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Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease

  • Authors:
    • Yoshiji Yamada
    • Kimihiko Kato
    • Mitsutoshi Oguri
    • Hideki Horibe
    • Tetsuo Fujimaki
    • Yoshiki Yasukochi
    • Ichiro Takeuchi
    • Jun Sakuma
  • View Affiliations / Copyright

    Affiliations: Department of Human Functional Genomics, Advanced Science Research Promotion Center, Mie University, Tsu, Mie 514‑8507, Japan, Department of Cardiovascular Medicine, Gifu Prefectural Tajimi Hospital, Tajimi, Gifu 507‑8522, Japan, Department of Cardiovascular Medicine, Northern Mie Medical Center Inabe General Hospital, Inabe, Mie 511‑0428, Japan, CREST, Japan Science and Technology Agency, Kawaguchi, Saitama 332‑0012, Japan
    Copyright: © Yamada et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 2415-2436
    |
    Published online on: September 4, 2018
       https://doi.org/10.3892/ijmm.2018.3852
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Abstract

Early‑onset cardiovascular and renal diseases have a strong genetic component. In the present study, exome‑wide association studies (EWASs) were performed to identify genetic variants that confer susceptibility to early‑onset myocardial infarction (MI), hypertension, or chronic kidney disease (CKD) in Japanese individuals. A total of 8,093 individuals aged ≤65 years was enrolled in the study. The EWASs for MI, hypertension, and CKD were performed in 6,926 subjects (1,152 cases, 5,774 controls), 8,080 subjects (3,444 cases, 4,636 controls), and 2,556 subjects (1,051 cases, 1,505 controls), respectively. Genotyping of single nucleotide polymorphisms (SNPs) was performed with Illumina Human Exome‑12 DNA Analysis BeadChip or Infinium Exome‑24 BeadChip arrays. The associations of allele frequencies for 31,245, 31,276, or 31,514 SNPs that passed quality control to MI, hypertension, and CKD, respectively, was examined with Fisher's exact test. Bonferroni's correction for statistical significance of association was applied to compensate for multiple comparisons of genotypes with MI, hypertension, or CKD. The EWASs of allele frequencies revealed that 25, 11, and 11 SNPs were significantly associated with MI (P<1.60x10‑6), hypertension (P<1.60x10‑6), or CKD (P<1.59x10‑6), respectively. Multivariable logistic regression analysis with adjustment for covariates showed that all 25, 11, and 11 SNPs were significantly associated with MI (P<0.0005), hypertension (P<0.0011), or CKD (P<0.0011), respectively. On examination of the results from previous genome‑wide association studies and linkage disequilibrium of the identified SNPs, 11 loci (TMOD4, COL6A3, ADGRL3‑CXCL8‑MARCH1, OR52E4, TCHP‑GIT2, CCDC63, 12q24.1, OAS3, PLCB2‑VPS33B, GOSR2, ZNF77), six loci (MOB3C‑TMOD4, COL6A3, COL6A5, CXCL8‑MARCH1, NFKBIL1‑6p21.3‑NCR3, PLCB2‑VPS33B), and seven loci (MOB3C‑TMOD4, COL6A3, COL6A5, ADGRL3‑CXCL8‑MARCH1, MUC17, PLCB2‑VPS33B, ZNF77) were identified as novel loci significantly associated with MI, hypertension, and CKD, respectively. Furthermore, six genes (TMOD4, COL6A3, CXCL8, MARCH1, PLCB2, VPS33B) were significantly associated with MI, hypertension and CKD; two genes (ADGRL3, ZNF77) with MI and CKD; and two genes (COL6A5, MOB3C) with hypertension and CKD. Therefore, 13 novel loci (MOB3C‑TMOD4, COL6A3, ADGRL3‑CXCL8‑MARCH1, OR52E4, TCHP‑GIT2, CCDC63, 12q24.1, OAS3, PLCB2‑VPS33B, ZNF77, COL6A5, NFKBIL1‑NCR3, MUC17) were identified that confer susceptibility to early‑onset MI, hypertension, or CKD. The determination of genotypes for the SNPs at these loci may provide informative for assessment of the genetic risk for MI, hypertension, or CKD.
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View References

