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Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice

  • Authors:
    • Joo Wan Kim
    • You‑Suk Lee
    • Du Jin Seol
    • Il Je Cho
    • Sae Kwang Ku
    • Jae‑Suk Choi
    • Hae‑Jeung Lee
  • View Affiliations / Copyright

    Affiliations: Aribio Co. Ltd., Seongnam, Gyeonggi 13487, Republic of Korea, Department of Food and Nutrition, College of BioNano Technology, Gachon University, Seongnam, Gyeonggi 13120, Republic of Korea, The Medical Research Center for Globalization of Herbal Formulation and Department of Herbal Formulation, College of Oriental Medicine, Gyeongsan, Gyeongsangbuk 38610, Republic of Korea , Department of Anatomy and Histology, College of Korean Medicine, Daegu Haany University, Gyeongsan, Gyeongsangbuk 38610, Republic of Korea , Division of Bioindustry, College of Medical and Life Sciences, Silla University, Sasang, Busan 46958, Republic of Korea
    Copyright: © Kim et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3047-3064
    |
    Published online on: September 14, 2018
       https://doi.org/10.3892/ijmm.2018.3879
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Abstract

Blue honeysuckle (BH, Lonicera caerulea) is used as a traditional medicine in Russia, Japan and China, but is not commonly considered as an edible berry in Europe, USA or Korea. BH has been revealed to decrease serum cholesterol and triacylglycerol (triglyceride or TG) levels through the activation of AMP‑activated protein kinase (AMPK), thus it is expected to be a health functional food and pharmaceutical agent for the prevention of non‑alcoholic liver damage, in addition to effects as a suppressor of hyperlipidemia and as an anti‑obesity agent. In the present study, the pharmacological activity of BH extract (BHe) was observed in high‑fat diet (HFD)‑fed mice. Significant increases in fat pad weight, body weight, fat accumulation (body and abdominal fat density, and thickness of the periovarian and abdominal wall) and serum biochemical levels (aspartate transaminase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase, γ‑glutamyltransferase, total cholesterol, low‑density lipoprotein and TG, with the exception of high‑density lipoprotein) were observed in HFD‑fed mice. In addition, increases in adipocyte hypertrophy, the area of steatohepatitis and hepatocyte hypertrophy were observed, whereas decreased zymogen content was identified upon histopathological observation. Increased deterioration of the endogenous antioxidant defense system (liver catalase, glutathione and superoxide dismutase) and hepatic lipid peroxidation was observed. In addition, there were decreases in hepatic glucokinase activity, AMPKα1 and AMPKα2 mRNA expression, adipose tissue uncoupling protein 2 expression, and adiponectin mRNA expression, increases in phosphoenolpyruvate carboxykinase and glucose‑6‑phosphatase activity, hepatic acetyl‑CoA carboxylase 1 mRNA expression, and the expression of leptin, CCAAT/enhancer‑binding protein (C/EBP) α, C/EBPβ and sterol‑regulatory‑element‑binding protein 1c mRNA in the periovarian tissue. Furthermore, non‑alcoholic fatty liver disease (NAFLD) and obesity were significantly inhibited by the continuous administration of BHe for 84 days. These results revealed that BHe may be a promising novel drug or functional food candidate for the treatment of obesity and NAFLD.
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1 

Wendel AA, Purushotham A, Liu LF and Belury MA: Conjugated linoleic acid fails to worsen insulin resistance but induces hepatic steatosis in the presence of leptin in ob/ob mice. J Lipid Res. 49:98–106. 2008. View Article : Google Scholar

2 

Tilg H and Moschen AR: Adipocytokines: Mediators linking adipose tissue, inflammation and immunity. Nat Rev Immunol. 6:772–783. 2006. View Article : Google Scholar : PubMed/NCBI

3 

James PT, Leach R, Kalamara E and Shayeghi M: The worldwide obesity epidemic. Obes Res. 9(Suppl 4): 228S–233S. 2001. View Article : Google Scholar : PubMed/NCBI

