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International Journal of Molecular Medicine
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Print ISSN: 1107-3756 Online ISSN: 1791-244X
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International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

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Journal Cover
December-2018 Volume 42 Issue 6

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review

Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

Chongyang Ma, Shuling Liu, Shuang Zhang, Tian Xu, Xue Yu, Yushan Gao, Changming Zhai, Changxiang Li, Chaofang Lei, Shuning Fan, Yuxi Chen, Huiling Tian, Qingguo Wang, Fafeng Cheng, Xueqian Wang
Pages: 2979-2990
Published online on: 02 October 2018

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Review

TRAPPC9: Novel insights into its trafficking and signaling pathways in health and disease (Review)

Thomas Mbimba, Nazar J. Hussein, Ayesha Najeed, Fayez F. Safadi
Pages: 2991-2997
Published online on: 21 September 2018

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Review Open Access

Maintenance of intracellular Ca2+ basal concentration in airway smooth muscle (Review)

Jorge Reyes‑García, Edgar Flores‑Soto, Abril Carbajal‑García, Bettina Sommer, Luis M. Montaño
Pages: 2998-3008
Published online on: 02 October 2018

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Article Open Access

Suppressive effect of an analog of the antimicrobial peptide of LL‑37 on colon cancer cells via exosome‑encapsulated miRNAs

Miwa Hayashi, Kengo Kuroda, Kohei Ihara, Takahiro Iwaya, Emiko Isogai
Pages: 3009-3016
Published online on: 13 September 2018

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Article Open Access

Silencing of NOD2 protects against diabetic cardiomyopathy in a murine diabetes model

Lin Shen, Li Li, Man Li, Weiling Wang, Wenbin Yin, Wei Liu, Yanyan Hu
Pages: 3017-3026
Published online on: 14 September 2018

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Article Open Access

miR-214 regulates papillary thyroid carcinoma cell proliferation and metastasis by targeting PSMD10

Fangzhou Liu, Kexin Lou, Xiaotong Zhao, Jia Zhang, Wei Chen, Yichun Qian, Yanbin Zhao, Yan Zhu, Yuan Zhang
Pages: 3027-3036
Published online on: 27 September 2018

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Article Open Access

Ghrelin protects the myocardium with hypoxia/reoxygenation treatment through upregulating the expression of growth hormone, growth hormone secretagogue receptor and insulin-like growth factor-1, and promoting the phosphorylation of protein kinase B

Yang Liu, Yanling Liu, Guolin Li, Zhengrong Chen, Guixiong Gu
Pages: 3037-3046
Published online on: 18 September 2018

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Article Open Access

Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice

Joo Wan Kim, You‑Suk Lee, Du Jin Seol, Il Je Cho, Sae Kwang Ku, Jae‑Suk Choi, Hae‑Jeung Lee
Pages: 3047-3064
Published online on: 14 September 2018

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Article Open Access

DPY30 is required for the enhanced proliferation, motility and epithelial-mesenchymal transition of epithelial ovarian cancer cells

Lili Zhang, Shuguang Zhang, Aihua Li, Anqi Zhang, Shiqian Zhang, Liang Chen
Pages: 3065-3072
Published online on: 11 September 2018

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Article Open Access

Protective effect of luteolin on skin ischemia-reperfusion injury through an AKT-dependent mechanism

Gang Chen, Hugang Shen, Linlin Zang, Zhonglan Su, Jilong Huang, Yong Sun, Hongwei Wang
Pages: 3073-3082
Published online on: 02 October 2018

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Article Open Access

BML-111 suppresses TGF-β1-induced lung fibroblast activation in vitro and decreases experimental pulmonary fibrosis in vivo

Yu‑Dong Ji, Zhen‑Long Luo, Chun‑Xiu Chen, Bo Li, Jie Gong, Ya‑Xin Wang, Lin Chen, Shang‑Long Yao, You Shang
Pages: 3083-3092
Published online on: 02 October 2018

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Article Open Access

Astragalus polysaccharide combined with 10-hydroxycamptothecin inhibits metastasis in non-small cell lung carcinoma cell lines via the MAP4K3/mTOR signaling pathway

Yang Zhou, Tao Hong, Li Tong, Wei Liu, Xueting Yang, Jianghan Luo, Fuling Wang, Jian Li, Lijun Yan
Pages: 3093-3104
Published online on: 07 September 2018

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Article Open Access

A 44-gene set constructed for predicting the prognosis of clear cell renal cell carcinoma Corrigendum in /10.3892/ijmm.2019.4138

Yonggang Wang, Yao Wang, Feng Liu
Pages: 3105-3114
Published online on: 26 September 2018

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Article Open Access

miR-1307-3p suppresses the chondrogenic differentiation of human adipose-derived stem cells by targeting BMPR2

Zhen Yang, Rui Li, Jun Ao, Qing‑De Wa, Yi Zhang, Long Chen, Jing Wen, Biao Chen, Wei Pan, Bo Li, Xiao‑Bin Tian
Pages: 3115-3124
Published online on: 21 September 2018

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Article Open Access

Silencing of Annexin A1 suppressed the apoptosis and inflammatory response of preeclampsia rat trophoblasts

