Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Oncology Letters
      • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Biomedical Reports
      • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • Information for Authors
    • Information for Reviewers
    • Information for Librarians
    • Information for Advertisers
    • Conferences
  • Language Editing
Spandidos Publications Logo
  • About
    • About Spandidos
    • Aims and Scopes
    • Abstracting and Indexing
    • Editorial Policies
    • Reprints and Permissions
    • Job Opportunities
    • Terms and Conditions
    • Contact
  • Journals
    • All Journals
    • Biomedical Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Experimental and Therapeutic Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Epigenetics
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Functional Nutrition
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Molecular Medicine
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • International Journal of Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Medicine International
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular and Clinical Oncology
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Molecular Medicine Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Letters
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • Oncology Reports
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
    • World Academy of Sciences Journal
      • Information for Authors
      • Editorial Policies
      • Editorial Board
      • Aims and Scope
      • Abstracting and Indexing
      • Bibliographic Information
      • Archive
  • Articles
  • Information
    • For Authors
    • For Reviewers
    • For Librarians
    • For Advertisers
    • Conferences
  • Language Editing
Login Register Submit
  • This site uses cookies
  • You can change your cookie settings at any time by following the instructions in our Cookie Policy. To find out more, you may read our Privacy Policy.

    I agree
Search articles by DOI, keyword, author or affiliation
Search
Advanced Search
presentation
International Journal of Molecular Medicine
Join Editorial Board Propose a Special Issue
Print ISSN: 1107-3756 Online ISSN: 1791-244X
Journal Cover
December-2018 Volume 42 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

Journals

International Journal of Molecular Medicine

International Journal of Molecular Medicine

International Journal of Molecular Medicine is an international journal devoted to molecular mechanisms of human disease.

International Journal of Oncology

International Journal of Oncology

International Journal of Oncology is an international journal devoted to oncology research and cancer treatment.

Molecular Medicine Reports

Molecular Medicine Reports

Covers molecular medicine topics such as pharmacology, pathology, genetics, neuroscience, infectious diseases, molecular cardiology, and molecular surgery.

Oncology Reports

Oncology Reports

Oncology Reports is an international journal devoted to fundamental and applied research in Oncology.

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine

Experimental and Therapeutic Medicine is an international journal devoted to laboratory and clinical medicine.

Oncology Letters

Oncology Letters

Oncology Letters is an international journal devoted to Experimental and Clinical Oncology.

Biomedical Reports

Biomedical Reports

Explores a wide range of biological and medical fields, including pharmacology, genetics, microbiology, neuroscience, and molecular cardiology.

Molecular and Clinical Oncology

Molecular and Clinical Oncology

International journal addressing all aspects of oncology research, from tumorigenesis and oncogenes to chemotherapy and metastasis.

World Academy of Sciences Journal

World Academy of Sciences Journal

Multidisciplinary open-access journal spanning biochemistry, genetics, neuroscience, environmental health, and synthetic biology.

International Journal of Functional Nutrition

International Journal of Functional Nutrition

Open-access journal combining biochemistry, pharmacology, immunology, and genetics to advance health through functional nutrition.

International Journal of Epigenetics

International Journal of Epigenetics

Publishes open-access research on using epigenetics to advance understanding and treatment of human disease.

Medicine International

Medicine International

An International Open Access Journal Devoted to General Medicine.

Journal Cover
December-2018 Volume 42 Issue 6

Full Size Image

Sign up for eToc alerts
Recommend to Library

  • Article
  • Citations
    • Cite This Article
    • Download Citation
    • Create Citation Alert
    • Remove Citation Alert
    • Cited By
  • Similar Articles
    • Related Articles (in Spandidos Publications)
    • Similar Articles (Google Scholar)
    • Similar Articles (PubMed)
  • Download PDF
  • Download XML
  • View XML
Article Open Access

Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway

  • Authors:
    • Panpan Zhang
    • Lingyue Hua
    • Huan Hou
    • Xingyue Du
    • Zhiqiang He
    • Menghan Liu
    • Xiaojuan Hu
    • Nianlong Yan
  • View Affiliations / Copyright

    Affiliations: Department of Biochemistry and Molecular Biology, School of Basic Medical Science, Nanchang University, Nanchang, Jiangxi 330006, P.R. China
    Copyright: © Zhang et al. This is an open access article distributed under the terms of Creative Commons Attribution License.
  • Pages: 3344-3354
    |
    Published online on: September 19, 2018
       https://doi.org/10.3892/ijmm.2018.3888
  • Expand metrics +
Metrics: Total Views: 0 (Spandidos Publications: | PMC Statistics: )
Metrics: Total PDF Downloads: 0 (Spandidos Publications: | PMC Statistics: )
Cited By (CrossRef): 0 citations Loading Articles...

