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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2018 Volume 42 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Chongyang Ma, Shuling Liu, Shuang Zhang, Tian Xu, Xue Yu, Yushan Gao, Changming Zhai, Changxiang Li, Chaofang Lei, Shuning Fan, Yuxi Chen, Huiling Tian, Qingguo Wang, Fafeng Cheng, Xueqian Wang
Pages: 2979-2990
Published online on: 02 October 2018

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Review

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)

Thomas Mbimba, Nazar J. Hussein, Ayesha Najeed, Fayez F. Safadi
Pages: 2991-2997
Published online on: 21 September 2018

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Review Open Access

Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)

Jorge Reyes‑García, Edgar Flores‑Soto, Abril Carbajal‑García, Bettina Sommer, Luis M. Montaño
Pages: 2998-3008
Published online on: 02 October 2018

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Article Open Access

Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs

Miwa Hayashi, Kengo Kuroda, Kohei Ihara, Takahiro Iwaya, Emiko Isogai
Pages: 3009-3016
Published online on: 13 September 2018

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Article Open Access

Silencing of NOD2 protects against diabetic cardiomyopathy in a murine diabetes model

Lin Shen, Li Li, Man Li, Weiling Wang, Wenbin Yin, Wei Liu, Yanyan Hu
Pages: 3017-3026
Published online on: 14 September 2018

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Article Open Access

miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10

Fangzhou Liu, Kexin Lou, Xiaotong Zhao, Jia Zhang, Wei Chen, Yichun Qian, Yanbin Zhao, Yan Zhu, Yuan Zhang
Pages: 3027-3036
Published online on: 27 September 2018

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Article Open Access

Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B

Yang Liu, Yanling Liu, Guolin Li, Zhengrong Chen, Guixiong Gu
Pages: 3037-3046
Published online on: 18 September 2018

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Article Open Access

Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice

Joo Wan Kim, You‑Suk Lee, Du Jin Seol, Il Je Cho, Sae Kwang Ku, Jae‑Suk Choi, Hae‑Jeung Lee
Pages: 3047-3064
Published online on: 14 September 2018

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Article Open Access

DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells

Lili Zhang, Shuguang Zhang, Aihua Li, Anqi Zhang, Shiqian Zhang, Liang Chen
Pages: 3065-3072
Published online on: 11 September 2018

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Article Open Access

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism

Gang Chen, Hugang Shen, Linlin Zang, Zhonglan Su, Jilong Huang, Yong Sun, Hongwei Wang
Pages: 3073-3082
Published online on: 02 October 2018

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Article Open Access

BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo

Yu‑Dong Ji, Zhen‑Long Luo, Chun‑Xiu Chen, Bo Li, Jie Gong, Ya‑Xin Wang, Lin Chen, Shang‑Long Yao, You Shang
Pages: 3083-3092
Published online on: 02 October 2018

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Article Open Access

Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway

Yang Zhou, Tao Hong, Li Tong, Wei Liu, Xueting Yang, Jianghan Luo, Fuling Wang, Jian Li, Lijun Yan
Pages: 3093-3104
Published online on: 07 September 2018

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Article Open Access

A 44-gene set constructed for predicting the prognosis of clear cell renal cell carcinoma Corrigendum in /10.3892/ijmm.2019.4138

Yonggang Wang, Yao Wang, Feng Liu
Pages: 3105-3114
Published online on: 26 September 2018

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Article Open Access

miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2

Zhen Yang, Rui Li, Jun Ao, Qing‑De Wa, Yi Zhang, Long Chen, Jing Wen, Biao Chen, Wei Pan, Bo Li, Xiao‑Bin Tian
Pages: 3115-3124
Published online on: 21 September 2018

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Article Open Access

Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts

Jing Feng, Xinling Wang, Hongyan Li, Li Wang, Zengjun Tang
Pages: 3125-3134
Published online on: 18 September 2018

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Article Open Access

Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway

Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi Li
Pages: 3135-3148
Published online on: 17 September 2018

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Article Open Access

(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity

Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3149-3156
Published online on: 18 September 2018

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Article Open Access

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Zhenhui Wu, Yingyu Wang, Xian Meng, Xinjie Wang, Zhenlin Li, Shihui Qian, Yingjie Wei, Luan Shu, Yongfang Ding, Peijuan Wang, Yunru Peng
Pages: 3157-3170
Published online on: 25 September 2018

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Article Open Access

MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1

Yong Yang, Xiao‑Jia Li, Peng Li, Xiu‑Tian Guo
Pages: 3171-3180
Published online on: 01 October 2018