1 

Benjamin EJ, Virani SS, Callaway CW, Chamberlain AM, Chang AR, Cheng S, Chiuve SE, Cushman M, Delling FN, Deo R, et al: Heart disease and stroke statistics-2018 update: A report from the american heart association. Circulation. 137:e67–e492. 2018. View Article : Google Scholar : PubMed/NCBI

2 

McPherson R and Tybjaerg-Hansen A: Genetics of coronary artery disease. Circ Res. 118:564–578. 2016. View Article : Google Scholar : PubMed/NCBI

3 

Peden JF and Farrall M: Thirty-five common variants for coronary artery disease: The fruits of much collaborative labour. Hum Mol Genet. 20:R198–R205. 2011. View Article : Google Scholar : PubMed/NCBI

4 

McPherson R, Pertsemlidis A, Kavaslar N, Stewart A, Roberts R, Cox DR, Hinds DA, Pennacchio LA, Tybjaerg-Hansen A, Folsom AR, et al: A common allele on chromosome 9 associated with coronary heart disease. Science. 316:1488–1491. 2007. View Article : Google Scholar : PubMed/NCBI

5 

Helgadottir A, Thorleifsson G, Manolescu A, Gretarsdottir S, Blondal T, Jonasdottir A, Jonasdottir A, Sigurdsson A, Baker A, Palsson A, et al: A common variant on chromosome 9p21 affects the risk of myocardial infarction. Science. 316:1491–1493. 2007. View Article : Google Scholar : PubMed/NCBI

6 

Wellcome Trust Case Control Consortium: Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls. Nature. 447:661–678. 2007. View Article : Google Scholar : PubMed/NCBI

7 

Samani NJ, Erdmann J, Hall AS, Hengstenberg C, Mangino M, Mayer B, Dixon RJ, Meitinger T, Braund P, Wichmann HE, et al: Genomewide association analysis of coronary artery disease. N Engl J Med. 357:443–453. 2007. View Article : Google Scholar : PubMed/NCBI

8 

Schunkert H, König IR, Kathiresan S, Reilly MP, Assimes TL, Holm H, Preuss M, Stewart AF, Barbalic M, Gieger C, et al: Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease. Nat Genet. 43:333–338. 2011. View Article : Google Scholar : PubMed/NCBI

9 

CARDIoGRAMplusC4D Consortium; Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D, Erdmann J, et al: Large-scale association analysis identifies new risk loci for coronary artery disease. Nat Genet. 45:25–33. 2013. View Article : Google Scholar

10 

van der Harst P and Verweij N: Identification of 64 novel genetic loci provides an expanded view on the genetic architecture of coronary artery disease. Circ Res. 122:433–443. 2018. View Article : Google Scholar :

11 

Lettre G, Palmer CD, Young T, Ejebe KG, Allayee H, Benjamin EJ, Bennett F, Bowden DW, Chakravarti A, Dreisbach A, et al: Genome-wide association study of coronary heart disease and its risk factors in 8,090 african americans: The NHLBI CARe Project. PLoS Genet. 7:e10013002011. View Article : Google Scholar : PubMed/NCBI

12 

Wang F, Xu CQ, He Q, Cai JP, Li XC, Wang D, Xiong X, Liao YH, Zeng QT, Yang YZ, et al: Genome-wide association identifies a susceptibility locus for coronary artery disease in the chinese han population. Nat Genet. 43:345–349. 2011. View Article : Google Scholar : PubMed/NCBI

13 

Lu X, Wang L, Chen S, He L, Yang X, Shi Y, Cheng J, Zhang L, Gu CC, Huang J, et al: Genome-wide association study in han chinese identifies four new susceptibility loci for coronary artery disease. Nat Genet. 44:890–894. 2012. View Article : Google Scholar : PubMed/NCBI

14 

Nikpay M, Goel A, Won HH, Hall LM, Willenborg C, Kanoni S, Saleheen D, Kyriakou T, Nelson CP, Hopewell JC, et al: A comprehensive 1000 Genomes-based genome-wide association meta-analysis of coronary artery disease. Nat Genet. 47:1121–1130. 2015. View Article : Google Scholar : PubMed/NCBI