This article is mentioned in:



Abstract

Atherosclerosis (AS) is the primary cause of various cardiovascular and cerebrovascular diseases and has high morbidity and mortality rates. Oxidative stress‑induced endothelial cells (ECs) dysfunction is the pathological basis of AS. In addition, sphingomyelin (SM) and the Wnt/β‑catenin signaling pathway are considered to be closely associated with AS; however, the specific mechanism is not clear. Therefore, the present study investigated whether SM may induce ECs dysfunction through the Wnt/β‑catenin signaling pathway. Firstly, a sphingomyelin synthase 2 (SMS2) overexpression cell model was constructed. It was identified that the expression of SMS2 was increased when ECs were treated with H2O2. In addition, these results demonstrated that SMS2 overexpression promoted apoptosis and macrophage adhesion of H2O2‑induced ECs, thereby increasing the expression of β‑catenin. Furthermore, SMS activity was inhibited with Dy105, combined with simultaneous treatment with LiCl or H2O2. This additionally confirmed that Dy105 significantly inhibited SMS activity and decreased the level of ECs dysfunction and β‑catenin content; however, LiCl served a key role in activating the Wnt/β‑catenin signaling pathway to promote ECs dysfunction. Collectively, these results suggested that SMS2 overexpression may promote ECs dysfunction by activating the Wnt/β‑catenin signaling pathway, while Dy105 may inhibit the evolution of oxidative stress‑induced dysfunction.
View Figures

Figure 1

Figure 2

Figure 3

Figure 4

Figure 5

Figure 6

View References

1 

Luscher TF, Landmesser U, von Eckardstein A and Fogelman AM: High-density lipoprotein: Vascular protective effects, dysfunction, and potential astherapeutic target. Circ Res. 114:171–182. 2014. View Article : Google Scholar

2 

Otsuka F, Finn AV, Yazdani SK, Nakano M, Kolodgie FD and Virmani R: The importance of the endothelium in atherothrombosis and coronary stenting. Nat Rev Cardiol. 9:439–453. 2012. View Article : Google Scholar : PubMed/NCBI

3 

Minuz P, Fava C, Vattemi G, Arcaro G, Riccadonna M, Tonin P, Meneguzzi A, Degan M, Guglielmi V, Lechi A and Tomelleri G: Endothelial dysfunction and increased oxidative stress in mitochondrial diseases. Clin Sci (Lond). 122:289–297. 2012. View Article : Google Scholar

4 

Zhang M, Pan H, Xu Y, Wang X, Qiu Z and Jiang L: Allicin decreases lipopolysaccharide-induced oxidative stress and inflammation in human umbilical vein endothelial cells through suppression of mitochondrial dysfunction and activation of nrf2. Cell Physiol Biochem. 41:2255–2267. 2017. View Article : Google Scholar : PubMed/NCBI

5 

Wu D, Li D, Liu Z, Liu X, Zhou S and Duan H: Role and underlying mechanism ofSPATA12in oxidative damage. Oncol Lett. 15:3676–3684. 2018.PubMed/NCBI

6 

Nohl H, Kozlov AV, Gille L and Staniek K: Cell respiration and formation of reactive oxygen species: Facts and artefacts. Biochem Soc Trans. 31:1308–1311. 2003. View Article : Google Scholar : PubMed/NCBI

7 

Dong L, Watanabe K, Itoh M, Huan CR, Tong XP, Nakamura T, Miki M, Iwao H, Nakajima A, Sakai T, et al: CD4+ T-cell dysfunctions through the impaired lipid rafts ameliorate concanavalin A-induced hepatitis in sphingomyelin synthase 1-knockout mice. Int Immunol. 24:327–337. 2012. View Article : Google Scholar : PubMed/NCBI

8 

Adada M, Luberto C and Canals D: Inhibitors of the sphingomyelin cycle: Sphingomyelin synthases and sphingomyelinases. Chem Phys Lipids. 197:45–59. 2016. View Article : Google Scholar

9 

Yeang C, Ding T, Chirico WJ and Jiang XC: Subcellular targeting domains of sphingomyelin synthase 1–2. Nutr Metab. 8:892011. View Article : Google Scholar

