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Article

In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells

  • Authors:
    • Kaiwen Bai
    • Luyi Jiang
    • Ligen Zhang
    • Yongwei Zhao
    • Yi Lu
    • Jingya Zhu
    • Jie Cai
    • Lili Zhang
    • Tian Wang
  • View Affiliations / Copyright

    Affiliations: College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, P.R. China, College of Animal Science, Zhejiang University, Hangzhou, Zhejiang 310000, P.R. China
  • Pages: 3447-3458
    |
    Published online on: September 13, 2018
       https://doi.org/10.3892/ijmm.2018.3876
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Abstract

The aim of the present study was to evaluate the in vitro free radical scavenging capacity of dimethylglycine sodium (DMG‑Na) and its protective ability against oleic acid hydroperoxide (OAHPx)‑induced oxidative damage in IPEC‑J2 cells. Initially, the free radical scavenging activities of water‑soluble pigments (DMG‑Na, betalain, capsanthin and cyanidin‑3‑rutinoside) were measured and compared with those of Trolox. Subsequently, freshly collected swine blood was mixed with heparin and centrifuged to obtain erythrocytes. In order to induce the free radical chain oxidation in erythrocytes, the aqueous peroxyl radicals were generated by thermal decomposition of 2,2'‑azobis(2‑amidinopropane) dihydrochloride (AAPH) in oxygen. A 2% suspension of porcine erythrocytes in PBS buffer were pre‑incubated for 30 min at 37˚C with DMG‑Na (32 µM), followed by incubation with or without AAPH (75 mM) for 5 h with gentle shaking. Additionally, IPEC‑J2 cells were randomly assigned to four groups (n=6 per group): Cells treated with phosphate buffered saline (PBS); cells treated with DMG‑Na (32 µM); cells treated with oleic acid hydroperoxides (OAHPx, 20 µM; TO group); cells treated with DMG‑Na (32 µM) followed by OAHPx (20 µM; DTO group). The cells were cultured in Dulbecco's modified Eagle's medium, Ham's F‑12 mixture, 1.5 mM HEPES, 5% (v/v) fetal bovine serum, 1% (v/v) insulin‑transferrin‑selenium mixture, 1% (v/v) penicillin‑streptomycin mixture and 2.5 µg/ml fungizone (37˚C, 5% CO2). The results showed that DMG‑Na exerted the strongest free radical scavenging capacity at 0.32 M from 0.08‑0.64 M, and that it could prevent AAPH‑induced porcine erythrocyte hemolysis by increasing its antioxidant capacity (P<0.05). The results also demonstrated that antioxidant capacity and antioxidant‑associated gene expression increased in the DTO group relative to the TO group (P<0.05), indicating that DMG‑Na prevented the OAHPx‑induced oxidative damage in IPEC‑J2 cells by improving the antioxidant capacity and antioxidant‑associated gene expression.
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1 

Friesen RW, Novak EM, Hasman D and Inniset SM: Relationship of dimethylglycine, choline, and betaine with oxoproline in plasma of pregnant women and their newborn infants. J Nutr. 137:2641–2646. 2007. View Article : Google Scholar : PubMed/NCBI

2 

Hariganesh K and Prathiba J: Effect of dimethylglycine on gastric ulcers in rats. J Pharm Pharmacol. 52:1519–1522. 2000. View Article : Google Scholar

3 

Clapes P and Infante MR: Amino acid-based surfactants: Enzymatic synthesis, properties and potential applications. J Biocatalys Biotransformation. 20:215–233. 2002. View Article : Google Scholar

4 

Giacco F and Brownlee M: Oxidative stress and diabetic complications. Circ Res. 107:1058–1070. 2010. View Article : Google Scholar : PubMed/NCBI

5 

Grune T: Oxidative stress, aging and the proteasomal system. Biogerontology. 1:31–40. 2000. View Article : Google Scholar

