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O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats

  • Authors:
    • Lin Huang
    • Ping Yuan
    • Peng Yu
    • Qiling Kong
    • Zixuan Xu
    • Xia Yan
    • Yang Shen
    • Juesheng Yang
    • Rong Wan
    • Kui Hong
    • Yanhua Tang
    • Jinzhu Hu
  • View Affiliations / Copyright

    Affiliations: Department of Cardiovascular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, The Jiangxi Key Laboratory of Molecular Medicine, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China, Department of Cardiovascular Surgery, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Huang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3278-3290
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    Published online on: September 7, 2018
       https://doi.org/10.3892/ijmm.2018.3866
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Abstract

The O‑linked β‑N‑acetylglucosamine (O‑GlcNAc) modification and autophagy are associated with diabetic myocardial injury, however, the molecular mechanisms between the two processes remain to be fully elucidated. The purpose of the present study was to elucidate the molecular regulation of autophagy by O‑GlcNAc‑modified synaptosomal‑associated protein 29 (SNAP29) in diabetic myocardial injury. A rat model of type I diabetes was established via intraperitoneal injection of streptozotocin (STZ; 55 mg/kg). Significant increases in the O‑GlcNAc modification and accumulation of the autophagy markers microtubule‑associated protein 1 light chain 3α II/I and P62, which suggest that autophagic flux is inhibited, were observed in rats 8 weeks following STZ induction. Subsequently, the selective O‑GlcNAcase inhibitor, thiamet G, increased the level of O‑GlcNAc modification, which further disrupted autophagic flux; deteriorated cardiac diastolic function, as indicated by an increased left ventricular filling peak velocity/atrial contraction flow peak velocity ratio shown by echocardiography; and exacerbated myocardial abnormalities, as characterized by cardiomyocyte disorganization and fat and interstitial fibrosis accumulation. By contrast, 6‑diazo‑5‑oxo‑L‑norleucine, an inhibitor of glucosamine fructose‑6‑phosphate aminotransferase isomerizing 1, acted as an O‑GlcNAc antagonist and reduced the level of O‑GlcNAc modification, which maintained autophagic flux and improved cardiac diastolic function. In vitro, high glucose (25 mM) was used to stimulate primary neonatal rat cardiomyocytes (NRCMs). Consistent with the myocardium of diabetic rats, it was also shown in the NRCMs that O‑GlcNAc modification of SNAP29 negatively regulated autophagic flux. The application of the short hairpin RNA interference lysosome‑associated membrane protein (LAMP2) and the autophagy inhibitor 3‑methyladenine demonstrated that high glucose inhibited autophagy‑mediated degradation rather than affected the initial stage of autophagy. Finally, co‑immunoprecipitation was used to determine the role of the O‑GlcNAc‑modified substrate protein SNAP29, which acted as an SNAP29‑syntaxin‑17 (STX17)‑vesicle‑associated membrane protein 8 (VAMP8) complex during disease progression. The present study is the first, to the best of our knowledge, to demonstrate that SNAP29 is an O‑GlcNAc substrate and that an increase in O‑GlcNAc‑modified SNAP29 inhibits SNAP29‑STX17‑VAMP8 complex formation, thereby inhibiting the degradation of autophagy and exacerbating myocardial injury in type I diabetic rats.
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View References

1 

Huynh K, Bernardo BC, McMullen JR and Ritchie RH: Diabetic cardiomyopathy: Mechanisms and new treatment strategies targeting antioxidant signaling pathways. Pharmacol Ther. 142:375–415. 2014. View Article : Google Scholar : PubMed/NCBI

2 

Chavali V, Tyagi SC and Mishra PK: Predictors and prevention of diabetic cardiomyopathy. Diabetes Metab Syndr Obes. 6:151–160. 2013.PubMed/NCBI

3 

Dei CA, Khan SS, Butler J, Mentz RJ, Bonow RO, Avogaro A, Tschoepe D, Doehner W, Greene SJ, Senni M, et al: Impact of diabetes on epidemiology, treatment, and outcomes of patients with heart failure. JACC Heart Fail. 3:136–145. 2015. View Article : Google Scholar

4 

Yi W, Clark PM, Mason DE, Keenan MC, Hill C, Goddard WA III, Peters EC, Driggers EM and Hsieh-Wilson LC: Phosphofructokinase 1 glycosylation regulates cell growth and metabolism. Science. 337:975–980. 2012. View Article : Google Scholar : PubMed/NCBI

5 

Wang P and Hanover JA: Nutrient-driven O-GlcNAc cycling influences autophagic flux and neurodegenerative proteotoxicity. Autophagy. 9:604–606. 2013. View Article : Google Scholar : PubMed/NCBI

