Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)

  • Authors:
    • Chongyang Ma
    • Shuling Liu
    • Shuang Zhang
    • Tian Xu
    • Xue Yu
    • Yushan Gao
    • Changming Zhai
    • Changxiang Li
    • Chaofang Lei
    • Shuning Fan
    • Yuxi Chen
    • Huiling Tian
    • Qingguo Wang
    • Fafeng Cheng
    • Xueqian Wang
  • View Affiliations

  • Published online on: October 2, 2018     https://doi.org/10.3892/ijmm.2018.3911
  • Pages: 2979-2990
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Abstract

Ischemic stroke is one of the main causes of death and disablement globally. The NLR family pyrin domain containing 3 (NLRP3) inflammasome is established as a sensor of detecting cellular damage and modulating inflammatory responses to injury during the progress of ischemic stroke. Inhibiting or blocking the NLRP3 inflammasome at different stages, including expression, assembly, and secretion, may have great promise to improve the neurological deficits during ischemic stroke. The current review provides a comprehensive summary of the current understanding in the literature of the molecular structure, expression, and assembly of the NLRP3 inflammasome, and highlights its potential as a novel therapeutic target for ischemic stroke.
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December-2018
Volume 42 Issue 6

Print ISSN: 1107-3756
Online ISSN:1791-244X

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Copy and paste a formatted citation
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Spandidos Publications style
Ma C, Liu S, Zhang S, Xu T, Yu X, Gao Y, Zhai C, Li C, Lei C, Fan S, Fan S, et al: Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review). Int J Mol Med 42: 2979-2990, 2018
APA
Ma, C., Liu, S., Zhang, S., Xu, T., Yu, X., Gao, Y. ... Wang, X. (2018). Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review). International Journal of Molecular Medicine, 42, 2979-2990. https://doi.org/10.3892/ijmm.2018.3911
MLA
Ma, C., Liu, S., Zhang, S., Xu, T., Yu, X., Gao, Y., Zhai, C., Li, C., Lei, C., Fan, S., Chen, Y., Tian, H., Wang, Q., Cheng, F., Wang, X."Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)". International Journal of Molecular Medicine 42.6 (2018): 2979-2990.
Chicago
Ma, C., Liu, S., Zhang, S., Xu, T., Yu, X., Gao, Y., Zhai, C., Li, C., Lei, C., Fan, S., Chen, Y., Tian, H., Wang, Q., Cheng, F., Wang, X."Evidence and perspective for the role of the NLRP3 inflammasome signaling pathway in ischemic stroke and its therapeutic potential (Review)". International Journal of Molecular Medicine 42, no. 6 (2018): 2979-2990. https://doi.org/10.3892/ijmm.2018.3911