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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2018 Volume 42 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Chongyang Ma, Shuling Liu, Shuang Zhang, Tian Xu, Xue Yu, Yushan Gao, Changming Zhai, Changxiang Li, Chaofang Lei, Shuning Fan, Yuxi Chen, Huiling Tian, Qingguo Wang, Fafeng Cheng, Xueqian Wang
Pages: 2979-2990
Published online on: 02 October 2018

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Review

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)

Thomas Mbimba, Nazar J. Hussein, Ayesha Najeed, Fayez F. Safadi
Pages: 2991-2997
Published online on: 21 September 2018

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Review Open Access

Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)

Jorge Reyes‑García, Edgar Flores‑Soto, Abril Carbajal‑García, Bettina Sommer, Luis M. Montaño
Pages: 2998-3008
Published online on: 02 October 2018

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Article Open Access

Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs

Miwa Hayashi, Kengo Kuroda, Kohei Ihara, Takahiro Iwaya, Emiko Isogai
Pages: 3009-3016
Published online on: 13 September 2018

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Article Open Access

Silencing of NOD2 protects against diabetic cardiomyopathy in a murine diabetes model

Lin Shen, Li Li, Man Li, Weiling Wang, Wenbin Yin, Wei Liu, Yanyan Hu
Pages: 3017-3026
Published online on: 14 September 2018

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Article Open Access

miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10

Fangzhou Liu, Kexin Lou, Xiaotong Zhao, Jia Zhang, Wei Chen, Yichun Qian, Yanbin Zhao, Yan Zhu, Yuan Zhang
Pages: 3027-3036
Published online on: 27 September 2018

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Article Open Access

Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B

Yang Liu, Yanling Liu, Guolin Li, Zhengrong Chen, Guixiong Gu
Pages: 3037-3046
Published online on: 18 September 2018

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Article Open Access

Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice

Joo Wan Kim, You‑Suk Lee, Du Jin Seol, Il Je Cho, Sae Kwang Ku, Jae‑Suk Choi, Hae‑Jeung Lee
Pages: 3047-3064
Published online on: 14 September 2018

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Article Open Access

DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells

Lili Zhang, Shuguang Zhang, Aihua Li, Anqi Zhang, Shiqian Zhang, Liang Chen
Pages: 3065-3072
Published online on: 11 September 2018

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Article Open Access

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism

Gang Chen, Hugang Shen, Linlin Zang, Zhonglan Su, Jilong Huang, Yong Sun, Hongwei Wang
Pages: 3073-3082
Published online on: 02 October 2018

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Article Open Access

BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo

Yu‑Dong Ji, Zhen‑Long Luo, Chun‑Xiu Chen, Bo Li, Jie Gong, Ya‑Xin Wang, Lin Chen, Shang‑Long Yao, You Shang
Pages: 3083-3092
Published online on: 02 October 2018

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Article Open Access

Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway

Yang Zhou, Tao Hong, Li Tong, Wei Liu, Xueting Yang, Jianghan Luo, Fuling Wang, Jian Li, Lijun Yan
Pages: 3093-3104
Published online on: 07 September 2018

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Article Open Access

A 44-gene set constructed for predicting the prognosis of clear cell renal cell carcinoma Corrigendum in /10.3892/ijmm.2019.4138

Yonggang Wang, Yao Wang, Feng Liu
Pages: 3105-3114
Published online on: 26 September 2018

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Article Open Access

miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2

Zhen Yang, Rui Li, Jun Ao, Qing‑De Wa, Yi Zhang, Long Chen, Jing Wen, Biao Chen, Wei Pan, Bo Li, Xiao‑Bin Tian
Pages: 3115-3124
Published online on: 21 September 2018

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Article Open Access

Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts

Jing Feng, Xinling Wang, Hongyan Li, Li Wang, Zengjun Tang
Pages: 3125-3134
Published online on: 18 September 2018

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Article Open Access

Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway

Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi Li
Pages: 3135-3148
Published online on: 17 September 2018

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Article Open Access

(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity

Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3149-3156
Published online on: 18 September 2018

