. Development. 127:4531–4540. 2000.PubMed/NCBI

7 

Cao L, Zhang L, Chen S, Yuan Z, Liu S, Shen X, Zheng X, Qi X, Lee KK, Chan JY and Cai D: BDNF-mediated migration of cardiac microvascular endothelial cells is impaired during ageing. J Cell Mol Med. 16:3105–3115. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Liu Y, Sun L, Huan Y, Zhao H and Deng J: Application of bFGF and BDNF to improve angiogenesis and cardiac function. J Surg Res. 136:85–91. 2006. View Article : Google Scholar : PubMed/NCBI

9 

Feng N, Huke S, Zhu G, Tocchetti CG, Shi S, Aiba T, Kaludercic N, Hoover DB, Beck SE, Mankowski JL, et al: Constitutive BDNF/TrkB signaling is required for normal cardiac contraction and relaxation. Proc Natl Acad Sci USA. 112:1880–1885. 2015. View Article : Google Scholar : PubMed/NCBI

10 

Fulgenzi G, Tomassoni-Ardori F, Babini L, Becker J, Barrick C, Puverel S and Tessarollo L: BDNF modulates heart contraction force and long-term homeostasis through truncated TrkB. T1 receptor activation J Cell Biol. 210:1003–1012. 2015.

11 

Fukushima A, Kinugawa S, Homma T, Masaki Y, Furihata T, Yokota T, Matsushima S, Abe T, Suga T, Takada S, et al: Decreased serum brain-derived neurotrophic factor levels are correlated with exercise intolerance in patients with heart failure. Int J Cardiol. 168:e142–e144. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Swardfager W, Herrmann N, Marzolini S, Saleem M, Shammi P, Oh PI, Albert PR, Daigle M, Kiss A and Lanctôt KL: Brain derived neurotrophic factor, cardiopulmonary fitness and cognition in patients with coronary artery disease. Brain Behav Immun. 25:1264–1271. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Circulating brain-derived neurotrophic factor concentrations and the risk of cardiovascular disease in the community. J Am Heart Assoc. 5:e0020982016.PubMed/NCBI

14 

Möbius-Winkler S, Uhlemann M, Adams V, Sandri M, Erbs S, Lenk K, Mangner N, Mueller U, Adam J, Grunze M, et al: Coronary collateral growth induced by physical exercise: Results of the impact of intensive exercise training on coronary collateral circulation in patients with stable coronary artery disease (EXCITE) trial. Circulation. 133:1438–1448. 2016. View Article : Google Scholar : PubMed/NCBI

15 

Leosco D, Rengo G, Iaccarino G, Golino L, Marchese M, Fortunato F, Zincarelli C, Sanzari E, Ciccarelli M, Galasso G, et al: Exercise promotes angiogenesis and improves beta-adrenergic receptor signalling in the post-ischaemic failing rat heart. Cardiovasc Res. 78:385–394. 2008. View Article : Google Scholar

16 

Tang XY, Hong HS, Chen LL, Lin XH, Lin JH and Lin Z: Effects of exercise of different intensities on the angiogenesis, infarct healing, and function of the left ventricle in postmyocardial infarction rats. Coron Artery Dis. 22:497–506. 2011. View Article : Google Scholar : PubMed/NCBI

17 

Tinken TM, Thijssen DH, Hopkins N, Dawson EA, Cable NT and Green DJ: Shear stress mediates endothelial adaptations to exercise training in humans. Hypertension. 55:312–318. 2010. View Article : Google Scholar : PubMed/NCBI

18 

Duncker DJ and Bache RJ: Regulation of coronary blood flow during exercise. Physiol Rev. 88:1009–1086. 2008. View Article : Google Scholar : PubMed/NCBI

19 

Marsh SA and Coombes JS: Exercise and the endothelial cell. Int J Cardiol. 99:165–169. 2005. View Article : Google Scholar : PubMed/NCBI

20 

Zoladz JA and Pilc A: The effect of physical activity on the brain derived neurotrophic factor: From animal to human studies. J Physiol Pharmacol. 61:533–541. 2010.

