Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
November-2018 Volume 42 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
November-2018 Volume 42 Issue 5

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model

  • Authors:
    • Rui Lin
    • Jialin Duan
    • Fei Mu
    • Haixu Bian
    • Meina Zhao
    • Min Zhou
    • Yao Li
    • Aidong Wen
    • Yong Yang
    • Miaomiao Xi
  • View Affiliations / Copyright

    Affiliations: Department of Pharmacy, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710032, P.R. China, Department of Pharmacy, Xijing Hospital, Air Force Military Medical University, Xi'an, Shaanxi 710032, P.R. China , School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi 712046, P.R. China, Department of Pharmacy, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China
    Copyright: © Lin et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2628-2640
    |
    Published online on: August 27, 2018
       https://doi.org/10.3892/ijmm.2018.3844
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Traditional Chinese medicines, including Radix Salvia miltiorrhiza (SM) and Lignum Dalbergia odorifera (DO) extracts, have historically been used to treat myocardial ischemia and other cardiovascular diseases. The volatile oil of DO (DOO) is one of the main components of DO. The aim of the present study was to assess the cardioprotective effects and possible underlying mechanisms of SM‑DOO in pigs with ameroid constriction‑induced chronic myocardial ischemia. An ameroid constrictor was placed around the left anterior descending coronary artery of pigs to induce chronic myocardial ischemia. At weeks 2, 6 and 8, myocardial injury markers and blood gas levels were detected. At week 8, coronary angiography, echocardiography and hemodynamics analysis were performed to evaluate myocardial function. Following sacrifice, myocardial tissue was collected and subjected to morphological, histopathological and apoptosis assays. Western blotting was used to detect the protein expression of Bcl‑2 associated X (Bax), Bcl‑2, Akt, phosphorylated (p)‑Akt, glycogen synthase kinase (GSK)‑3β and p‑GSK‑3β. It was revealed that SM‑DOO treatment following chronic myocardial ischemia significantly downregulated the expression of myocardial injury markers, ameliorated myocardial oxygen consumption, increased collateralization, reduced regional cardiac dysfunction and limited the extent of myocardial damage. Furthermore, the results of an apoptosis assay revealed that the apoptosis rate was decreased, the expression of Bax decreased and Bcl‑2 increased, and the ratio of Bcl‑2/Bax was increased. Further experiments indicated that treatment with SM‑DOO increased the phosphorylation of Akt and GSK‑3β. These findings suggest that SM‑DOO treatment ameliorates myocardial injury in a chronic myocardial ischemia model, and that the underlying mechanisms responsible may be associated with the activation of the Akt/GSK‑3β signal pathway. Thus, experimental evidence that SM‑DOO may be an effective drug for the prevention and treatment of chronic myocardial ischemia in clinical applications has been provided.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

Figure 7

Figure 8

Figure 9

Figure 10

View References

1 

Shimokawa H and Yasuda S: Myocardial ischemia: Current concepts and future perspectives. J Cardiol. 52:67–78. 2008. View Article : Google Scholar : PubMed/NCBI

2 

Lv Y, Liu X, Yan S, Liang X, Yang Y, Dai W and Zhang W: Metabolomic study of myocardial ischemia and intervention effects of Compound Danshen Tablets in rats using ultra-performance liquid chromatography/quadrupole time-of-flight mass spectrometry. J Pharm Biomed Anal. 52:129–135. 2010. View Article : Google Scholar : PubMed/NCBI

3 

Xu T, Wu X, Chen Q, Zhu S, Liu Y, Pan D, Chen X and Li D: The anti-apoptotic and cardioprotective effects of salvianolic acid a on rat cardiomyocytes following ischemia/reperfusion by DUSP-mediated regulation of the ERK1/2/JNK pathway. PLoS One. 9:e1022922014. View Article : Google Scholar :

4 

JianXin C, Xue X, ZhongFeng L, Kuo G, FeiLong Z, ZhiHong L, Xian W and HongCai S: Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia. Sci Rep. 6:243832016. View Article : Google Scholar : PubMed/NCBI

5 

Zhang Y, Shi P, Yao H, Shao Q and Fan X: Metabolite profiling and pharmacokinetics of herbal compounds following oral administration of a cardiovascular multi-herb medicine (Qishen yiqi pills) in rats. Curr Drug Metab. 13:510–523. 2012. View Article : Google Scholar : PubMed/NCBI