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Article Open Access

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Zhenhui Wu, Yingyu Wang, Xian Meng, Xinjie Wang, Zhenlin Li, Shihui Qian, Yingjie Wei, Luan Shu, Yongfang Ding, Peijuan Wang, Yunru Peng
Pages: 3157-3170
Published online on: 25 September 2018

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Article Open Access

MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1

Yong Yang, Xiao‑Jia Li, Peng Li, Xiu‑Tian Guo
Pages: 3171-3180
Published online on: 01 October 2018

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Article Open Access

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

Hao Li, Xiaojuan Li, Xingzhi Jing, Mi Li, Ye Ren, Jingyuan Chen, Caihong Yang, Hua Wu, Fengjing Guo
Pages: 3181-3192
Published online on: 09 October 2018

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Article Open Access

THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans

Yuan‑Ti Lee, Yi‑Ya Fang, Yu Wen Sun, Hsiao‑Chi Hsu, Shan‑Mei Weng, Tzu‑Ling Tseng, Ting‑Hui Lin, Jia‑Ching Shieh
Pages: 3193-3208
Published online on: 12 October 2018

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Article Open Access

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway

Wanmin Pei, Yi Zou, Wenting Wang, Lai Wei, Yuan Zhao, Li Li
Pages: 3209-3219
Published online on: 13 September 2018

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Article Open Access

Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation

Su‑Ping Xu, Yong‑Sheng Li
Pages: 3220-3230
Published online on: 01 October 2018

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Article Open Access

Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay

Kang Xiao, Qi Shi, Wei Zhou, Chen Gao, Cao Chen, Bao‑Yun Zhang, Jing Wang, Xiao‑Ping Dong
Pages: 3231-3237
Published online on: 07 September 2018

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Article Open Access

Anti-microRNA-132 causes sevoflurane‑induced neuronal apoptosis via the PI3K/AKT/FOXO3a pathway

Ping Dong, Xiyan Zhang, Jian Zhao, Dongliang Li, Liang Li, Bo Yang
Pages: 3238-3246
Published online on: 25 September 2018

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Article Open Access

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Xin Chen, Shujun Zhou, Hui Li
Pages: 3247-3255
Published online on: 11 October 2018

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Article Open Access

Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis

Rongrong Li, Youlei Wang, Xiaodong Song, Wenjing Sun, Jinjin Zhang, Yuxia Liu, Hongbo Li, Chao Meng, Jie Zhang, Qingyin Zheng, Changjun Lv
Pages: 3256-3268
Published online on: 24 September 2018

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Article Open Access

Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma

Wassiliki Daskalaki, Eva Wardelmann, Matthias Port, Katharina Stock, Julie Steinestel, Sebastian Huss, Jan Sperveslage, Konrad Steinestel, Stefan Eder
Pages: 3269-3277
Published online on: 25 September 2018

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Article Open Access

O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats

Lin Huang, Ping Yuan, Peng Yu, Qiling Kong, Zixuan Xu, Xia Yan, Yang Shen, Juesheng Yang, Rong Wan, Kui Hong, Yanhua Tang, Jinzhu Hu
Pages: 3278-3290
Published online on: 07 September 2018

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Article Open Access

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Tianzhu Lu, Hongjing Liu, Ganhua You
Pages: 3291-3299
Published online on: 02 October 2018

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Article Open Access

Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line

Xiaozhong Chen, Xiaoquan Luo, Yuan Cheng
Pages: 3300-3308
Published online on: 18 September 2018

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Article Open Access

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Chao Li, Zi Wang, Shuangjiang Chen, Jingyao Zhang, Kai Qu, Chang Liu
Pages: 3309-3317
Published online on: 17 September 2018

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Article Open Access

Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions

Zuzana Danková, Dušan Braný, Dana Dvorská, Marcela Ňachajová, Roman Fiolka, Marián Grendár, Jozef Hatok, Peter Kubatka, Veronika Holubeková, Erika Halašová, Tibor Bielik, Pavol Žúbor
Pages: 3318-3328
Published online on: 12 September 2018

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Article Open Access

Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution

Qianwen Ma, Yong Tan, Xuan Chen, Shuping Chen, Yuying Sun, Beibei Zhou
Pages: 3329-3343
Published online on: 13 September 2018