6 

Pekkurnaz G, Trinidad JC, Wang X, Kong D and Schwarz TL: Glucose regulates mitochondrial motility via Milton modification by O-GlcNAc transferase. Cell. 158:54–68. 2014. View Article : Google Scholar : PubMed/NCBI

7 

Ruan HB, Dietrich MO, Liu ZW, Zimmer MR, Li MD, Singh JP, Zhang K, Yin R, Wu J, Horvath TL and Yang X: O-GlcNAc transferase enables AgRP neurons to suppress browning of white fat. Cell. 159:306–317. 2014. View Article : Google Scholar : PubMed/NCBI

8 

Peng C, Zhu Y, Zhang W, Liao Q, Chen Y, Zhao X, Guo Q, Shen P, Zhen B, Qian X, et al: Regulation of the Hippo-YAP pathway by glucose sensor O-GlcNAcylation. Mol Cell. 68:591–604. 2017. View Article : Google Scholar : PubMed/NCBI

9 

Ngoh GA, Facundo HT, Zafir A and Jones SP: O-GlcNAc signaling in the cardiovascular system. Circ Res. 107:171–185. 2010. View Article : Google Scholar : PubMed/NCBI

10 

Zhang Z, Costa FC, Tan EP, Bushue N, DiTacchio L, Costello CE, McComb ME, Whelan SA, Peterson KR and Slawson C: O-Linked N-Acetylglucosamine (O-GlcNAc) Transferase and O-GlcNAcase Interact with Mi2β Protein at the Aγ-Globin Promoter. J Biol Chem. 291:15628–15640. 2016. View Article : Google Scholar : PubMed/NCBI

11 

Erickson JR, Pereira L, Wang L, Han G, Ferguson A, Dao K, Copeland RJ, Despa F, Hart GW, Ripplinger CM and Bers DM: Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature. 502:372–376. 2013. View Article : Google Scholar : PubMed/NCBI

12 

Park MJ, Kim DI, Lim SK, Choi JH, Han HJ, Yoon KC and Park SH: High glucose-induced O-GlcNAcylated carbohydrate response element-binding protein (ChREBP) mediates mesangial cell lipogenesis and fibrosis: The possible role in the development of diabetic nephropathy. J Biol Chem. 289:13519–13530. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Xie S, Jin N, Gu J, Shi J, Sun J, Chu D, Zhang L, Dai CL, Gu JH, Gong CX, et al: O-GlcNAcylation of protein kinase A catalytic subunits enhances its activity: A mechanism linked to learning and memory deficits in Alzheimer’s disease. Aging Cell. 15:455–464. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Ma J and Hart GW: Protein O-GlcNAcylation in diabetes and diabetic complications. Expert Rev Proteomics. 10:365–380. 2013. View Article : Google Scholar : PubMed/NCBI

15 

Banerjee PS, Ma J and Hart GW: Diabetes-associated dysregulation of O-GlcNAcylation in rat cardiac mitochondria. Proc Natl Acad Sci USA. 112:6050–6055. 2015. View Article : Google Scholar : PubMed/NCBI

16 

Hu Y, Belke D, Suarez J, Swanson E, Clark R, Hoshijima M and Dillmann WH: Adenovirus-mediated overexpression of O-GlcNAcase improves contractile function in the diabetic heart. Circ Res. 96:1006–1013. 2005. View Article : Google Scholar : PubMed/NCBI

17 

Gustafsson AB and Gottlieb RA: Recycle or die: The role of autophagy in cardioprotection. J Mol Cell Cardiol. 44:654–661. 2008. View Article : Google Scholar : PubMed/NCBI

18 

Yorimitsu T and Klionsky DJ: Autophagy: Molecular machinery for self-eating. Cell Death Differ. 12(Suppl 2): S1542–S1552. 2005. View Article : Google Scholar

19 

Hohenstein AC and Roche PA: SNAP-29 is a promiscuous syntaxin-binding SNARE. Biochem Biophys Res Commun. 285:167–171. 2001. View Article : Google Scholar : PubMed/NCBI

20 

Diao J, Liu R, Rong Y, Zhao M, Zhang J, Lai Y, Zhou Q, Wilz LM, Li J, Vivona S, et al: ATG14 promotes membrane tethering and fusion of autophagosomes to endolysosomes. Nature. 520:563–566. 2015. View Article : Google Scholar : PubMed/NCBI

21 

Bernard A and Klionsky DJ: Toward an understanding of autophagosome-lysosome fusion: The unsuspected role of ATG14. Autophagy. 11:583–584. 2015. View Article : Google Scholar : PubMed/NCBI