21 

Lee HW, Ahmad M, Wang HW and Leenen FH: Effects of exercise training on brain-derived neurotrophic factor in skeletal muscle and heart of rats post myocardial infarction. Exp Physiol. 102:314–328. 2017. View Article : Google Scholar : PubMed/NCBI

22 

Prigent-Tessier A, Quirié A, Maguin-Gaté K, Szostak J, Mossiat C, Nappey M, Devaux S, Marie C and Demougeot C: Physical training and hypertension have opposite effects on endo-thelial brain-derived neurotrophic factor expression. Cardiovasc Res. 100:374–382. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Nakahashi T, Fujimura H, Altar CA, Li J, Kambayashi J, Tandon NN and Sun B: Vascular endothelial cells synthesize and secrete brain-derived neurotrophic factor. FEBS Lett. 470:113–117. 2000. View Article : Google Scholar : PubMed/NCBI

24 

Hiraoka Y, Kishimoto C, Takada H, Nakamura M, Kurokawa M, Ochiai H and Shiraki K: Nitric oxide and murine coxsackievirus B3 myocarditis: Aggravation of myocarditis by inhibition of nitric oxide synthase. J Am Coll Cardiol. 28:1610–1615. 1996. View Article : Google Scholar : PubMed/NCBI

25 

Jiménez-Maldonado A, de Álvarez-Buylla ER, Montero S, Melnikov V, Castro-Rodríguez E, Gamboa-Domínguez A, Rodríguez-Hernández A, Lemus M and Murguía JM: Chronic exercise increases plasma brain-derived neurotrophic factor levels, pancreatic islet size, and insulin tolerance in a TrkB-dependent manner. PLoS One. 9:e1151772014. View Article : Google Scholar : PubMed/NCBI

26 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(−Delta Delta C(T)) method. Method. 25:402–408. 2001. View Article : Google Scholar

27 

Siemerink MJ, Klaassen I, Vogels IM, Griffioen AW, Van Noorden CJ and Schlingemann RO: CD34 marks angiogenic tip cells in human vascular endothelial cell cultures. Angiogenesis. 15:151–163. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Frisén J, Verge VM, Fried K, Risling M, Persson H, Trotter J, Hökfelt T and Lindholm D: Characterization of glial trkB receptors: Differential response to injury in the central and peripheral nervous systems. Proc Natl Acad Sci USA. 90:4971–4975. 1993. View Article : Google Scholar : PubMed/NCBI

29 

Suh GY, Les AS, Tenforde AS, Shadden SC, Spilker RL, Yeung JJ, Cheng CP, Herfkens RJ, Dalman RL and Taylor CA: Hemodynamic changes quantified in abdominal aortic aneurysms with increasing exercise intensity using mr exercise imaging and image-based computational fluid dynamics. Ann Biomed Eng. 39:2186–2202. 2011. View Article : Google Scholar : PubMed/NCBI

30 

Rodriguez I and Gonzalez M: Physiological mechanisms of vascular response induced by shear stress and effect of exercise in systemic and placental circulation. Front Pharmacol. 5:2092014.PubMed/NCBI

31 

Wragg JW, Durant S, McGettrick HM, Sample KM, Egginton S and Bicknell R: Shear stress regulated gene expression and angiogenesis in vascular endothelium. Microcirculation. 21:290–300. 2014. View Article : Google Scholar : PubMed/NCBI

32 

Papaioannou TG and Stefanadis C: Vascular wall shear stress: Basic principles and methods. Hellenic J Cardiol. 46:9–15. 2005.PubMed/NCBI

33 

Barnes JM, Nauseef JT and Henry MD: Resistance to fluid shear stress is a conserved biophysical property of malignant cells. PLoS One. 7:e509732012. View Article : Google Scholar : PubMed/NCBI

34 

Galie PA, Nguyen DH, Choi CK, Cohen DM, Janmey PA and Chen CS: Fluid shear stress threshold regulates angiogenic sprouting. Proc Natl Acad Sci USA. 111:7968–7973. 2014. View Article : Google Scholar : PubMed/NCBI