6 

Wu SD, Wang J, Chen SC, Xu JB, Zheng Q, Yan YF, Wen TM and Tang YR: Effect of Xiangdan Injection on mRNA expression of endothelial vasoactive factors of patients with coronary heart disease and blood stasis. Zhong Xi Yi Jie He Xue Bao. 2:94–96. 2004.In Chinese. View Article : Google Scholar : PubMed/NCBI

7 

Wang SX, Luo K, Liang J, Fan F, Li H, Zheng JB and Zheng XH: Metabolomics study on the synergistic interaction between Salvia miltiorrhiza and Lignum dalbergiae odoriferae used as 'Jun-Shi' herbs in a S. miltiorrhiza recipe. Med Chem Res. 20:16–22. 2011. View Article : Google Scholar

8 

Sugiyama A, Zhu BM, Takahara A, Satoh Y and Hashimoto K: Cardiac effects of salvia miltiorrhiza/dalbergia odorifer a mixture, an intravenously applicable Chinese medicine widely used for patients with ischemic heart disease in China. Circ J. 66:182–184. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Mu F, Duan J, Bian H, Zhai X, Shang P, Lin R, Zhao M, Hu D, Yin Y, Wen A, et al: Metabonomic strategy for the evaluation of Chinese medicine salvia miltiorrhiza and dalbergia odorifera interfering with myocardial ischemia/reperfusion injury in rats. Rejuvenation Res. 20:263–277. 2017. View Article : Google Scholar : PubMed/NCBI

10 

Zheng X, Zhao X, Wang S, Luo K, Wei Y and Zheng J: Co-administration of Dalbergia odorifera increased bioavailability of Salvia miltiorrhiza e in rabbits. Am J Chin Med. 35:831–840. 2007. View Article : Google Scholar

11 

Zhou L, Zuo Z and Chow MS: Danshen: An overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol. 45:1345–1359. 2005. View Article : Google Scholar : PubMed/NCBI

12 

Liu R, Ye M, Guo H, Bi K and Guo DA: Liquid chromatography/electrospray ionization mass spectrometry for the characterization of twenty-three flavonoids in the extract of Dalbergia odorifera. Rapid Commun Mass Spectrom. 19:1557–1565. 2005. View Article : Google Scholar : PubMed/NCBI

13 

Tu J and Song K: Curative effect observation on Xiangdan injection in the treatment of coronary artery disease. Chin Med Pharm. 22:110–111. 2011.In Chinese.

14 

Qin F and Huang X: Guanxin II for the management of coronary heart disease. Chin J Integr Med. 15:472–476. 2009. View Article : Google Scholar

15 

Mu F, Duan J, Bian H, Yin Y, Zhu Y, Wei G, Guan Y, Wang Y, Guo C, Wen A, et al: Cardioprotective effects and mechanism of Radix Salviae miltiorrhizae and Lignum Dalbergiae odoriferae on rat myocardial ischemia/reperfusion injury. Mol Med Rep. 16:1759–1770. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Krishnamoorthy K and Subramaniam P: Phytochemical profiling of leaf, stem, and tuber parts of Solena amplexicaulis (Lam.) Gandhi using GC-MS. Int Sch Res Notices. 2014:5674092014.PubMed/NCBI

17 

Huang JH, Huang XZ, Chen ZY, Zheng QS and Sun RY: Dose conversion among different animals and healthy volunteers in pharmacological study. Chin J Clin Pharmacol Therap. 9:1069–1072. 2004.

18 

Henriques JP, Zijlstra F, van 't Hof AW, de Boer MJ, Dambrink JH, Gosselink M, Hoorntje JC and Suryapranata H: Angiographic assessment of reperfusion in acute myocardial infarction by myocardial blush grade. Circulation. 107:2115–2119. 2003. View Article : Google Scholar : PubMed/NCBI

19 

Liu Z, Chen JM, Huang H, Kuznicki M, Zheng S, Sun W, Quan N, Wang L, Yang H, Guo HM, et al: The protective effect of trimetazidine on myocardial ischemia/reperfusion injury through activating AMPK and ERK signaling pathway. Metabolism. 65:122–130. 2016. View Article : Google Scholar : PubMed/NCBI

20 

Saito N: Letter by Saito regarding article, 'Collateral donor artery physiology and the influence of a chronic total occlusion on fractional flow reserve'. Circ Cardiovasc Interv. 8:e0027942015. View Article : Google Scholar

21 

Zhao HW, Qin F, Liu YX, Huang X and Ren P: Antiapoptotic mechanisms of Chinese medicine formula, Guan-Xin-Er-Hao, in the rat ischemic heart. Tohoku J Exp Med. 216:309–316. 2008. View Article : Google Scholar