4 

Flegal KM, Kruszon-Moran D, Carroll MD, Fryar CD and Ogden CL: Trends in obesity among adults in the United States 2005 to 2014. JAMA. 315:2284–2291. 2016. View Article : Google Scholar : PubMed/NCBI

5 

Ogden CL, Carroll MD, Lawman HG, Fryar CD, Kruszon-Moran D, Kit BK and Flegal KM: Trends in obesity prevalence among children and adolescents in the United States, 1988–1004 through 2013–2014. JAMA. 315:2292–2299. 2016. View Article : Google Scholar : PubMed/NCBI

6 

Kunitomi M, Wada J, Takahashi K, Tsuchiyama Y, Mimura Y, Hida K, Miyatake N, Fujii M, Kira S, Shikata K and Maknio H: Relationship between reduced serum IGF-I levels and accumu-lation of visceral fat in Japanese men. Int J Obes Relat Metab Disord. 26:361–369. 2002. View Article : Google Scholar : PubMed/NCBI

7 

Hida K, Wada J, Eguchi J, Zhang H, Baba M, Seida A, Hashimoto I, Okada T, Yasuhara A, Nakatsuka A, et al: Visceral adipose tissue-derived serine protease inhibitor: A unique insulin-sensitizing adipocytokine in obesity. Proc Natl Acad Sci USA. 102:10610–10615. 2005. View Article : Google Scholar : PubMed/NCBI

8 

Angulo P: Nonalcoholic fatty liver disease. N Engl J Med. 346:1221–1231. 2002. View Article : Google Scholar : PubMed/NCBI

9 

Park SH, Ko SK and Chung SH: Euonymus alatus prevents the hyperglycemia and hyperlipidemia induced by high-fat diet in ICR mice. J Ethnopharmacol. 102:326–335. 2005. View Article : Google Scholar : PubMed/NCBI

10 

Kim UH, Yoon JH, Li H, Kang JH, Ji HS, Park KH, Shin DH, Park HY and Jeong TS: Pterocarpan-enriched soy leaf extract ameliorates insulin sensitivity and pancreatic β-cell proliferation in type 2 diabetic mice. Molecules. 19:18493–18510. 2014. View Article : Google Scholar : PubMed/NCBI

11 

Tan Y, Kim J, Cheng J, Ong M, Lao WG, Jin XL, Lin YG, Xiao L, Zhu XQ and Qu XQ: Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats. World J Gastroenterol. 23:3805–3814. 2017. View Article : Google Scholar : PubMed/NCBI

12 

Lin CH, Kuo YH and Shih CC: Effects of Bofu-Tsusho-San on diabetes and hyperlipidemia associated with AMP-activated protein kinase and glucose transporter 4 in high-fat-fed mice. Int J Mol Sci. 15:20022–20044. 2014. View Article : Google Scholar : PubMed/NCBI

13 

Steinberg GR and Kemp BE: AMPK in Health and disease. Physiol Rev. 89:1025–1078. 2009. View Article : Google Scholar : PubMed/NCBI

14 

Xu XJ, Gauthier MS, Hess DT, Apovian CM, Cacicedo JM, Gokce N, Farb M, Valentine RJ and Ruderman NB: Insulin sensitive and resistant obesity in humans: AMPK activity, oxidative stress, and depot-specific changes in gene expression in adipose tissue. J Lipid Res. 53:792–801. 2012. View Article : Google Scholar : PubMed/NCBI

15 

Hasanvand A, Amini-Khoei H, Hadian MR, Abdollahi A, Tavangar SM, Dehpour AR, Semiei E and Mehr SE: Anti-inflammatory effect of AMPK signaling pathway in rat model of diabetic neuropathy. Inflammopharmacology. 24:207–219. 2016. View Article : Google Scholar : PubMed/NCBI

16 

Smith BK, Marcinko K, Desjardins EM, Lally JS, Ford RJ and Steinberg GR: Treatment of nonalcoholic fatty liver disease: Role of AMPK. Am J Physiol Endocrinol Metab. 311:E730–E740. 2016. View Article : Google Scholar : PubMed/NCBI