Jing Feng, Xinling Wang, Hongyan Li, Li Wang, Zengjun Tang
Pages: 3125-3134
Published online on: 18 September 2018

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Article Open Access

Aspirin promotes apoptosis and inhibits proliferation by blocking G0/G1 into S phase in rheumatoid arthritis fibroblast-like synoviocytes via downregulation of JAK/STAT3 and NF-κB signaling pathway

Xiaoqi Zhang, Hao Feng, Juan Du, Jing Sun, Dongfang Li, Tomoka Hasegawa, Norio Amizuka, Minqi Li
Pages: 3135-3148
Published online on: 17 September 2018

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Article Open Access

(-)-Epigallocatechin gallate but not chlorogenic acid suppresses EGF-stimulated migration of osteoblasts via attenuation of p38 MAPK activity

Tetsu Kawabata, Takanobu Otsuka, Kazuhiko Fujita, Go Sakai, Rie Matsushima‑Nishiwaki, Osamu Kozawa, Haruhiko Tokuda
Pages: 3149-3156
Published online on: 18 September 2018

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Article Open Access

Total C-21 steroidal glycosides, isolated from the root tuber of Cynanchum auriculatum Royle ex Wight, attenuate hydrogen peroxide-induced oxidative injury and inflammation in L02 cells

Zhenhui Wu, Yingyu Wang, Xian Meng, Xinjie Wang, Zhenlin Li, Shihui Qian, Yingjie Wei, Luan Shu, Yongfang Ding, Peijuan Wang, Yunru Peng
Pages: 3157-3170
Published online on: 25 September 2018

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Article Open Access

MicroRNA-145 regulates the proliferation, migration and invasion of human primary colon adenocarcinoma cells by targeting MAPK1

Yong Yang, Xiao‑Jia Li, Peng Li, Xiu‑Tian Guo
Pages: 3171-3180
Published online on: 01 October 2018

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Article Open Access

Hypoxia promotes maintenance of the chondrogenic phenotype in rat growth plate chondrocytes through the HIF-1α/YAP signaling pathway

Hao Li, Xiaojuan Li, Xingzhi Jing, Mi Li, Ye Ren, Jingyuan Chen, Caihong Yang, Hua Wu, Fengjing Guo
Pages: 3181-3192
Published online on: 09 October 2018

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Article Open Access

THR1 mediates GCN4 and CDC4 to link morphogenesis with nutrient sensing and the stress response in Candida albicans

Yuan‑Ti Lee, Yi‑Ya Fang, Yu Wen Sun, Hsiao‑Chi Hsu, Shan‑Mei Weng, Tzu‑Ling Tseng, Ting‑Hui Lin, Jia‑Ching Shieh
Pages: 3193-3208
Published online on: 12 October 2018

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Article Open Access

Tizanidine exerts anti-nociceptive effects in spared nerve injury model of neuropathic pain through inhibition of TLR4/NF-κB pathway

Wanmin Pei, Yi Zou, Wenting Wang, Lai Wei, Yuan Zhao, Li Li
Pages: 3209-3219
Published online on: 13 September 2018

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Article Open Access

Fisetin inhibits pristine-induced systemic lupus erythematosus in a murine model through CXCLs regulation

Su‑Ping Xu, Yong‑Sheng Li
Pages: 3220-3230
Published online on: 01 October 2018

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Article Open Access

Evaluation of the effect of various main elements on the PrPSc detection by real-time quaking-induced conversion assay

Kang Xiao, Qi Shi, Wei Zhou, Chen Gao, Cao Chen, Bao‑Yun Zhang, Jing Wang, Xiao‑Ping Dong
Pages: 3231-3237
Published online on: 07 September 2018

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Article Open Access

Anti-microRNA-132 causes sevoflurane‑induced neuronal apoptosis via the PI3K/AKT/FOXO3a pathway

Ping Dong, Xiyan Zhang, Jian Zhao, Dongliang Li, Liang Li, Bo Yang
Pages: 3238-3246
Published online on: 25 September 2018

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Article Open Access

Evodiamine alleviates severe pneumonia induced by methicillin-susceptible Staphylococcus aureus following cytomegalovirus reactivation through suppressing NF-κB and MAPKs

Xin Chen, Shujun Zhou, Hui Li
Pages: 3247-3255
Published online on: 11 October 2018

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Article Open Access

Potential regulatory role of circular RNA in idiopathic pulmonary fibrosis

Rongrong Li, Youlei Wang, Xiaodong Song, Wenjing Sun, Jinjin Zhang, Yuxia Liu, Hongbo Li, Chao Meng, Jie Zhang, Qingyin Zheng, Changjun Lv
Pages: 3256-3268
Published online on: 24 September 2018

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Article Open Access

Expression levels of hnRNP K and p21WAF1/CIP1 are associated with resistance to radiochemotherapy independent of p53 pathway activation in rectal adenocarcinoma

Wassiliki Daskalaki, Eva Wardelmann, Matthias Port, Katharina Stock, Julie Steinestel, Sebastian Huss, Jan Sperveslage, Konrad Steinestel, Stefan Eder
Pages: 3269-3277
Published online on: 25 September 2018

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Article Open Access

O-GlcNAc-modified SNAP29 inhibits autophagy-mediated degradation via the disturbed SNAP29-STX17-VAMP8 complex and exacerbates myocardial injury in type I diabetic rats