22 

Liu R, Zhi X and Zhong Q: ATG14 controls SNARE-mediated autophagosome fusion with a lysosome. Autophagy. 11:847–849. 2015. View Article : Google Scholar : PubMed/NCBI

23 

Guo B, Liang Q, Li L, Hu Z, Wu F, Zhang P, Ma Y, Zhao B, Kovács AL, Zhang Z, et al: O-GlcNAc-modification of SNAP-29 regulates autophagosome maturation. Nat Cell Biol. 16:1215–1226. 2014. View Article : Google Scholar : PubMed/NCBI

24 

Bell RC, Carlson JC, Storr KC, Herbert K and Sivak J: High-fructose feeding of streptozotocin-diabetic rats is associated with increased cataract formation and increased oxidative stress in the kidney. Br J Nutr. 84:575–582. 2000.PubMed/NCBI

25 

Kanamori H, Takemura G, Goto K, Tsujimoto A, Mikami A, Ogino A, Watanabe T, Morishita K, Okada H, Kawasaki M, et al: Autophagic adaptations in diabetic cardiomyopathy differ between type 1 and type 2 diabetes. Autophagy. 11:1146–1160. 2015. View Article : Google Scholar : PubMed/NCBI

26 

Barefield DY, Puckelwartz MJ, Kim EY, Wilsbacher LD, Vo AH, Waters EA, Earley JU, Hadhazy M, Dellefave-Castillo L, Pesce LL and McNally EM: Experimental modeling supports a role for MyBP-HL as a Novel myofilament component in arrhythmia and dilated cardiomyopathy. Circulation. 136:1477–1491. 2017. View Article : Google Scholar : PubMed/NCBI

27 

Riha H, Papoušek F, Neckář J, Pirk J and Ošťádal B: Effects of isoflurane concentration on basic echocardiographic parameters of the left ventricle in rats. Physiol Res. 61:419–423. 2012.PubMed/NCBI

28 

Reinecke H, Zhang M, Bartosek T and Murry CE: Survival, integration, and differentiation of cardiomyocyte grafts: A study in normal and injured rat hearts. Circulation. 100:193–202. 1999. View Article : Google Scholar : PubMed/NCBI

29 

Peng X, Shao J, Shen Y, Zhou Y, Cao Q, Hu J, He W, Yu X, Liu X, Marian AJ and Hong K: FAT10 protects cardiac myocytes against apoptosis. J Mol Cell Cardiol. 59:1–10. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Mellor KM, Bell JR, Young MJ, Ritchie RH and Delbridge LM: Myocardial autophagy activation and suppressed survival signaling is associated with insulin resistance in fructose-fed mice. J Mol Cell Cardiol. 50:1035–1043. 2011. View Article : Google Scholar : PubMed/NCBI

31 

Tanida I, Wakabayashi M, Kanematsu T, Minematsu-Ikeguchi N, Sou YS, Hirata M, Ueno T and Kominami E: Lysosomal turnover of GABARAP-phospholipid conjugate is activated during differentiation of C2C12 cells to myotubes without inactivation of the mTor kinase-signaling pathway. Autophagy. 2:264–271. 2006. View Article : Google Scholar : PubMed/NCBI

32 

Darley-Usmar VM, Ball LE and Chatham JC: Protein O-linked β-N-acetylglucosamine: A novel effector of cardiomyocyte metabolism and function. J Mol Cell Cardiol. 52:538–549. 2012. View Article : Google Scholar

33 

Jesmin S, Zaedi S, Shimojo N, Iemitsu M, Masuzawa K, Yamaguchi N, Mowa CN, Maeda S, Hattori Y and Miyauchi T: Endothelin antagonism normalizes VEGF signaling and cardiac function in STZ-induced diabetic rat hearts. Am J Physiol Endocrinol Metab. 292:E1030–E1040. 2007. View Article : Google Scholar

34 

Chen ZC, Cheng YZ, Chen LJ, Cheng KC, Li Y and Cheng J: Increase of ATP-sensitive potassium (K(ATP)) channels in the heart of type-1 diabetic rats. Cardiovasc DiabetoL. 11:82012. View Article : Google Scholar : PubMed/NCBI

35 

Li HT, Wu XD, Davey AK and Wang J: Antihyperglycemic effects of baicalin on streptozotocin-nicotinamide induced diabetic rats. Phytother Res. 25:189–194. 2011.