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Article Open Access

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

Hao Li, Xiaojuan Li, Xingzhi Jing, Mi Li, Ye Ren, Jingyuan Chen, Caihong Yang, Hua Wu, Fengjing Guo
Pages: 3181-3192
Published online on: 09 October 2018

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Article Open Access

THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans

Yuan‑Ti Lee, Yi‑Ya Fang, Yu Wen Sun, Hsiao‑Chi Hsu, Shan‑Mei Weng, Tzu‑Ling Tseng, Ting‑Hui Lin, Jia‑Ching Shieh
Pages: 3193-3208
Published online on: 12 October 2018

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Article Open Access

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway

Wanmin Pei, Yi Zou, Wenting Wang, Lai Wei, Yuan Zhao, Li Li
Pages: 3209-3219
Published online on: 13 September 2018

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Article Open Access

Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation

Su‑Ping Xu, Yong‑Sheng Li
Pages: 3220-3230
Published online on: 01 October 2018

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Article Open Access

Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay

Kang Xiao, Qi Shi, Wei Zhou, Chen Gao, Cao Chen, Bao‑Yun Zhang, Jing Wang, Xiao‑Ping Dong
Pages: 3231-3237
Published online on: 07 September 2018

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Article Open Access

Anti-microRNA-132 causes sevoflurane‑induced neuronal apoptosis via the PI3K/AKT/FOXO3a pathway

Ping Dong, Xiyan Zhang, Jian Zhao, Dongliang Li, Liang Li, Bo Yang
Pages: 3238-3246
Published online on: 25 September 2018

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Article Open Access

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Xin Chen, Shujun Zhou, Hui Li
Pages: 3247-3255
Published online on: 11 October 2018

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Article Open Access

Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis

Rongrong Li, Youlei Wang, Xiaodong Song, Wenjing Sun, Jinjin Zhang, Yuxia Liu, Hongbo Li, Chao Meng, Jie Zhang, Qingyin Zheng, Changjun Lv
Pages: 3256-3268
Published online on: 24 September 2018

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Article Open Access

Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma

Wassiliki Daskalaki, Eva Wardelmann, Matthias Port, Katharina Stock, Julie Steinestel, Sebastian Huss, Jan Sperveslage, Konrad Steinestel, Stefan Eder
Pages: 3269-3277
Published online on: 25 September 2018

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Article Open Access

O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats

Lin Huang, Ping Yuan, Peng Yu, Qiling Kong, Zixuan Xu, Xia Yan, Yang Shen, Juesheng Yang, Rong Wan, Kui Hong, Yanhua Tang, Jinzhu Hu
Pages: 3278-3290
Published online on: 07 September 2018

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Article Open Access

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Tianzhu Lu, Hongjing Liu, Ganhua You
Pages: 3291-3299
Published online on: 02 October 2018

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Article Open Access

Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line

Xiaozhong Chen, Xiaoquan Luo, Yuan Cheng
Pages: 3300-3308
Published online on: 18 September 2018

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Article Open Access

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Chao Li, Zi Wang, Shuangjiang Chen, Jingyao Zhang, Kai Qu, Chang Liu
Pages: 3309-3317
Published online on: 17 September 2018

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Article Open Access

Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions

Zuzana Danková, Dušan Braný, Dana Dvorská, Marcela Ňachajová, Roman Fiolka, Marián Grendár, Jozef Hatok, Peter Kubatka, Veronika Holubeková, Erika Halašová, Tibor Bielik, Pavol Žúbor
Pages: 3318-3328
Published online on: 12 September 2018

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Article Open Access

Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution

Qianwen Ma, Yong Tan, Xuan Chen, Shuping Chen, Yuying Sun, Beibei Zhou
Pages: 3329-3343
Published online on: 13 September 2018

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Article Open Access

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

Panpan Zhang, Lingyue Hua, Huan Hou, Xingyue Du, Zhiqiang He, Menghan Liu, Xiaojuan Hu, Nianlong Yan
Pages: 3344-3354
Published online on: 19 September 2018

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Article Open Access

Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway

Feibiao Yang, Zhangsheng Xiao, Songze Zhang
Pages: 3355-3363
Published online on: 25 September 2018

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Article Open Access

In vitro analysis of microRNA-26a in chronic lymphocytic leukemia cells

Jing Li, Chang‑Kui Sun
Pages: 3364-3370
Published online on: 10 October 2018

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Article Open Access

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

Yongqin Li, Xueyan Zhao, Yujuan Hu, Haiying Sun, Zuhong He, Jie Yuan, Hua Cai, Yu Sun, Xiang Huang, Wen Kong, Weijia Kong
Pages: 3371-3385
Published online on: 01 October 2018