Lin Huang, Ping Yuan, Peng Yu, Qiling Kong, Zixuan Xu, Xia Yan, Yang Shen, Juesheng Yang, Rong Wan, Kui Hong, Yanhua Tang, Jinzhu Hu
Pages: 3278-3290
Published online on: 07 September 2018

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Article Open Access

Long non-coding RNA C5orf66-AS1 prevents oral squamous cell carcinoma through inhibiting cell growth and metastasis

Tianzhu Lu, Hongjing Liu, Ganhua You
Pages: 3291-3299
Published online on: 02 October 2018

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Article Open Access

Trifluoperazine prevents FOXO1 nuclear excretion and reverses doxorubicin-resistance in the SHG44/DOX drug-resistant glioma cell line

Xiaozhong Chen, Xiaoquan Luo, Yuan Cheng
Pages: 3300-3308
Published online on: 18 September 2018

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Article Open Access

MicroRNA-552 promotes hepatocellular carcinoma progression by downregulating WIF1

Chao Li, Zi Wang, Shuangjiang Chen, Jingyao Zhang, Kai Qu, Chang Liu
Pages: 3309-3317
Published online on: 17 September 2018

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Article Open Access

Methylation status of KLF4 and HS3ST2 genes as predictors of endometrial cancer and hyperplastic endometrial lesions

Zuzana Danková, Dušan Braný, Dana Dvorská, Marcela Ňachajová, Roman Fiolka, Marián Grendár, Jozef Hatok, Peter Kubatka, Veronika Holubeková, Erika Halašová, Tibor Bielik, Pavol Žúbor
Pages: 3318-3328
Published online on: 12 September 2018

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Article Open Access

Regulation of the MAPK signaling pathway by miR-421-5p in rats under light pollution

Qianwen Ma, Yong Tan, Xuan Chen, Shuping Chen, Yuying Sun, Beibei Zhou
Pages: 3329-3343
Published online on: 13 September 2018

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Article Open Access

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

Panpan Zhang, Lingyue Hua, Huan Hou, Xingyue Du, Zhiqiang He, Menghan Liu, Xiaojuan Hu, Nianlong Yan
Pages: 3344-3354
Published online on: 19 September 2018

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Article Open Access

Knockdown of miR-194-5p inhibits cell proliferation, migration and invasion in breast cancer by regulating the Wnt/β-catenin signaling pathway

Feibiao Yang, Zhangsheng Xiao, Songze Zhang
Pages: 3355-3363
Published online on: 25 September 2018

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Article Open Access

In vitro analysis of microRNA-26a in chronic lymphocytic leukemia cells

Jing Li, Chang‑Kui Sun
Pages: 3364-3370
Published online on: 10 October 2018

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Article Open Access

Age-associated decline in Nrf2 signaling and associated mtDNA damage may be involved in the degeneration of the auditory cortex: Implications for central presbycusis

Yongqin Li, Xueyan Zhao, Yujuan Hu, Haiying Sun, Zuhong He, Jie Yuan, Hua Cai, Yu Sun, Xiang Huang, Wen Kong, Weijia Kong
Pages: 3371-3385
Published online on: 01 October 2018

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Article Open Access

Anti-metastatic effect of 131I-labeled Buthus martensii Karsch chlorotoxin in gliomas

Shan Wu, Ke Ma, Wen‑Li Qiao, Ling‑Zhou Zhao, Chang‑Cun Liu, Li‑Lei Guo, Yan Xing, Mei‑Lin Zhu, Jin‑Hua Zhao
Pages: 3386-3394
Published online on: 01 October 2018

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Article Open Access

TGF-β1 secreted by M2 phenotype macrophages enhances the stemness and migration of glioma cells via the SMAD2/3 signalling pathway

Zhengzheng Liu, Weilu Kuang, Qin Zhou, Yingying Zhang
Pages: 3395-3403
Published online on: 09 October 2018

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Article Open Access

Cytokine-induced alterations of BAMBI mediate the reciprocal regulation of human Th17/Treg cells in response to cigarette smoke extract

Hong‑Ju Liu, Gang Chen, Long Chen, Mei Zhou, Xian‑Zhi Xiong, Zhao‑Ji Meng, Sheng‑Wen Sun, Xiao‑Nan Tao
Pages: 3404-3414
Published online on: 09 October 2018

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Article Open Access

Rosuvastatin reduces the pro-inflammatory effects of adriamycin on the expression of HMGB1 and RAGE in rats

Haiyan Zhang, Xiang Lu, Zhengxia Liu, Kang Du
Pages: 3415-3423
Published online on: 11 October 2018

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Article Open Access

SOSTDC1 inhibits bone metastasis in non-small cell lung cancer and may serve as a clinical therapeutic target

Guanghui Chen, Haiyi Gong, Ting Wang, Jian Wang, Zhitao Han, Guangjian Bai, Shuai Han, Xinghai Yang, Wang Zhou, Tielong Liu, Jianru Xiao
Pages: 3424-3436
Published online on: 10 October 2018

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Article

Calcium‑sensing receptors in human peripheral T lymphocytes and AMI: Cause and effect