6 

Ma K, Zhang Y, Zhu D and Lou Y: Protective effects of asiatic acid against D-galactosamine/lipopolysaccharide-induced hepa-totoxicity in hepatocytes and kupffer cells co-cultured system via redox-regulated leukotriene C4 synthase expression pathway. Eur J Pharmacol. 603:98–107. 2009. View Article : Google Scholar

7 

Balaban RS, Nemoto S and Finkel T: Mitochondria, oxidants, and aging. Cell. 120:4832005. View Article : Google Scholar : PubMed/NCBI

8 

Andreyev AY, Kushnareva YE and Starkov AA: Mitochondrial metabolism of reactive oxygen species. Biochemistry (Mosc). 70:200–214. 2005. View Article : Google Scholar

9 

Dong L, Zhong X, He J, Zhang L, Bai K, Xu W, Wang T and Huang X: Supplementation of tributyrin improves the growth and intestinal digestive and barrier functions in intrauterine growth-restricted piglets. Clin Nutr. 35:399–407. 2016. View Article : Google Scholar

10 

Inoue J, Miki I, Tanahashi T, Kawauchi S, Azuma T and Mizuno S: Mo2016 effect of ghrelin on indomethacin-induced small intestinal injury in mice. Gastroenterology. 144:S-7192013. View Article : Google Scholar

11 

Konaka A, Kato S, Tanaka A, Kunikata T, Korolkiewicz R and Takeuchi K: Roles of enterobacteria, nitric oxide and neutrophil in pathogenesis of indomethacin-induced small intestinal lesions in rats. Pharmacol Res. 40:517–524. 1999. View Article : Google Scholar

12 

Liu F, Li G, Wen K, Bui T, Cao D, Zhang Y and Yuan L: Porcine small intestinal epithelial cell line (IPEC-J2) of rotavirus infection as a new model for the study of innate immune responses to rota-viruses and probiotics. Viral Immunol. 23:135–149. 2010. View Article : Google Scholar : PubMed/NCBI

13 

Brosnahan AJ and Brown DR: Porcine IPEC-J2 intestinal epithelial cells in microbiological investigations. Vet Microbiol. 156:229–237. 2012. View Article : Google Scholar :

14 

Arce C, Ramírez-Boo M, Lucena C and Garrido JJ: Innate immune activation of swine intestinal epithelial cell lines (IPEC-J2 and IPI-2I) in response to LPS from salmonella typhimurium. Comp Immunol Microbiol Infect Dis. 33:161–174. 2010. View Article : Google Scholar

15 

Moon JK and Shibamoto T: Antioxidant assays for plant and food components. J Agric Food Chem. 57:1655–1666. 2009. View Article : Google Scholar : PubMed/NCBI

16 

Siddhuraju P and Manian S: The antioxidant activity and free radical-scavenging capacity of dietary phenolic extracts from horse gram (Macrotyloma uniflorum (Lam) Verdc) seeds. Food Chem. 105:950–958. 2007. View Article : Google Scholar

17 

Chen HY and Yen GC: Antioxidant activity and free radical-scavenging capacity of extracts from guava (Psidium guajava L.) leaves. Food Chem. 101:686–694. 2007. View Article : Google Scholar

18 

Zhang J, Hou X, Ahmad H, Zhang H, Zhang L and Wang T: Assessment of free radicals scavenging activity of seven natural pigments and protective effects in AAPH-challenged chicken erythrocytes. Food Chem. 145:57–65. 2014. View Article : Google Scholar

19 

Benzie IF and Strain JJ: The ferric reducing ability of plasma (FRAP) as a measure of ‘antioxidant power’: The frap assay. Anal Biochem. 239:70–76. 1996. View Article : Google Scholar : PubMed/NCBI

20 

Magalhães AS, Silva BM, Pereira JA, Andrade PB, Valentão P and Carvalho M: Protective effect of quince (cydonia oblonga miller) fruit against oxidative hemolysis of human erythrocytes. Food Chem Toxicol. 47:1372–1377. 2009. View Article : Google Scholar : PubMed/NCBI

21 

Lawrence RA and Burk RF: Glutathione peroxidase activity in selenium-deficient rat liver. Biochem Biophys Res Commun. 71:952–958. 1976. View Article : Google Scholar : PubMed/NCBI