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Article Open Access

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

Panpan Zhang, Lingyue Hua, Huan Hou, Xingyue Du, Zhiqiang He, Menghan Liu, Xiaojuan Hu, Nianlong Yan
Pages: 3344-3354
Published online on: 19 September 2018

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Article Open Access

Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway

Feibiao Yang, Zhangsheng Xiao, Songze Zhang
Pages: 3355-3363
Published online on: 25 September 2018

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Article Open Access

In vitro analysis of microRNA-26a in chronic lymphocytic leukemia cells

Jing Li, Chang‑Kui Sun
Pages: 3364-3370
Published online on: 10 October 2018

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Article Open Access

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

Yongqin Li, Xueyan Zhao, Yujuan Hu, Haiying Sun, Zuhong He, Jie Yuan, Hua Cai, Yu Sun, Xiang Huang, Wen Kong, Weijia Kong
Pages: 3371-3385
Published online on: 01 October 2018

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Article Open Access

Anti-metastatic effect of 131I-labeled Buthus martensii Karsch chlorotoxin in gliomas

Shan Wu, Ke Ma, Wen‑Li Qiao, Ling‑Zhou Zhao, Chang‑Cun Liu, Li‑Lei Guo, Yan Xing, Mei‑Lin Zhu, Jin‑Hua Zhao
Pages: 3386-3394
Published online on: 01 October 2018

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Article Open Access

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway

Zhengzheng Liu, Weilu Kuang, Qin Zhou, Yingying Zhang
Pages: 3395-3403
Published online on: 09 October 2018

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Article Open Access

Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract

Hong‑Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian‑Zhi Xiong, Zhao‑Ji Meng, Sheng‑Wen Sun, Xiao‑Nan Tao
Pages: 3404-3414
Published online on: 09 October 2018

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Article Open Access

Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats

Haiyan Zhang, Xiang Lu, Zhengxia Liu, Kang Du
Pages: 3415-3423
Published online on: 11 October 2018

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Article Open Access

SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target

Guanghui Chen, Haiyi Gong, Ting Wang, Jian Wang, Zhitao Han, Guangjian Bai, Shuai Han, Xinghai Yang, Wang Zhou, Tielong Liu, Jianru Xiao
Pages: 3424-3436
Published online on: 10 October 2018

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Article

Calcium‑sensing receptors in human peripheral T lymphocytes and AMI: Cause and effect

Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun
Pages: 3437-3446
Published online on: 10 October 2018

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Article

In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells

Kaiwen Bai, Luyi Jiang, Ligen Zhang, Yongwei Zhao, Yi Lu, Jingya Zhu, Jie Cai, Lili Zhang, Tian Wang
Pages: 3447-3458
Published online on: 13 September 2018

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Article

Hyperosmotic stress stimulates autophagy via the NFAT5/mTOR pathway in cardiomyocytes

Hong Zhu, Wei Cao, Peng Zhao, Jieyu Wang, Yuying Qian, Yun Li
Pages: 3459-3466
Published online on: 12 September 2018

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Article

Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells

Yuwei Zhang, Yingquan Luo, Yina Wang, Hong Liu, Yu Yang, Qiong Wang
Pages: 3467-3476
Published online on: 17 September 2018

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Article

LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK

Su‑Min Yang, Yu‑Kyoung Park, Jee In Kim, Yun‑Han Lee, Tae‑Yun Lee, Byeong‑Churl Jang
Pages: 3477-3484
Published online on: 21 September 2018

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Article

Lithocarpus polystachyus Rehd. leaves aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway

Jianmei Gao, Yingshu Xu, Jianyong Zhang, Jingshan Shi, Qihai Gong
Pages: 3485-3494
Published online on: 05 October 2018

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Article

Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery Corrigendum in /10.3892/ijmm.2019.4308

Youbei Qiao, Bao Liu, Yifan Peng, Erlong Ji, Hong Wu
Pages: 3495-3502
Published online on: 25 September 2018

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Article

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin Lu
Pages: 3503-3512
Published online on: 25 September 2018