15 

Nelson CP, Goel A, Butterworth AS, Kanoni S, Webb TR, Marouli E, Zeng L, Ntalla I, Lai FY, Hopewell JC, et al: Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet. 49:1385–1391. 2017. View Article : Google Scholar : PubMed/NCBI

16 

Takeuchi F, Yokota M, Yamamoto K, Nakashima E, Katsuya T, Asano H, Isono M, Nabika T, Sugiyama T, Fujioka A, et al: Genome-wide association study of coronary artery disease in the japanese. Eur J Hum Genet. 20:333–340. 2012. View Article : Google Scholar :

17 

Hirokawa M, Morita H, Tajima T, Takahashi A, Ashikawa K, Miya F, Shigemizu D, Ozaki K, Sakata Y, Nakatani D, et al: A genome-wide association study identifies PLCL2 and AP3D1-DOT1L-SF3A2 as new susceptibility loci for myocardial infarction in japanese. Eur J Hum Genet. 23:374–380. 2015. View Article : Google Scholar :

18 

Padmanabhan S, Caulfield M and Dominiczak AF: Genetic and molecular aspects of hypertension. Circ Res. 116:937–959. 2015. View Article : Google Scholar : PubMed/NCBI

19 

Byars SG, Ewbank D, Govindaraju DR and Stearns SC: Natural selection in a contemporary human population. Proc Natl Acad Sci USA. 107(Suppl 1): S1787–S1792. 2010. View Article : Google Scholar

20 

Rapsomaniki E, Timmis A, George J, Pujades-Rodriguez M, Shah AD, Denaxas S, White IR, Caulfield MJ, Deanfield JE, Smeeth L, et al: Blood pressure and incidence of twelve cardiovascular diseases: Lifetime risks, healthy life-years lost, and age-specific associations in 1.25 million people. Lancet. 383:1899–1911. 2014. View Article : Google Scholar : PubMed/NCBI

21 

Levy D, Ehret GB, Rice K, Verwoert GC, Launer LJ, Dehghan A, Glazer NL, Morrison AC, Johnson AD, Aspelund T, et al: Genome-wide association study of blood pressure and hypertension. Nat Genet. 41:677–687. 2009. View Article : Google Scholar : PubMed/NCBI

22 

Newton-Cheh C, Johnson T, Gateva V, Tobin MD, Bochud M, Coin L, Najjar SS, Zhao JH, Heath SC, Eyheramendy S, et al: Genome-wide association study identifies eight loci associated with blood pressure. Nat Genet. 41:666–676. 2009. View Article : Google Scholar : PubMed/NCBI

23 

International Consortium for Blood Pressure Genome-Wide Association Studies; Ehret GB, Munroe PB, Rice KM, Bochud M, Johnson AD, Chasman DI, Smith AV, Tobin MD, Verwoert GC, et al: Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk. Nature. 478:103–109. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Warren HR, Evangelou E, Cabrera CP, Gao H, Ren M, Mifsud B, Ntalla I, Surendran P, Liu C, Cook JP, et al: Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk. Nat Genet. 49:403–415. 2017. View Article : Google Scholar : PubMed/NCBI

25 

Adeyemo A, Gerry N, Chen G, Herbert A, Doumatey A, Huang H, Zhou J, Lashley K, Chen Y, Christman M and Rotimi C: A genome-wide association study of hypertension and blood pressure in african americans. PLoS Genet. 5:e10005642009. View Article : Google Scholar : PubMed/NCBI

26 

Liang J, Le TH Edwards, DRV Tayo, BO Gaulton, KJ Smith, JA Lu Y, Jensen RA, Chen G, Yanek LR, et al: Single-trait and multi-trait genome-wide association analyses identify novel loci for blood pressure in african-ancestry populations. PLoS Genet. 13:e10067282017. View Article : Google Scholar : PubMed/NCBI