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Article Open Access

Anti-metastatic effect of 131I-labeled Buthus martensii Karsch chlorotoxin in gliomas

Shan Wu, Ke Ma, Wen‑Li Qiao, Ling‑Zhou Zhao, Chang‑Cun Liu, Li‑Lei Guo, Yan Xing, Mei‑Lin Zhu, Jin‑Hua Zhao
Pages: 3386-3394
Published online on: 01 October 2018

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Article Open Access

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway

Zhengzheng Liu, Weilu Kuang, Qin Zhou, Yingying Zhang
Pages: 3395-3403
Published online on: 09 October 2018

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Article Open Access

Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract

Hong‑Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian‑Zhi Xiong, Zhao‑Ji Meng, Sheng‑Wen Sun, Xiao‑Nan Tao
Pages: 3404-3414
Published online on: 09 October 2018

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Article Open Access

Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats

Haiyan Zhang, Xiang Lu, Zhengxia Liu, Kang Du
Pages: 3415-3423
Published online on: 11 October 2018

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Article Open Access

SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target

Guanghui Chen, Haiyi Gong, Ting Wang, Jian Wang, Zhitao Han, Guangjian Bai, Shuai Han, Xinghai Yang, Wang Zhou, Tielong Liu, Jianru Xiao
Pages: 3424-3436
Published online on: 10 October 2018

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Article

Calcium‑sensing receptors in human peripheral T lymphocytes and AMI: Cause and effect

Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun
Pages: 3437-3446
Published online on: 10 October 2018

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Article

In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells

Kaiwen Bai, Luyi Jiang, Ligen Zhang, Yongwei Zhao, Yi Lu, Jingya Zhu, Jie Cai, Lili Zhang, Tian Wang
Pages: 3447-3458
Published online on: 13 September 2018

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Article

Hyperosmotic stress stimulates autophagy via the NFAT5/mTOR pathway in cardiomyocytes

Hong Zhu, Wei Cao, Peng Zhao, Jieyu Wang, Yuying Qian, Yun Li
Pages: 3459-3466
Published online on: 12 September 2018

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Article

Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells

Yuwei Zhang, Yingquan Luo, Yina Wang, Hong Liu, Yu Yang, Qiong Wang
Pages: 3467-3476
Published online on: 17 September 2018

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Article

LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK

Su‑Min Yang, Yu‑Kyoung Park, Jee In Kim, Yun‑Han Lee, Tae‑Yun Lee, Byeong‑Churl Jang
Pages: 3477-3484
Published online on: 21 September 2018

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Article

Lithocarpus polystachyus Rehd. leaves aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway

Jianmei Gao, Yingshu Xu, Jianyong Zhang, Jingshan Shi, Qihai Gong
Pages: 3485-3494
Published online on: 05 October 2018

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Article

Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery Corrigendum in /10.3892/ijmm.2019.4308

Youbei Qiao, Bao Liu, Yifan Peng, Erlong Ji, Hong Wu
Pages: 3495-3502
Published online on: 25 September 2018

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Article

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin Lu
Pages: 3503-3512
Published online on: 25 September 2018

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Article

Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis

Qian Zhao, Hui Zhang, Junhua Huang, Huajun Yu, Jiajia Li, Qinfen Che, Yangjie Sun, Yin Jin, Jiansheng Wu
Pages: 3513-3521
Published online on: 09 October 2018

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Article

Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production Corrigendum in /10.3892/ijmm.2026.6001

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Pages: 3522-3529
Published online on: 08 October 2018

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Article

LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway

Xiaohong Wen, Yuan Liu, Yu Bai, Mingwei Li, Qiang Fu, Yi Zheng
Pages: 3530-3541
Published online on: 11 October 2018

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Article

Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses

Zhu Wang, Jianwen Zhang, Ying Zhang, Qiong Deng, Hui Liang
Pages: 3542-3550
Published online on: 11 September 2018

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Article

Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics

Ying Zhou, Ling Li, Jun Qian, Haoyuan Jia, Yubao Cui
Pages: 3551-3561
Published online on: 13 September 2018

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Article

miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene

Yuan Yuan, Youwei Zhang, Liang Han, Sanyuan Sun, Yongqian Shu
Pages: 3562-3570
Published online on: 11 September 2018

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Article

Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway

Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li
Pages: 3571-3581
Published online on: 26 September 2018

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Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway