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Article

Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis

Qian Zhao, Hui Zhang, Junhua Huang, Huajun Yu, Jiajia Li, Qinfen Che, Yangjie Sun, Yin Jin, Jiansheng Wu
Pages: 3513-3521
Published online on: 09 October 2018

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Article

Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Pages: 3522-3529
Published online on: 08 October 2018

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Article

LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway

Xiaohong Wen, Yuan Liu, Yu Bai, Mingwei Li, Qiang Fu, Yi Zheng
Pages: 3530-3541
Published online on: 11 October 2018

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Article

Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses

Zhu Wang, Jianwen Zhang, Ying Zhang, Qiong Deng, Hui Liang
Pages: 3542-3550
Published online on: 11 September 2018

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Article

Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics

Ying Zhou, Ling Li, Jun Qian, Haoyuan Jia, Yubao Cui
Pages: 3551-3561
Published online on: 13 September 2018

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Article

miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene

Yuan Yuan, Youwei Zhang, Liang Han, Sanyuan Sun, Yongqian Shu
Pages: 3562-3570
Published online on: 11 September 2018

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Article

Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway

Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li
Pages: 3571-3581
Published online on: 26 September 2018

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Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway

Longfei Pan, Lei Yu, Liming Wang, Juntao He, Jiangli Sun, Xiaobo Wang, Hai Wang, Zhenghai Bai, Hui Feng, Honghong Pei
Pages: 3582-3590
Published online on: 01 October 2018

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The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells

Jie Liu, Dan Xu, Jingming Li, Ning Gao, Chongbing Liao, Ruihua Jing, Bogang Wu, Bo Ma, Yongping Shao, Cheng Pei
Pages: 3591-3601
Published online on: 02 October 2018

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eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration

Zhengrong Xu, Tao Li, Man Li, Lei Yang, Rudan Xiao, Li Liu, Xin Chi, Dianwu Liu
Pages: 3602-3612
Published online on: 26 September 2018

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Anemarrhena asphodeloides Bunge ameliorates osteoporosis by suppressing osteoclastogenesis

Jae Sung Lee, Mi Hye Kim, Haesu Lee, Woong Mο Yang
Pages: 3613-3621
Published online on: 01 October 2018

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Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process

Xiaoni Zhan, Fengrui Li, Qiaohong Chu, Hao Pang
Pages: 3622-3630
Published online on: 01 October 2018

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Repetitive magnetic stimulation promotes the proliferation of neural progenitor cells via modulating the expression of miR-106b

Hua Liu, Gaohua Li, Chunlian Ma, Yanfang Chen, Jinju Wang, Yi Yang
Pages: 3631-3639
Published online on: 09 October 2018

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Retraction Open Access

[Retracted] Piezo1 protein induces the apoptosis of human osteoarthritis‑derived chondrocytes by activating caspase‑12, the signaling marker of ER stress

Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang
Pages: 3640-3640
Published online on: 08 October 2018

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September-2026 Volume 58 Issue 3

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Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Mechanisms and therapeutic strategies of pyroptosis in sepsis‑induced acute lung injury (Review)

Wenyu Wu, Nuoran Li, Guoshu Deng, Suyi Yang, Ruifeng Zeng, Rui Chen, Jun Li
Article Number: 264
Published online on: 22 July 2026

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Gut‑bone metabolites: SCFAs, polyamines and microbial metabolomics in osteoporosis risk and therapy (Review)

Fuchao Chen, Jingyue Sun, Xiao Wang
Article Number: 263
Published online on: 21 July 2026

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Expression of Concern Open Access

[Expression of Concern] Exposure to acoustic stimuli promotes the development and differentiation of neural stem cells from the cochlear nuclei through the clusterin pathway

Tao Xue, Li Wei, Ding-Jun Zha, Li Qiao, Lian-Jun Lu, Fu-Quan Chen, Jian-Hua Qiu
Article Number: 262
Published online on: 20 July 2026

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Cepharanthine inhibits tick‑borne encephalitis virus infection through modulation of the stress and inflammation response

Wan-Da Tang, Lan-Juan Zhao
Article Number: 261
Published online on: 16 July 2026

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circCACNA1D drives pulmonary fibrosis by regulating pyruvate kinase M2 dimer‑tetramer switching