22 

Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W, Richards DR, McDonald-Smith GP, Gao H, Hennessy L, et al: Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci USA. 110:3507–3512. 2013. View Article : Google Scholar : PubMed/NCBI

23 

Elmadhun NY, Sabe AA, Robich MP, Chu LM, Lassaletta AD and Sellke FW: The pig as a valuable model for testing the effect of resveratrol to prevent cardiovascular disease. Ann NY Acad Sci. 1290:130–135. 2013. View Article : Google Scholar : PubMed/NCBI

24 

Ikonen TS, Pätilä T, Virtanen K, Lommi J, Lappalainen K, Kankuri E, Krogerus L and Harjula A: Ligation of ameroid-stenosed coronary artery leads to reproducible myocardial infarction-a pilot study in a porcine model. J Surg Res. 142:195–201. 2007. View Article : Google Scholar : PubMed/NCBI

25 

Caillaud D, Calderon J, Réant P, Lafitte S, Dos Santos P, Couffinhal T, Roques X and Barandon L: Echocardiographic analysis with a two-dimensional strain of chronic myocardial ischemia induced with ameroid constrictor in the pig. Interact Cardiovasc Thorac Surg. 10:689–693. 2010. View Article : Google Scholar : PubMed/NCBI

26 

Tuzun E, Oliveira E, Narin C, Khalil H, Jimenez-Quevedo P, Perin E and Silva G: Correlation of ischemic area and coronary flow with ameroid size in a porcine model. J Surg Res. 164:38–42. 2010. View Article : Google Scholar

27 

von Degenfeld G, Raake P, Kupatt C, Lebherz C, Hinkel R, Gildehaus FJ, Münzing W, Kranz A, Waltenberger J, Simoes M, et al: Selective pressure-regulated retroinfusion of fibroblast growth factor-2 into the coronary vein enhances regional myocardial blood flow and function in pigs with chronic myocardial ischemia. J Am Coll Cardiol. 42:1120–1128. 2003. View Article : Google Scholar : PubMed/NCBI

28 

Eisenman A: Troponin assays for the diagnosis of myocardial infarction and acute coronary syndrome: Where do we stand. Expert Rev Cardiovasc Ther. 4:509–514. 2006. View Article : Google Scholar : PubMed/NCBI

29 

Li X, Shao D, Wang G, Jiang T, Wu H, Gu B, Cao K, Zhang J, Qi L and Chen Y: Effects of different LAD-blocked sites on the development of acute myocardial infarction and malignant arrhythmia in a swine model. J Thorac Dis. 6:1271–1277. 2014.PubMed/NCBI

30 

Tsaroucha A, Chondrogiannis C, Mani A and Staikou C: Myocardial involvement during ischemia-induced acute liver failure in the pig. J Invest Surg. 26:99–104. 2013. View Article : Google Scholar : PubMed/NCBI

31 

Arya DS, Bansal P, Ojha SK, Nandave M, Mohanty I and Gupta SK: Pyruvate provides cardioprotection in the experimental model of myocardial ischemic reperfusion injury. Life Sci. 79:38–44. 2006. View Article : Google Scholar

32 

Doganci S, Yildirim V, Bolcal C, Korkusuz P, Gumusel B, Demirkilic U and Aydin A: Sodium nitrite and cardioprotective effect in pig regional myocardial ischemia-reperfusion injury model. Adv Clin Exp Med. 21:713–726. 2012.

33 

Elizondo-Montemayor L, Ugalde-Casas PA, Lam-Franco L, Bustamante-Careaga H, Serrano-González M, Gutiérrez NG and Martínez U: Association of ALT and the metabolic syndrome among Mexican children. Obes Res Clin Pract. 8:e79-e872014. View Article : Google Scholar

34 

Xu Q, Higgins T and Cembrowski GS: Limiting the testing of AST: A diagnostically nonspecific enzyme. Am J Clin Pathol. 144:423–426. 2015. View Article : Google Scholar : PubMed/NCBI

35 

Solymoss BC, Bourassa MG, Fortier A and Théroux P: Evaluation and risk stratification of acute coronary syndromes using a low cut-off level of cardiac troponin T, combined with CK-MB mass determination. Clin Biochem. 37:286–292. 2004. View Article : Google Scholar : PubMed/NCBI

36 

Zhang M, Dong W, Lu S, Yu Y, Liu H, Li G, Qiang W, Wang L and Lou J: Study on blood-gas changes in the coronary artery of myocardial ischemia reperfusion injury of rabbit. J Naval Med College. 1:9–12. 1996.In Chinese.