Longfei Pan, Lei Yu, Liming Wang, Juntao He, Jiangli Sun, Xiaobo Wang, Hai Wang, Zhenghai Bai, Hui Feng, Honghong Pei
Pages: 3582-3590
Published online on: 01 October 2018

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Article

The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells

Jie Liu, Dan Xu, Jingming Li, Ning Gao, Chongbing Liao, Ruihua Jing, Bogang Wu, Bo Ma, Yongping Shao, Cheng Pei
Pages: 3591-3601
Published online on: 02 October 2018

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Article

eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration

Zhengrong Xu, Tao Li, Man Li, Lei Yang, Rudan Xiao, Li Liu, Xin Chi, Dianwu Liu
Pages: 3602-3612
Published online on: 26 September 2018

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Article

Anemarrhena asphodeloides Bunge ameliorates osteoporosis by suppressing osteoclastogenesis

Jae Sung Lee, Mi Hye Kim, Haesu Lee, Woong Mο Yang
Pages: 3613-3621
Published online on: 01 October 2018

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Article

Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process

Xiaoni Zhan, Fengrui Li, Qiaohong Chu, Hao Pang
Pages: 3622-3630
Published online on: 01 October 2018

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Article

Repetitive magnetic stimulation promotes the proliferation of neural progenitor cells via modulating the expression of miR-106b

Hua Liu, Gaohua Li, Chunlian Ma, Yanfang Chen, Jinju Wang, Yi Yang
Pages: 3631-3639
Published online on: 09 October 2018

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Retraction Open Access

[Retracted] Piezo1 protein induces the apoptosis of human osteoarthritis‑derived chondrocytes by activating caspase‑12, the signaling marker of ER stress

Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang
Pages: 3640-3640
Published online on: 08 October 2018

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Journal Cover
November-2026 Volume 58 Issue 5

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Article Open Access

Spatial multi‑omics identifies an SPP1+ macrophage‑driven anti‑apoptotic niche in osteoarthritis synovium via the SPP1‑CD44 axis

Han Gong, Hao Shen, Feng Zhang, Wei Wang, Sheng Zhou, Lei Wang, Yu Sun
Article Number: 334
Published online on: 29 September 2026

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Review Open Access

Novel insights into the role of the renal interstitial microenvironment in Randall's plaque formation (Review)

Jialiang Wang, Zhangcheng Liao, Minghui Liu, Yizhou Wang, Yu Cui, Hequn Chen, Feng Zeng, Zewu Zhu
Article Number: 333
Published online on: 29 September 2026

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Correction Open Access

[Corrigendum] Alteration of the Wnt/GSK3β/β‑catenin signalling pathway by rapamycin ameliorates pathology in an Alzheimer's disease model

Jingfei Chen, Zhimin Long, Yanzhen Li, Min  Luo, Shifang  Luo, Guiqiong He
Article Number: 332
Published online on: 28 September 2026

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miR‑222‑3p inhibits diabetic skin wound healing by targeting APLN

Ruyan Jie, Ying Tang, Tingting Wu, Chenfan Zhang, Man Song, Xiaotong Zhao, Mingwei Chen
Article Number: 331
Published online on: 25 September 2026

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Correction Open Access

[Corrigendum] Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Article Number: 330
Published online on: 23 September 2026

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Salidroside attenuates myocardial ischemia‑reperfusion‑induced oxidative stress and ferroptosis by promoting USP11‑mediated  deubiquitination of PRDX2

Zhi-Cong Qiu, Jian-Nan Li, Yi-Zhou Li, Zi-Ming Wu, Xu-Dong Luo, Rui-Yuan Zeng, Song-Qing Lai, Shi-Tao Zhao, Li Wan
Article Number: 329
Published online on: 23 September 2026

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Reprogramming of cell death in gastric cancer: From molecular mechanisms to therapeutic potential (Review)

Mengru Liu, Zhujun Wu, Qiao Chen, Weiguo Ni, Ying Chen, Yixin Zhu, Yu Chen, Haifeng Ma, Yan Lin
Article Number: 328
Published online on: 23 September 2026

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Remimazolam attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis involving the AKT/SLC7A11/GPX4 axis

Xiyuan Chen, Jianghong Zhao, Xingtong He, Yuqi Zhang, Jiao Wu, Chao Jiang, Yi Yang, Ji Xiao
Article Number: 327
Published online on: 22 September 2026

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Tumor‑immune spatiotemporal co‑evolution: A new paradigm for understanding and overcoming therapy resistance in metastatic castration‑resistant prostate cancer (Review)