Yujie Wang, Xiaoting Li, Meirong Wang, Nailiang Zhai, Mengqi Jiang, Bo Liu, Changjun Lv, Songzi Zhang, Xiaodong Song, Jinjin Zhang
Article Number: 260
Published online on: 15 July 2026

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Recent progress and therapeutic strategies in the treatment of cervical neuroendocrine neoplasms (Review)

Yanpeng Tian, Yu Zhang, Liling Wang, Zhongkang Li, Xiaotong Xu, Shouze Liu, Shenyu Yang, Xiangyang Ren, Menghan Xu, Xingzi Chang, Xianghua Huang, Qian Zhao, Ruixia Guo
Article Number: 259
Published online on: 15 July 2026

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Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review)

Shuhong Zhang, Ge Yang
Article Number: 258
Published online on: 14 July 2026

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Exercise‑induced exosomal noncoding RNAs: Molecular signaling cascades in bone remodeling and translational applications in sports‑related bone injuries (Review)

Bin Tian, Xuesong Chen, Jiang Zheng, Xin Kang
Article Number: 257
Published online on: 14 July 2026

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Targeting alveolar type II cell dysfunction in idiopathic pulmonary fibrosis: Molecular mechanisms and emerging therapeutic strategies (Review)

Tianhao Xie, Kang Hu, Shu Pan, Xin Tong, Haitong Huang, Hao Ding, Jun Zhao
Article Number: 256
Published online on: 13 July 2026

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Tubular PFKFB3 drives diabetic kidney fibrosis via lactate‑dependent H4K12 lactylation and HIPK2 transactivation

Mingkun Xu, Linhang Fu, Yulong Zhang, Xiuli Guo, Han Wu, Sijing Gao, Fei Xiao, Li Xu
Article Number: 255
Published online on: 13 July 2026

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[Retracted] p73 participates in WWOX-mediated apoptosis in leukemia cells

Donghong Lin, Zhaolei Cui, Lingying Kong, Feng Cheng, Jianping Xu, Fenghua Lan
Article Number: 254
Published online on: 13 July 2026

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Role of hyperthermia in overcoming HPV‑mediated MHC‑Ⅰ downregulation and promoting immune surveillance

Hanyu Wang, Hongxin Lang, Yaoxing Guo, Te Sun, Yuansong Bai, Tao Zhang, Rui-Qun Qi
Article Number: 253
Published online on: 10 July 2026

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Endocrine‑metabolic imbalance drives osteoarthritis: From whole‑joint pathobiology to precision therapy (Review)

Ruhui Yang, Haimin Zeng, Qi Xiao, Yining Xie, Yi Long, Xiang Chen
Article Number: 252
Published online on: 09 July 2026

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Expression of Concern Open Access

[Expression of Concern] Roles and mechanisms of action of HNF‑4α in the hepatic differentiation of WB‑F344 cells

Yumeng Shi, Dehua Zhou, Bingyi Wang, Deren Zhou, Baomin Shi
Article Number: 251
Published online on: 08 July 2026

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Phenylalanine exacerbates psoriasiform inflammation through NF‑κB‑mediated dendritic cell activation and Th17 polarization

Yaohan Xu, Jing Pan, Jie Chen, Yutao Zhu, Miaolian Cai, Zeyu Ma, Siji Chen, Tianze Yu, Yushu Wei, Jingying Pan, Kunliang Luo, Yinjing Song, Stijn Van Der Veen, Hao Cheng
Article Number: 250
Published online on: 08 July 2026

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Protective effects of Astragaloside IV on various liver diseases: From chemistry to herbal medicines (Review)

Jialu Shi, Xiaoyu Zhou, Jiabin Wu, Liru Zeng, Xia Wang, Wei Li, Xiao Huang, Xiaoyu Deng, Wenhong Wang
Article Number: 249
Published online on: 07 July 2026

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GRP78 dysregulation: A proposed molecular mechanism linking the tumor microenvironment to sepsis susceptibility in patients with cancer (Review)

Hang Ruan, Meipeng Zhu, Shi-Yan Liu, Li-Juan Zou, Shu-Sheng Li
Article Number: 248
Published online on: 07 July 2026