17 

Ma A, Wang J, Yang L, An Y and Zhu H: AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE−/− mice. J Lipid Res. 58:1536–1547. 2017. View Article : Google Scholar : PubMed/NCBI

18 

Mottillo EP, Desjardins EM, Fritzen AM, Zou VZ, Crane JD, Yabut JM, Kiens B, Erion DM, Lanba A, Granneman JG, et al: FGF21 does not require adipocyte AMP-activated protein kinase (AMPK) or the phosphorylation of acetyl-CoA carboxylase (ACC) to mediate improvements in whole-body glucose homeostasis. Mol Metab. 6:471–481. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Kang SJ, Lee JE, Lee EK, Jung DH, Song CH, Park SJ, Choi SH, Han CH, Ku SK and Lee YJ: Fermentation with Aquilariae Lignum enhances the anti-diabetic activity of green tea in type II diabetic db/db mouse. Nutrients. 6:3536–3571. 2014. View Article : Google Scholar : PubMed/NCBI

20 

Kim E, Liu NC, Yu IC, Lin HY, Lee YF, Sparks JD, Chen LM and Chang C: Metformin inhibits nuclear receptor TR4-mediated hepatic stearoyl-CoA desaturase 1 gene expression with altered insulin sensitivity. Diabetes. 60:1493–1503. 2011. View Article : Google Scholar : PubMed/NCBI

21 

Torres TP, Sasaki N, Donahue EP, Lacy B, Printz RL, Cherrington AD, Treadway JL and Shiota M: Impact of a glycogen phosphorylase inhibitor and metformin on basal and glucagon-stimulated hepatic glucose flux in conscious dogs. J Pharmacol Exp Ther. 337:610–620. 2011. View Article : Google Scholar : PubMed/NCBI

22 

Jones G, Macklin J and Alexander W: Contraindications to the use of metformin. BMJ. 326:4–5. 2003. View Article : Google Scholar : PubMed/NCBI

23 

Bolen S, Feldman L, Vassy J, Wilson L, Yeh HC, Marinopoulos S, Wiley C, Selvin E, Wilson R, Bass EB and Brancati FL: Systematic review: Comparative effectiveness and safety of oral medications for type 2 diabetes mellitus. Ann Intern Med. 147:386–399. 2007. View Article : Google Scholar : PubMed/NCBI

24 

Khurana R and Malik IS: Metformin: Safety in cardiac patients. Heart. 96:99–102. 2010.

25 

Chaovanalikit A, Thompson MM and Wrolstad RE: Characterization and quantification of anthocyanins and polyphenolics in blue honeysuckle (Lonicera caerulea L.). J Agric Food Chem. 52:848–852. 2004. View Article : Google Scholar : PubMed/NCBI

26 

Svarcova I, Heinrich J and Valentova K: Berry fruits as a source of biologically active compounds: The case of Lonicera caerulea. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 151:163–174. 2007. View Article : Google Scholar

27 

Zhao H, Wang Z, Ma F, Yang X, Cheng C and Yao L: Protective effect of anthocyanin from lonicera caerulea var. Edulis on Radiation-induced damage in mice. Int J Mol Sci. 13:11773–11782. 2012. View Article : Google Scholar : PubMed/NCBI

28 

Jurgoński A, Juśkiewicz J and Zduńczyk Z: An anthocyanin-rich extract from Kamchatka honeysuckle increases enzymatic activity within the gut and ameliorates abnormal lipid and glucose metabolism in rats. Nutrition. 29:898–902. 2013. View Article : Google Scholar

29 

Palíková I, Valentová K, Oborná I and Ulrichová J: Protectivity of blue honeysuckle extract against oxidative human endothelial cells and rat hepatocyte damage. J Agric Food Chem. 57:6584–6589. 2009. View Article : Google Scholar : PubMed/NCBI