Li Yan, Xiaoke Sun, Pengxiao Su
Article Number: 326
Published online on: 21 September 2026

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Research progress on the role of IL‑37 in gynecological and obstetrics‑related diseases (Review)

Hongjing Wang, Renukha Arjune, Weiyu Gan, Na Guo, Nan Yu, Ting Xiong
Article Number: 325
Published online on: 21 September 2026

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Expression of Concern Open Access

[Expression of Concern] PAT protein mRNA expression in primary rat hepatocytes: Effects of exposure to fatty acids

Elena Grasselli, Adriana Voci, Carlo Pesce, Laura Canesi, Emilia Fugassa, Gabriella Gallo, Laura Vergani
Article Number: 324
Published online on: 21 September 2026

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Neutrophil extracellular traps in cardiovascular disease: Mechanisms and therapeutic implications (Review)

Zhao Wang, Mingde Chang, Wenyu Shang, Yunfeng Jia, Xiaoyu Shan, Xinnong Chen, Yingxi Yang, Junping Zhang
Article Number: 323
Published online on: 18 September 2026

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Article Open Access

Sirt1 attenuates calcific aortic valve disease by inhibiting ferroptosis and enhancing mitochondrial function via the activation of the Nrf2/HO‑1/FTH1 axis

Fei Yan, Lei Shi, Yuechan Wang, Ying Zhao, Yuanyuan Wu, Dubiao Xian, Yunheng Liang, Ning Wang, Hongwang Cui, Minni Zhang
Article Number: 322
Published online on: 18 September 2026

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Article Open Access

Ketogenic diet attenuates Müller cell activation and retinal neuroinflammation in autoimmune glaucoma through acetylation‑mediated FOXO signalling

Sisi Tan, Xiaochen Wang, Yunfan Zheng, Zhenni Mou, Lihong Zeng, Jingchang Yuan, Xiao Fan, Miao Wei, Yujia Huo, Ruotong Ouyang, Yanyu Pu, Junqin Lei, Xi Gao, Dangdang Wang, Yang Peng, Hong Li
Article Number: 321
Published online on: 17 September 2026

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ILC3s as central regulators of mucosal homeostasis and disease pathogenesis (Review)

Jingwen Zhang, Lili Bao, Jiaxi Li, Xia Li, Lu Qiao, Jiaxian Cui, Xiaoxia He, Mingyu Zhang, Jingkun Lu, Xuan Zhang, Jing Dong, Gesi Tao, Yaoqing Feng, Yun Peng Tian, Pengwei Zhao, Ya Tuo
Article Number: 320
Published online on: 17 September 2026

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Small extracellular vesicles in osteoarthritis: A double‑edged sword regulating inflammation and cartilage homeostasis (Review)

Yifan Yang, Jiachen Liang, Xiangyu Shi, Anqi Niu, Ruifang Gao, Xiuping Wu, Xiaojuan Guo, Xiaotong Shi, Kejie Cao, Bing Li, Ran Li
Article Number: 319
Published online on: 17 September 2026

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Exosomal circular RNAs in the tumor immune microenvironment: From regulatory mechanisms to therapeutic opportunities and translational hurdles (Review)

Wenlong Zhang, Nuo Chen, Liya Gong, Yu Dong, Hui Shen, Xin Liu, Jie Sun, Luxuan Liu, Zhe Jin, Liaoyuan Wang, Xue Han, Bin Zhang, Shuixing Zhang
Article Number: 318
Published online on: 17 September 2026

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Expression of Concern Open Access

[Expression of Concern] Ginsenoside Rg1 protects against H2O2‑induced neuronal damage due to inhibition of the NLRP1 inflammasome signalling pathway in hippocampal neurons in vitro

Tan-Zhen Xu, Xiao-Yan Shen, Ling-Ling Sun, Ya-Li Chen, Bi-Qiong Zhang, Da-Ke Huang, Wei-Zu Li
Article Number: 317
Published online on: 16 September 2026

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Review Open Access

tRNA‑derived RNAs in hepatic diseases: From biological functions to clinical translation (Review)

Yaotian Cai, Yifei Chen, Fuji Yang, Yongmin Yan, Ting Jiang
Article Number: 316
Published online on: 15 September 2026

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Review Open Access

Monocytes in pneumonia: Functional plasticity and innate memory (Review) 

Run-Ze Li, Zhi-Han Xie, Li Chen, Yun-Xiao Shang, Fei Wang, Wan-Jie Huang, Qi Cheng
Article Number: 315
Published online on: 15 September 2026