10 

Jiang XC, Paultre F, Pearson TA, Reed RG, Francis CK, Lin M, Berglund L and Tall AR: Plasma sphingomyelin level as a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol. 20:2614–2618. 2000. View Article : Google Scholar : PubMed/NCBI

11 

Schlitt A, Blankenberg S, Yan D, Von Gizycki H, Buerke M, Werdan K, Bickel C, Lackner KJ, Meyer J, Rupprecht HJ and Jiang XC: Further evaluation of plasma sphingomyelin levels as a risk factor for coronary artery disease. Nutr Metab (Lond). 3:52006. View Article : Google Scholar

12 

Park TS, Panek RL, Rekhter MD, Mueller SB, Rosebury WS, Robertson A, Hanselman JC, Kindt E, Homan R and Karathanasis SK: Modulation of lipoprotein metabolism by inhibition of sphingomyelin synthesis in apoe knockout mice. Atherosclerosis. 189:264–272. 2006. View Article : Google Scholar : PubMed/NCBI

13 

Mou D, Yang H, Qu C, Chen J and Zhang C: Pharmacological activation of peroxisome proliferator-activated receptor {delta increases sphingomyelin synthase activity in THP-1 macrophage-derived foam cell. Inflammation. 39:1538–1546. 2016. View Article : Google Scholar : PubMed/NCBI

14 

Dong J, Liu J, Lou B, Li Z, Ye X, Wu M and Jiang XC: Adenovirus-mediated overexpression of sphingomyelin synthases 1 and 2 increases the atherogenic potential in mice. J Lipid Res. 47:1307–1314. 2006. View Article : Google Scholar : PubMed/NCBI

15 

Yan N, Ding T, Dong J, Li Y and Wu M: Sphingomyelin synthase overexpression increases cholesterol accumulation and decreases cholesterol secretion in liver cells. Lipids Health Dis. 10:462011. View Article : Google Scholar : PubMed/NCBI

16 

Zhou Q, Luo A and Kummerow FA: Lovastatin reversed the enhanced sphingomyelin caused by 27-hydroxycholesterol in cultured vascular endothelial cells. Biochem Biophys Rep. 5:127–133. 2015.PubMed/NCBI

17 

de Jaime-Soguero A, Abreu de Oliveira WA and Lluis F: The pleiotropic effects of the canonical wnt pathway in early development and pluripotency. Genes Bales. 9:932018. View Article : Google Scholar

18 

Nusse R and Clevers H: Wnt/β-catenin signaling, disease, and emerging therapeutic modalities. Cell. 169:985–999. 2017. View Article : Google Scholar : PubMed/NCBI

19 

Foulquier S, Daskalopoulos EP, Lluri G, Hermans KCM, Deb A and Blankesteijn WM: WNT signaling in cardiac and vascular disease. Pharmacol Rev. 70:68–141. 2018. View Article : Google Scholar

20 

Badimon L and Borrell-Pages M: Wnt signaling in the vessel wall. Curr Opin Hematol. 24:230–239. 2017. View Article : Google Scholar : PubMed/NCBI

21 

Christman MA II, Goetz DJ, Dickerson E, McCall KD, Lewis CJ, Benencia F, Silver MJ, Kohn LD and Malgor R: Wnt5a is expressed in murine and human atherosclerotic lesions. Am J Physiol Heart Circ Physiol. 294:H2864–H2870. 2008. View Article : Google Scholar : PubMed/NCBI

22 

Malgor R, Bhatt PM, Connolly BA, Jacoby DL, Feldmann KJ, Silver MJ, Nakazawa M, McCall KD and Goetz DJ: Wnt5a, TLR2 and TLR4 are elevated in advanced human atherosclerotic lesions. Inflamm Res. 63:277–285. 2014. View Article : Google Scholar :

23 

Tsaousi A, Mill C and George SJ: The Wnt pathways in vascular disease: Lessons from vascular development. Curr Opin Lipidol. 22:350–357. 2011. View Article : Google Scholar : PubMed/NCBI

24 

Lee DK, Nathan Grantham R, Trachte AL, Mannion JD and Wilson CL: Activation of the canonical Wnt/beta-Catenin pathway enhances monocyte adhesion to endothelial cells. Biochem Biophys Res Commun. 347:109–116. 2006. View Article : Google Scholar : PubMed/NCBI