Jingya Zeng, Ying Pan, Baohong Cui, Taiyu Zhai, Song Gao, Qianyu Zhao, Yihua Sun
Pages: 3437-3446
Published online on: 10 October 2018

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Article

In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells

Kaiwen Bai, Luyi Jiang, Ligen Zhang, Yongwei Zhao, Yi Lu, Jingya Zhu, Jie Cai, Lili Zhang, Tian Wang
Pages: 3447-3458
Published online on: 13 September 2018

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Article

Hyperosmotic stress stimulates autophagy via the NFAT5/mTOR pathway in cardiomyocytes

Hong Zhu, Wei Cao, Peng Zhao, Jieyu Wang, Yuying Qian, Yun Li
Pages: 3459-3466
Published online on: 12 September 2018

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Article

Effect of deubiquitinase USP8 on hypoxia/reoxygenation‑induced inflammation by deubiquitination of TAK1 in renal tubular epithelial cells

Yuwei Zhang, Yingquan Luo, Yina Wang, Hong Liu, Yu Yang, Qiong Wang
Pages: 3467-3476
Published online on: 17 September 2018

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Article

LY3009120, a pan-Raf kinase inhibitor, inhibits adipogenesis of 3T3-L1 cells by controlling the expression and phosphorylation of C/EBP-α, PPAR-γ, STAT‑3, FAS, ACC, perilipin A, and AMPK

Su‑Min Yang, Yu‑Kyoung Park, Jee In Kim, Yun‑Han Lee, Tae‑Yun Lee, Byeong‑Churl Jang
Pages: 3477-3484
Published online on: 21 September 2018

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Article

Lithocarpus polystachyus Rehd. leaves aqueous extract protects against hydrogen peroxide‑induced SH-SY5Y cells injury through activation of Sirt3 signaling pathway

Jianmei Gao, Yingshu Xu, Jianyong Zhang, Jingshan Shi, Qihai Gong
Pages: 3485-3494
Published online on: 05 October 2018

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Article

Preparation and biological evaluation of a novel pH-sensitive poly (β-malic acid) conjugate for antitumor drug delivery Corrigendum in /10.3892/ijmm.2019.4308

Youbei Qiao, Bao Liu, Yifan Peng, Erlong Ji, Hong Wu
Pages: 3495-3502
Published online on: 25 September 2018

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Article

SFMBT2 positively regulates SOX9 and chondrocyte proliferation

Safdar Hussain, Mengyao Sun, Yuanxu Guo, Nosheen Mushtaq, Yitong Zhao, Ying Yuan, Nazim Hussain, Ezra Osoro, Abubakar Suleiman, Muhammad Sadiq, Fujun Zhang, Yan Han, Jian Sun, Shemin Lu
Pages: 3503-3512
Published online on: 25 September 2018

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Article

Melatonin attenuates the inflammatory response via inhibiting the C/EBP homologous protein-mediated pathway in taurocholate-induced acute pancreatitis

Qian Zhao, Hui Zhang, Junhua Huang, Huajun Yu, Jiajia Li, Qinfen Che, Yangjie Sun, Yin Jin, Jiansheng Wu
Pages: 3513-3521
Published online on: 09 October 2018

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Article

Adjudin delays cellular senescence through Sirt3‑mediated attenuation of ROS production

Keyi Geng, Ningzhen Fu, Xiao Yang, Weiliang Xia
Pages: 3522-3529
Published online on: 08 October 2018

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Article

LOXL2, a copper-dependent monoamine oxidase, activates lung fibroblasts through the TGF-β/Smad pathway

Xiaohong Wen, Yuan Liu, Yu Bai, Mingwei Li, Qiang Fu, Yi Zheng
Pages: 3530-3541
Published online on: 11 October 2018

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Article

Expression and mutations of BRCA in breast cancer and ovarian cancer: Evidence from bioinformatics analyses

Zhu Wang, Jianwen Zhang, Ying Zhang, Qiong Deng, Hui Liang
Pages: 3542-3550
Published online on: 11 September 2018

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Article

Identification of three aquaporin subgroups from Blomia tropicalis by transcriptomics

Ying Zhou, Ling Li, Jun Qian, Haoyuan Jia, Yubao Cui
Pages: 3551-3561
Published online on: 13 September 2018

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Article

miR-183 inhibits autophagy and apoptosis in gastric cancer cells by targeting ultraviolet radiation resistance-associated gene

Yuan Yuan, Youwei Zhang, Liang Han, Sanyuan Sun, Yongqian Shu
Pages: 3562-3570
Published online on: 11 September 2018

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Article

Schisandrin B protects human keratinocyte-derived HaCaT cells from tert-butyl hydroperoxide-induced oxidative damage through activating the Nrf2 signaling pathway

Ming Ding, Peng Shu, Shuang Gao, Fenglou Wang, Yitian Gao, Yu Chen, Wenjuan Deng, Gaiying He, Zhenlin Hu, Tianduo Li
Pages: 3571-3581
Published online on: 26 September 2018

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Inflammatory stimuli promote oxidative stress in pancreatic acinar cells via Toll-like receptor 4/nuclear factor-κB pathway