30 

Jin XH, Ohgami K, Shiratori K, Suzuki Y, Koyama Y, Yoshida K, Ilieva I, Tanaka T, Onoe K and Ohno S: Effects of blue honeysuckle (Lonicera caerulea L.) extract on lipopoly-saccharide-induced inflammation in vitro and in vivo. Exp Eye Res. 82:860–867. 2006. View Article : Google Scholar

31 

Park SI, Lee YJ, Choi SH, Park SJ, Song CH and Ku SK: Therapeutic effects of blue honeysuckle on lesions of hyperthyroidism in rats. Am J Chin Med. 44:1441–1456. 2016. View Article : Google Scholar : PubMed/NCBI

32 

Chen L, Xin X, Yuan Q, Su D and Liu W: Phytochemical proper-ties and antioxidant capacities of various colored berries. J Sci Food Agric. 94:180–188. 2014. View Article : Google Scholar

33 

Vostálová J, Galandáková A, Palíková I, Ulrichová J, Doležal D, Lichnovská R, Vrbková J and Rajnochová Svobodová A: Lonicera caerulea fruits reduce UVA-induced damage in hairless mice. J Photochem Photobiol B. 128:1–11. 2013. View Article : Google Scholar : PubMed/NCBI

34 

Korea Food and Drug Administration: Testing Guidelines for Safety Evaluation of Drugs. Notification No. 2015–082. 2015.

35 

Kim CM, Yi SJ, Cho IJ and Ku SK: Red-koji fermented red ginseng ameliorates high fat diet-induced metabolic disorders in mice. Nutrients. 5:4316–4332. 2013. View Article : Google Scholar : PubMed/NCBI

36 

Folch J, Lees M and Sloane-Stanley GH: A simple method for the isolation and purification of total lipids from animal tissues. J Biol Chem. 226:497–509. 1957.PubMed/NCBI

37 

Jamall IS and Smith JC: Effects of cadmium on glutathione peroxidase, superoxidase dismutase and lipid peroxidation in the rat heart: A possible mechanism of cadmium cardiotoxicity. Toxicol Appl Pharmacol. 80:33–42. 1985. View Article : Google Scholar : PubMed/NCBI

38 

Lowry OH, Rosenbrough NJ, Farr AL and Randall RJ: Protein measurement with the Folin phenol reagent. J Biol Chem. 193:265–275. 1951.PubMed/NCBI

39 

Sedlak J and Lindsay RH: Estimation of total, protein-bound, and nonprotein sulfhydryl groups in tissue with Ellman’s reagent. Anal Biochem. 25:192–205. 1968. View Article : Google Scholar : PubMed/NCBI

40 

Aebi H: Catalase. Methods in Enzymatic Analysis. Bergmeyer HU: Academic Press; New York NY: pp. 673–686. 1974, View Article : Google Scholar

41 

Sun Y, Larry WO and Ying L: A simple method for clinical assay of superoxide dismutase. Clin Chem. 34:497–500. 1988.PubMed/NCBI

42 

Hulcher FH and Oleson WH: Simplified spectrophotometric assay for microsomal 3-hydroxy-3-methylglutaryl CoA reductase by measurement of coenzyme A. J Lipid Res. 14:625–631. 1973.PubMed/NCBI

43 

Davidson AL and Arion WJ: Factors underlying significant underestimations of glucokinase activity in crude liver extracts: Physiological implications of higher cellular activity. Arch Biochem Biophys. 253:156–167. 1987. View Article : Google Scholar : PubMed/NCBI

44 

Alegre M, Ciudad CJ, Fillat C and Guinovart JJ: Determination of glucose-6-phosphatase activity using the glucose dehydrogenase-coupled reaction. Anal Biochem. 173:185–189. 1988. View Article : Google Scholar : PubMed/NCBI

45 

Bentle LA and Lardy HA: Interaction of anions and divalent metal ions with phosphoenolpyruvate carboxykinase. J Biol Chem. 251:2916–2921. 1976.PubMed/NCBI

46 

Sung YY, Kim DS, Kim SH and Kim HK: Anti-obesity activity, acute toxicity, and chemical constituents of aqueous and ethanol Viola mandshurica extracts. BMC Complement Altern Med. 17:2972017. View Article : Google Scholar : PubMed/NCBI

47 

Bashir KMI, Kim MS, Stahl U and Cho MG: Agrobacterium-mediated genetic transformation of Dictyosphaerium pulchellum for the expression of erythropoietin. J Appl Phycol. 1–16. 2018.