35 

Ueda A, Koga M, Ikeda M, Kudo S and Tanishita K: Effect of shear stress on microvessel network formation of endothelial cells with in vitro three-dimensional model. Am J Physiol Heart Circ Physiol. 287:H994–H1002. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Guo W, Ji Y, Wang S, Sun Y and Lu B: Neuronal activity alters BDNF-TrkB signaling kinetics and downstream functions. J Cell Sci. 127:2249–2260. 2014. View Article : Google Scholar : PubMed/NCBI

37 

Ji Y, Lu Y, Yang F, Shen W, Tang TT, Feng L, Duan S and Lu B: Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in neurons. Nat Neurosci. 13:302–309. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Ando J, Ohtsuka A, Korenaga R and Kamiya A: Effect of extracellular ATP level on flow-induced Ca++ response in cultured vascular endothelial cells. Biochem Biophys Res Commun. 179:1192–1199. 1991. View Article : Google Scholar : PubMed/NCBI

39 

Yamamoto K, Korenaga R, Kamiya A and Ando J: Fluid shear stress activates Ca(2+) influx into human endothelial cells via P2X4 purinoceptors. Circ Res. 87:385–391. 2000. View Article : Google Scholar : PubMed/NCBI

40 

Jin H, Chen Y, Wang B, Zhu Y, Chen L, Han X, Ma G and Liu N: Association between brain-derived neurotrophic factor and von Willebrand factor levels in patients with stable coronary artery disease. BMC Cardiovasc Disord. 18:232018. View Article : Google Scholar : PubMed/NCBI

41 

Calvert JW: Cardioprotective effects of nitrite during exercise. Cardiovasc Res. 89:499–506. 2011. View Article : Google Scholar :

42 

Cui X, Chopp M, Zacharek A, Ning R, Ding X, Roberts C and Chen J: Endothelial nitric oxide synthase regulates white matter changes via the BDNF/TrkB pathway after stroke in mice. PLoS One. 8:e803582013. View Article : Google Scholar : PubMed/NCBI

43 

Li ST, Pan J, Hua XM, Liu H, Shen S, Liu JF, Li B, Tao BB, Ge XL, Wang XH, et al: Endothelial nitric oxide synthase protects neurons against ischemic injury through regulation of brain-derived neurotrophic factor expression. CNS Neurosci Ther. 20:154–164. 2014. View Article : Google Scholar : PubMed/NCBI

44 

Kolluru GK, Sinha S, Majumder S, Muley A, Siamwala JH, Gupta R and Chatterjee S: Shear stress promotes nitric oxide production in endothelial cells by sub-cellular delocalization of eNOS: A basis for shear stress mediated angiogenesis. Nitric Oxide. 22:304–315. 2010. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Wang BL, Jin H, Han XQ, Xia Y and Liu NF: Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats . Int J Mol Med 42: 2867-2880, 2018.
APA
Wang, B., Jin, H., Han, X., Xia, Y., & Liu, N. (2018). Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats . International Journal of Molecular Medicine, 42, 2867-2880. https://doi.org/10.3892/ijmm.2018.3841
MLA
Wang, B., Jin, H., Han, X., Xia, Y., Liu, N."Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats ". International Journal of Molecular Medicine 42.5 (2018): 2867-2880.
Chicago
Wang, B., Jin, H., Han, X., Xia, Y., Liu, N."Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats ". International Journal of Molecular Medicine 42, no. 5 (2018): 2867-2880. https://doi.org/10.3892/ijmm.2018.3841
Copy and paste a formatted citation
x
Spandidos Publications style
Wang BL, Jin H, Han XQ, Xia Y and Liu NF: Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats . Int J Mol Med 42: 2867-2880, 2018.
APA
Wang, B., Jin, H., Han, X., Xia, Y., & Liu, N. (2018). Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats . International Journal of Molecular Medicine, 42, 2867-2880. https://doi.org/10.3892/ijmm.2018.3841
MLA
Wang, B., Jin, H., Han, X., Xia, Y., Liu, N."Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats ". International Journal of Molecular Medicine 42.5 (2018): 2867-2880.
Chicago
Wang, B., Jin, H., Han, X., Xia, Y., Liu, N."Involvement of brain-derived neurotrophic factor in exercise‑induced cardioprotection of post-myocardial infarction rats ". International Journal of Molecular Medicine 42, no. 5 (2018): 2867-2880. https://doi.org/10.3892/ijmm.2018.3841
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