Longfei Pan, Lei Yu, Liming Wang, Juntao He, Jiangli Sun, Xiaobo Wang, Hai Wang, Zhenghai Bai, Hui Feng, Honghong Pei
Pages: 3582-3590
Published online on: 01 October 2018

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Article

The role of focal adhesion kinase in transforming growth factor-β2 induced migration of human lens epithelial cells

Jie Liu, Dan Xu, Jingming Li, Ning Gao, Chongbing Liao, Ruihua Jing, Bogang Wu, Bo Ma, Yongping Shao, Cheng Pei
Pages: 3591-3601
Published online on: 02 October 2018

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eRF3b-37 inhibits the TGF-β1-induced activation of hepatic stellate cells by regulating cell proliferation, G0/G1 arrest, apoptosis and migration

Zhengrong Xu, Tao Li, Man Li, Lei Yang, Rudan Xiao, Li Liu, Xin Chi, Dianwu Liu
Pages: 3602-3612
Published online on: 26 September 2018

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Article

Anemarrhena asphodeloides Bunge ameliorates osteoporosis by suppressing osteoclastogenesis

Jae Sung Lee, Mi Hye Kim, Haesu Lee, Woong Mο Yang
Pages: 3613-3621
Published online on: 01 October 2018

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Article

Secretogranin III may be an indicator of paraquat-induced astrocyte activation and affects the recruitment of BDNF during this process

Xiaoni Zhan, Fengrui Li, Qiaohong Chu, Hao Pang
Pages: 3622-3630
Published online on: 01 October 2018

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Article

Repetitive magnetic stimulation promotes the proliferation of neural progenitor cells via modulating the expression of miR-106b

Hua Liu, Gaohua Li, Chunlian Ma, Yanfang Chen, Jinju Wang, Yi Yang
Pages: 3631-3639
Published online on: 09 October 2018

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Retraction Open Access

[Retracted] Piezo1 protein induces the apoptosis of human osteoarthritis‑derived chondrocytes by activating caspase‑12, the signaling marker of ER stress

Xiao-Fei Li, Zhao Zhang, Zhu-Ke Chen, Zhao-Wei Cui, Hai-Ning Zhang
Pages: 3640-3640
Published online on: 08 October 2018

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Journal Cover
July-2026 Volume 58 Issue 1

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Sex differences in cardiovascular‑kidney‑metabolic syndrome: From pathogenesis to treatment response (Review)

Yanqin Fan, Hongtu Hu, Jing Cheng
Article Number: 202
Published online on: 27 May 2026

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Retraction Open Access

[Retracted] BAMBI inhibits inflammation through the activation of autophagy in experimental spinal cord injury

Yin Yang, Chunyang Guo, Bo Liao, Junjun Cao, Chen Liang, Xijing He
Article Number: 201
Published online on: 25 May 2026

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Article Open Access

Integrative transcriptomic analysis unveils FXR as a key regulator of intestinal stemness and inflammation in ulcerative colitis

Hao Lin, Xinran Cheng, Yangyang Ren, Yongmei Zhang, Weixu Chen, Qingyan Lu, Yiqing Tian
Article Number: 200
Published online on: 22 May 2026

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Article Open Access

Ginsenoside Rg3 potentiates cisplatin antitumor activity while mitigating nephrotoxicity through SIRT1‑mediated suppression of the NLRP3 inflammasome

Jinghui Zhai, Yueming Zhang, Jiawei Gong, Li Fu, Sixi Zhang
Article Number: 199
Published online on: 22 May 2026

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Article Open Access

Identification of diagnostic markers for diabetic kidney disease by weighted gene co‑expression network analysis and machine learning

Qiming Xu, Chunjing Xu, Ziyang Liu, Jianrao Lu, Jing Hu, Lin Liao
Article Number: 198
Published online on: 21 May 2026

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Article Open Access

CTRP3 alleviates neuropathic pain by improving mitochondrial biogenesis and mitochondrial unfolded protein response via spinal SIRT1 in rats

Tianzhu Liu, Longqing Zhang, Wei Mei
Article Number: 197
Published online on: 21 May 2026

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Correction Open Access

[Corrigendum] Activated Wnt signaling induces myofibroblast differentiation of mesenchymal stem cells, contributing to pulmonary fibrosis

Zhaorui Sun, Cong Wang, Chaowen Shi, Fangfang Sun, Xiaomeng Xu, Weiping Qian, Shinan Nie, Xiaodong Han
Article Number: 196
Published online on: 20 May 2026

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Article Open Access

Ganoderma lucidum polysaccharides improve liver metabolic disorders by modulating gut microbiota of ovariectomized mice

Xin Jin, Xuan Liu, Yun-Juan Wang, Zi-Li Lei, Yan-Hong Yang
Article Number: 195
Published online on: 20 May 2026

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Article Open Access

Endothelial NOX4‑driven oxidative stress inhibition reverses HtrA1 deficiency‑induced blood‑brain barrier disruption and cognitive impairment

Shi-Na Song, Jun-Ying Wu, Mao-Mei Song, Xiao-Feng Li, Jian-Ming Wang, Wen-Hui Jia, Chang-Xin Li, Sui-Yi Xu
Article Number: 194
Published online on: 19 May 2026