27 

Kato N, Takeuchi F, Tabara Y, Kelly TN, Go MJ, Sim X, Tay WT, Chen CH, Zhang Y, Yamamoto K, et al: Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east asians. Nat Genet. 43:531–538. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Kato N, Loh M, Takeuchi F, Verweij N, Wang X, Zhang W, Kelly TN, Saleheen D, Lehne B, Mateo Leach I, et al: Trans-ancestry genome-wide association study identifies 12 genetic loci influencing blood pressure and implicates a role for DNA methylation. Nat Genet. 47:1282–1293. 2015. View Article : Google Scholar : PubMed/NCBI

29 

Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, et al: Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension. Nat Genet. 48:1151–1161. 2016. View Article : Google Scholar : PubMed/NCBI

30 

Kato N, Miyata T, Tabara Y, Katsuya T, Yanai K, Hanada H, Kamide K, Nakura J, Kohara K, Takeuchi F, et al: High-density association study and nomination of susceptibility genes for hypertension in the japanese national project. Hum Mol Genet. 17:617–627. 2008. View Article : Google Scholar

31 

Webster AC, Nagler EV, Morton RL and Masson P: Chronic kidney disease. Lancet. 389:1238–1252. 2017. View Article : Google Scholar

32 

Weiner DE, Tighiouart H, Amin MG, Stark PC, MacLeod B, Griffith JL, Salem DN, Levey AS and Sarnak MJ: Chronic kidney disease as a risk factor for cardiovascular disease and all-cause mortality: A pooled analysis of community-based studies. J Am Soc Nephrol. 15:1307–1315. 2004. View Article : Google Scholar : PubMed/NCBI

33 

James MT, Hemmelgarn BR and Tonelli M: Early recognition and prevention of chronic kidney disease. Lancet. 375:1296–1309. 2010. View Article : Google Scholar : PubMed/NCBI

34 

Yamagata K, Ishida K, Sairenchi T, Takahashi H, Ohba S, Shiigai T, Narita M and Koyama A: Risk factors for chronic kidney disease in a community-based population: A 10-year follow-up study. Kidney Int. 71:159–166. 2007. View Article : Google Scholar

35 

Vivante A and Hildebrandt F: Exploring the genetic basis of early-onset chronic kidney disease. Nat Rev Nephrol. 12:133–146. 2016. View Article : Google Scholar : PubMed/NCBI

36 

Bochud M, Elston RC, Maillard M, Bovet P, Schild L, Shamlaye C and Burnier M: Heritability of renal function in hypertensive families of African descent in the Seychelles (Indian Ocean). Kidney Int. 67:61–69. 2005. View Article : Google Scholar

37 

Köttgen A, Glazer NL, Dehghan A, Hwang SJ, Katz R, Li M, Yang Q, Gudnason V, Launer LJ, Harris TB, et al: Multiple loci associated with indices of renal function and chronic kidney disease. Nat Genet. 41:712–717. 2009. View Article : Google Scholar : PubMed/NCBI

38 

Chambers JC, Zhang W, Lord GM, van der Harst P, Lawlor DA, Sehmi JS, Gale DP, Wass MN, Ahmadi KR, Bakker SJ, et al: Genetic loci influencing kidney function and chronic kidney disease. Nat Genet. 42:373–375. 2010. View Article : Google Scholar : PubMed/NCBI

39 

Köttgen A, Pattaro C, Böger CA, Fuchsberger C, Olden M, Glazer NL, Parsa A, Gao X, Yang Q, Smith AV, et al: New loci associated with kidney function and chronic kidney disease. Nat Genet. 42:376–384. 2010. View Article : Google Scholar : PubMed/NCBI

40 

Böger CA, Gorski M, Li M, Hoffmann MM, Huang C, Yang Q, Teumer A, Krane V, O'Seaghdha CM, Kutalik Z, et al: Association of eGFR-related loci identified by GWAS with incident CKD and ESRD. PLoS Genet. 7:e10022922011. View Article : Google Scholar : PubMed/NCBI

41 

Pattaro C, Köttgen A, Teumer A, Garnaas M, Böger CA, Fuchsberger C, Olden M, Chen MH, Tin A, Taliun D, et al: Genome-wide association and functional follow-up reveals new loci for kidney function. PLoS Genet. 8:e10025842012. View Article : Google Scholar : PubMed/NCBI