25 

Ma S, Yao S, Tian H, Jiao P, Yang N, Zhu P and Qin S: Pigment epithelium-derived factor alleviates endothelial injury by inhibiting Wnt/β-Catenin pathway. Lipids Health Dis. 16:312017. View Article : Google Scholar

26 

Quasnichka H, Slater SC, Beeching CA, Boehm M, Sala-Newby GB and George SJ: Regulation of smooth muscle cell proliferation by beta-catenin/T-cell factor signaling involves modulation of cyclin D1 and p21 expression. Circ Res. 99:1329–1337. 2006. View Article : Google Scholar : PubMed/NCBI

27 

Tsaousi A, Williams H, Lyon CA, Taylor V, Swain A, Johnson JL and George SJ: Wnt4/β-Catenin signaling induces VSMC proliferation and is associated with intimal thickening. Circ Res. 108:427–436. 2011. View Article : Google Scholar : PubMed/NCBI

28 

Luo S, Pan Z, Liu S, Yuan S and Yan N: Sphingomyelin synthase 2 overexpression promotes cisplatin-induced apoptosis of HepG2 cells. Oncol Lett. 15:483–488. 2018.PubMed/NCBI

29 

Chengye Z, Daixing Z, Qiang Z and Shusheng L: PGC-1-related coactivator (PRC) negatively regulates endothelial adhesion of monocytes via inhibition of NF κB activity. Biochem Biophys Res Commun. 439:121–125. 2013. View Article : Google Scholar : PubMed/NCBI

30 

Song Z, Liu Y, Hao B, Yu S, Zhang H, Liu D, Zhou B, Wu L, Wang M, Xiong Z, et al: Ginsenoside Rb1 prevents H2O2-induced HUVEC senescence by stimulating sirtuin-1 pathway. PLoS One. 9:e1126992014. View Article : Google Scholar : PubMed/NCBI

31 

Livak KJ and Schmittgen TD: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) method. Methods. 25:402–408. 2001. View Article : Google Scholar

32 

Zhang D, Wang Y, Dai Y, Wang J, Suo T, Pan H and Liu H, Shen S and Liu H: Downregulation of RIP140 in hepatocellular carcinoma promoted the growth and migration of the cancer cells. Tumour Biol. 36:2077–2085. 2015. View Article : Google Scholar

33 

Lou B, Dong J, Li Y, Ding T, Bi T, Li Y, Deng X, Ye D and Jiang XC: Pharmacologic inhibition of sphingomyelin synthase (SMS) activity reduces apolipoprotein-B secretion from hepatocytes and attenuates endotoxin-mediated macrophage inflammation. PLoS One. 9:e1026412014. View Article : Google Scholar : PubMed/NCBI

34 

Duan J, Yu Y, Li Y, Yu Y, Li Y, Zhou X, Huang P and Sun Z: Toxic effect of silica nanoparticles on endothelial cells through DNA damage response via chk1-dependent G2/M checkpoint. PLoS One. 8:e620872013. View Article : Google Scholar : PubMed/NCBI

35 

Arlian LG, Elder BL and Morgan MS: House dust mite extracts activate cultured human dermal endothelial cells to express adhesion molecules and secrete cytokines. J Med Entomol. 46:595–604. 2009. View Article : Google Scholar : PubMed/NCBI

36 

Han R, Tang F, Lu M, Xu C, Hu J, Mei M and Wang H: Astragalus polysaccharide ameliorates H2O2-induced human umbilical vein endothelial cell injury. Mol Med Rep. 15:4027–4034. 2017. View Article : Google Scholar : PubMed/NCBI

37 

Wang YK, Hong YJ, Wei M, Wu Y, Huang ZQ, Chen RZ and Chen HZ: Curculigoside attenuates human umbilical vein endothelial cell injury induced by H2O2. J Ethnopharmacol. 132:233–239. 2010. View Article : Google Scholar : PubMed/NCBI

38 

Liu M, Yu P, Jiang H, Yang X, Zhao J, Zou Y and Ge J: The essential role of Pin1 via NF-κB signaling in vascular inflammation and atherosclerosis in ApoE−/− mice. Int J Mol Sci. 18:E6442017. View Article : Google Scholar

39 

Liu M, Yu Y, Jiang H, Zhang L, Zhang PP, Yu P, Jia JG, Chen RZ, Zou YZ and Ge JB: Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis. Acta Pharmacol Sin. 34:830–836. 2013. View Article : Google Scholar : PubMed/NCBI