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Correction Open Access

[Corrigendum] Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 314
Published online on: 14 September 2026

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Review Open Access

Ferroptosis in heatstroke: Mechanisms and therapeutic perspectives (Review)

Hongguang Gao, Yang Chen, Tianshan Zhang, Yujun Shi, Rong Yao
Article Number: 313
Published online on: 10 September 2026

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Correction Open Access

[Corrigendum] Inactivation of von Hippel‑Lindau increases ovarian cancer cell aggressiveness through the HIF1α/miR‑210/VMP1 signaling pathway

Ting Liu, Le Zhao, Wei Chen, Zhen Li, Huilian Hou, Lu Ding, Xu Li
Article Number: 312
Published online on: 10 September 2026

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Review Open Access

Interferon regulatory factors orchestrate CD8+ T cell function (Review)

Fa-Xi Wang, Chun-Liang Yang, Shan-Jie Rong, Qi-Jie Chen, Xiong-Tao Yue, Fei Sun
Article Number: 311
Published online on: 08 September 2026

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Expression of Concern Open Access

[Expression of Concern] Rapamycin‑induced miR‑30a downregulation inhibits senescence of VSMCs by targeting Beclin1

Pan Tan, Haiqin Wang, Junkun Zhan, Xinyu Ma, Xingjun Cui, Yanjiao Wang, Yi Wang, Jiayu Zhong, Youshuo Liu
Article Number: 310
Published online on: 07 September 2026

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Review Open Access

Deciphering the function and mechanism of extracorporeal shock wave therapy in knee osteoarthritis (Review)

Yixuan Chen, Siqi Song, Yuchen Zhu, Shiqi Wang, Jieyuan Hu, Chenxu Liu, Yuchen Cai, Yushi Hu
Article Number: 309
Published online on: 04 September 2026

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Multi‑omics integration in osteoarthritis: Unraveling cell‑type‑specific gene‑metabolite networks for precision medicine (Review)

Ying Yang, Ruichen Zheng, Yun Zhang, Dongmei Ye, Jiale Xie, Changliang Zhu
Article Number: 308
Published online on: 03 September 2026

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Review Open Access

Autophagy determines the fate of immune cells by regulating metabolic remodeling and PANoptosis (Review)

Yanan Guo, Xinyue Zhou, Yixiao Tian, Dan Chen, Xiaofeng Xie, Bin Zhou, Yingxia Tian, Yaqing Zhang
Article Number: 307
Published online on: 03 September 2026

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Review Open Access

Programmed cell death in metabolic syndrome: From molecular mechanisms to therapeutic strategies (Review)

Jialin Zhong, Maofu Zhang, Yafang Zheng, Cuicui Gong, Yasheng Deng, Lisha Sun, Dongqi Zhou, Qian Zhou, Qiu Chen
Article Number: 306
Published online on: 03 September 2026

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Review Open Access

Research progress on lysine acetylation (Review)

Minghui Zhang, Yuqi Zhang, Haoxin Yin, Junyuan Yan, Yingling Dong, Xin Zhao, Tianyi Cui, Bin Lv, Xiumei Gao
Article Number: 305
Published online on: 02 September 2026

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Expression of Concern Open Access

[Expression of Concern] Human ether‑à‑go‑go‑related gene mutation L539fs/47‑hERG leads to cell apoptosis through the endoplasmic reticulum stress pathway

Shuting Ma, Yun Zhao, Miaomiao Cao, Chaofeng Sun
Article Number: 304
Published online on: 02 September 2026

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Review Open Access

Targeting integrated cell death networks in sepsis‑associated acute kidney injury: Shared regulatory nodes and diet‑related small molecule modulation (Review)

Lin Song, Aifeng He, Wei Jiang, Keran Shi, Jing Wang, Lu Xu, Jiangquan Yu, Ruiqiang Zheng
Article Number: 303
Published online on: 31 August 2026

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Article Open Access

Effect of MALT1 inhibition by MI‑2 on the microglial phenotype switch, inflammatory cytokine secretion, neuronal loss and oxidative stress in Alzheimer's disease

Yuanlong Li, Hua Fan, Xiong Han, Ming Ni, Xiaodan Hou, Hailan Xia, Yinzhu Shi, Lin Zhang, Jun Sun
Article Number: 302
Published online on: 31 August 2026

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Review Open Access

Salvianolic acid monomers against metastasis: Decoding the multilayered interception of EMT, angiogenesis and immune evasion (Review)

Shiting Jiang, Dan Liu, Tingting Wei, Qiwei Shi, Haowen Wang, Yidan Gao, Pingsu Mao, Wenli Yang
Article Number: 301
Published online on: 31 August 2026