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Review Open Access

Bone‑origin repair in diabetic foot ulcers: Mechanisms of callus formation and endocrine effects in healing (Review)

Sen Chen, Xiaofei Cui
Article Number: 193
Published online on: 19 May 2026

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Unraveling the molecular landscape of chronic radiation injury: From oxidative stress signaling to translational modeling (Review)

Zhenjun Xi, Xiaodong Li, Chunhui Yang, Li Wang, Jingxin Mao, Qianqian Liu, Chang Liu, Qian Li, Yuanfang Hou, Jie Wan, Chengzhuo Yang, Feiji Sun, Chao Yu, Miao Wang, Baocheng Yuan, Yongsheng Liu, Qing Hu, Li Zhang, Xuemei Li, Xiaobing Li
Article Number: 192
Published online on: 19 May 2026

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Retraction Open Access

[Retracted] Cocktail therapy with a combination of interferon, ribavirin and angiotensin‑II type 1 receptor blocker attenuates murine liver fibrosis development

Hitoshi Yoshiji, Ryuichi Noguchi, Yasuhide Ikenaka, Kosuke Kaji, Yosuke Aihara, Yusaku Shirai, Junichi Yoshii, Koji Yanase, Hiroshi Fukui
Article Number: 191
Published online on: 18 May 2026

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Autophagy and metabolic homeostasis: Exploration in obesity‑related metabolic diseases (Review)

Chenglin Lu, Xiangyu Qi, Yuting Tong, Peng Lu, Dandan Luo, Qingbo Guan, Chunxiao Yu
Article Number: 190
Published online on: 14 May 2026

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Primary cilia dysfunction: A critical driver of metabolic diseases (Review)

Xiaojing Wang, Yi Jin, Kejia Xie, Pengfei Yao, Liguo Song, Hongdan Liu, Yanjie Tan
Article Number: 189
Published online on: 14 May 2026

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Gut‑brain axis in anesthesia and critical illness: Molecular crosstalk and its impact on delirium and outcome (Review)

Xigang Ma, Yongsen Zhao
Article Number: 188
Published online on: 14 May 2026

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Article Open Access

Betulinic acid alleviates the inflammatory injury of osteoblasts in osteoporosis by augmenting autophagy via the AMPK-mTOR signaling pathway

Yiwei Zhao, Zechao Qu, Lin Liu, Yong Zhang, Xiaohao Wang, Bo Zhang, Yining Gong, Liang Yan
Article Number: 187
Published online on: 13 May 2026

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Correction Open Access

[Corrigendum] Induction of cardiomyocyte‑like cells from hair follicle cells in mice

Yong-Hee Kim, Bang-Jin Kim, Seok-Man Kim, Sun-Uk Kim, Buom-Yong Ryu
Article Number: 186
Published online on: 13 May 2026

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Spatial hepatology: Decoding liver zonation for metabolic and regenerative therapeutics (Review)

Guiqing Chen, Hongyan Jia, Kai Zhao, Chang Gao, Yue Liu, Hong Zhu, Dakai Yang, Yun Cai
Article Number: 185
Published online on: 13 May 2026

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Article Open Access

Hepatic p38γ exacerbates acetaminophen‑induced acute liver injury via PI3K/Akt‑dependent mechanisms

Hui Fang, Min Shu, Jiaju Wang, Heng Tian, Jianguo Zhang, Ying Hu, He Li, Huan Zhou, Kangsheng Gu, Zhenhua Ren
Article Number: 184
Published online on: 12 May 2026

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Pharmacological activity, molecular mechanisms and therapeutic potential of erianin (Review)

Chengyi Ming, Ni Zhu, You Yu, Hong Zhou, Meichun Hu
Article Number: 183
Published online on: 12 May 2026

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Review Open Access

Rab27: Molecular switch of tumor exosome secretion (Review)

Mengtian Tang, Zhongjian Zhu, Huaxin Duan, Shiming Tan, Mengzhou Shen, Xianjie Jiang, Qiu Peng, Linda Oyang, Zongyao Ren, Yujuan Zhou, Qianjin Liao
Article Number: 182
Published online on: 12 May 2026

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Article Open Access

IL‑17A+ γδT cell activation via the HMGB1‑TLR2/4‑NF‑κB signaling pathways in biliary atresia

Meng-Xin Zhang, Jing-Feng Tang, Mei Hong, Ying Yang, Yun Zhou, Shui-Qing Chi, Li-Ying Rong, Guo-Qing Cao, Xi Zhang, Jin-Xiang Zhang, Shao-Tao Tang
Article Number: 181
Published online on: 11 May 2026

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Article Open Access

CircRAD18 promotes glioblastoma proliferation, migration and invasion via the miR‑1231/LUC7L2 axis

Lumeng Song, Ping Xiong, Amu Jike, Xiaochao Xia, Lifang Mao, Zihao Wang, Yinchuan Cheng, Shumin Wang, Shizheng Tan, Dongnan Yu, Zheng Li, Xiaoping Tang, Shun Li
Article Number: 180
Published online on: 11 May 2026

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Correction Open Access

[Corrigendum] Expression of FKBP52 in the ovaries of PCOS rats

Shiyan Song, Yong Tan
Article Number: 179
Published online on: 11 May 2026

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Article Open Access

miR‑223‑3p promotes microglial lactylation and M1 polarization via the FBXW7/Notch1/Hes1/SIRT1 axis