36 

Sun D, Shen M, Li J, Li W, Zhang Y, Zhao L, Zhang Z, Yuan Y, Wang H and Cao F: Cardioprotective effects of tanshinone IIA pretreatment via kinin B2 receptor-Akt-GSK-3β dependent pathway in experimental diabetic cardiomyopathy. Cardiovasc Diabetol. 10:42011. View Article : Google Scholar

37 

Qiao L, Guo B, Zhang H, Yang R, Chang L, Wang Y, Jin X, Liu S and Li Y: The clock gene, brain and muscle Arnt-like 1, regulates autophagy in high glucose-induced cardiomyocyte injury. Oncotarget. 8:80612–80624. 2017. View Article : Google Scholar : PubMed/NCBI

38 

Xie Z, Lau K, Eby B, Lozano P, He C, Pennington B, Li H, Rathi S, Dong Y, Tian R, et al: Improvement of cardiac functions by chronic metformin treatment is associated with enhanced cardiac autophagy in diabetic OVE26 mice. Diabetes. 60:1770–1778. 2011. View Article : Google Scholar : PubMed/NCBI

39 

Wang B, Yang Q, Sun YY, Xing YF, Wang YB, Lu XT, Bai WW, Liu XQ and Zhao YX: Resveratrol-enhanced autophagic flux ameliorates myocardial oxidative stress injury in diabetic mice. J Cell Mol Med. 18:1599–1611. 2014. View Article : Google Scholar : PubMed/NCBI

40 

Li Q, Frank M, Akiyama M, Shimizu H, Ho SY, Thisse C, Thisse B, Sprecher E and Uitto J: Abca12-mediated lipid transport and Snap29-dependent trafficking of lamellar granules are crucial for epidermal morphogenesis in a zebrafish model of ichthyosis. Dis Model Mech. 4:777–785. 2011. View Article : Google Scholar : PubMed/NCBI

41 

Morelli E, Ginefra P, Mastrodonato V, Beznoussenko GV, Rusten TE, Bilder D, Stenmark H, Mironov AA and Vaccari T: Multiple functions of the SNARE protein Snap29 in autophagy, endocytic, and exocytic trafficking during epithelial formation in Drosophila. Autophagy. 10:2251–2268. 2014. View Article : Google Scholar

42 

Jiu Y, Hasygar K, Tang L, Liu Y, Holmberg CI, Bürglin TR, Hietakangas V and Jäntti J: par-1, atypical pkc, and PP2A/B55 sur-6 are implicated in the regulation of exocyst-mediated membrane trafficking in Caenorhabditis elegans. G3 (Bethesda). 4:173–183. 2014. View Article : Google Scholar

43 

Sato M, Saegusa K and Sato K, Hara T, Harada A and Sato K: Caenorhabditis elegans SNAP-29 is required for organellar integrity of the endomembrane system and general exocytosis in intestinal epithelial cells. Mol Biol Cell. 22:2579–2587. 2011. View Article : Google Scholar : PubMed/NCBI

44 

Itakura E, Kishi-Itakura C and Mizushima N: The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes. Cell. 151:1256–1269. 2012. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Huang L, Yuan P, Yu P, Kong Q, Xu Z, Yan X, Shen Y, Yang J, Wan R, Hong K, Hong K, et al: O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. Int J Mol Med 42: 3278-3290, 2018.
APA
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X. ... Hu, J. (2018). O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. International Journal of Molecular Medicine, 42, 3278-3290. https://doi.org/10.3892/ijmm.2018.3866
MLA
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X., Shen, Y., Yang, J., Wan, R., Hong, K., Tang, Y., Hu, J."O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats". International Journal of Molecular Medicine 42.6 (2018): 3278-3290.
Chicago
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X., Shen, Y., Yang, J., Wan, R., Hong, K., Tang, Y., Hu, J."O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats". International Journal of Molecular Medicine 42, no. 6 (2018): 3278-3290. https://doi.org/10.3892/ijmm.2018.3866
Copy and paste a formatted citation
x
Spandidos Publications style
Huang L, Yuan P, Yu P, Kong Q, Xu Z, Yan X, Shen Y, Yang J, Wan R, Hong K, Hong K, et al: O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. Int J Mol Med 42: 3278-3290, 2018.
APA
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X. ... Hu, J. (2018). O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats. International Journal of Molecular Medicine, 42, 3278-3290. https://doi.org/10.3892/ijmm.2018.3866
MLA
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X., Shen, Y., Yang, J., Wan, R., Hong, K., Tang, Y., Hu, J."O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats". International Journal of Molecular Medicine 42.6 (2018): 3278-3290.
Chicago
Huang, L., Yuan, P., Yu, P., Kong, Q., Xu, Z., Yan, X., Shen, Y., Yang, J., Wan, R., Hong, K., Tang, Y., Hu, J."O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats". International Journal of Molecular Medicine 42, no. 6 (2018): 3278-3290. https://doi.org/10.3892/ijmm.2018.3866
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