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Retraction Open Access

[Retracted] Silencing of decoy receptor 3 (DcR3) expression by siRNA in pancreatic carcinoma cells induces Fas ligand‑mediated apoptosis in vitro and in vivo

Jian Zhou, Shiduo Song, Songbin He, Zhenxin Wang, Bing Zhang, Dechun Li, Dongming Zhu
Article Number: 300
Published online on: 31 August 2026

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Review Open Access

Research progress on BTG2 in non‑tumor diseases (Review)

Shuling Li, Xiaomei Liu, Zheng Zhang, Ling Yang, Yuxuan Li, Qiongdan Hu
Article Number: 299
Published online on: 28 August 2026

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Review Open Access

Breaking the cycle of fibrosis: Ferroptosis as a therapeutic target (Review)

Xincheng Feng, Jue Zhang, Qinghong Ma, Chao Sun
Article Number: 298
Published online on: 27 August 2026

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Correction Open Access

[Corrigendum] Tumor‑targeting novel manganese complex induces ROS‑mediated apoptotic and autophagic cancer cell death

Jia Liu, Wenjie Guo, Jing Li, Xiang Li, Ji Geng, Qiuyun Chen, Jing Gao
Article Number: 297
Published online on: 26 August 2026

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Advances in sirtuin research in lung diseases (Review)

Shuangyun Xi, Weijun Chen, Xiuli Li, Yudan Wang, Yong Ke
Article Number: 296
Published online on: 25 August 2026

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Article Open Access

lncRNA TUG1 mediates palmitic acid‑induced neuronal lipotoxic injury via the miR‑449a‑5p/caspase‑3 and Akt/GSK‑3β axes

Ya-Dong Wei, Peng-Quan Chen, Xin Zheng, Le-Qi Wu, Xin-Yi Wang, Xin-Ran Gao, Jin-Fang Ge
Article Number: 295
Published online on: 25 August 2026

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Retraction Open Access

[Retracted] Downregulation of LINC00707 promotes osteogenic differentiation of human bone marrow‑derived mesenchymal stem cells by regulating DKK1 via targeting miR‑103a‑3p

Jun Liu, Minfei Wu, Guang Feng, Rui Li, Yang Wang, Jianhang Jiao
Article Number: 294
Published online on: 24 August 2026

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Journal Cover
December-2026 Volume 58 Issue 6

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Journal Metrics

Impact Factor: 8.5

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Immune remodeling in inflammatory bowel disease-associated colorectal cancer: Mechanisms and immunotherapeutic implications (Review)

Tao Zhang, Zhetan Ren, Ling Wang, Ru Man, Lin Wang, Jing Wang, Xiaozhen Cheng, Jirun Peng, Yongduo Yu
Article Number: 353
Published online on: 22 October 2026

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Inflammatory regulatory mechanisms and targeted therapy of antineutrophil cytoplasmic antibodies in atherosclerosis (Review)

Jingjing Cui, Qi Cui, Jinying Dou, Xiaoyan Li, Wenlong Chang, Lanchun Shi, Liyun An
Article Number: 352
Published online on: 22 October 2026

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Article Open Access

HMGN5 promotes renal tubular inflammation and pyroptosis‑associated signaling in chronic kidney disease via the IFNAR2 axis

Xue Rong, Jing Xu, Jienan Zhang, Qi Zhang, Jiangli Wang, Guoxin Zhang, Limin Nie
Article Number: 351
Published online on: 22 October 2026

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Correction Open Access

[Corrigendum] Radiation induces primary osteocyte senescence phenotype and affects osteoclastogenesis in vitro

Yuyang Wang, Linshan Xu, Jianping Wang, Jiangtao Bai, Jianglong Zhai, Guoying Zhu
Article Number: 350
Published online on: 21 October 2026

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Transcription factors in liver fibrosis: Mechanistic insights and nanotechnology‑driven therapeutic strategies (Review)

Xianfei Zhou, Chongjun Yang, Zhiyong Weng, Lihua Li
Article Number: 349
Published online on: 21 October 2026

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From RNA fate to cancer state transitions: m5C‑driven metabolic and immune reprogramming (Review)

Yuanli Zhou, Bolv Zhu, Xingzhou Tang, Shuishui Yin
Article Number: 348
Published online on: 20 October 2026

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Correction Open Access

[Corrigendum] Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis 

Dong Ding, Jiangbo Yan, Gangning Feng, Yong Zhou, Long Ma, Qunhua Jin
Article Number: 347
Published online on: 19 October 2026