Xiaoyu Wang, Lin Song, Jiafeng Wang, Qianqian Xie, Yan Wang, Chunyan Li, Tianqi Wang, Yifeng Du
Article Number: 178
Published online on: 08 May 2026

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Review Open Access

Radiotherapy and cytokines: A systems view of immunotherapy and toxicity (Review)

Siyuan Zhou, Yurong Jiang, Jixu Fan, Minjie Guo, Yi Wen, Chunhua Dai
Article Number: 177
Published online on: 08 May 2026

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Advances in understanding the NLRP3 inflammasome‑mediated mechanisms and therapeutic targets in diabetic nephropathy (Review)

Xiwei Wang, Shuang Li, Xiaotian Ge, Tao Xie, Sainan Li, Ruiqi Yuan, Tianxi Li, Hui Yuan
Article Number: 176
Published online on: 06 May 2026

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Expression of Concern Open Access

[Expression of Concern] ISL1 promotes cancer progression and inhibits cisplatin sensitivity in triple‑negative breast cancer cells

Yang Zhang, Lu Wang, Peng Gao, Zhiguo Sun, Ning Li, Yanqin Lu, Jianglun Shen, Jian Sun, Yiming Yang, Hao Dai, Haifeng Cai
Article Number: 175
Published online on: 06 May 2026

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Phosphorylation beyond the plasma membrane: How secretory pathway kinases sculpt the cellular dialogue in cancer (Review)

Ziang Geng, Shu Guan, Shaoqi Du, Shuo Zhang, Jiaxin Hao, Siyuan Tian, Chen Zhu, Shaonan Du
Article Number: 174
Published online on: 06 May 2026

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Ferroptosis in musculoskeletal disorders: Emerging mechanisms and therapeutic opportunities (Review)

Wenhui Gu, Haifeng Zhang, Lisha Ye, Fangming Liu, Ting Xu, Yinxian Yu, Guohua Wang
Article Number: 173
Published online on: 05 May 2026

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Retraction Open Access

[Retracted] Regulation of p38 MAPK phosphorylation inhibits chondrocyte apoptosis in response to heat stress or mechanical stress

Ken Takebe, Takayuki Nishiyama, Shinya Hayashi, Shingo Hashimoto, Takaaki Fujishiro, Noriyuki Kanzaki, Kohei Kawakita, Kenjiro Iwasa, Ryosuke Kuroda, Masahiro Kurosaka
Article Number: 172
Published online on: 04 May 2026

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Article Open Access

Dapagliflozin attenuates ferroptosis in diabetic nephropathy through activation of the Nrf2/HO‑1 signaling pathway

Hanshuang Liu, Xiaoxiao Zhang, Yubing Cui, Shengxi Xiong, Linjuan Huang, Min Li, Chen Shao, Xiaolei Hu
Article Number: 171
Published online on: 30 April 2026

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Article Open Access

Ligustroflavone protects against acute kidney injury by inhibiting ferroptosis via acting on GSK3β/NRF2 signaling

Jiayu Song, Long Wang, Yaru Wang, Jie Meng, Jingyi Sheng, Yongfeng Zhao, San Yan Xu, Juan Lei, Fangfang Cai, Yunwen Yang
Article Number: 170
Published online on: 30 April 2026

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Correction Open Access

[Corrigendum] Differential regulation of the biosynthesis of glucose transporters by the PI3‑K and MAPK pathways of insulin signaling by treatment with novel compounds from Liriope platyphylla

Yoen Kyung Lee, Ji Eun Kim, So Hee Nam, Jun Seo Goo, Sun Il Cho, Young Hwan Choi, Chang Jun Bae, Ong Min Woo, Jung Sik Cho, Dae Youn Hwang
Article Number: 169
Published online on: 28 April 2026

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Journal Cover
August-2026 Volume 58 Issue 2

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Journal Metrics

Impact Factor: 5.8

CiteScore: 9.7

CiteScore Rank: Q1: #35/357 Biochemistry, Genetics and Molecular Biology

Source Normalized Impact per Paper (SNIP): 1.28

SCImago Journal Rank (SJR): 1.381

Review Open Access

Effects of exercise‑derived extracellular vesicles: Epigenetic regulatory mechanisms and protective roles (Review)

Xinxin Zhang, Biao Zhang
Article Number: 220
Published online on: 15 June 2026

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Moderate downregulation of NDUFA13 promotes cardiomyocytes proliferation and heart regeneration through the glycolysis/c‑Myc/Ccnd1 axis

Ying Gao, Ningjing Qian, Junyan Jin, Jiayi Liu, Bingqi Wang, Yaping Wang
Article Number: 219
Published online on: 12 June 2026

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[Corrigendum] (‑)‑Epigallocatechin‑3‑gallate attenuates myocardial injury induced by ischemia/reperfusion in diabetic rats and in H9c2 cells under hyperglycemic conditions

Yang Wu, Zhong-Yuan Xia, Bo Zhao, Yan Leng, Juan Dou, Qing-Tao Meng, Shao-Qing Lei, Zhi-Ze Chen, Jie Zhu
Article Number: 218
Published online on: 10 June 2026