42 

Gorski M, van der Most PJ, Teumer A, Chu AY, Li M, Mijatovic V, Nolte IM, Cocca M, Taliun D, Gomez F, et al: 1000 Genomes-based meta-analysis identifies 10 novel loci for kidney function. Sci Rep. 7:468352017. View Article : Google Scholar

43 

Liu CT, Garnaas MK, Tin A, Kottgen A, Franceschini N, Peralta CA, de Boer IH, Lu X, Atkinson E, Ding J, et al: Genetic association for renal traits among participants of African ancestry reveals new loci for renal function. PLoS Genet. 7:e10022642011. View Article : Google Scholar : PubMed/NCBI

44 

Okada Y, Sim X, Go MJ, Wu JY, Gu D, Takeuchi F, Takahashi A, Maeda S, Tsunoda T, Chen P, et al: Meta-analysis identifies multiple loci associated with kidney function-related traits in east asian populations. Nat Genet. 44:904–909. 2012. View Article : Google Scholar : PubMed/NCBI

45 

Pattaro C, Teumer A, Gorski M, Chu AY, Li M, Mijatovic V, Garnaas M, Tin A, Sorice R, Li Y, et al: Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function. Nat Commun. 7:100232016. View Article : Google Scholar : PubMed/NCBI

46 

Marenberg ME, Risch N, Berkman LF, Floderus B and de Faire U: Genetic susceptibility to death from coronary heart disease in a study of twins. N Engl J Med. 330:1041–1046. 1994. View Article : Google Scholar : PubMed/NCBI

47 

Nora JJ, Lortscher RH, Spangler RD, Nora AH and Kimberling WJ: Genetic-epidemiologic study of early-onset ischemic heart disease. Circulation. 61:503–508. 1980. View Article : Google Scholar : PubMed/NCBI

48 

Roncaglioni MC, Santoro L, D'Avanzo B, Negri E, Nobili A, Ledda A, Pietropaolo F, Franzosi MG, La Vecchia C, Feruglio GA, et al: Role of family history in patients with myocardial infarction. An italian case-control study. GISSI-EFRIM investigators. Circulation. 85:2065–2072. 1992. View Article : Google Scholar : PubMed/NCBI

49 

Niiranen TJ, McCabe EL, Larson MG, Henglin M, Lakdawala NK, Vasan RS and Cheng S: Heritability and risks associated with early onset hypertension: Multigenerational, prospective analysis in the framingham heart study. BMJ. 357:j19492017. View Article : Google Scholar : PubMed/NCBI

50 

Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, et al: Identification of STXBP2 as a novel susceptibility locus for myocardial infarction in Japanese individuals by an exome-wide association study. Oncotarget. 8:33527–33535. 2017.PubMed/NCBI

51 

Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, et al: Identification of polymorphisms in 12q24.1, ACAD10, and BRAP as novel genetic determinants of blood pressure in Japanese by exome-wide association studies. Oncotarget. 8:43068–43079. 2017.PubMed/NCBI

52 

Yamada Y, Sakuma J, Takeuchi I, Yasukochi Y, Kato K, Oguri M, Fujimaki T, Horibe H, Muramatsu M, Sawabe M, et al: Identification of C21orf59 and ATG2A as novel determinants of renal function-related traits in Japanese by exome-wide association studies. Oncotarget. 8:45259–45273. 2017.PubMed/NCBI

53 

Yamada Y, Matsui K, Takeuchi I, Oguri M and Fujimaki T: Association of genetic variants with hypertension in a longitudinal population-based genetic epidemiological study. Int J Mol Med. 35:1189–1198. 2015. View Article : Google Scholar : PubMed/NCBI

54 

Matsuo S, Imai E, Horio M, Yasuda Y, Tomita K, Nitta K, Yamagata K, Tomino Y, Yokoyama H and Hishida A; Collaborators developing the Japanese equation for estimated GFR: Revised equations for estimated GFR from serum creatinine in japan. Am J Kidney Dis. 53:982–992. 2009. View Article : Google Scholar : PubMed/NCBI