22 

Panchenko LF, Brusov OS, Gerasimov AM and Loktaeva TD: Intramitochondrial localization and release of rat liver superoxide dismutase. FEBS Lett. 55:84–87. 1975. View Article : Google Scholar : PubMed/NCBI

23 

Sang H, Zhang L and Li J: Anti-benzopyrene-7,8-diol-9,10-epoxide induces apoptosis via mitochondrial pathway in human bronchiolar epithelium cells independent of the mitochondria permeability transition pore. Food Chem Toxicol. 50:2417–2423. 2012. View Article : Google Scholar : PubMed/NCBI

24 

AOAC: Official Methods of Analysis. 14th edition. Association of Official Analytical Chemists; Washington, DC: 1985

25 

Aw TY, Williams MW and Gray L: Absorption and lymphatic transport of peroxidized lipids by rat small intestine in vivo: Role of mucosal GSH. Am J Physiol. 262:G99–G106. 1992.PubMed/NCBI

26 

Repetto G, Peso AD and Zurita JL: Neutral red uptake assay for the estimation of cell viability/cytotoxicity. Nat Protoc. 3:1125–1131. 2008. View Article : Google Scholar : PubMed/NCBI

27 

Tang X, Gao J, Wang Y, Fan YM, Xu LZ, Zhao XN, Xu Q and Qian ZM: Effective protection of terminalia catappa l. Leaves from damage induced by carbon tetrachloride in liver mitochondria. J Nutr Biochem. 17:177–182. 2006. View Article : Google Scholar

28 

Langston JW, Li W, Harrison L and Aw TY: Activation of promoter activity of the catalytic subunit of γ-glutamylcysteine ligase (GCL) in brain endothelial cells by insulin requires antioxidant response element 4 and altered glycemic status: Implication for GCL expression and GSH synthesis. Free Radic Biol Med. 51:1749–1757. 2011. View Article : Google Scholar : PubMed/NCBI

29 

Van Remmen H, Ikeno Y, Hamilton M, Pahlavani M, Wolf N, Thorpe SR, Alderson NL, Baynes JW, Epstein CJ, Huang TT, et al: Life-long reduction in MnSOD activity results in increased DNA damage and higher incidence of cancer but does not accelerate aging. Physiol Genomics. 16:29–37. 2003. View Article : Google Scholar : PubMed/NCBI

30 

Wei QY, Chen WF, Zhou B, Yang L and Liu ZL: Inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues. Biochim Biophys Acta. 1760:70–77. 2006. View Article : Google Scholar

31 

Zhang Q, Zou P, Zhan H, Zhang M, Zhang L, Ge RS and Huang Y: Dihydrolipoamide dehydrogenase and cAMP are associated with cadmium-mediated leydig cell damage. Toxicol Lett. 205:183–189. 2011. View Article : Google Scholar : PubMed/NCBI

32 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative pcr and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

33 

Naik GH, Priyadarsini KI, Satav JG, Banavalikar MM, Sohoni DP, Biyani MK and Mohan H: Comparative antioxidant activity of individual herbal components used in ayurvedic medicine. Phytochemistry. 63:97–104. 2003. View Article : Google Scholar : PubMed/NCBI

34 

JiSang K and YoungSoon L: Antioxidant activity of Maillard reaction products derived from aqueous glucose/glycine, diglycine, and triglycine model systems as a function of heating time. Food Chem. 116:227–232. 2009. View Article : Google Scholar

35 

Rollet-Labelle E, Grange MJ, Elbim C, Marquetty C, Gougerot-Pocidalo MA and Pasquier C: Hydroxyl radical as a potential intracellular mediator of polymorphonuclear neutrophil apoptosis. Free Radic Biol Med. 24:563–572. 1998. View Article : Google Scholar : PubMed/NCBI

36 

Wang J, Yuan X, Jin Z, Tian Y and Song H: Free radical and reactive oxygen species scavenging activities of peanut skins extract. Food Chem. 104:242–250. 2007. View Article : Google Scholar