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Centrosomal protein 55: Research progress on biological characteristics, disease associations and clinical translational potential (Review)

Sanmei Nong, Qiudong Huang, Kuibo Huang, Xiao Luo, Yin Huang, Wenlian Zheng, Weiyi Huang, Zhaoyun Liu
Article Number: 346
Published online on: 16 October 2026

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Multiple strategies to improve the therapeutic efficacy of mesenchymal stem cell‑derived exosome transplantation in ischemic stroke (Review)

Yan Xu, Xiaolei Zhou, Wenhui Zeng, Jiabing Wang, Lin Zhou, Lincai Li, Zhengwei Zou, Cixiang Chen, Yichi Zhang, Zhengyi He, Junsong Ye
Article Number: 345
Published online on: 14 October 2026

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Article Open Access

Resveratrol alleviates osteoarthritis progression by inhibiting NLRP3 inflammasome response via the AMPK/PPARγ signaling pathway

Shanshan Cui, Zifan Luo, Wen Qin, Bo Chen, Qiaoxia Zhang, Jianbing Ma, Jie Ma, Rui Zhang
Article Number: 344
Published online on: 14 October 2026

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Expression of Concern Open Access

[Expression of Concern] Anti‑metastatic and differential effects on protein expression of epigallocatechin‑3‑gallate in HCCLM6 hepatocellular carcinoma cells

Yunjuan Zhang, Lawrence Owusu, Wei Duan, Tao Jiang, Shizhu Zang, Ayaz Ahmed, Yi Xin
Article Number: 343
Published online on: 14 October 2026

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Article Open Access

Six3 promoting the migration and neural differentiation of BMSCs via Btg2‑mediated Akt signaling pathway activation: A therapeutic strategy for stroke

Zhenqiang Fu, Zhixin Li, Limin Zhang, Wentao Hu, Hecheng Yang, Jingtao Wang
Article Number: 342
Published online on: 12 October 2026

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Expression of Concern Open Access

[Expression of Concern] EETs and CYP2J2 inhibit TNF‑α‑induced apoptosis in pulmonary artery endothelial cells and TGF‑β1‑induced migration in pulmonary artery smooth muscle cells

Wenjing Feng, Xizhen Xu, Gang Zhao, Geng Li, Tiantian Liu, Junjie Zhao, Ruolan Dong, Dao Wen Wang, Ling Tu
Article Number: 341
Published online on: 12 October 2026

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Gomisin A as a multi‑target therapeutic agent: Pharmacological mechanisms, pharmacokinetics and network pharmacology (Review)

Jiaqi Xu, Sha Shi, Chengkai Zhu, Qi Sui, Shanhao Zhu, Jingnan Zhang, Yi Zhang, Peng Chen
Article Number: 340
Published online on: 09 October 2026

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Multi‑target mechanisms of paeoniflorin in inflammatory regulation: A network pharmacology (Review)

Jin Zhang, Junjie Ye, Kun Jin, Xuan Sun, Xinyu Yu, Yuan Zhao, Ni Zhu
Article Number: 339
Published online on: 09 October 2026

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Mechanisms of neuroimmune crosstalk in vestibular disorders: Linking inflammation with neural circuit dysfunction (Review)

Xianfang Pan, Jin Fan, Zhiyi Yang, Zegang Yin, Zhen Li, Zhifeng Rui, Hujun Zhang, Yujie Li, Hongjuan Zhang
Article Number: 338
Published online on: 08 October 2026

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Expression of Concern Open Access

[Expression of Concern] Gambogic acid inhibits invasion of osteosarcoma via upregulation of TIMP‑1

Zeng-Feng Xin, Cheng-Chun Shen, Li-Jiang Tao, Shi-Gui Yan, Hao-Bo Wu
Article Number: 337
Published online on: 08 October 2026

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Anesthetics and cancer biology: Translational evidence from perioperative modulation to drug repurposing (Review)

Ting Yang, Jiao Tang, Muhammad Saqib Mudabbar, Huan Hu, Qiang Fu, Chunlan Pu
Article Number: 336
Published online on: 05 October 2026

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Expression of Concern Open Access

[Expression of Concern] Multiple roles of SOCS proteins: Differential expression of SOCS1 and SOCS3 in atherosclerosis

Xiao Liang, Ming He, Tao Chen, Yan Liu, Yu-Ling Tian, Yu-Liang Wu, Yan Zhao, Yan Shen, Zu-Yi Yuan
Article Number: 335
Published online on: 30 September 2026

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