48 

Schmittgen TD and Livak KJ: Analyzing real-time PCR data by the comparative C(T) method. Nat Protoc. 3:1101–1108. 2008. View Article : Google Scholar : PubMed/NCBI

49 

Levene A: Pathological factors influencing excision of tumours in the head and neck. Part I. Clin Otolaryngol Allied Sci. 6:145–151. 1981. View Article : Google Scholar : PubMed/NCBI

50 

Choi JS, Kim JW, Park JB, Pyo SE, Hong YK, Ku SK and Kim MR: Blood glycemia-modulating effects of melanian snail protein hydrolysates in mice with type II diabetes. Int J Mol Med. 39:1437–1451. 2017. View Article : Google Scholar : PubMed/NCBI

51 

Williams CD, Stengel J, Asike MI, Torres DM, Shaw J, Contreras M, Landt CL and Harrison SA: Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middleaged population utilizing ultrasound and liver biopsy: A prospective study. Gastroenterology. 140:124–131. 2011. View Article : Google Scholar

52 

Wong VW, Chu WC, Wong GL, Chan RS, Chim AM, Ong A, Yeung DK, Yiu KK, Chu SH, Woo J, et al: Prevalence of non-alcoholic fatty liver disease and advanced fibrosis in Hong Kong Chinese: A population study using proton-magnetic resonance spectroscopy and transient elastography. Gut. 61:409–415. 2012. View Article : Google Scholar

53 

Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ and Shulman GI: Mechanism of hepatic insulin resistance in nonalcoholic fatty liver disease. J Biol Chem. 279:32345–32353. 2004. View Article : Google Scholar : PubMed/NCBI

54 

Savage DB, Petersen KF and Shulman GI: Disordered lipid metabolism and the pathogenesis of insulin resistance. Physiol Rev. 87:507–520. 2007. View Article : Google Scholar : PubMed/NCBI

55 

Rotman Y and Sanyal AJ: Current and upcoming pharmaco-therapy for non-alcoholic fatty liver disease. Gut. 66:180–190. 2017. View Article : Google Scholar

56 

Jung YM, Lee SH, Lee DS, You MJ, Chung IK, Cheon WH, Kwon YS, Lee YJ and Ku SK: Fermented garlic protects diabetic, obese mice when fed a high-fat diet by antioxidant effects. Nutr Res. 31:387–396. 2011. View Article : Google Scholar : PubMed/NCBI

57 

Lee JE, Kang SJ, Choi SH, Song CH, Lee YJ and Ku SK: Fermentation of green tea with 2% Aquilariae lignum increases the anti-diabetic activity of green tea aqueous extracts in the high fat-fed mouse. Nutrients. 7:9046–9078. 2015. View Article : Google Scholar : PubMed/NCBI

58 

Fujita H, Fujishima H, Koshimura J, Hosoba M, Yoshioka N, Shimotomai T, Morii T, Narita T, Kakei M and Ito S: Effects of antidiabetic treatment with metformin and insulin on serum and adipose tissue adiponectin levels in db/db mice. Endocr J. 52:427–433. 2005. View Article : Google Scholar : PubMed/NCBI

59 

Gartner LP and Hiatt JL: Color Textbook of Histology. 3rd edition. Saunders; Philadelphia: pp. 417–422. 2007

60 

Bertrand RL, Senadheera S, Markus I, Liu L, Howitt L, Chen H, Murphy TV, Sandow SL and Bertrand PP: A Western diet increases serotonin availability in rat small intestine. Endocrinology. 152:36–47. 2011. View Article : Google Scholar