37 

Bernaert N, De Paepe D, Bouten C, De Clercq H, Stewart D, Van Bockstaele E, De Loose M and Van Droogenbroeck B: Antioxidant capacity, total phenolic and ascorbate content as a function of the genetic diversity of leek (Allium ampeloprasum var. porrum) Food Chem. 134:669–677. 2012. View Article : Google Scholar

38 

Ajila CM and Prasada Rao UJ: Protection against hydrogen peroxide induced oxidative damage in rat erythrocytes by mangifera indica L. peel extract. Food Chem Toxicol. 46:303–309. 2008. View Article : Google Scholar

39 

Mendes L, de Freitas V, Baptista P and Carvalho M: Comparative antihemolytic and radical scavenging activities of strawberry tree (Arbutus unedo L.) leaf and fruit. Food Chem Toxicol. 49:2285–2291. 2011. View Article : Google Scholar : PubMed/NCBI

40 

Lang F, Lang KS, Lang PA, Huber SM and Wieder T: Mechanisms and significance of eryptosis. Antioxid Redox Signal. 8:1183–1192. 2006. View Article : Google Scholar : PubMed/NCBI

41 

Bayrak O, Uz E, Bayrak R, Turgut F, Atmaca AF, Sahin S, Yildirim ME, Kaya A, Cimentepe E and Akcayet A: Curcumin protects against ischemia/reperfusion injury in rat kidneys. World J Urol. 26:285–291. 2008. View Article : Google Scholar : PubMed/NCBI

42 

Forman HJ, Zhang H and Rinna A: Glutathione: Overview of its protective roles, measurement, and biosynthesis. Mol Aspects Med. 30:1–12. 2009. View Article : Google Scholar :

43 

Deng SL, Chen WF, Zhou B, Yang L and Liu ZL: Protective effects of curcumin and its analogues against free radical-induced oxidative haemolysis of human red blood cells. Food Chem. 98:112–119. 2006. View Article : Google Scholar

44 

Tedesco I, Luigi Russo G, Nazzaro F, Russo M and Palumbo R: Antioxidant effect of red wine anthocyanins in normal and catalase-inactive human erythrocytes. J Nutr Biochem. 12:505–511. 2001. View Article : Google Scholar

45 

Nusrat A, Parkos CA, Verkade P, Foley CS, Liang TW, Innis-Whitehouse W, Eastburn KK and Madara JL: Tight junctions are membrane microdomains. J Cell Sci. 113:1771–1781. 2000.PubMed/NCBI

46 

Kowaltowski AJ and Vercesi AE: Mitochondrial damage induced by conditions of oxidative stress. Free Radic Biol Med. 26:463–471. 1999. View Article : Google Scholar : PubMed/NCBI

47 

Bai K, Xu W, Zhang J, Kou T, Niu Y, Wan X, Zhang L, Wang C and Wang T: Assessment of free radical scavenging activity of dimethylglycine sodium salt and its role in providing protection against lipopolysaccharide-induced oxidative stress in mice. PLoS One. 11:e01553932016. View Article : Google Scholar : PubMed/NCBI

48 

Lee HJ, Oh YK, Rhee M, Lim JY, Hwang JY, Park YS, Kwon Y, Choi KH, Jo I, Park SI, et al: The role of STAT1/IRF-1 on synergistic ROS production and loss of mitochondrial transmembrane potential during hepatic cell death induced by LPS/d-GalN. J Mol Biol. 369:967–984. 2007. View Article : Google Scholar : PubMed/NCBI

49 

Wilhelm EA, Jesse CR, Roman SS, Nogueira CW and Savegnago L: Hepatoprotective effect of 3-alkynyl selenophene on acute liver injury induced by D-galactosamine and lipopoly-saccharide. Exp Mol Pathol. 87:20–26. 2009. View Article : Google Scholar : PubMed/NCBI

50 

Chen JJ and Yu BP: Alterations in mitochondrial membrane fluidity by lipid peroxidation products. Free Radic Biol Med. 17:411–418. 1994. View Article : Google Scholar : PubMed/NCBI