40 

Chen Y and Cao Y: The sphingomyelin synthase family: Proteins, diseases and inhibitors. Biol Chem. 398:1319–1325. 2017. View Article : Google Scholar : PubMed/NCBI

41 

Wang N, Huo R, Cai B, Lu Y, Ye B, Li X, Li F and Xu H: Activation of Wnt/β-Catenin signaling by hydrogen peroxide transcriptionally inhibits NaV1.5 expression. Free Radic Biol Med. 96:34–44. 2017. View Article : Google Scholar

42 

Liu P, Su J, Song X and Wang S: Activation of nuclear β-Catenin/c-Myc axis promotes oxidative stress injury in strep-tozotocin-induced diabetic cardiomyopathy. Biochem Biophys Res Commun. 493:1573–1580. 2017. View Article : Google Scholar : PubMed/NCBI

43 

Tao J, Chen BD, Ma YT, Yang YN, Li XM, Ma X, Yu ZX, Liu F, Xiang Y and Chen Y: FrzA gene protects cardiomyocytes from H2O2-induced oxidative stress through restraining the Wnt/frizzled pathway. Lipids Health Dis. 14:902015. View Article : Google Scholar

44 

Thakkar S, Wang X, Khaidakov M, Dai Y, Gokulan K, Mehta JL and Varughese KI: Structure-based design targeted at LOX-1, a receptor for oxidized low-density lipoprotein. Sci Rep. 5:167402015. View Article : Google Scholar : PubMed/NCBI

45 

Yao Y, Wang Y, Zhang Y and Liu C: Klotho ameliorates oxidized low density lipoprotein (ox-LDL)-induced oxidative stress via regulating LOX-1 and PI3K/Akt/eNOS pathways. Lipids Health Dis. 16:772017. View Article : Google Scholar : PubMed/NCBI

46 

Luberto C and Hannun YA: Sphingomyelin synthase, a potential regulator of intracellular levels of ceramide and diacylglycerol during SV40 transformation. Does sphingomyelin synthase account for the putative phosphatidylcholine-specific phospholipase C. J Biol Chem. 273:14550–14559. 1998. View Article : Google Scholar : PubMed/NCBI

47 

Yang Z, Kim S, Mahajan S, Zamani A and Faccio R: Phospholipase cγ1 (PLCγ1) controls osteoclast numbers via colony-stimulating factor 1 (csf-1)-dependent diacylglycerol/β-catenin/cyclind1 pathway. J Biol Chem. 292:1178–1186. 2017. View Article : Google Scholar

Related Articles

  • Abstract
  • View
  • Download
  • Twitter
Copy and paste a formatted citation
Spandidos Publications style
Zhang P, Hua L, Hou H, Du X, He Z, Liu M, Hu X and Yan N: Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. Int J Mol Med 42: 3344-3354, 2018.
APA
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M. ... Yan, N. (2018). Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. International Journal of Molecular Medicine, 42, 3344-3354. https://doi.org/10.3892/ijmm.2018.3888
MLA
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M., Hu, X., Yan, N."Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway". International Journal of Molecular Medicine 42.6 (2018): 3344-3354.
Chicago
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M., Hu, X., Yan, N."Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway". International Journal of Molecular Medicine 42, no. 6 (2018): 3344-3354. https://doi.org/10.3892/ijmm.2018.3888
Copy and paste a formatted citation
x
Spandidos Publications style
Zhang P, Hua L, Hou H, Du X, He Z, Liu M, Hu X and Yan N: Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. Int J Mol Med 42: 3344-3354, 2018.
APA
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M. ... Yan, N. (2018). Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway. International Journal of Molecular Medicine, 42, 3344-3354. https://doi.org/10.3892/ijmm.2018.3888
MLA
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M., Hu, X., Yan, N."Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway". International Journal of Molecular Medicine 42.6 (2018): 3344-3354.
Chicago
Zhang, P., Hua, L., Hou, H., Du, X., He, Z., Liu, M., Hu, X., Yan, N."Sphingomyelin synthase 2 promotes H2O2-induced endothelial dysfunction by activating the Wnt/β-catenin signaling pathway". International Journal of Molecular Medicine 42, no. 6 (2018): 3344-3354. https://doi.org/10.3892/ijmm.2018.3888
Follow us
  • Twitter
  • LinkedIn
  • Facebook
About
  • Spandidos Publications
  • Careers
  • Cookie Policy
  • Privacy Policy
How can we help?
  • Help
  • Live Chat
  • Contact
  • Email to our Support Team