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FGFR1 signaling in rheumatoid arthritis: Mechanisms of bone destruction and therapeutic targeting (Review)

Changzhong Qian, Zhenyu Zhang, Xian Wu, Huibo Ti, Junjie Wu, Zhengdong Yuan, Xia Li, Feng-Lai Yuan
Article Number: 247
Published online on: 06 July 2026

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Retraction Open Access

[Retracted] β‑catenin signaling induces the osteoblastogenic differentiation of human pre‑osteoblastic and bone marrow stromal cells mainly through the upregulation of osterix expression

Bo Liu, Song Wu, Lihua Han, Chaoyue Zhang
Article Number: 246
Published online on: 06 July 2026

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Single‑cell atlas reveals a Wilms' tumor 1‑mediated axis driving granulosa cell senescence in human ovarian aging

Yanfang Du, Congyu Zhou, Yanpeng Tian, Zhongkang Li, Xianghua Huang
Article Number: 245
Published online on: 03 July 2026

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TRPV1‑mediated central sensitisation: Core mechanisms of migraine chronification and novel targeted therapeutic strategies (Review)

Mingxia Zhang, Yuting Pu, Yujie Zhang, Jia Hu, Shuangyang Li, Hongmei Tang, Bangjiang Fang, Xue Bai
Article Number: 244
Published online on: 02 July 2026

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Correction Open Access

[Corrigendum] Arginine ADP‑ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway

Lian Yang, Ming Xiao, Xian Li, Yi Tang, Ya-Lan Wang
Article Number: 243
Published online on: 02 July 2026

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Research progress on the chemical and pharmacological effects of Semen Strychni (Review)

Jingxin Mao, Xin Du, Dan Zeng, Xin Luo, Yan Li
Article Number: 242
Published online on: 02 July 2026

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FLI1 enhances the malignant phenotype of glioma cells and exerts immunomodulatory effects through feedback crosstalk with exonic circRNA FECR1 and interferon‑induced ISG15

Xue Wen, Xiaoyi Gu, Xu Yan, Naifei Chen, Lei Zhou, Hui Li, Andrew R. Hoffman, Wei Li, Ji-Fan Hu, Jiuwei Cui
Article Number: 241
Published online on: 01 July 2026

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Role of ZEB1 in angiogenesis and therapeutic potential (Review)

Ruoxin Ren, Chunxiao Yan, Yao Xiang, Lin Jin, Fang Cheng, Lijun Zhang
Article Number: 240
Published online on: 01 July 2026

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Endothelial dysfunction: A central mechanism linking autosomal dominant polycystic kidney disease and intracranial aneurysms (Review)

Xiaohong Xu, Ruyi Xu, Liexiang Zhang
Article Number: 239
Published online on: 01 July 2026

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Correction Open Access

[Corrigendum] Effect of SDF‑1/CXCR4 axis on the migration of transplanted bone mesenchymal stem cells mobilized by erythropoietin toward lesion sites following spinal cord injury

Jun Li, Weichun Guo, Min Xiong, Heng Han, Jie Chen, Dan Mao, Bing Tang, Hualong Yu, Yun Zeng
Article Number: 238
Published online on: 01 July 2026

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Exercise and fluoxetine in Alzheimer's disease: Molecular mechanisms of synergistic and antagonistic effects (Review)

Mei Wu, Yan Li
Article Number: 237
Published online on: 30 June 2026

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Oral‑gut axis in systemic disease: A barrier‑metabolism‑immunity three‑dimensional regulatory model (Review)

Qing Li, Mingrong Cheng, Weiwei Li, Xiaoyue Wang, Xiaoqing Liu, Yujie Yan
Article Number: 236
Published online on: 30 June 2026

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ABCG2 transporter: Structural and functional associations with gout (Review)

Muhammad Arslan Asif, Zeshan Zulfiqar, Bahar E. Mustafa, Usman Nazir, Jiamen Sun, Zhichang Wang, Yalei Cui, Sun Hao, Liu Boshuai, Yinghua Shi
Article Number: 235
Published online on: 30 June 2026