55 

National Kidney Foundation: K/DOQI clinical practice guidelines for chronic kidney disease: Evaluation, classification, and stratification. Am J Kidney Dis. 39(Suppl 1): S1–S266. 2002.PubMed/NCBI

56 

Go AS, Chertow GM, Fan D, McCulloch CE and Hsu CY: Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization. N Engl J Med. 351:1296–1305. 2004. View Article : Google Scholar

57 

Grove ML, Yu B, Cochran BJ, Haritunians T, Bis JC, Taylor KD, Hansen M, Borecki IB, Cupples LA, Fornage M, et al: Best practices and joint calling of the HumanExome BeadChip: The CHARGE Consortium. PLoS One. 8:e680952013. View Article : Google Scholar : PubMed/NCBI

58 

Anderson CA, Pettersson FH, Clarke GM, Cardon LR, Morris AP and Zondervan KT: Data quality control in genetic case-control association studies. Nat Protoc. 5:1564–1573. 2010. View Article : Google Scholar : PubMed/NCBI

59 

Price AL, Patterson NJ, Plenge RM, Weinblatt ME, Shadick NA and Reich D: Principal components analysis corrects for stratification in genome-wide association studies. Nat Genet. 38:904–909. 2006. View Article : Google Scholar : PubMed/NCBI

60 

Leslie R, O'Donnell CJ and Johnson AD: GRASP: Analysis of genotype-phenotype results from 1390 genome-wide association studies and corresponding open access database. Bioinformatics. 30:i185–i194. 2014. View Article : Google Scholar : PubMed/NCBI

61 

Eicher JD, Landowski C, Stackhouse B, Sloan A, Chen W, Jensen N, Lien JP, Leslie R and Johnson AD: GRASP v2.0: An update on the genome-wide repository of associations between SNPs and phenotypes. Nucleic Acids Res. 43:D799–D804. 2015. View Article : Google Scholar :

62 

Binns D, Dimmer E, Huntley R, Barrell D, O'Donovan C and Apweiler R: QuickGO: A web-based tool for gene ontology searching. Bioinformatics. 25:3045–3046. 2009. View Article : Google Scholar : PubMed/NCBI

63 

Huntley RP, Binns D, Dimmer E, Barrell D, O'Donovan C and Apweiler R: QuickGO: A user tutorial for the web-based gene ontology browser. Database (Oxford). 2009:bap0102009. View Article : Google Scholar

64 

Warde-Farley D, Donaldson SL, Comes O, Zuberi K, Badrawi R, Chao P, Franz M, Grouios C, Kazi F, Lopes CT, et al: The GeneMANIA prediction server: Biological network integration for gene prioritization and predicting gene function. Nucleic Acids Res. 38:W214–W220. 2010. View Article : Google Scholar : PubMed/NCBI

65 

Montojo J, Zuberi K, Rodriguez H, Kazi F, Wright G, Donaldson SL, Morris Q and Bader GD: GeneMANIA cytoscape plugin: Fast gene function predictions on the desktop. Bioinformatics. 26:2927–2928. 2010. View Article : Google Scholar : PubMed/NCBI

66 

Montojo J, Zuberi K, Rodriguez H, Bader GD and Morris Q: GeneMANIA: Fast gene network construction and function prediction for Cytoscape. F1000Res. 3:1532014.PubMed/NCBI

67 

Shannon P, Markiel A, Ozier O, Baliga NS, Wang JT, Ramage D, Amin N, Schwikowski B and Ideker T: Cytoscape: A software environment for integrated models of biomolecular interaction networks. Genome Res. 13:2498–2504. 2003. View Article : Google Scholar : PubMed/NCBI

68 

Piñero J, Queralt-Rosinach N, Bravo À, Deu-Pons J, Bauer-Mehren A, Baron M, Sanz F and Furlong LI: DisGeNET: A discovery platform for the dynamical exploration of human diseases and their genes. Database (Oxford). 2015. pp. bav0282015, View Article : Google Scholar

69 

Piñero J, Bravo À, Queralt-Rosinach N, Gutiérrez-Sacristán A, Deu-Pons J, Centeno E, García-García J, Sanz F and Furlong LI: DisGeNET: A comprehensive platform integrating information on human disease-associated genes and variants. Nucleic Acids Res. 45:D833–D839. 2017. View Article : Google Scholar :