37 

Feng YJ, Chen C, Fallon JT, Lai T, Chen L, Knibbs DR, Waters DD and Wu AH: Comparison of cardiac troponin I, creatine kinase-MB, and myoglobin for detection of acute ischemic myocardial injury in a swine model. Am J Clin Pathol. 110:70–77. 1998. View Article : Google Scholar : PubMed/NCBI

38 

Ishihara Y and Shimamoto N: Sulfaphenazole attenuates myocardial cell apoptosis accompanied with cardiac ischemia-reperfusion by suppressing the expression of BimEL and Noxa. J Pharmacol Sci. 119:251–259. 2012. View Article : Google Scholar : PubMed/NCBI

39 

Qu D, Han J, Ren H, Yang W, Zhang X, Zheng Q and Wang D: Cardioprotective effects of Astragalin against myocardial ischemia/reperfusion injury in isolated rat heart. Oxid Med Cell Longev. 2016:81946902016. View Article : Google Scholar : PubMed/NCBI

40 

Pan H, Li D, Fang F, Chen D, Qi L, Zhang R, Xu T and Sun H: Salvianolic acid A demonstrates cardioprotective effects in rat hearts and cardiomyocytes after ischemia/reperfusion injury. J Cardiovasc Pharmacolm. 58:535–542. 2011. View Article : Google Scholar

41 

Zhang Q, Wang G, Yuan W, Wu J, Wang M and Li C: The effects of phosphodiesterase-5 inhibitor sildenafil against post-resuscitation myocardial and intestinal microcirculatory dysfunction by attenuating apoptosis and regulating microRNAs expression: Essential role of nitric oxide syntheses signaling. J Transl Med. 13:1772015. View Article : Google Scholar : PubMed/NCBI

42 

Wang ZG, Wang Y, Huang Y, Lu Q, Zheng L, Hu D, Feng WK, Liu YL, Ji KT, Zhang HY, et al: bFGF regulates autophagy and ubiquitinated protein accumulation induced by myocardial ischemia/reperfusion via the activation of the PI3K/Akt/mTOR pathway. Sci Rep. 5:92872015. View Article : Google Scholar : PubMed/NCBI

43 

Liu S, Ai Q, Feng K, Li YB and Liu X: The cardioprotective effect of dihydromyricetin prevents ischemia-reperfusion-induced apoptosis in vivo and in vitro via the PI3K/Akt and HIF-1α signaling pathways. Apoptosis. 21:1366–1385. 2016. View Article : Google Scholar : PubMed/NCBI

44 

Zhai P, Sciarretta S, Galeotti J, Volpe M and Sadoshima J: Differential roles of GSK-3β during myocardial ischemia and ischemia_reperfusion. Circ Res. 109:502–511. 2011. View Article : Google Scholar : PubMed/NCBI

45 

Duan J, Guan Y, Mu F, Guo C, Zhang E, Yin Y, Wei G, Zhu Y, Cui J, Cao J, et al: Protective effect of butin against ischemia/reperfusion-induced myocardial injury in diabetic mice: Involvement of the AMPK/GSK-3β/Nrf2 signaling pathway. Sci Rep. 7:414912017. View Article : Google Scholar

46 

Nagaoka K, Matoba T, Mao Y, Nakano Y, Ikeda G, Egusa S, Tokutome M, Nagahama R, Nakano K, Sunagawa K, et al: A new therapeutic modality for acute myocardial infarction: Nanoparticle-mediated delivery of Pitavastatin induces cardio-protection from ischemia-reperfusion injury via activation of PI3K/Akt pathway and anti-inflammation in a rat model. PLoS One. 10:e01324512015. View Article : Google Scholar

47 

Liu ZJ, Shi ZL, Tu C, Zhang HZ, Gao D, Li CY, He Q, Li RS, Guo YM, Niu M, et al: An activity-calibrated chemical standardization approach for quality evaluation of Salvia miltiorrhiza Bge. RSC Adv. 7:5331–5339. 2017. View Article : Google Scholar

48 

Zhou GJ, Wang W, Xie XM, Qin MJ, Kuai BK and Zhou TS: Post-harvest induced production of salvianolic acids and significant promotion of antioxidant properties in roots of Salvia miltiorrhiza (Danshen). Molecules. 19:7207–7222. 2014. View Article : Google Scholar : PubMed/NCBI