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Neuropilin‑1: Emerging roles in nerve‑vessel‑bone coupling during fracture repair (Review)

Keyue Zhang, Tong Li, Huan Liu, Huibo Ti, Zhenyu Zhang, Zhengdong Yuan, Junjie Wu, Xielin Yan, Zixin Luo, Haiting Hu, Xingchen Yao, Shuwen Shi, Xian Wu, Feng-Lai Yuan, Xiao Chen
Article Number: 234
Published online on: 30 June 2026

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Correction Open Access

[Corrigendum] Crocin exerts anti‑inflammatory and anti‑catabolic effects on rat intervertebral discs by suppressing the activation of JNK

Kang Li, Yan Li, Zhenjiang Ma, Jie Zhao
Article Number: 233
Published online on: 29 June 2026

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Skeletal muscle‑derived extracellular vesicles in multi‑organ degenerative disease: Mechanisms and therapeutic delivery perspectives (Review)

Xianji Wei, Chengyan Guo, Wei Zhang, Guanyi Wang, Wenjing Li, Binghong Gao, Bo Gao, Lingli Zhang
Article Number: 232
Published online on: 26 June 2026

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Journal Cover
October-2026 Volume 58 Issue 4

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Brazilin attenuates methylglyoxal‑induced endothelial injury by enhancing eIF5A hypusination and inhibiting the AMPK/mTOR‑mediated autophagy/apoptosis axis in vitro and in vivo

Yu Liang, Jinxiang Chen, Haiyang Li, Junjing Xiong, Jingcan You, Liqun Wang, Jianbo Wu, Youkun Zheng, Mao Luo
Article Number: 273
Published online on: 30 July 2026

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Post‑translational modifications in atherosclerosis: Roles, mechanisms and therapeutic potential (Review)

Xiaoxiang Xu, Fei Ma, Wei Yu
Article Number: 272
Published online on: 30 July 2026

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Role of extracellular matrix in liver fibrosis regression and regeneration (Review)

Yuanzhi Zhou, Zeyuan Qiang, Yang Duan, Jiwei Huang, Haichuan Wang
Article Number: 271
Published online on: 29 July 2026

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Correction Open Access

[Corrigendum] Circulating microRNA profiles and the identification of miR‑593 and miR‑511 which directly target the PROP1 gene in children with combined pituitary hormone deficiency

Yanyan Hu, Qian Wang, Zengmin Wang, Fengxue Wang, Xiaobo Guo, Guimei Li
Article Number: 270
Published online on: 29 July 2026

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Unveiling the role of spatial transcriptomics in the analysis of the tumor immune microenvironment (Review)

Jialin Jiang, Xinyu Tu, Yi Cao, Qun Yan, Buqing Sai, Jian Ma
Article Number: 269
Published online on: 28 July 2026

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Expression of Concern Open Access

[Expression of Concern] Luteolin protects mice from severe acute pancreatitis by exerting HO‑1‑mediated anti‑inflammatory and antioxidant effects

Jie Xiong, Kezhou Wang, Chunxiao Yuan, Rong Xing, Jianbo Ni, Guoyong Hu, Fengling Chen, Xingpeng Wang
Article Number: 268
Published online on: 27 July 2026

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circRNA_013145‑miR‑185‑5p‑RhoA axis: A novel mechanism in the pathophysiology of diabetes‑induced erectile dysfunction

Wenhan Huang, Xin Lv, Jiahua Qian, Yihao Chen, Yuhe Si, Jingwei Wang, Jianxiong Ma
Article Number: 267
Published online on: 24 July 2026

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Gut‑liver‑kidney axis: A systems biology framework for understanding and treating chronic kidney disease (Review)

Jinyi Hou, Yaotan Li, Shijia Lin, Qingqing Liu, Huijuan Zheng, Weijing Liu, Yaoxian Wang, Liang Peng, Zhen Wang
Article Number: 266
Published online on: 23 July 2026

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Review Open Access

Effects of cuproptosis and its application in inflammatory bowel disease (Review)

Li Chen, Francis Atim Akanyibah, Jing Guan, Bing Pei, Bo Wang, Fei Mao
Article Number: 265
Published online on: 23 July 2026

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