61 

Snedeker SM and Hay AG: Do interactions between gut ecology and environmental chemicals contribute to obesity and diabetes. Environ Health Perspect. 120:332–339. 2012. View Article : Google Scholar

62 

Carter D, Howlett HC, Wiernsperger NF and Bailey C: Effects of metformin on bile salt transport by monolayers of human intestinal Caco-2 cells. Diabetes Obes Metab. 4:424–427. 2002. View Article : Google Scholar : PubMed/NCBI

63 

Carter D, Howlett HC, Wiernsperger NF and Bailey CJ: Differential effects of metformin on bile salt absorption from the jejunum and ileum. Diabetes Obes Metab. 5:120–125. 2003. View Article : Google Scholar : PubMed/NCBI

64 

Chen H, Qu Z, Fu L, Dong P and Zhang X: Physicochemical properties and antioxidant capacity of 3 polysaccharides from green tea, oolong tea, and black tea. J Food Sci. 74:C469–C474. 2009. View Article : Google Scholar : PubMed/NCBI

65 

Quine SD and Raghu PS: Effects of (−)-epicatechin, a flavonoid on lipid peroxidation and antioxidants in streptozotocin-induced diabetic liver, kidney and heart. Pharmacol Rep. 57:610–615. 2005.PubMed/NCBI

66 

Sodikoff CH: Laboratory profiles of small animal diseases: A guide to laboratory diagnosis. Mosby Inc.; St. Louise; pp. 1–36. 1995

67 

Wu X, Motoshima H, Mahadev K, Stalker TJ, Scalia R and Goldstein BJ: Involvement of AMP-activated protein kinase in glucose uptake stimulated by the globular domain of adiponectin in primary rat adipocytes. Diabetes. 52:1355–1363. 2013. View Article : Google Scholar

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Spandidos Publications style
Kim JW, Lee YS, Seol DJ, Cho IJ, Ku SK, Choi JS and Lee HJ: Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice. Int J Mol Med 42: 3047-3064, 2018.
APA
Kim, J.W., Lee, Y., Seol, D.J., Cho, I.J., Ku, S.K., Choi, J., & Lee, H. (2018). Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice. International Journal of Molecular Medicine, 42, 3047-3064. https://doi.org/10.3892/ijmm.2018.3879
MLA
Kim, J. W., Lee, Y., Seol, D. J., Cho, I. J., Ku, S. K., Choi, J., Lee, H."Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice". International Journal of Molecular Medicine 42.6 (2018): 3047-3064.
Chicago
Kim, J. W., Lee, Y., Seol, D. J., Cho, I. J., Ku, S. K., Choi, J., Lee, H."Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice". International Journal of Molecular Medicine 42, no. 6 (2018): 3047-3064. https://doi.org/10.3892/ijmm.2018.3879
Copy and paste a formatted citation
x
Spandidos Publications style
Kim JW, Lee YS, Seol DJ, Cho IJ, Ku SK, Choi JS and Lee HJ: Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice. Int J Mol Med 42: 3047-3064, 2018.
APA
Kim, J.W., Lee, Y., Seol, D.J., Cho, I.J., Ku, S.K., Choi, J., & Lee, H. (2018). Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice. International Journal of Molecular Medicine, 42, 3047-3064. https://doi.org/10.3892/ijmm.2018.3879
MLA
Kim, J. W., Lee, Y., Seol, D. J., Cho, I. J., Ku, S. K., Choi, J., Lee, H."Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice". International Journal of Molecular Medicine 42.6 (2018): 3047-3064.
Chicago
Kim, J. W., Lee, Y., Seol, D. J., Cho, I. J., Ku, S. K., Choi, J., Lee, H."Anti-obesity and fatty liver-preventing activities of Lonicera caerulea in high-fat diet-fed mice". International Journal of Molecular Medicine 42, no. 6 (2018): 3047-3064. https://doi.org/10.3892/ijmm.2018.3879
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