51 

Zhang J, Xu L, Zhang L, Ying Z, Su W and Wang T: Curcumin attenuates D-galactosamine/lipopolysaccharide-induced liver injury and mitochondrial dysfunction in mice. J Nutr. 144:1211–1218. 2014. View Article : Google Scholar : PubMed/NCBI

52 

Chiu H, Brittingham JA and Laskin DL: Differential induction of heme oxygenase-1 in macrophages and hepatocytes during acetaminophen-induced hepatotoxicity in the rat: Effects of hemin and biliverdin. Toxicol Appl Pharmacol. 181:106–115. 2002. View Article : Google Scholar : PubMed/NCBI

53 

Chung S, Yao H, Caito S, Hwang JW, Arunachalam G and Rahman I: Regulation of SIRT1 in cellular functions: Role of polyphenols. Arch Biochem Biophys. 501:79–90. 2010. View Article : Google Scholar : PubMed/NCBI

54 

Hwang JW, Yao H, Caito S, Sundar IK and Rahman I: Redox regulation of SIRT1 in inflammation and cellular senescence. Free Radic Biol Med. 61:95–110. 2013. View Article : Google Scholar : PubMed/NCBI

55 

Lee JM and Johnson JA: An important role of Nrf2-are pathway in the cellular defense mechanism. J Biochem Mol Biol. 37:139–143. 2004.PubMed/NCBI

56 

Michelet L, Zaffagnini M, Massot V, Keryer E, Vanacker H, Miginiac-Maslow M, Issakidis-Bourguet E and Lemai SD: Thioredoxins, glutaredoxins, and glutathionylation: New crosstalks to explore. Photosynth Res. 89:225–245. 2006. View Article : Google Scholar : PubMed/NCBI

57 

Gu L, Li N, Gong J, Li Q, Zhu W and Li J: Berberine ameliorates intestinal epithelial tight-junction damage and down-regulates myosin light chain kinase pathways in a mouse model of endotoxinemia. J Infect Dis. 203:1602–1612. 2011. View Article : Google Scholar : PubMed/NCBI

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Copy and paste a formatted citation
Spandidos Publications style
Bai K, Jiang L, Zhang L, Zhao Y, Lu Y, Zhu J, Cai J, Zhang L and Wang T: In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells. Int J Mol Med 42: 3447-3458, 2018.
APA
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J. ... Wang, T. (2018). In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells. International Journal of Molecular Medicine, 42, 3447-3458. https://doi.org/10.3892/ijmm.2018.3876
MLA
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J., Cai, J., Zhang, L., Wang, T."In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells". International Journal of Molecular Medicine 42.6 (2018): 3447-3458.
Chicago
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J., Cai, J., Zhang, L., Wang, T."In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells". International Journal of Molecular Medicine 42, no. 6 (2018): 3447-3458. https://doi.org/10.3892/ijmm.2018.3876
Copy and paste a formatted citation
x
Spandidos Publications style
Bai K, Jiang L, Zhang L, Zhao Y, Lu Y, Zhu J, Cai J, Zhang L and Wang T: In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells. Int J Mol Med 42: 3447-3458, 2018.
APA
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J. ... Wang, T. (2018). In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells. International Journal of Molecular Medicine, 42, 3447-3458. https://doi.org/10.3892/ijmm.2018.3876
MLA
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J., Cai, J., Zhang, L., Wang, T."In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells". International Journal of Molecular Medicine 42.6 (2018): 3447-3458.
Chicago
Bai, K., Jiang, L., Zhang, L., Zhao, Y., Lu, Y., Zhu, J., Cai, J., Zhang, L., Wang, T."In vitro free radical scavenging capacity of dimethylglycine sodium salt and its protective ability against oleic acid hydroperoxide-induced oxidative damage in IPEC-J2 cells". International Journal of Molecular Medicine 42, no. 6 (2018): 3447-3458. https://doi.org/10.3892/ijmm.2018.3876
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