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Melatonin ameliorates circadian rhythm disruption induced erectile dysfunction by inhibiting oxidative stress mediated pyroptosis via Nrf2/HO‑1 axis

Qingtao Yang, Wei Li, Qi Yu, Jiang Shi, Lu Yang, Jun Qiao, Xi Wei, Changshi Gu, Fa Sun, Tao Li
Article Number: 217
Published online on: 09 June 2026

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Spatial architecture of immunometabolism: Mitochondrial‑organelle interfaces in immune signaling (Review)

Yaping Wu, Hao Yu, Ling Xia, Li Yang, Yu Zhou, Qian Yu
Article Number: 216
Published online on: 08 June 2026

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Urea cycle dysregulation and arginine pathways in the pathogenesis of NAFLD and NASH (Review)

Boying Zhu, Chaoyang Wang, Peng Liu, Zhifeng Qu, Ran Qi, Shengjiang Chen, Huanzhang Niu
Article Number: 215
Published online on: 08 June 2026

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Article Open Access

Withaferin A, a candidate drug for lupus nephritis, confers renal protection via Pon1‑mediated attenuation of oxidative stress

Miao Xue, Junshuai Feng, Xiaorong Mao
Article Number: 214
Published online on: 08 June 2026

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Retraction Open Access

[Retracted] Classical dendritic cells regulate acute lung inflammation and injury in mice with lipopolysaccharide‑induced acute respiratory distress syndrome

Lang Li, Liang Dong, Dan Zhao, Fei Gao, Jie Yan
Article Number: 213
Published online on: 08 June 2026

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Review Open Access

Plant‑derived natural products alleviate dexamethasone‑induced skeletal muscle atrophy by modulating FoxO (Review)

Wei Dai, Jiabin Wu, Xiaotong Ma, Mingyu Wu, Ke Li, Haoyang Gao, Wenhong Wang, Weihua Xiao
Article Number: 212
Published online on: 05 June 2026

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Functional hydrogels in cardiovascular therapy: Design, applications and clinical challenges (Review)

Zheming Yang, Jiayin Li, Lingxiao Zhao, Dali Zhang, Chenghui Yan, Dan Liu, Yaling Han
Article Number: 211
Published online on: 04 June 2026

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Review Open Access

Experimental rodent models of cardiorenal syndrome types 3 and 4: Insights and clinical relevance (Review)

Stefanny M. Figueroa, Siyi Huang, Javier Reyes‑Osorio, Jean-Jacques Boffa, Cristián A. Amador, Christos E. Chadjichristos, Louis Boutin
Article Number: 210
Published online on: 04 June 2026

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Expression of Concern Open Access

[Expression of Concern] Novel insights into the role of HSP90 in cytoprotection of H2S against chemical hypoxia‑induced injury in H9c2  cardiac myocytes

Zhanli Yang, Chuntao Yang, Liangcan Xiao, Xinxue Liao, Aiping Lan, Xiuyu Wang, Ruixian Guo, Peixi Chen, Chengheng Hu, Jianqiang Feng
Article Number: 209
Published online on: 03 June 2026

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Article Open Access

Microbiota‑derived indole‑3‑propionic acid reprograms bone marrow stem cell fate via PPARγ suppression to rescue osteoporosis

Jinwu Bai, Ruideng Wang, Jixing Fan, Shilong Su, Gao Si, Qinyong You, Ao Sun, Daole Hu, Shan Gao, Yang Lv, Fang Zhou
Article Number: 208
Published online on: 03 June 2026

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Article Open Access

Lactate regulates osteoclastogenesis via H3k18la in osteoarthritis

Zhibo Fan, Qiyue Fu, Tao Sun, Yutong Zhong, Yuefan Ma, Jingwei Jian, Shuosheng Yuan, Shenghong Li, Xiaomei Xu
Article Number: 207
Published online on: 02 June 2026

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Retraction Open Access

[Retracted] miR‑215 promotes epithelial to mesenchymal transition and proliferation by regulating LEFTY2 in endometrial cancert

Xiaoxu Gao, Yan Cai, Ruifang An
Article Number: 206
Published online on: 02 June 2026

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Review

Multi‑scale experimental models for the study of angiogenesis (Review)

Qin Yu, Jiarui Hu, Shuangshuang Yuan, Jiexia Gan, Mao Luo, Jianbo Wu, Liqun Wang
Article Number: 205
Published online on: 28 May 2026

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Review Open Access

Targeting lactylation in hepatocellular carcinoma: Mechanistic insights and therapeutic opportunities (Review)

Lianting Chen, Feiqiong Gao, Qianru Mei, Yujie Li, Qun Cai, Xudong Feng
Article Number: 204
Published online on: 28 May 2026

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Article Open Access

Oxygen‑sensing histone demethylase KDM6A modulates chondrocyte‑to‑osteoblast transdifferentiation by activating the Wnt/β‑catenin pathway

Yi Rong, Hao Yu, Heng Yin, Shaoshuo Li, Jianwei Wang, Zhongyuan Shen, Xinxin Ding, Fanchen Bu, Tianyi Dai, Gean Wu, Zhen Hua
Article Number: 203
Published online on: 28 May 2026

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