70 

Asselbergs FW, Guo Y, van Iperen EP, Sivapalaratnam S, Tragante V, Lanktree MB, Lange LA, Almoguera B, Appelman YE, Barnard J, et al: Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. Am J Hum Genet. 91:823–838. 2012. View Article : Google Scholar : PubMed/NCBI

71 

Jee SH, Sull JW, Lee JE, Shin C, Park J, Kimm H, Cho EY, Shin ES, Yun JE, Park JW, et al: Adiponectin concentrations: A genome-wide association study. Am J Hum Genet. 87:545–552. 2010. View Article : Google Scholar : PubMed/NCBI

72 

Kim YJ, Go MJ, Hu C, Hong CB, Kim YK, Lee JY, Hwang JY, Oh JH, Kim DJ, Kim NH, et al: Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits. Nat Genet. 43:990–995. 2011. View Article : Google Scholar : PubMed/NCBI

73 

Morris AP, Voight BF, Teslovich TM, Ferreira T, Segrè AV, Steinthorsdottir V, Strawbridge RJ, Khan H, Grallert H, Mahajan A, et al: Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes. Nat Genet. 44:981–990. 2012. View Article : Google Scholar : PubMed/NCBI

74 

Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S, Chasman DI, Willer CJ, et al: Biological, clinical and population relevance of 95 loci for blood lipids. Nature. 466:707–713. 2010. View Article : Google Scholar : PubMed/NCBI

75 

Klarin D, Zhu QM, Emdin CA, Chaffin M, Horner S, McMillan BJ, Leed A, Weale ME, Spencer CCA, Aguet F, et al: Genetic analysis in UK Biobank links insulin resistance and transendothelial migration pathways to coronary artery disease. Nat Genet. 49:1392–1397. 2017. View Article : Google Scholar : PubMed/NCBI

76 

Howson JMM, Zhao W, Barnes DR, Ho WK, Young R, Paul DS, Waite LL, Freitag DF, Fauman EB, Salfati EL, et al: Fifteen new risk loci for coronary artery disease highlight arterial-wall-specific mechanisms. Nat Genet. 49:1113–1119. 2017. View Article : Google Scholar : PubMed/NCBI

77 

Lempiäinen H, Brænne I, Michoel T, Tragante V, Vilne B, Webb TR, Kyriakou T, Eichner J, Zeng L, Willenborg C, et al: Network analysis of coronary artery disease risk genes elucidates disease mechanisms and druggable targets. Sci Rep. 8:34342018. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I and Sakuma J: Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. Int J Mol Med 42: 2415-2436, 2018.
APA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y. ... Sakuma, J. (2018). Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. International Journal of Molecular Medicine, 42, 2415-2436. https://doi.org/10.3892/ijmm.2018.3852
MLA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease". International Journal of Molecular Medicine 42.5 (2018): 2415-2436.
Chicago
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease". International Journal of Molecular Medicine 42, no. 5 (2018): 2415-2436. https://doi.org/10.3892/ijmm.2018.3852
Copy and paste a formatted citation
x
Spandidos Publications style
Yamada Y, Kato K, Oguri M, Horibe H, Fujimaki T, Yasukochi Y, Takeuchi I and Sakuma J: Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. Int J Mol Med 42: 2415-2436, 2018.
APA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y. ... Sakuma, J. (2018). Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease. International Journal of Molecular Medicine, 42, 2415-2436. https://doi.org/10.3892/ijmm.2018.3852
MLA
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease". International Journal of Molecular Medicine 42.5 (2018): 2415-2436.
Chicago
Yamada, Y., Kato, K., Oguri, M., Horibe, H., Fujimaki, T., Yasukochi, Y., Takeuchi, I., Sakuma, J."Identification of 13 novel susceptibility loci for early-onset myocardial infarction, hypertension, or chronic kidney disease". International Journal of Molecular Medicine 42, no. 5 (2018): 2415-2436. https://doi.org/10.3892/ijmm.2018.3852
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