49 

Fan G, Yu J, Asare PF, Wang L, Zhang H, Zhang B, Zhu Y and Gao X: Danshensu alleviates cardiac ischaemia/reperfusion injury by inhibiting autophagy and apoptosis via activation of mTOR signalling. J Cell Mol Med. 20:1908–1919. 2016. View Article : Google Scholar : PubMed/NCBI

50 

Jia LQ, Yang GL, Ren L, Chen WN, Feng JY, Cao Y, Zhang L, Li XT and Lei P: Tanshinone IIA reduces apoptosis induced by hydrogen peroxide in the human endothelium-derived EA.hy926 cells. J Ethnopharmacol. 143:100–108. 2012. View Article : Google Scholar : PubMed/NCBI

51 

Zhuang P, Zhang Y, Cui G, Bian Y, Zhang M, Zhang J, Liu Y, Yang X, Isaiah AO, Lin Y, et al: Direct stimulation of adult neural stem/progenitor cells in vitro and neurogenesis in vivo by salvianolic acid B. PLoS One. 7:e356362012. View Article : Google Scholar : PubMed/NCBI

52 

Li XL, Liu JX, Li P and Zheng YQ: Protective effect of rosmarinic acid on hypoxia/reoxygenation injury in cardiomyocytes. Zhongguo Zhong Yao Za Zhi. 39:1897–1901. 2014.In Chinese. PubMed/NCBI

53 

Jung SH, Seol HJ, Jeon SJ, Son KH and Lee JR: Insulin-sensitizing activities of tanshinones, diterpene compounds of the root of Salvia miltiorrhiza Bunge. Phytomedicine. 16:327–335. 2009. View Article : Google Scholar : PubMed/NCBI

54 

Guo C, Yin Y, Duan J, Zhu Y, Yan J, Wei G, Guan Y, Wu X, Wang Y, Xi M and Wen A: Neuroprotective effect and underlying mechanism of sodium danshensu [3-(3,4-dihydroxyphenyl) lactic acid from Radix and Rhizoma Salviae miltiorrhizae = Danshen] against cerebral ischemia and reperfusion injury in rats. Phytomedicine. 22:283–289. 2015. View Article : Google Scholar : PubMed/NCBI

55 

Gao Q, Hu X, Jiang XJ, Guo MJ, Ji H, Wang Y and Fan YC: Cardiomyocyte-like cells differentiation from non β-catenin expression mesenchymal stem cells. Cytotechnology. 66:575–584. 2014. View Article : Google Scholar : PubMed/NCBI

56 

Li XL, Fan JP, Liu JX and Liang LN: Salvianolic acid A protects neonatal cardiomyocytes against hypoxia/reoxygenation-induced injury by preserving mitochondrial function and activating Akt/GSK-3beta signals. Chin J Integr Med. 1–8. 2017.

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Lin R, Duan J, Mu F, Bian H, Zhao M, Zhou M, Li Y, Wen A, Yang Y, Xi M, Xi M, et al: Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. Int J Mol Med 42: 2628-2640, 2018.
APA
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M. ... Xi, M. (2018). Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. International Journal of Molecular Medicine, 42, 2628-2640. https://doi.org/10.3892/ijmm.2018.3844
MLA
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M., Li, Y., Wen, A., Yang, Y., Xi, M."Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model". International Journal of Molecular Medicine 42.5 (2018): 2628-2640.
Chicago
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M., Li, Y., Wen, A., Yang, Y., Xi, M."Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model". International Journal of Molecular Medicine 42, no. 5 (2018): 2628-2640. https://doi.org/10.3892/ijmm.2018.3844
Copy and paste a formatted citation
x
Spandidos Publications style
Lin R, Duan J, Mu F, Bian H, Zhao M, Zhou M, Li Y, Wen A, Yang Y, Xi M, Xi M, et al: Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. Int J Mol Med 42: 2628-2640, 2018.
APA
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M. ... Xi, M. (2018). Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model. International Journal of Molecular Medicine, 42, 2628-2640. https://doi.org/10.3892/ijmm.2018.3844
MLA
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M., Li, Y., Wen, A., Yang, Y., Xi, M."Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model". International Journal of Molecular Medicine 42.5 (2018): 2628-2640.
Chicago
Lin, R., Duan, J., Mu, F., Bian, H., Zhao, M., Zhou, M., Li, Y., Wen, A., Yang, Y., Xi, M."Cardioprotective effects and underlying mechanism of Radix Salvia miltiorrhiza and Lignum Dalbergia odorifera in a pig chronic myocardial ischemia model". International Journal of Molecular Medicine 42, no. 5 (2018): 2628-2640. https://doi.org/10.3892/ijmm.2018.3844
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team